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All Journal Jurnal Ilmiah Farmasi Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Sains dan Praktis Usadha Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Aji Winanta
Fakultas Kedokteran Dan Ilmu Kesehatan, Prodi Farmasi, Universitas Muhammadiyah Yogyakarta, Jln. Brawijaya, Kasihan, Bantul, Yogyakarta 55183.
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Phytochemical profiling and in vitro biological evaluation of white dragon fruit (Hylocereus undatus) peel fractions toward HeLa cell line Krisridwany, Annisa; Sari, Sindi Novita; Winanta, Aji; Heresmita, Perdana Priya; Febriansah, Rifki
Jurnal Ilmiah Farmasi Vol. 22 No. 1 (2026): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol22.iss1.art9

Abstract

Background: Cancer is a complex disease characterized by dysregulated cell growth and the potential to invade surrounding tissues. Current therapeutic approaches continue to expand, including increasing interest in bioactive compounds derived from natural products. This study aims to evaluate the biological activity of ethanol, n-hexane, and ethyl acetate fractions of Hylocereus undatus (white dragon fruit) peel extract against the HeLa cervical cancer cell line.Method: The extraction process was performed using the maceration method, and phytochemical screening was conducted using stain reagents. The cytotoxicity test was carried out using the MTT assay with concentrations of 1000, 500, 250, 125, 62.5, and 31.25 µg/mL, while morphological changes were observed under an inverted microscope.Results: The phytochemical screening indicated that alkaloids, steroids, and triterpenoids were present in the n-hexane fraction; flavonoids and tannins in the ethanol fraction; and flavonoids, alkaloids, and tannins in the ethyl acetate fraction. The highest IC50 value (311.27 µg/mL) was observed on the n-hexane fraction compared to the other fractions. The HeLa cell line showed shrinkage after treatment with all fractions. Conclusion: Of the three tested fractions, cytotoxicity was observed solely in the n-hexane fraction, whereas the ethyl acetate and ethanol fractions remained inactive against HeLa cells.
OPTIMIZATION AND CHARACTERIZATION OF SNAIL MUCUS (Achatina fulica) PEEL-OFF GEL USING FACTORIAL DESIGN METHOD Ramadhani, Dwi Asih; Winanta, Aji; Putra Taufan, Indra
Jurnal Farmasi Sains dan Praktis Vol 12 No 1 (May-August 2026)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/v043sx25

Abstract

Indonesia, a tropical country characterized by year-round sun exposure, faces increasing demand for innovative cosmetic formulations with stable and acceptable physicochemical properties. This study aimed to optimize the formulation of a snail mucus peel-off gel mask using a 2² factorial design approach. A peel-off gel snail mask containing 9% snail mucus combined with polyvinyl alcohol (PVA) and sodium carboxymethyl cellulose (CMC-Na) as gelling agents was developed and evaluated. The physical properties of the peel-off gel snail mask were evaluated through organoleptic observations, stickiness tests, spread ability assessments, drying speed measurements, viscosity analysis and pH determination. Subsequently, contour plots were generated and superimposed to delineate the feasible formulation region. Two formulations located within the feasible region were identified: F1 (4.25% CMC-Na and 14.89% PVA) and F2 (4.5% CMC-Na and 14.61% PVA). Rather than representing a single absolute optimum, these formulations exhibited different performance characteristics within the defined optimization constraints. Further investigation into the gelling agents indicated that CMC-Na significantly influenced stickiness and spread ability, while PVA primarily affected viscosity. Drying speed was influenced by the interaction between both polymers.  The factorial design approach successfully defined a formulation space that satisfies predefined physicochemical criteria for peel-off gel masks, providing a rational basis for further formulation refinement.  
Co-Authors Agustin S, Salwa Dwi Andy Eko Wibowo Anggreani, Ira Dini, Riyanti Raf'al Fajarani, Rizky Anita Fatichah, Dinda Rizka Fitri, Dhiva Andarika Ghozali, MT Gumilang, Tresna Sriwahyuni Hanik, Linta Sabila Heresmita, Perdana Priya Ingenida Hadning Jannah, Asni F. Krisridwany, Annisa Kurniawan, Muhammad Fariez Lutfi Chabib, Lutfi Muhammad Thesa Ghozali Nisa, Lia Fakila Pinasti Utami, Pinasti Putra Taufan, Indra Ramadhani, Dwi Asih Rifki Febriansah Rifki Febriansyah Sabeta, Meilidya Vani Sari, Sindi Novita Vella Lailli Damarwati Yandi Syukri