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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Bioteknologi & Biosains Indonesia (JBBI) Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology Agritrop : Jurnal Ilmu-Ilmu Pertanian (Journal of Agricultural Science) YARSI Medical Journal Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Sosial Dharma: Jurnal Pengabdian Masyarakat Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia Jurnal Biodiversitas dan Bioteknologi
Hernahadini, Nelis
Universitas Muhammadiyah Bandung
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Cytogenotoxicity Test and Biological Evaluation of Curculigo latifolia Extract with Bioindicators Allium cepa L. var. aggregate Susan Susanti; Nelis Hernahadini; Subagio Joko Suprapto; Haryanto Haryanto
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.609-614

Abstract

Curculigo latifolia plants have secondary metabolites that can suppress cell division. Compounds that suppress cell division can be used as anticancer drug candidates. This research aims to determine the effect of C. latifolia root extract on cell division and genotoxic effects using bioindicator A. cepa L. var. aggregatum. This study was conducted experimentally with a completely randomized design (CRD) using 6 treatment levels and 5 replications. The treatment levels in this study were K (water), K + (H2O2 300 Mm), K - (H2O2 26 hours + water 46 hours) and a combination of treatments at P1, P2, and P3 with H2O2 immersion (26 hours) and continued immersion of C. latifolia root extract concentrations of 400 µg mL-1, 600 µg mL-1 and 800 µg mL-1 (46 hours). The roots of A. cepa from the soaking treatment of C. latifolia extract were used to make preparations using the squash method. The results of the ANOVA test showed that the administration of C. latifolia root extract had a significant effect on the mitotic index and cell abnormalities (P<0.05). P1 had the most effective value in reducing the mitotic index and cell chromosome abnormalities.
Review: Teknologi Biosensor dalam Mendeteksi Senyawa Antidiabetes pada Tanaman Muhammad Farid Maksum; Nurhaifa Azzahra; Nelis Hernahadini
Jurnal Biodiversitas dan Bioteknologi Vol 2 No 2 (2025): Biodiverse: Jurnal Biodiversitas dan Bioteknologi
Publisher : Jurnal Biodiversitas dan Bioteknologi

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Abstract

Type 2 diabetes is a serious, widespread health problem worldwide that causes reduced quality of life, mortality, mortality and significant economic burden. The high number of diabetes sufferers in Indonesia has encouraged the development of anti-diabetic drugs, including those derived from plants used as traditional medicine. The role of biosensors in detecting antidiabetic compounds in plants is very important because they can provide fast, accurate and sensitive methods for biochemical analysis. The purpose of this review is to provide an overview of biosensor technology used for detecting antidiabetic compounds in plant leaves by discussing the general principles of biosensors, their mechanisms using electrochemical biosensor devices, paper-based biosensors, and microzone plastic-based biosensors. The literature study was carried out by searching articles from various leading journal databases, such as PubMed, Google Scholar, and ResearchGate. A review was carried out regarding biosensor devices as anti-diabetic compound detectors with three technical types, namely electrochemical, paperbased and microzone plastic-based. Based on sensitivity and other advantages, microzone plastic-based biosensors are the best biosensors compared to the other two biosensors. The use of microzone plastic-based biosensors is also very simple, requiring only the placement of the sample on the detection area, after which the compound can be detected through the scanner/sensor features embedded in the device
Co-Authors Al Rahmat, Saddam Riszky Amirullah, Saepul Muhyi Dyah Ayu Dyah Ayu, Dyah Erico, Geby Salsabilla Faturohman, M Fauziyyah, Fasya Fitriani Fitriani Fulqihayati, Nurathfal Nissa Gheta, Fernando Ilham Pate Haryanto Haryanto Herawati Herawati Ihsani, Nisa Ihsani, Nisa Istiqomah, Noviani Arifina Jannah, Nandita Qolbu Kahfi N.F., Muhammad Linda Permatasari Luhtfia Hastiani M Luthfia Hastiani M Luthfia Hastiani Muharram MAELITA RAMDANI MOEIS Muhammad - Fauzi Muhammad Farid Maksum Muharram, Luthfia Hastiani Nadya Nur Afifah , Arifa Nadya Nur Afifah Namira, Azmy Jasmine Noer Fadhillah, Sara Noviani Arifina Noviani Arifina Istiqomah Nurathfal Nissa Fulqihayati Nurhaifa Azzahra Nurissalma, Zahra Salsabila Nurul Huda, Annisa Pertiwi, Wulan Qori Atur Suhada R Rahma Nur Syamsiyah, Ninda Ramadhani, Danu Arya Ramdhani, Rafly Muhammad Sabila, Andhini Fasya Safana, Annisa Shyfa Saqila, Nahda Sartika, Tiwi Subagio Joko Suprapto Susan Susanti