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INDONESIA
IDJP (Indonesian Journal of Pharmaceutics)
Published by Universitas Padjadjaran
ISSN : -     EISSN : 25978748     DOI : -
Core Subject :
The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 5, Issue 3, Sept - Dec 2023" : 5 Documents clear
Review Article: Advancing Cancer Treatment With Mesoporous Silica Nanoparticle-Based Theranostics Wirawan, Delphine; Hulwana, Alfa Fildzah; Herdiana, Yedi
Indonesian Journal of Pharmaceutics Vol 5, Issue 3, Sept - Dec 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.56808

Abstract

Cancer is a major cause of death globally. It is often detected at a late stage, whileconventional treatments are more effective during the early and middle stages.These traditional treatments also cause many side effects due to the lack oftargeted delivery. Nanotechnology, particularly mesoporous silica nanoparticles(MSNs), has been investigated for cancer treatment and diagnosis. Theranostics,which combine therapy and diagnostics, can provide simultaneous treatment anddetection, potentially lowering mortality rates. A literature review was conductedusing keywords such as mesoporous silica nanoparticles, cancer, diagnosis, andtherapy in online databases like PubMed. The results of this review were analyzedand compared with existing literature, aiming to provide a comprehensiveoverview of mesoporous silica nanoparticles as current cancer treatment anddiagnosis.Keywords: MSNs, cancer, theranostic, therapy, literature.
Optimization Matrix Formulas Using Hypromellose and Carboxymethylcellulose Sodium for Metformin HCl Extended Release Caplets Andrie, Agus; Kurniawan Syah, Insan Sunan; Chaerunisaa, Anis Yohana
Indonesian Journal of Pharmaceutics Vol 5, Issue 3, Sept - Dec 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i3.53135

Abstract

The first-line pharmacological therapy in type II diabetes patients in people who are overweight and have normal kidney function is metformin. However, metformin with immediate release has been found to have some weaknesses, namely that a maximum dose of 2,000 mg/day requires use 2 to 3 times a day, which leads to a potential patient's non-compliance, in addition to causing disorders in the intestinal tract. To overcome this problem, a formulation was developed that was modified with extended release using the direct compressed method. This study aims to determine the influence of variations in the concentration of hypromellose and carboxymethylcellulose natrium (Na-CMC) matrices in the extended-release of metformin HCl 500 mg to obtain an optimal and similar extended-release system capsule formula to the originator drug, as well as to prove the quality of the selected formula through stability monitoring. This research is expected to produce the optimum formula for metformin HCl capsules extended release and can be applied in the pharmaceutical industry into commercial products.Keywords: Diabetes, Metformin HCl, Extended release, Direct compressed,                     Hypromellose, Carboxymethylcellulose natrium.
Formulation and Characterization of Tretinoin Nanostructured Lipid Carriers Using Apifil and Cremophore Jafar, Garnadi; Putriyanti, Al-fira; Muhsinin, Soni
Indonesian Journal of Pharmaceutics Vol 5, Issue 3, Sept - Dec 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i3.54349

Abstract

The most widely used vitamin A derivative for mild to severe acne is tretinoin. However, it is lipophilic (LogP 6.3). Tretinoin must be transformed into liquid lipids and NLC (nanostructured lipid carriers) based on Apifil® and stabilized by surfactants to address permeability and stability concerns. Heat homogenization and sonication with a sonicator probe were used to formulate tretinoin into NLC. Apifil®, Myritol®, and Chremophore® RH 40 were the materials utilized. Particle size, polydispersity index, zeta potential, adsorption effectiveness, and morphological measurements were then used to describe NLC. The characterization results showed that NLC tretinoin has a particle size of <200 nm for 2 measurements over 30 days, a polydispersity index value of 0.5, a zeta potential range of -7 mV to -19.3 mV, and an efficiency entrapment value of >80% for all formulas. Spherical shape emerged from the morphology data. Conclusion: The findings demonstrate that tretinoin's nanostructured lipid carriers provide favorable characterization outcomes. Keywords: Diabetes, Metformin HCl, Extended release, Direct compressed,                     Hypromellose, Carboxymethylcellulose natrium.
Formulation and Evaluation Of Poly Herbal Anti-Diabetic Capsule Dosage Form Aggrey, Ernest; Ofori-Kwakye, Ph.D.,, Kwabena; Johnson, Ph.D.,, Raphael; El Boakye-Gyasi, Ph.D.,, Mariam; Asantewaa Osei, Ph.D., Yaa
Indonesian Journal of Pharmaceutics Vol 5, Issue 3, Sept - Dec 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.54973

Abstract

Traditional herbal liquid remedies may be converted into solid dosage forms for enhanced product stability, patient convenience and compliance. Hidden Treasure mixture (HTM) is an herbal decoction produced and used by Hidden Treasure Herbal Clinic(HTHC) in Ghana for the management of diabetes. The objective of the study was to transform the HTM herbal decoction into oral capsules. The amount of dried extract per dose (120 ml) of HTM decoction was determined together with the maximum wavelength of absorption. Different adsorbents were incorporated in the HTM extract at 75, 150, 225 and 300 mg per dose of HTM to facilitate adsorption of water and enhance the processing of the dried extracts. The adsorbent-HTM extract mix were dried in hot air oven at 60 ºC for 72 hours and subsequently processed into granules by dry granulation. The granules were evaluated for their ease of scrapping and processing, percentage loss in weight, flow properties and dissolution in aqueous medium. The weight of dried extract per dose was 350 mg. Light magnesium carbonate produced granules with the best ease of scrapping and processing and showed optimum release of 80.29% at 75 mg per dose. A maximum weight of 560 mg of HTM granules were used to fill size O capsule shells. Using LMC as adsorbent, the adsorbent-HTM granules were processed into capsules with talc and lactose as glidant and diluent respectively. The HTM capsules produced passed the stipulated British Pharmacopoeia quality control tests for hard capsules and can be used as replacement for the HTM decoction.Keywords: Decoction, Adsorbent extract-mix, Dry granulation, percent release,Granules.
Determination of Standard Parameters and Phytochemical Screening of Ethanol Extract of Burdock Root (Arctium lappa L.) Aliifah, Maitsa Wafaa; Nurdianti, Lusi; Wildan Muhtar, Mohammad; Arif Maulana Yusuf, Fitra; Octavia, Tasya; Nur Fadilah, Yayang
Indonesian Journal of Pharmaceutics Vol 5, Issue 3, Sept - Dec 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i3.52738

Abstract

Gobo root (Arctium lappa L.) is one plant that is empirically used to lower blood sugar levels. The phytochemical content and standard parameters of Gobo root ethanol extract were investigated in this study. The maceration method was used to extract the samples using 70% ethanol solvent. The thick extract was obtained by evaporation. The percentage yield of gobo root extract (Arctium lappa L.) obtained was 46.24%. The results of organoleptic (macroscopic) examination produce blackish-brown extracts, thick, slightly sour taste, and a distinctive smell. Furthermore, phytochemical screening tests were carried out and determination of extract standard parameters which included water-soluble pollen, ethanol-soluble juice, drying shrinkage, water content, and total ash content. Obtained chemical compounds from gobo root extract, namely alkaloids, flavonoids, tannins, polyphenols, and triterpenoids. The results of determining the standard parameters of gobo root extract showed the value of water soluble juice content of 84.55% and ethanol soluble juice content of 27.8%.The drying shrinkage value is 25.52%, the moisture content is 5%, and the total ash content is 0.41%.Keywords: Arctium lappa L., Extract standardization, Phytochemical screening,                    Maseration extraction

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