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All Journal Jurnal SOLMA Community Empowerment Medimuh : Jurnal Kesehatan Muhammadiyah Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis SIKAP : Sinar Inovasi Kajian Pemberdayaan Masyarakat Medimuh : Jurnal Kesehatan Muhammadiyah Medical Sains : Jurnal Ilmiah Kefarmasian Baktimu : Jurnal Pengabdian Kepada Masyarakat Baktimu : Jurnal Pengabdian Kepada Masyarakat Medimuh : Jurnal Kesehatan Muhammadiyah
Didin Ahidin
Sekolah Tinggi Farmasi Muhammadiyah Cirebon
Arts Humanities Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Jurnal Farmasi Sains dan Praktis

 1 
ANALGETIC POWER OF ETHANOL EXTRACT BROTOWALI (TINOSPORA CORDIFOLIA) IN SWISS MICE Deni Firmansyah; Didin Ahidin; Sulistiorini Indriaty; Siti Nurhasanah; Nahdia Fajri Mahmudah; Titin Sumarni
Jurnal Farmasi Sains dan Praktis Vol 8 No 3 (September-December 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i3.7909

Abstract

Brotowali (Tinospora cordifolia) plants are usually used for various kinds of treatment it is often used as a febrifuge, brotowali stems are proven to contain flavonoid compounds that have benefits in the treatment of various diseases, one of which is analgesic. This purpose is to determine the effectiveness of analgesics on male Swiss mice induced by acetic acid from the ethanol extract of brotowali stem (EETC) doses of 100 mg/Kg BW, 200 mg/Kg BW, and 400 mg/Kg BW. Brotowali stem extraction using maceration method with 70% ethanol solvent. EETC was tested by phytochemical screening and TLC to determine the content of active compounds. The test animals used Swiss male mice, the treatment group was divided into 5, negative control group, positive control, and the dose groups were 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW. Testing is done by the writhing test method. Induction of pain stimuli using acetic acid, the number of mice writhing every 10 minutes for 1 hour, and the percentage of analgesic power. Research shows the yield of EETC is 16.35%. The percentage of analgetic power of dose I was 39%, dose II was 47% and dose III was 56% less than the percentage of analgesic power of methampyrone dose of 65 mg/KgBB which was 64%. Conclusion EETC doses of 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW have analgesic activity equivalent to methampyrone at a dose of 65 mg/kg BW, with the largest percentage of analgesic protection at a dose of 400 mg/Kg BW of 56%.
ANTIOXIDANT ACTIVITY TEST OF AFRICAN LEAVES PURIFICATION EXTRACT (Vernonia amygdalina Del) WITH DPPH METHOD Nina Karlina; Aan Kunaedi; Didin Ahidin; Uzlifatul Jannah; Yasmin Zahiyah
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.7912

Abstract

African leaves (Vernonia amygdalina Del) is a plant that can be used as a medicinal plant because it contains flavonoid compounds that are effective as natural antioxidants that can suppress free radicals. The purpose of this study was to determine the antioxidant activity of the purified extract of Vernonia amygdalina Del. Antioxidant activity test of purified extract of Vernonia amygdalina Del leaves against 1,1-diphenyl-2-picrylhydrazil (DPPH) was measured with a UV-Vis spectrophotometer at a wavelength of 516nm using Vitamin C as a comparison. The results of the non-specific parameters of Vernonia amygdalina Del leaf Simplicia were drying shrinkage of 0.79±0.02%; water content of 7.33±2.08%; water-soluble essence content of 20.5±1.73 %; and ethanol of 14.5±4.35 %. The results of purified extract screening of Vernonia amygdalina Del leaves, contained chemical compounds, namely the class of flavonoid compounds, tannin compounds, steroid compounds, and saponin compounds. Testing for flavonoids using the Thin Layer Chromatography method on the purified extract contained two spots with Rf values of 0.68 and 0.5 while in quercetin there was one spot with an Rf value of 0.68, thus the purified extract of Vernonia amygdalina Del leaves contained flavonoids. Vernonia amygdalina Del leaf purified extract has a very strong antioxidant activity with an IC50 value of 13.54±0.10 µg/mL. The results showed that the purified extract of Vernonia amygdalina Del leaves had very strong antioxidant activity.
ANTIBACTERIAL ACTIVITY OF PURIFIED EXTRACT OF AFRICAN LEAVES (Vernonia amygdalina Delile) AGAINST Escherichia coli Karlina, Nina; Septiyati, Tri Putri; Ahidin, Didin; Zam Zam, Muhammad Yani; Setyaningsih, Indah; Indriaty, Sulistiorini; Kunaedi, Aan; Supriyadi, Yadi
Jurnal Farmasi Sains dan Praktis Vol 10 No 3 (September-December 2024)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v10i3.10781

Abstract

The African leaf (Vernonia amygdalina Delile) is an Indonesian plant used by the community as a traditional medicine. V.amygdalina contains active compounds such as flavonoids, tannins, saponins, and steroids which have antibacterial properties. This study aims to determine the antibacterial activity and the most effective concentration of purified extracts of V.amygdalina against the Escherichia coli bacteria. V.amygdalina simplicia was extracted using the maceration method. Ethanolic extract V.amygdalina was tested for the quality of the extract parameters and purified. Then, the purified extract V.amygdalina was tested for phytochemical screening and antibacterial activity against Escherichia coli bacteria by well-diffusion with concentrations of 30%, 40%, and 50%. The result of the quality parameter test for ethanolic extract V.amygdalina meets the requirements of specific and non-specific parameters. Purified extract V.amygdalina positively contains flavonoids, tannins, saponins, and steroids. Antibacterial activity of 0.05% chloramphenicol and purified extract V.amygdalina concentrations of 30%, 40%, and 50% against Escherichia coli bacteria had inhibition of 23.42 mm, 8.40± 0.315 mm, 9.44± 0.543 mm, and 11.59 ± 1,640 mm. The produced most effective inhibition was at a concentration of 50%. The results showed that the purified extract of V.amygdalina has antibacterial activity in the moderate to strong category, and the most effective concentration against Escherichia coli bacteria is the concentration of 50%.
Co-Authors Aan Kunaedi Agus Khurniawan Ahmad Alfateh Rahanyamtel Alvionita, Elina Amanda Safitri Andriana Arfa Maulana Kusumawijaya Aris Slamet Widodo Arsyad Bachtiar Auderina Aliza Zahra Fathin Awanda Rahma Ayu Gita Hamdani Bachtiar, Arsyad bayu pamungkas Della Nur Nadya Della Pariska Deni Firmansyah Desiyanti Desiyanti Dewi Kartika Parwati Dewi Kartika Parwati Diana Amelia Putri Didi Rohadi Dinda Aprilia Gumilang Elina Alvionita Elis Setiawati Ellen Maylina Endah Yuningsih Gina Khairunisah Gufron Amirullah Hayatun Nega Amna Hulman Taufik Azhar IIN INDAWATI Intan Indriyani Iqbal Bagus Prayogo Jafar Izzudin Johan Karni Susanti Khairunisah, Gina Lala Komalasari Lela Sulastri Lela Sulastri, Lela Lia Hawangi Sukma Taryadi M. Agung Miftahuddin Muayyadah Milla Muchammad Agung Miftahuddin Mudrikah Zaen Muh Yani Zamzam Muhamad Kusnendar Muhammad Fikri Fanillah Muhimatul Umur Nabila, Syakira Putri Nahdia Fajri Mahmudah Naida Rahma Almira Nanda Riandita Rizky Kinanti Nenden Anindya Koesmaedhy Nina Karlina Nina Karlina Nina Karlina Nisa Dwi Nurindah Nur Rahmi Hidayati, Nur Rahmi Nurcholisah Puspita Afriliani Putri Ayu Fiddiyana Putri Dwi Jayanti Putri Salma Rajjiya Ridwan, Mohammad Yusup Rima Yulia Senja, Rima Yulia Risa Rusliani Rizky Fitra Ramadhan Rizqah Sely Salsabil Sapitri Hikmatul Aziz Selfi Nur Rohmah Septiyati, Tri Putri Setyaningsih, Indah Sidik Lingga Kusuma Sindy Putri Pratama Siti Fauziyah Siti Fauziyah Siti Nurhasanah Solehah Nurfadilah Suci Eka Sari Sulistiorini Indriaty Susilo, Rinto Sutjahjo Sutjahjo Suwarno Suwarno Syakira Putri Nabila Tina Anggia Lestari Titin Sumarni Trisna Lestari Umur, Muhimatul Unggul Nirwikoro Prihadmoko Uzlifatul Jannah Winny Setyonugroho Yadi Supriyadi Yahya Adi Rahman Yasmin Zahiyah Yora Azizah Zahrah Zakiyyah Mukaromah Zam Zam, Muhammad Yani Zamzam, Muhammad Yani