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All Journal Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical)
Jeane Mongie
Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Christian University of Indonesia in Tomohon
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Antipyretic Activity of Ethanol Extract of Malay Apple Leaves (Syzygium malaccense L.) in Peptone-Induced Male White Rats (Rattus norvegicus) Jeane Mongie; Rosalia V. Manti; Ferdy A. Karauwan; Silvana L. Tumbel; Nerni O. Potalangi; Rachmat Santoso; Christel N. Sambou
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 9 No. 1 (2026): APRIL 2026
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v9i1.543

Abstract

Malay apple leaves (Syzygium malaccense L.) have traditionally been used to reduce fever. This study aimed to evaluate the antipyretic activity of the ethanol extract of Malay apple leaves in peptone-induced male white rats (Rattus norvegicus). A completely randomized design was used with five treatment groups: negative control (distilled water), positive control (paracetamol), and ethanol extract doses of 125, 250, and 500 mg/200 g body weight. Fever was induced by intramuscular injection of 5% peptone (1 mL/200 g body weight), and rectal temperature was recorded every 30 minutes for 180 minutes. Data were analyzed using Kruskal–Wallis followed by Mann–Whitney tests. The results showed that all extract doses reduced rectal temperature compared with the negative control, with the 500 mg dose producing the greatest antipyretic effect. Statistical analysis indicated significant differences among treatment groups (p < 0.05). In conclusion, the ethanol extract of Malay apple leaves possesses antipyretic activity in peptone-induced male white rats, with the 500 mg dose showing the highest effectiveness.
Antibacterial Activity of Ethanol Extract of Pomelo Leaves (Citrus maxima Merr.) Against Helicobacter pylori Jeane Mongie; Jenifer Rawis; Nerni O. Potalangi; Hariyadi; Mitra W. Timburas; Silvana L. Tumbel
Biofarmasetikal Tropis (The Tropical Journal of Biopharmaceutical) Vol. 9 No. 1 (2026): APRIL 2026
Publisher : FMIPA UKIT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55724/jbiofartrop.v9i1.542

Abstract

Helicobacter pylori merupakan bakteri Gram-negatif penyebab gastritis, tukak peptik, dan kanker lambung. Daun jeruk bali (Citrus maxima Merr.) diketahui mengandung senyawa bioaktif yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk mengevaluasi aktivitas antibakteri ekstrak etanol daun jeruk bali terhadap H. pylori menggunakan metode difusi cakram. Ekstrak diuji pada konsentrasi 25%, 50%, 100%, dan 200% dengan tiga kali pengulangan. Ciprofloxacin dan akuades digunakan sebagai kontrol positif dan negatif. Hasil menunjukkan bahwa ekstrak memiliki aktivitas antibakteri dengan diameter zona hambat berturut-turut sebesar 10,76 mm, 11,68 mm, 12,50 mm, dan 15,71 mm. Kontrol positif menghasilkan zona hambat 35,13 mm, sedangkan kontrol negatif tidak menunjukkan zona hambat. Analisis ANOVA menunjukkan adanya perbedaan yang signifikan antar perlakuan (p < 0,05). Dengan demikian, ekstrak etanol daun C. maxima berpotensi sebagai sumber antibakteri alami terhadap H. pylori.
Co-Authors Ferdy A. Karauwan Hariyadi Jenifer Rawis Mitra W. Timburas Nerni O. Potalangi Nerni O. Potalangi Rachmat Santoso Rosalia V. Manti Sambou, Christel N. Silvana L. Tumbel