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Prayogo, Fitra Adi
Biomedical Sciences Study Program, Karya Husada University, Jl. R. Kompol Soekanto No.46, Semarang 50276, Indonesia
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HARNESSING THE POTENTIAL OF ASTAXANTHIN FROM Haematococcus pluvialis IN BIOMEDICAL SCIENCE: A NARRATIVE REVIEW Fitra Adi Prayogo; Mellyaning Oktavia Sonya Kirana Sari; Ni Nyoman Maryaningtyas Adinatha
Journal of Biomedical Sciences and Health (JBSH) Volume 2 Nomor 1 Bulan Februari 2025
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/bp77ad50

Abstract

Astaxanthin merupakan karotenoid bernilai tinggi dengan berbagai aplikasi, salah satunya dalam bidang ilmu biomedis. Haematococcus pluvialis dianggap sebagai sumber astaxanthin alami yang paling menjanjikan karena dapat mengakumulasi hingga 5% dari berat keringnya dalam kondisi yang penuh tekanan. Potensi aplikasi astaxanthin dalam biomedis sangat luas. Dari efek neuroprotektif hingga sifat antikanker dan manfaat kardiovaskularnya, astaxanthin telah menunjukkan janji dalam mengatasi beberapa tantangan kesehatan yang paling mendesak. Selain itu, sifat antiinflamasinya dan kemampuannya untuk memodulasi berbagai jalur pensinyalan semakin menggarisbawahi potensinya sebagai agen terapeutik. Tinjauan naratif ini memberikan sintesis komprehensif dari penelitian terkini tentang astaxanthin, merinci sifat biologisnya, tantangan budidaya, dan aplikasi terapeutik yang luas. Wawasan utama meliputi efek neuroprotektif, antiinflamasi, antikanker, dan kardioprotektifnya, yang didukung oleh struktur molekulnya yang unik dan sifat amfifiliknya. Dengan mengevaluasi secara kritis kemajuan terkini dalam teknik budidaya, ekstraksi, dan formulasi, tinjauan ini mengidentifikasi keterbatasan saat ini dan menguraikan berbagai kemungkinan untuk penelitian di masa mendatang. Secara keseluruhan, astaxanthin merupakan agen multifaset dengan potensi klinis yang signifikan, yang memerlukan penelitian lebih lanjut untuk mengoptimalkan bioavailabilitas dan kemanjuran terapeutiknya..   Kata kunci: Astaxanthin; Haematococcus pluvialis; Antioksidan; Aplikasi biomedis   ABSTRACT Astaxanthin is a high-value carotenoid with various applications, one of which is in biomedical science. Haematococcus pluvialis is considered the most promising source of natural astaxanthin as it can accumulate up to 5% of its dry weight under stressful conditions. The potential applications of astaxanthin in biomedicine are vast. From its neuroprotective effects to its anticancer properties and cardiovascular benefits, astaxanthin has shown promise in addressing some of the most pressing health challenges. Moreover, its anti-inflammatory properties and ability to modulate various signaling pathways further underscore its potential as a therapeutic agent. This narrative review provides a comprehensive synthesis of current research on astaxanthin, detailing its biological properties, cultivation challenges, and wide-ranging therapeutic applications. Key insights include its neuroprotective, anti-inflammatory, anti-cancer, and cardioprotective effects, underpinned by its unique molecular structure and amphiphilic nature. By critically evaluating recent advancements in cultivation, extraction, and formulation techniques, this review identifies current limitations and outlines potential avenues for future research. Overall, astaxanthin represents a multifaceted agent with significant clinical potential, warranting further studies to optimize its bioavailability and therapeutic efficacy. Keywords: Astaxanthin; Haematococcus pluvialis; Antioxidant; Biomedical applications
Co-Authors Adinatha, Ni Nyoman Maryaningtyas Agung Suprihadi AMELIA, POPPY FRANSISCA Anto Budiharjo Anto Budiharjo Benjarat Bunterngsook Budi Raharjo Budiatmoko, Aurelia Wibowo Budiharjo Anto Budiharjo, Anto - Dyah Wulandari Dyah Wulandari Edwin Setiawan Heni Wijayanti, Heni Hermin Pancasakti Kusumaningrum Huda, Muhammad Badrul Hwang, Chin-Fa Irfanul chakim, Irfanul Iswandilevani, Atalia Nilam Mellyaning Oktavia Sonya Kirana Sari Michael Einstein Hermanto Ni Nyoman Maryaningtyas Adinatha Novita Rahmawati, Novita Novita Sari Pattanop Kanokratana Riani Catur Royhanaty, Isy Sonya Kirana Sari, Mellyaning Oktaviani Yanuar Ahmad