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All Journal Journal of Food and Pharmaceutical Science Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Sasambo Journal of Pharmacy Journal of Health Science Jurnal Kesehatan Terapan Journal of Food and Pharmaceutical Sciences Jurnal Lantera Ilmiah Kesehatan Journal of Pharmascience
ERISKA AGUSTIN
Universitas Kader Bangsa
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Evaluation and Characterization of Caryophyllene Nanoemulsion Preparations from Clove Oil (Syzigium aromaticum) Eriska Agustin; Whilly Martavinus
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/zz7g4329

Abstract

The clove plant (Syzygium aromaticum) is a plant from the Myrtaceae family. Clove plants can be found in various countries, including Indonesia. The contents of the clove plant have been studied to have beneficial pharmacological effects, one of which is the caryophyllene content in the clove plant which has antioxidant, antibacterial, etc. activities. This research aims to create a formula and evaluate the physical characteristics of a karyophyllene nanoemulsion preparation from clove oil. The method for making nanoemulsion preparations is made into three formulas with varying concentrations of karyophyllene compounds as active substances, namely F0 (0%), F1 (0.5%), and F2 (1%). Evaluation of the preparation includes organoleptic tests, pH tests, particle morphology tests, stability tests, and nanoemulsion globule size tests. The results showed that the nanoemulsion preparations of caryophyllene compounds F0, F1, and F2 had globule sizes of 82 ± 1.45 nm, 95 ± 2.67 nm, 89 ± 1.46 nm on day 1, while on day 28 the globule sizes were 99±2.87 nm, 116±2.56 nm, and 121±1.56 nm. The nanoemulsion preparation is clear white, semi-thick, and has a distinctive aroma. The morphology of the nanoemulsion globules is spherical and homogeneous. All three nanoemulsion formulations demonstrated good physical stability, as indicated by the absence of precipitation, phase separation, and turbidity, as well as pH values within the acceptable range for nanoemulsion systems, despite a slight increase in globule size observed over the 28-day storage period.
Antioxidant activity and formulation evaluation of Morinda citrifolia L.leaf ethanol extract nanoparticles incorporated into moisturizing gel Eriska Agustin; Ranti Ayu Anjelina; Yola Yernianti
Sasambo Journal of Pharmacy Vol. 7 No. 1 (2026): April
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v7i1.679

Abstract

Skin is continuously exposed to environmental stressors such as ultraviolet radiation and pollution, which trigger the formation of reactive oxygen species (ROS) leading to oxidative stress, premature aging, and skin damage. Therefore, the development of topical antioxidant formulations from natural sources has become increasingly important. This study aimed to develop nanoparticles of Morinda citrifolia L. leaf ethanol extract and incorporate them into a moisturizing gel, followed by evaluation of their physicochemical properties and antioxidant activity. The extract was prepared by maceration using 96% ethanol, while nanoparticles were synthesized using the ionic gelation method with chitosan and sodium tripolyphosphate. Particle size, polydispersity index, morphology, and antioxidant activity (DPPH method) were evaluated. The nanoparticles exhibited sizes below 200 nm with a uniform distribution (PDI< 0.3). The optimized formulation showed the smallest particle size (FIII=77.5±6.36 nm) and good stability. Antioxidant activity increased after nanoparticle formulation, with IC₅₀ values decreasing from 182.4±2.26 ppm (extract) to 145.4±6.89 ppm (FIII), indicating moderate activity. The gel formulations showed good physical stability and acceptable viscosity, although pH values were below the ideal skin range. The moisturizing test demonstrated significant improvement in skin hydration. In conclusion, nanoparticle incorporation enhanced antioxidant and moisturizing performance, indicating potential for topical applications.
Formulation and Antibacterial Activity Of a Natural Deodorant Spray Containing Extracts Of Pandanus amaryllifolius (Roxb) and Ocimum bacilicum L. Against Staphylococcus aureus Amelia Soyata; Sephia Panorama; Eriska Agustin
JURNAL LENTERA ILMIAH KESEHATAN Vol. 4 No. 1 (2026): Jurnal Lentera Ilmiah Kesehatan
Publisher : CV. Q2 Lantera Ilmiah Institut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52120/jlik.v4i1.109

Abstract

Body odor is a personal hygiene concern associated with the activity of skin microorganisms that metabolize sweat components into odor producing compounds. Pandan and basil leaves have potential as antibacterial agents. This study aimed to formulate a natural deodorant spray containing a combination of pandan leaf (Pandanus amaryllifolius) and basil leaf (Ocimum bacilicum L.) extracts and to evaluate its physical characteristics, physical stability, and antibacterial activity against Staphylococcus aureus. This laboratory experimental study employed an ethanolic maceration method. The extracts were formulated into deodorant spray preparations at different concentrations: F0 (control), F1 (10%), F2 (20%), and F3 (30%). The formulations were evaluated for organoleptic characteristics, homogeneity, pH, viscosity, spreadability, drying time, physical stability, and antibacterial activity using the disk diffusion method. Each evaluation was performed in triplicate (n=3), and the data were analyzed descriptively. The results showed that all formulations exhibited acceptable physical characteristics and remained stable throughout the observation period. Formula F3 demonstrated the highest antibacterial activity, with an inhibition zone of 39.8 mm, which was larger than that of the positive control. In conclusion, the combination of Pandanus amaryllifolius and Ocimum bacilicum L. extracts has potential for development as a natural ingredient in deodorant spray formulations, exhibiting acceptable physical characteristics, good physical stability, and antibacterial activity against Staphylococcus aureus.
Comparative Study of Nanoparticle and Nanoemulsion of Vernonia amygdalina : Characterization and Pharmacological Activity Eriska Agustin; Rahma Fatmawati; Annisa Syahrani
Jurnal FARMASIMED (JFM) Vol 9 No 1 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v9i1.3729

Abstract

Nanotechnology-based delivery systems have become an effective strategy to enhance the physicochemical properties and biological activity of natural extracts in cosmetic formulations. This study comparatively evaluated nanoparticle (NDA) and nanoemulsion (NEDA) systems containing African leaf extract (Vernonia amygdalina) based on their physical characteristics and pharmacological activity. Nanoparticles were prepared via ionic gelation using Chitosan (15%) and NaTPP (1%), while nanoemulsions were prepared via waterbath sonication using Cremophor® RH (12%), PEG 400 (2%), and Oleic Acid (1%), each at three different concentration ratios. The extract yielded 13.56% with a total flavonoid content of 29.066±0.547 mg QE/g (2.907±0.055%), indicating a high bioactive compound content. Particle size analysis showed that the optimum nanoparticle formula (NDA 3) had a particle size of 91.5±0.74 nm, while the optimum nanoemulsion formula (NEDA 3) produced a smaller droplet size of 71.5±0.70 nm. Transmittance values ranged from 90.31–95.01% for nanoparticles and 93.01–96.43% for nanoemulsions, indicating good clarity and nanoscale particle dispersion. In antioxidant testing, NEDA 3 exhibited higher activity (IC50 86.697±1.042 ppm) than NDA 3 (IC50 251.947±3.457 ppm). Conversely, in anti-inflammatory testing, NDA 3 showed better activity (IC50 229.001±1.229 ppm) than NEDA 3 (IC50 325.612±0.927 ppm), with Diclofenac Sodium as positive control (IC50 47.193±0.706 ppm). These findings indicate that the nanoemulsion system is more effective in enhancing antioxidant activity by improving solubility and surface contact area of active compounds, while the nanoparticle system provides superior anti-inflammatory activity through controlled-release mechanisms and the intrinsic biological contribution of chitosan as the carrier matrix.
Co-Authors Agustin, Rani Felisia Agustina, Maulia Amelia Soyata Annisa Syahrani Arrajib, Rahmad Arsa, Arvianida Nafilah Dani Prasetyo Deny Puryani Garnadi Jafar, Garnadi Hardiyanti, Trirahmi Kameliani, Desti Muchtar, Muni’ah Nia Azzahra Purnama Purnama Rahma Fatmawati Ranti Ayu Anjelina Sari, Gita Deslia Sephia Panorama Soyata, Amelia Whilly Martavinus Yola Yernianti Zahara, Ega