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ANTIFUNGAL ACTIVITY POTENTIAL AND VOLATILE COMPOUND PROFILE OF Bacillus sp. HSFI-6 Extract Maya Dian Rakhmawatie; Mazidatu Khoirinnisa’ Adiyanti; Nur Fadhila Sari; Fadhil Widya Dharma Putra; Kanti Ratnaningrum; Ika Dyah Kurniati; Devita Diatri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2026.14982

Antifungal resistance has implications for the development of bioactive compounds. Bacillus sp. has been widely studied for the discovery of antifungal volatile compounds. This study aims to explore the antifungal activity of Bacillus sp. HSFI-6 isolated from sea cucumber (Holothuria scabra Fermented Intestine-HSFI) against Malassezia furfur, Candida albicans, and Aspergillus fumigatus. Bacillus sp. HSFI-6 was identified molecularly by 16S rRNA sequencing. Ethyl acetate extract of Bacillus sp. HSFI-6 was produced using media containing starch, yeast, peptone, and its metabolites were profiled using Gas Chromatography-Mass Spectroscopy (GC-MS). A disc diffusion antifungal assay was performed. Bacillus sp. HSFI-6 has 93.47% similarities with Bacillus albus strain MCCC 102146 and moderately inhibit C. albicans (7.00 ± 1.15 mm), A. fumigatus (9.25 ± 0.96 mm). The GC-MS metabolomics analysis showed two antifungal volatile compounds, namely cycloheptasiloxane, tetradecamethyl- and cyclononasiloxane, octadecamethyl-. These results conclude that Bacillus sp. HSFI-6 is suitable for the development of antifungal drugs.

ANTIFUNGAL ACTIVITY POTENTIAL AND VOLATILE COMPOUND PROFILE OF Bacillus sp. HSFI-6 Extract Maya Dian Rakhmawatie; Mazidatu Khoirinnisa’ Adiyanti; Nur Fadhila Sari; Fadhil Widya Dharma Putra; Kanti Ratnaningrum; Ika Dyah Kurniati; Devita Diatri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2026.14982

Antifungal resistance has implications for the development of bioactive compounds. Bacillus sp. has been widely studied for the discovery of antifungal volatile compounds. This study aims to explore the antifungal activity of Bacillus sp. HSFI-6 isolated from sea cucumber (Holothuria scabra Fermented Intestine-HSFI) against Malassezia furfur, Candida albicans, and Aspergillus fumigatus. Bacillus sp. HSFI-6 was identified molecularly by 16S rRNA sequencing. Ethyl acetate extract of Bacillus sp. HSFI-6 was produced using media containing starch, yeast, peptone, and its metabolites were profiled using Gas Chromatography-Mass Spectroscopy (GC-MS). A disc diffusion antifungal assay was performed. Bacillus sp. HSFI-6 has 93.47% similarities with Bacillus albus strain MCCC 102146 and moderately inhibit C. albicans (7.00 ± 1.15 mm), A. fumigatus (9.25 ± 0.96 mm). The GC-MS metabolomics analysis showed two antifungal volatile compounds, namely cycloheptasiloxane, tetradecamethyl- and cyclononasiloxane, octadecamethyl-. These results conclude that Bacillus sp. HSFI-6 is suitable for the development of antifungal drugs.

Enhancing Success of Stunting Eradication: Risk Factor Identification and Booklet-Based Intervention in Stunting Communities Gharini Sumbaga Narhadina; Devita Diatri; Rifka Widianingrum; Umniatuz Zahroh
Jurnal Empathy Pengabdian Kepada Masyarakat Jurnal Empathy Pengabdian Kepada Masyarakat Volume 6 Number 2 Year 2025
Publisher : Poltekkes Kemenkes Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37341/jurnalempathy.v6i2.347

Background: Stunting is a form of chronic malnutrition that affects growth and development during early life. Stunting remains a government priority, with a target to reduce its prevalence to 14%, yet it continues to rank high in the Lamper Tengah Sub-district. This situation is attributed to the lack of family knowledge regarding the risks and long-term impacts of stunting. Therefore, this program aimed to implement stunting risk screening and a booklet-based intervention entitled “Control of Stunting Risk Factors” within the Stunting Community in Lamper Tengah Sub-district, Semarang City. Methods: This community service activity was carried out in Lamper Tengah Village, targeting 10 families with stunted children. The activity methods included preparation, anthropometric measurements, filling out questionnaires on stunting risk factors, and distributing and presenting the booklet “Stunting Risk Factors.” The evaluation stage was carried out by assessing the mothers' level of knowledge about stunting before and after the intervention. Results: Among stunted toddlers, 60% are female, 60% do not receive exclusive breastfeeding, and only 20% practice responsive feeding. After the intervention, the proportion of families with good knowledge levels increased from 80% before the activity to 100% after the activity. Conclusion: The results of the activities show that this community service program is able to increase mothers' knowledge about the risk factors for stunting. Therefore, similar activities need to be continued and expanded to include more participants, accompanied by in-depth counseling and practical guidance on active feeding practices before pregnancy, during pregnancy, and after childbirth to support efforts to reduce stunting rates in Semarang City.

Peningkatan Pengetahuan dan Gaya Hidup Pasien Hipertensi Melalui Edukasi Audiovisual Devita Diatri; Alif Adlan Zulizar; Romadhoni Romadhoni; Maya Dian Rakhmawatie; Nafi Akbar
Jompa Abdi: Jurnal Pengabdian Masyarakat Vol. 5 No. 1 (2026): Jompa Abdi: Jurnal Pengabdian Masyarakat
Publisher : Yayasan Jompa Research and Development

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57218/jompaabdi.v5i1.2548

Hipertensi merupakan salah satu penyakit tidak menular dengan prevalensi tinggi dan menjadi faktor risiko utama berbagai penyakit kardiovaskular. Di wilayah kerja Puskesmas Tlogosari Wetan, hipertensi tercatat sebagai penyakit dengan jumlah kasus tertinggi, sehingga diperlukan upaya promotif dan preventif berbasis komunitas. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan pemahaman masyarakat mengenai hipertensi dan gaya hidup sehat melalui edukasi kesehatan berbasis audiovisual. Metode pelaksanaan berupa edukasi edukatif-partisipatif yang dilaksanakan secara langsung kepada masyarakat dewasa dan lanjut usia dengan hipertensi atau faktor risiko hipertensi di Kelurahan Tlogosari Wetan. Evaluasi dilakukan menggunakan kuesioner pretest dan posttest tingkat pengetahuan hipertensi serta kuesioner gaya hidup. Hasil kegiatan menunjukkan bahwa sebelum intervensi, tingkat pengetahuan responden masih relatif rendah pada aspek kepatuhan minum obat dan penerapan gaya hidup sehat, serta sebagian besar responden memiliki aktivitas fisik, pola makan, dan kebiasaan istirahat yang belum optimal. Setelah intervensi edukasi, terjadi peningkatan pengetahuan yang signifikan pada seluruh materi yang diberikan, yang diperkuat oleh hasil uji Wilcoxon Signed-Rank (p < 0,05). Kegiatan ini menunjukkan bahwa edukasi kesehatan berbasis audiovisual efektif dalam meningkatkan pengetahuan masyarakat mengenai pengelolaan hipertensi. Disarankan agar kegiatan edukasi serupa dapat dilaksanakan secara berkelanjutan oleh puskesmas dengan melibatkan kader kesehatan untuk mendukung pengendalian hipertensi di tingkat komunitas.

Hubungan Kadar Hemoglobin Dengan Kejadian Ketuban Pecah Dini Di RSUD dr. Adhyatma, MPH Semarang Syarifah Ayu Hashifah Fadhilah Luthfiansah Alqadrie; Muhammad Irsam; Devita Diatri
ANATOMICA MEDICAL JOURNAL | AMJ Vol 9, No 3 (2026)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/amj.v9i3.31105

Ketuban Pecah Dini (KPD) merupakan salah satu faktor yang berkontribusi terhadap angka kematian ibu dan bayi. Kasus KPD terus meningkat dari tahun ketahun dan menjadi faktor risiko timbulnya infeksi yang dapat mengakibatkan kematian pada ibu. Salah satu pemicunya adalah kadar Hb di bawah 11 gr/dL pada ibu hamil yang dapat mengakibatkan hipoksia jaringan dan peningkatan kadar konsentrasi norepinefrin, yang berpotensi memicu stres baik pada ibu maupun janin. Anemia juga berdampak pada regulasi sistem imun, termasuk fungsi sel T dan B. Kaitan antara anemia dan infeksi berawal dari melemahnya aktivitas fagosit serta kemampuan bakterisida, sehingga meningkatkan risiko infeksi yang dapat mengganggu mekanisme degradasi kolagen. Akibatnya, berdampak pada ketidakseimbangan antara matrix metalloproteinase (MMP) dan tissue inhibitor of metalloproteinase (TIMP), yang menyebabkan penurunan kadar kolagen dan memicu respons inflamasi sehingga selaput ketuban lebih mudah mengalami ruptur secara spontan dan pada akhirnya terjadi KPD. Tujuan: Menganalisis adanya Hubungan Kadar Hemoglobin dengan kejadian KPD pada Ibu Hamil di RSUD dr. Adhyatma, MPH Semarang. Metode: Penelitian ini menggunakan metode kuantitatif observasional analitik dengan pendekatan cross sectional. Subjek penelitian ini yaitu ibu hamil dengan usia kehamilan 37 minggu di RSUD dr. Adhyatma, MPH Semarang tahun 2022 dan 2023. Teknik pengambilan data penelitian ini adalah total sampling. Penelitian ini menggunakan data rekam medis dan diolah menggunakan uji chi-square. Total sampel yaitu 195 responden. Hasil: Didapatkan nilai p-value 0.001 (0,05) pada hubungan antara anemia dengan kejadian ketuban pecah dini pada ibu hamil.Kata kunci: ketuban pecah dini dan kadar hemoglobin

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