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All Journal Medical Journal of Indonesia JAM : Jurnal Aplikasi Manajemen Indonesian Journal of Human Nutrition Berkala Kedokteran Universa Medicina Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Ilmiah Kesehatan Rustida
Achmad Rudijanto
Endocrine And Metabolic Division, Faculty Of Medicine, Brawijaya University
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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DiabCare Asia 2012: diabetes management, control, and complications in patients with type 2 diabetes in Indonesia Cholil, Achmad Rudijanto; Lindarto, Dharma; Pemayun, Tjokorda Gde Dalem; Wisnu, Wismandari; Kumala, Poppy; Puteri, Happy Helene Sulung
Medical Journal of Indonesia Vol 28, No 1 (2019): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.802 KB) | DOI: 10.13181/mji.v28i1.2931

Abstract

BACKGROUND Indonesia was a part of the most recent edition of DiabCare Asia held in 2008. DiabCare Asia 2012 is modeled after a similar project to provide the latest information to facilitate healthcare policymaking in this area.METHODS This was an observational, non-interventional, cross-sectional study of patients with type 2 diabetes mellitus from primary, secondary, and tertiary care centers in Indonesia. Patient data collected included demography, medical history complications, eye and foot examinations, diabetes management, and most recent laboratory investigations. Blood samples were collected from all patients for the analysis of glycated hemoglobin (HbA1c).RESULTS A total of 1,967 patients participated in the study, with a mean (SD) age of 58.4 (9.5) years and a median (range) duration of diabetes 6.0 (0.1−47.0) years. The percentage of patients with HbA1c <7.0% was 30.8% and the mean (SD) HbA1c level was 8.3 (2.2%). The proportion of patients using insulin was 34.7% with a mean (SD) total daily dose of 37.9 (24.1) IU. The most common diabetes-related complications were peripheral neuropathy (59.1%), erectile dysfunction (32.4%), and eye complications (29.1%).CONCLUSIONS Glycemic and metabolic control remain unsatisfactory in type 2 diabetes patients in Indonesia. Efforts are needed to optimize control and prevent complications in these patients.
THE EFFECT OF SERVICE QUALITY ON OUTPATIENT SATISFACTION OF DR. SOEGIRI GENERAL HOSPITAL LAMONGAN Maya Dewi Hanggraningrum; Tita Hariyanti; Achmad Rudijanto
Jurnal Aplikasi Manajemen Vol 15, No 4 (2017)
Publisher : Jurusan Manajemen Fakultas Ekonomi dan Bisnis Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (79.063 KB) | DOI: 10.21776/ub.jam2017.015.04.11

Abstract

Recently, tight competition requires hospitals to provide the best service and quality. Quality services may cause satisfaction to the patient. This study aims to determine the effect of quality service on satisfaction of outpatients at Hospital Dr. Soegiri Lamongan simultaneously and partially. This study utilizes cross sectional approach which involves 235 respondents of simultaneous outpatients. The instrument uses a questionnaire by employing independent and the dependent variables of satisfaction on quality service. The sample was taken by applying proposed sampling method. The data were analyzed using multiple linear regressions. The results of this study indicate that the service quality influence outpatients’ satisfactions.
Catechins inhibit atherosclerosis in male rats on a high fat diet Erna Susanti; Achmad Rudijanto; Retty Ratnawati
Universa Medicina Vol. 31 No. 2 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.81-87

Abstract

BackgroundA catechin isolate from the green tea clone GMB 4, which shows antioxidant activity, may be a candidate drug for prevention of atherosclerosis. The aim of this study was to analyze the effect of catechin on endothelial nitric oxide synthase (eNOS) and p110 phosphoinositide 3-kinase inhibitor (PI3K) expression and on p38 mitogen activated protein kinase (MAPK) activity in male rats fed a high fat diet.MethodsTwenty five male Wistar rats were divided into the following five groups: rats on standard diet; rats on high fat diet; rats on high fat diet + catechin 3 mg/day; rats on high fat diet + catechin 6 mg/day; and rats on high fat diet + catechin 24 mg/day. eNOS and p110 PI3K expression and p38 MAPK activity were measured by means of ELISA. ResultsHigh fat diet significantly increased eNOS expression, decreased p110 PI3K expression, and increased p38 MAPK activity in male rats, in comparison with standard diet (p<0.05). Administration of 3 mg/day catechin decreased eNOS expression compared to that in the high fat diet group without catechin (p<0.05). The administration of catechin increased p100 PI3K expression to a similar extent as that in the high fat diet groups with catechin 6 mg/day and 24 mg/day. Administration of catechin at all doses decreased p38 MAPK activity to the level of the standard diet group. ConclusionsHigh fat diet increases eNOS expression, decreases PI3K expression, and increases p38 MAPK activity. Administration of catechin decreases eNOS expression, increases PI3K expression, and decreases p38 MAPK activity.
Ungkapan Psikologis Pasien Diabetes Mellitus terhadap “Health Seeking Behaviour” ke Rumah Sakit Endiki Surya Wira Pratama; Achmad Rudijanto; Tita Hariyanti
Jurnal Ilmiah Kesehatan Rustida Vol 4 No 1 (2017): Juli
Publisher : Akademi Kesehatan Rustida

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (522.117 KB)

Abstract

Pasien diabates mellitus (DM) merupakan suatu keadaan yang mengalami kenaikan kadar gula dalam darah. Pasien DM sering melakukan kontrol berulang, sehingga mempunyai pengalaman dan persepsi yang dirasakannya selama perawatan di poli rawat jalan. Instalasi rawat jalan di Rumah Sakit merupakan langkah utama dalam upaya pelayan kesehatan. Tiap tahun pelayanan poli rawat jalan mengalami peningkatan. Dalam upaya mewujudkan mutu pelayanan rawat jalan, manajemen poli harus bisa memahami psikologis pasien dan menerapkan standar prosedur operasional (SPO) yang baik. Metode penelitian ini menggunakan jenis penelitian kualitatif dengan pendekatan fenomenologi. Informan yang digunakan dalam penelitian ini terdiri atas lima informan, yaitu tiga laki-laki dan dua perempuan. Metode yang digunakan yaitu dengan melakukan wawancara secara mendalam kepada informan. Hasil penelitian menunjukkan bahwa pasien DM dengan psikologis yang berbeda ingin mendapatkan pelayanan yang maksimal. Selain itu, pasien juga ingin mendapatkan pelayanan yang menyenangkan tanpa sedikit keluhan. Keluhan yang dimaksud seperti antrian pendaftaran yang lama dan antrian pengambilan obat.Simpulan penelitian ini adalah merekomendasikan untuk dilakukan pengawasan pelayanan secara berskala mulai dari pendaftaran sampai pasien pulang. Hal ini akan menyebabkan kemaksimalan kepuasan pelayanan.
Scanning Electron Microscopy of Glucose-Induced Cataract Treated with Garcinia mangostana Linn Pericarp Extract Muhammad Ali Faisal; Ika Kustiyah Oktaviyanti; Hidayat Sujuti; Achmad Rudijanto
Berkala Kedokteran Vol 18, No 2 (2022)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v18i2.14507

Abstract

Garcinia Mangostana Linn (GML) plant is one of the biodiversity of wetland area in South Kalimantan. GML pericarp contain various secondary metabolites, one of which is xanthones. Xanthones have antioxidant, antiinflammatory, reductase aldose inhibitor activity. This study aims to prove the potential of GML pericarp in the prevention of cataractogenesis by incubating the clear goat eye lens into a growth medium 199 for 120 hours in 5 groups. The positive control group which only given 30 mM glucose into the medium and the treatment groups that were given 30 mM glucose together with the mangosteen pericarp ethanol extract (EEKM) at a dose of 100, 500 and 1000 µg/ml. The results of scanning electron microscope (SEM) on the lens of the positive control group show irregularities of the cell arrangement of the lens fibers were evident. The lens fiber cells in the group given 100 µg/ml EEKM are still regularly arranged. In the group given 500 µg/ml EEKM, the lens fiber cells are still arranged regularly. In the group given 1000 µg/ml EEKM, the lens fiber cells are arranged regularly like the arrangement of fiber cells in the negative control group. This study proves that EEKM is able to prevent cataracts at least through the maintain the regularity of lens fibre cells and the clarity of the lenses. The drawback of this study is the use of crude extracts from EEKM so that it cannot be known specifically which active compounds are involved in the prevention of cataractogenesis. It can be concluded that the administration of EEKM at doses of 100, 500 and 1000 µg/ml can prevent cataracts and damage to the lens structure of the eye.
Asupan Magnesium Hubungannya dengan Kontrol Glukosa Darah pada Penderita DM Tipe 2 Setelah Diberi Intervensi Beras Putih dan Beras Coklat Etik Sulistyowati; Dian Handayani; Achmad Rudijanto
Indonesian Journal of Human Nutrition Vol. 9 No. 2 (2022)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2022.009.02.1

Abstract

Terapi gizi medis (MNT) sangat penting dalam rencana manajemen diabetes secara keseluruhan. Beras coklat berpotensi mengendalikan kadar glukosa darah, karena indeks glikemiknya yang lebih rendah, serat dan magnesium yang lebih tinggi dibandingkan dengan beras putih. Namun, masih belum diketahui perbedaan pengaruh nasi coklat dan nasi putih terhadap kontrol glukosa darah pasien diabetes tipe 2. Penelitian ini bertujuan untuk membandingkan perubahan kontrol glukosa darah pasien diabetes tipe 2 yang diberikan diet berbasis nasi coklat dan nasi putih. Penelitian ini merupakan penelitian eksperimental cross over design pada 18 pasien wanita diabetes tipe 2 yang memenuhi kriteria inklusi. Subyek diberikan diet beras coklat selama 12 minggu berturut-turut, dilanjutkan dengan wash out selama 2 minggu, dan diet berbasis nasi putih selama 12 minggu berturut-turut. Data glukosa darah diukur sebelum dan sesudah 2 periode intervensi. Riwayat diet sebelum intervensi dikumpulkan melalui Kuesioner Frekuensi Makanan Semi-Kuantitatif, dan asupan makanan selama intervensi dipantau menggunakan formulir catatan makanan, kemudian dianalisis dengan perangkat lunak NutriSurvey. Hasil penelitian menunjukkan bahwa dibandingkan dengan diet berbasis nasi putih, diet berbasis beras coklat secara signifikan meningkatkan asupan magnesium, serta menurunkan kadar glukosa darah puasa (FBG), glukosa darah 2 jam postprandial (PBG 2 jam) dan HbA1c (p<0,05). Kesimpulannya, pasien diabetes tipe 2 yang diberi diet beras coklat selama 12 minggu terbukti mengalami peningkatan asupan magnesium dan menurunkan kadar glukosa darah, dibandingkan saat diberi diet berbasis nasi putih. Oleh karena itu, beras coklat dapat dijadikan sebagai alternatif makanan pokok sehat bagi penderita diabetes tipe 2.
Characterization of TPO Enzyme and its Immunogenecity in New Zealand White Rabbits (Oryctolagus cuniculus) Devi Ramadani; Andreas Budi Wijaya; Arie Srihardyastutie; Dyah Kinasih Wuragil; Rulli Rosandi; Achmad Rudijanto; Aulanni'am Aulanni'am
Jurnal Penelitian Pendidikan IPA Vol 10 No 12 (2024): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i12.9539

Abstract

Hypothyroidism is characterized by inadequate production of thyroid hormones, chiefly thyroxine (T4) and triiodothyronine (T3). Thyroid peroxidase (TPO), is an enzyme and crucial for producing thyroid hormones, and also serves as a primary autoantigen in autoimmune thyroid conditions, such as Hashimoto's thyroiditis and Graves' disease. The existence of anti-thyroid peroxidase antibodies (anti-TPO) indicates an autoimmune response in which the immune system TPO which is normally recognized as part of the body (self), begins to be identified by the immune system as a something foreign (non-self). This study aimed to characterize, measure TPO activity, and evaluate the immunogenicity of TPO protein derived from patient serum and its ability to induce TPO antibody production in New Zealand White Rabbits. TPO protein isolation was achieved through SDS-PAGE and confirmed by western blot technique have molecular weight of 52 kDa. In samples from normal patients, the average TPO enzyme activity was 31.34 U/mL, while in hypothyroid patients, the average activity increased to 49.46 U/mL. TPO polyclonal antibody production in rabbits indicated its immunogenicity, peaking in week eight post-immunization, with an ELISA absorbance of 0.555. Dot blot analysis further confirmed anti-TPO sensitivity at various dilutions, anti-TPO has a high sensitivity at 1:80 dilution still detects TPO in sera patient.
Co-Authors Andreas Budi Wijaya Arie Srihardyastutie Aulanni'am Aulanni'am Devi Ramadani dharma Lindarto, dharma Dian Handayani Dyah Kinasih Wuragil Endiki Surya Wira Pratama Erna Susanti Etik Sulistyowati Hidayat Sujuti Ika Kustiyah Oktaviyanti Kumala, Poppy Maya Dewi Hanggraningrum Mochamad Fachrureza Muhammad Ali Faisal Nur Samsu Puteri, Happy Helene Sulung Retty Ratnawati Rulli Rosandi Tita Hariyanti Tjokorda Gde Dalem Pemayun Wismandari Wisnu