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All Journal Paediatrica Indonesiana Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Diponegoro International Medical Journal (DIMJ) Jurnal Pemberdayaan Masyarakat Plexus Medical Journal Dirasat: Journal Islamic Studies
Iffa Mutmainah
Division Of Human Genetics, Center For Biomedical Research (CEBIOR), Diponegoro University Medical School, Semarang, Indonesia, And The Department Of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands
Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Clinical and molecular analysis of Noonan syndrome in Indonesia: a case report Iffa Mutmainah; Willy Nillesen; Farmaditya Mundhofir; Tri Winarni; Ineke van der Burgt; Helger Yntema; Sultana Faradz
Paediatrica Indonesiana Vol 56 No 1 (2016): January 2016
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (488.374 KB) | DOI: 10.14238/pi56.1.2016.62-6

Abstract

Noonan syndrome (NS; OMIM#163950) is a relatively common autosomal dominant disorder with a worldwide prevalence of approximately 1:1,000 to 1:2,500. The syndrome is characterized by distinctive facial features, congenital heart defects (CHD), and short stature. Distinctive facial features consist of a broad and high forehead, hypertelorism, downslanting palpebral fissures, a high arched palate, low set and posteriorly rotated ears with a thick helix, and a short neck with excess nuchal skin and low posterior hairline. Additional relatively frequent features include chest deformities, cryptorchidism in males, mild intellectual disability, and bleeding diathesis.1,2In 2001, missense mutations in
A COVID-19 Ringan Pada Tenaga Medis: Evaluasi Temuan Klinis dan Risiko Transmisi Mahrani; Hana Khairina Putri Faisal; Paramita Khairan; Iffa Mutmainah; Fitriana Nur Rahmawati; Sarah Shafa Marwadhani; Gadistya Novitri Adinda; Uti Sari; Pukovisa Prawirohardjo
Majalah Kedokteran Indonesia Vol 70 No 4 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.4-2020-223

Abstract

Objective: Since December 2019, COVID-19 has become a global concern causing more than thousands of deaths worldwide. The major challenge in fighting against this new emerging disease is the limited data regarding the heterogeneity of its clinical and epidemiological features. We aim to fill this knowledge gap by evaluating a mild case of COVID-19 infecting a health worker in Indonesia.Method: We report a 31-year-old male doctor who was hospitalized for mild pneumonia with positive SARS-CoV-2 swab testResult: This case presents an estimated incubation period of 2 days. The patient showed mild upper respiratory symptoms without significant pneumonia symptoms, however mild pneumonia was confirmed by the presence of fever and pulmonary infiltrates on imaging. Despite the seemingly mild symptoms, there was a complex systemic reaction as thrombocytopenia and elevated aminotransferase enzyme occurred. The patient is a health worker susceptible to SARS-CoV-2 transmission with a close contact history with a suspected COVID-19 patient, without wearing an adequate personal protective equipment (PPE).Conclusion: Patients with mild presentation of COVID-19 could exhibit a complex systemic reaction and organ injury. The use of an appropriate PPE among health workers is crucial to prevent patient-to-doctor transmission.
Empowering Digital Literacy through Computational Thinking, AI, and Renewable Energy in a Water-Scarce School Medria Kusuma Dewi Hardhienata; Wulandari Wulandari; Sheila Tobing; Andrew Schauf; Sita Rahmani; Gabriella Lumban Siantar; Hafidlotul Fatimah Ahmad; Auzi Asfarian; Takhta Pandu Padmanagara; Emir Raya Syuhada; Syaefudin Suminto; Iffa Mutmainah
Jurnal Pemberdayaan Masyarakat Vol 5, No 2 (2026)
Publisher : Yayasan Keluarga Guru Mandiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46843/jpm.v5i2.703

Abstract

Ongoing advances in digital technology require teachers to adapt and develop their technological competence continuously. However, a gap in technological understanding remains between teachers in rural and urban areas, particularly in Indonesia. SMA Negeri 1 Sukanagara, as the only public high school in its region, faces challenges related to water scarcity and limited access to energy, which affect both learning activities and the school community's basic needs. This community service program aims to enhance teachers' digital literacy through training in Computational Thinking (CT), Artificial Intelligence (AI), and Renewable Energy prior to the implementation of a smart rainwater-harvesting system at the school. The methods used included a survey, training sessions, and evaluation using a problem-based approach combined with pre-test and post-test assessments. A problem-based learning approach confirmed that the CT training had helped teachers to develop more structured problem-solving skills. Results of the test also show that AI and Renewable Energy training improved participants' understanding by an average of 17.08% and 14.28%, respectively, compared to their initial scores. These improvements demonstrate the potential of training programs like these to enhance teachers' understanding and better prepare them for implementing emerging technologies in schools.
TUMA’NINAH DALAM AL-QUR’AN SEBAGAI LANDASAN PENDIDIKAN JIWA: KAJIAN TAFSIR TARBAWI Isma Muhsonah; Iffa Mutmainah; Irfa Afrini
Dirasat: Journal Islamic Studies Vol. 3 No. 1, April (2026): Dirasat: Journal Islamic Studies
Publisher : STAI Dirosat Islamiyah Al-Hikmah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71287/dirasat.v3i1, April.642

Abstract

Mental health has become a global issue that is receiving increasing attention across various levels of society. Modern clinical psychology has contributed significantly to the understanding and addressing of various mental disorders through scientific approaches, behavioral therapy, and medical interventions. However, within Muslim societies, these approaches are not considered fully capable of responding to the needs of the human soul in a holistic manner, because aspects of faith and spirituality are often not placed at the center of mental development. This qualitative descriptive literature review positions the Qur’an as the primary source, particularly verses related to the concept of tuma’ninah. Secondary sources include authoritative works of Qur’anic exegesis and tafsir. Based on a tafsir tarbawi analysis of Qur’anic verses, tuma’ninah represents the true tranquility of the soul rooted in faith, dhikr, righteous deeds, and spiritual closeness to Allah. Tuma’ninah is not merely a temporary emotional condition but an inner stability that arises through an integral process of soul education, including the strengthening of creed, tazkiyatun nafs, spiritual formation, and comprehensive psychological management. Thus, tuma’ninah serves as an indicator of the success of Qur’anic education for the soul.
Efek Asam Klorogenat pada Ekspresi Mrna IL-6 dan CD86 Lobus Frontal Tikus Model Diabetes Mellitus Fauziyatul Munawaroh; Aisyah Amanda Hanif; Asri Ragil Kemuning; Iffa Mutmainah; Yenny Rachmawati; Naufal Muharam Nurdin
Plexus Medical Journal Vol. 3 No. 4 (2024): Agustus
Publisher : Fakultas Kedokteran, Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/plexus.v3i4.1815

Abstract

Pendahuluan: Diabetes Mellitus (DM) merupakan penyakit kronik dengan berbagai komplikasi, salah satunya yaitu Encephalopati Diabetikum (ED). Hiperglikemia pada DM akan mengakibatkan neuroinflamasi melalui jalur M1 proinflamatorik. Beberapa agen proinflamatori akan meningkat dengan aktifnya jalur ini, seperti IL-6. Neuroglia kemudian teraktivasi dan mengekspresikan CD86 pada membran sel. Asam klorogenat (CGA) merupakan senyawa polyphenol pada kopi  yang  memiliki  efek antiinflamasi.  Tujuan penelitian ini adalah untuk memperjelas efek CGA pada aktivasi mikroglia jalur M1 dengan melihat ekspresi mRNA IL-6 dan CD86 pada lobus frontal tikus dengan model DM. Metode: 24 ekor tikus jantan secara acak dibagi menjadi enam kelompok yaitu :  kontrol,   DM 1,5 bulan dan DM 2 bulan,  dan kelompok dengan pemberian  CGA dengan  tiga  dosis  berbeda  (CGA1,  CGA2,  CGA3).  Jaringan lobus frontal diambil untuk analisa ekspresi mRNA IL-6 dan CD86 menggunakan RT-PCR. Hasil: Ekspresi mRNA IL-6 lobus frontal berbeda signifikan antara kelompok kontrol dengan DM1,5 (p=0.010); kontrol dengan DM2 (p=0.001); kelompok DM2 dengan CGA2 (p=0.028). Ekspresi mRNA CD86 lobus frontal trdapat perbedaan signifikan antara kelompok kontrol dengan semua kelompok DM, baik dengan CGA atau tanpa CGA (p<0.05). Kelompok DM2 berbeda signifikan dengan kelompok CGA2 (p=0.000) dan kelompok CGA3 (p=0,000). Kesimpulan: Ekspresi mRNA penanda jaras proinflamatorik M1 (IL-6 dan CD86) pada neuroinflamasi lobus frontal akibat DM lebih rendah setelah pemberian CGA dengan dosis 25 mg/KgBB.
KONSEP PEMAAFAN (FORGIVENESS) DALAM AL-QUR'AN DAN HADITS SEBAGAI UPAYA MENJAGA KESEHATAN MENTAL GEN Z Isma Muhsonah; Irfa Afrini; Iffa Mutmainah
Dirasat: Journal Islamic Studies Vol. 2 No. 1, April (2025): Dirasat: Journal Islamic Studies
Publisher : STAI Dirosat Islamiyah Al-Hikmah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71287/dirasat.v2i1, April.375

Abstract

ABSTRAK Generasi Z (Gen Z), yang lahir antara pertengahan 1990-an hingga awal 2010-an, tumbuh dalam lingkungan digital yang serba cepat dan terhubung, namun menghadapi tantangan serius terkait kesehatan mental seperti depresi, kecemasan, dan ketergantungan teknologi. Artikel ini bertujuan untuk mengkaji konsep pemaafan (forgiveness) dalam perspektif Al-Qur’an dan Hadits, serta relevansinya sebagai mekanisme koping spiritual dalam menjaga kesehatan mental Gen Z. Melalui pendekatan kualitatif berbasis studi pustaka, artikel ini menelaah makna pemaafan berdasarkan ayat-ayat Al-Qur’an seperti QS. An-Nur: 22, QS. Ali Imran: 134, dan QS. Yusuf: 92 serta beberapa hadits shahih, yang menunjukkan bahwa memaafkan merupakan bagian dari akhlak mulia, sarana pengendalian emosi, dan jalan menuju ampunan Allah. Kisah-kisah tokoh Islam seperti Abu Bakar RA dan Aisyah RA dijadikan rujukan historis bagaimana pemaafan diterapkan secara konkret dalam kehidupan sosial. Temuan artikel ini menegaskan bahwa pemaafan bukan hanya ajaran moral, tetapi juga strategi spiritual yang efektif dalam mengatasi konflik interpersonal, mengelola emosi negatif, dan membentuk ketahanan psikologis pada Generasi Z. Oleh karena itu, integrasi nilai-nilai Islam dalam pendidikan emosional menjadi langkah penting dalam mencetak generasi yang sehat secara mental dan tangguh secara spiritual.
Erythrocyte Indices for Beta-thalassemia Trait (BTT) Screening in Indonesia: A Scoping Review Iffa Mutmainah; Asri Ragil Kemuning; Widya Eka Nugraha; Aisyah Amanda Hanif; Anna Vipta Resti Mauludyani
Diponegoro International Medical Journal Vol 6, No 1 (2025): July 2025
Publisher : Faculty of Medicine, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dimj.v6i1.27771

Abstract

Background: Thalassemia is a monogenic disorder that ranks fifth among the catastrophic diseases in Indonesia. Thalassemia screening plays an important role in preventing the birth of individuals with thalassemia major. Numerous erythrocyte indices have been used as first-line screening methods for beta-thalassemia trait, preceding definitive analysis using hemoglobin electrophoresis.Objective: This study aimed to conduct a literature review comparing the most frequently used erythrocyte indices in Indonesia with hemoglobin electrophoresis.Methods: A systematic search was conducted using PubMed, Scopus, EBSCO, and Google Scholar databases in July 2024. This study included full-text articles in Indonesian or English that compared erythrocyte indices and hemoglobin electrophoresis for thalassemia screening.Results: Six articles were included in this review. Two of the six articles analyzed the compatibility of erythrocyte indices and hemoglobin electrophoresis using kappa statistics. The remaining articles calculated the diagnostic values.  Among the ten erythrocyte indices, the Mentzer index was the most frequently assessed, appearing in six studies, followed by the indices of Shine & Lal and Sirdah, each evaluated in three studies. The Green-King, England & Fraser, and Srivastava indices were each examined in two studies. Additionally, Ehsani, Matos and Carvalho, RDW, and MCV and/or MCH indices were each assessed in one study.Conclusion: The compatibility between erythrocyte indices and hemoglobin electrophoresis, based on two studies, was fair indicating that hematological indices alone are insufficient for a definitive diagnosis. This finding aligns with the conclusions of four other studies, which also suggested that no single erythrocyte index is definitive. Among the indices, the Green-King Index demonstrated the highest reliability; however, further studies are needed to support this finding, while hemoglobin electrophoresis remains essential for an accurate diagnosis.
Abses Paru pada COVID-19 Adi Kurniawan; Paramita Khairan; Nurfanida Librianty; Mahrani Mahrani; Hana Faisal; Iffa Mutmainah; Fitriana Nur Rahmawati; Sarah Shafa Marwadhani; Gadistya Novitri Adinda; Uti Nilam Sari; Pukovisa Prawirohardjo
Majalah Kedokteran Indonesia Vol 70 No 8 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.8-2020-255

Abstract

Objective: COVID-19 is a new emerging disease since December 2019 that later was announced by WHO as a global pandemic. Radioimaging appearance of COVID-19 is varied yet dominantly showed as a ground glass appearance in CT-imaging. Lung abscess in COVID-19 is an extremely rare case, therefore it needs further discussion. Method: We report a 39 year-old male patient of COVID-19 with lung abscess.Result: This case report describe a COVID-19 patient who showed a very rare clinical manifestation; lung abscess. The patient showed negative result of TB molecular test. Chest tube insertion procedure was performed in this patient who showed an improvement after abscess being drained. Conclusion: Lung abscess may occur in COVID-19. Abscess drainage procedure may improve clinical condition of COVID-19 patient.
Co-Authors Adi Kurniawan Ahmad, Hafidlotul Fatimah Aisyah Amanda Hanif Andrew Schauf Anna Vipta Resti Mauludyani Asri Ragil Kemuning Auzi Asfarian Emir Raya Syuhada Faisal, Hana Khairina Putri Farmaditya Mundhofir Fauziyatul Munawaroh Fitriana Nur Rahmawati Fitriana Nur Rahmawati Gabriella Lumban Siantar Gadistya Novitri Adinda Gadistya Novitri Adinda Hardhienata, Medria Kusuma Dewi Helger Yntema Ineke van der Burgt Irfa Afrini Irfa Afrini Isma Muhsonah Isma Muhsonah Librianty, Nurfanida Mahrani Mahrani Mahrani Naufal Muharam Nurdin Paramita Khairan Pukovisa Prawirohardjo Pukovisa Prawiroharjo Sarah Shafa Marwadhani Sarah Shafa Marwadhani Sita Rahmani Sultana Faradz Syaefudin Suminto Takhta Pandu Padmanagara Tobing, Sheila Tri Winarni Uti Nilam Sari Uti Sari Widya Eka Nugraha Willy Nillesen Wulandari Wulandari Yenny Rachmawati