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All Journal Indonesian Journal of Jamu
Asriullah Jabbar
Department of Pharmacy, Faculty of Pharmacy, Universitas Halu Oleo, Kendari, 93232
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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Immunostimulatory Effect of Cayratia trifolia L. Domin on Granulocytes and Natural Killer Cells in Tuberculosis-Induced Rats Muhammad Ilyas Y Ilyas Y; Wa Ode Salma; Mubarak Mubarak; Nasrudin Nasrudin; Parawansah Parawansah; Fadhliyah Malik; Asriullah Jabbar; Asniar Pascayantri; Esti Badia; Sernita Sernita; Nirwati Rusli; Lukman La Basy
Jurnal Jamu Indonesia Vol. 11 No. 3 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i3.433

Abstract

Pulmonary tuberculosis (TB) remains a major public health problem in Indonesia and a leading cause of death from infectious diseases, partly because of impaired host immunity. Galing (Cayratia trifolia L. Domin) has been reported to exert immunomodulatory effects in bacterial infections. This study evaluated the immunostimulatory effect of galing leaf and stem extracts on granulocytes and natural killer (NK) cells in a TB-induced rat model. Leaf and stem extracts were administered orally to 28 Wistar rats at doses of 400 and 500 mg/kg body weight for seven days, followed by induction with TB ESAT-6 antigen. Granulocyte counts were measured using a hematology analyzer, whereas NK cells were quantified by ELISA. Galing extract significantly increased granulocyte and NK cell expression compared with the negative control (p<0.05). These findings indicate that galing extract has potential as an immunostimulatory agent in pulmonary TB by enhancing granulocyte and NK cell responses.
Co-Authors Asniar Pascayantri Esti Badia Fadhliyah Malik Lukman La Basy Mubarak Mubarak Muhammad Ilyas Y Ilyas Y Nasrudin Nasrudin Nirwati Rusli Parawansah Parawansah Sernita Sernita Wa Ode Salma