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All Journal JURNAL GIZI INDONESIA Medical Journal of Indonesia Medica Hospitalia Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal
Tjokorda Gde Dalem Pemayun
Bagian Ilmu Penyakit Dalam Fakultas Kedokteran Universitas Diponegoro/RSUP Dr. Kariadi, Jl. Dr. Sutomo 16-18 Semarang
Dentistry Education Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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DiabCare Asia 2012: diabetes management, control, and complications in patients with type 2 diabetes in Indonesia Cholil, Achmad Rudijanto; Lindarto, Dharma; Pemayun, Tjokorda Gde Dalem; Wisnu, Wismandari; Kumala, Poppy; Puteri, Happy Helene Sulung
Medical Journal of Indonesia Vol 28, No 1 (2019): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.802 KB) | DOI: 10.13181/mji.v28i1.2931

Abstract

BACKGROUND Indonesia was a part of the most recent edition of DiabCare Asia held in 2008. DiabCare Asia 2012 is modeled after a similar project to provide the latest information to facilitate healthcare policymaking in this area.METHODS This was an observational, non-interventional, cross-sectional study of patients with type 2 diabetes mellitus from primary, secondary, and tertiary care centers in Indonesia. Patient data collected included demography, medical history complications, eye and foot examinations, diabetes management, and most recent laboratory investigations. Blood samples were collected from all patients for the analysis of glycated hemoglobin (HbA1c).RESULTS A total of 1,967 patients participated in the study, with a mean (SD) age of 58.4 (9.5) years and a median (range) duration of diabetes 6.0 (0.1−47.0) years. The percentage of patients with HbA1c <7.0% was 30.8% and the mean (SD) HbA1c level was 8.3 (2.2%). The proportion of patients using insulin was 34.7% with a mean (SD) total daily dose of 37.9 (24.1) IU. The most common diabetes-related complications were peripheral neuropathy (59.1%), erectile dysfunction (32.4%), and eye complications (29.1%).CONCLUSIONS Glycemic and metabolic control remain unsatisfactory in type 2 diabetes patients in Indonesia. Efforts are needed to optimize control and prevent complications in these patients.
HUBUNGAN TEKANAN DARAH DENGAN KEJADIAN STROKE ISKEMIK PADA PENDERITA DIABETES MELLITUS TIPE 2 Muliawati, Ratna; Muliawati, Ratna; Pemayun, Tjokorda Gde Dalem; Hadisaputro, Suharyo
Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Vol 8 No 1 (2018): April
Publisher : LPPM STIKES KENDAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (188.333 KB) | DOI: 10.32583/pskm.8.1.2018.49-55

Abstract

ABSTRAK Stroke menempati urutan kedua penyebab kematian dan penyebab utama kecacatan jangka panjang. Prevalensi stroke pada penderita Diabetes Mellitus Tipe 2  (DMT2) mengalami peningkatan dan penderita diabetes berisiko 3-4 kali lebih besar menderita stroke iskemik dibandingkan non-diabetes. Penderita DMT2 seringkali disertai dengan tekanan darah tinggi. Informasi mengenai hubungan tekanan darah denganstroke iskemik pada penderita DMT2 masih terbatas. Penelitian ini bertujuan untuk mengetahui hubungan tekanan darah dengan stroke iskemik pada penderita DMT2. Penelitian ini merupakan penelitian observasional analitik dengan desain kasus-kontrol. Kelompok kasus adalah 48 orang penderita stroke iskemik dengan DMT2, dan kontrol adalah 48 orang penderita stroke iskemik non DM. Pengambilan sampel dengan consecutive sampling. Pengumpulan data melalui catatan rekam medis penderita stroke iskemik di RSUP dr. Kariadi Semarang. Data dianalisis secara bivariat dengan menggunakan chi square test. Hasil penelitian menunjukkan bahwa ada hubungan antara tekanan darah tinggi dengan kejadian stroke iskemik pada penderita DMT2 (nilai p 0,044, OR (95%CI) sebesar 2,88 (1,00 ? 8,30. Penderita DMT2 disarankan untuk mengontrol tekanan darah agar dapat meminimalkan risiko terjadinya stroke iskemik.   Kata kunci : Tekanan Darah, Stroke Iskemik, Diabetes Mellitus Tipe 2   THE RELATIONSHIP OF BLOOD PRESSURE WITH ISCHEMIC STROKE IN PATIENTS WITH DMT2   ABSTRACT Stroke is the second leading cause of death and the leading cause of long-term disability. The prevalence of stroke in patients with Diabetes Mellitus Type 2 (DMT2) has increased and diabetics are at 3-4 times greater risk of ischemic stroke than non-diabetics. People with DMT2 are often accompanied by high blood pressure. Information on the relationship of blood pressure with ischemic stroke in patients with DMT2 is still limited. This study aims to determine the relationship of blood pressure with ischemic stroke in patients with DMT2. This study is observational analytic study with case-control design. The case group was 48 ischemic stroke patients with DMT2, and control was 48 people with non-DM ischemic stroke patients. This study used consecutive sampling. Data collection through medical records of patients with ischemic stroke in dr. Kariadi Semarang. Data were analyzed by chi square test. The results showed that there was a correlation between high blood pressure and the incidence of ischemic stroke in patients with DMT2 (p value 0.044, OR (95% CI) of 2.88 (1.00 to 8.30). DMT2 patients were advised to control blood pressure in order to minimize the risk of ischemic stroke.   Keywords: Blood Pressure, Ischemic Stroke, Diabetes Mellitus Type 2
Hubungan status besi dan ioidum ibu hamil trimester III terhadap berat badan dan lingkar kepala bayi lahir didaerah endemik GAKI Novitasari, Sherly; Hadisaputro, Soeharyo; SS, Darmono; Rachmawati, Banundari; Pemayun, Tjokorda Gde Dalem
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 5, No 1 (2016)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (257.266 KB) | DOI: 10.14710/jgi.5.1.1-6

Abstract

Background: Iodine and iron were micronutrient that highly related with formation of thyroid hormone. Iodine and iron deficiency during pregnancy, will affect fetal development. Weight and born baby’s head circumference were early indicator of infant development, because it describe the result of interaction of several factors for fetus during pregnancy. Objectives: To determine correlation between iodine and iron status of pregnant women in third trimester with born baby’s weight and head circumference. Methods: Cross sectional study with 49 pregnant women on third trimester and their baby born. Measurement of iron status used sTfR level by ELISA and iodine status used EIU. Meanwhile for the born baby, measurement was taken place on the baby’s weight and head circumference. Results: The average of iron status is 22,15 nmol/L, meanwhile average of iodine status is 168,63 μg/L with urine median value 165 μg/L. Statistical analysis with multiple correlation test showed no significant relationship between iron and iodine status of third trimester pregnant women to birth weight (r = 0,286; p = 0,141) as well as the babies head circumference (r = 0,195; p = 0,412).Conclusion: Iron and iodine status of third trimester pregnant women have low correlation to the born babies weight or head circumference in endemic area.
Pengaruh pemberian ekstrak kedelai hitam (Glycine soja.) berbagai dosis terhadap kadar glukosa darah, kadar insulin, dan HOMA-IR Kurniawati, Dewi M; Dharmana, Edi; Rachmawati, Banundari; Pemayun, Tjokorda Gde Dalem
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 6, No 1 (2017)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (246.408 KB) | DOI: 10.14710/jgi.6.1.44-50

Abstract

Background: Obese is risk factor for abnormal glucose homeostasis and causes oxidative stress that can decrease insulin sensitivity resulting in hyperglycemia and hyperinsulinemia. Black soy bean contains anthocyanins and isoflavones, it is expected to reduce oxidative stress. Objective: Determine the effect of various dosage of black soybean extract (Glycine soja.) on blood glucose, insulin levels, and HOMA - IR in obese Sprague Dawley (SD) rats.Methods: True experimental study with randomized controlled pre test-post test design in male SD rats. Twenty four samples divided into 4 groups: control (K), 500 (P1), 750 (P2), and 1000 mg/kgBW (P3). Rats were induced to become obese with High Fat Sucrose Diet (HFSD) for 4 weeks then black soybean extracts were given for 2 weeks..Results: There was no difference in blood glucose before and after treatment (p> 0.05). There were differences on insulin levels in 500 (p = 0.012) and 750mg/kgBW (p = 0.020) doseges. There were differences on HOMA-IR in 500 (p = 0.043) and 750mg/kgBW (p = 0.028) dosages. There was difference in insulin levels’s difference (p = 0.009) between groups.Conclusion: There are differences on insulin levels and HOMA – IR in 500 and 750 mg/kgBW dosages groups. However, there is no difference on blood glucose before and after black soybean extract treatment. The most decreased levels of blood glucose, insulin and HOMA- IR were in 750mg/kgBW dosage.
Hubungan status iodium ibu hamil trimester III dengan status iodium dan nilai antropometri bayi baru lahir di daerah GAKI Pibriyanti, Kartika; SS, Darmono; Pemayun, Tjokorda Gde Dalem
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 5, No 2 (2017)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (357.208 KB) | DOI: 10.14710/jgi.5.2.75-81

Abstract

Background: Iodine essential for thyroid hormone synthesis. Women in their pregnancy are susceptible of Iodine Deficiency Disorder (IDD) since they are facing metabolism and hormonal alteration. IDD in pregnant women gave bad impact to the growth and development of the fetus. Determinant of the life continuity of the newborn babies and their life qualities could be seen through the newborn baby condition based on their body size proportions right after the birth. Objective : Explaining the impact of the iodine status of the pregnant women in their third trimester to the iodine status and anthropometric values of the newborn babies.Method : This research used non experimental study design cross sectional to 52 pregnant women in their third trimester with the babies. The Urinary Excretion of Iodine (UEI) for the examination of iodine status. To the newborn babies, UEI examination and anthropometric measurement, consists of weight birth (WB), length birth (LB), head circumference (HC) were done. Result : There is a significant correlation between the mothers’ UEI and the LB of the newborn babies (p=0,018). There is no significant correlation between mothers’ UEI and the babies’ UEI (p=1,000), mothers’ UEI and the WB of the newborn babies (p=0,548), mothers’ UEI and the newborn babies’ HC (p=0,885).Conclusion : There is a significant correlation iodine status of the pregnant women in their third trimester <150 µg/L with the LB of the newborn babies <48 cm, but there is no significant correlation with the UEI of the newborn babies <100 µg/L, WB <2500 gram, HC<34 cm.
Karakteristik dan Keluaran Pasien COVID-19 dengan DM di RS Umum Pusat Dr. Kariadi (Tinjauan pasien periode Maret-Juli 2020) Minuljo, Tania Tedjo; Anindita, Yohana Prima Ceria; Seno, Heri Nugroho Hario; Pemayun, Tjokorda Gde Dalem; Sofro, Muchlis Achsan Udji
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1A (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.883 KB) | DOI: 10.36408/mhjcm.v7i1A.473

Abstract

Pendahuluan Jawa Tengah merupakan propinsi dengan kasus COVID-19 terbanyak ke-4 di Indonesia (lebih dari 8.000 kasus). RS Umum Pusat Dr. Kariadi (RSDK) sebagai RS rujukan memiliki 436 kasus terkonfirmasi COVID-19 per 10 Juli 2020. Diabetes mellitus (DM) diketahui menurunkan sistem imun dan memperburuk reaksi inflamasi. Karakteristik dan keluaran pasien COVID-19 dengan DM di RSDK belum pernah dilaporkan sebelumnya. Metode Data dari rekam medis RSDK. Diagnosis DM: riwayat DM dan/atau GDS >200 mg/dL atau HbA1c >7%. Diagnosis COVID-19: PCR usapan nasofaring-orofaring positif. Karakteristik dasar: usia, jenis kelamin, keluhan, riwayat kontak, riwayat perjalanan, jenis dan tempat perawatan, lama perawatan, komorbid, serta terapi DM. Pemeriksaan penunjang: GDS, HbA1c, kreatinin, saturasi O2, C-reactive protein (CRP), proklasitonin, D-dimer, dan fibrinogen dikelompokkan berdasarkan keluaran (hidup vs. mati); dilakukan uji beda. Analisis dengan SPSS v.24 (IBM, New York, USA). Hasil Pasien COVID-19 dengan DM periode Maret-10 Juli 2020 sebanyak 42 dari total 436 kasus (9,63%). Pria lebih banyak (59,5%). Kasus terbanyak usia >50 tahun (64,3%). Batuk, demam, dan sesak nafas adalah keluhan tersering. Mayoritas pasien menyangkal riwayat kontak ataupun bepergian (>75%). Hampir separuh perlu perawatan intensif sejak awal (40,5%). Komorbid terbanyak hipertensi. Separuh kasus mendapat insulin. Persentase kematian 42,9% (18 dari 42). Rerata kendali glikemik (HbA1c 9,7%) dan saturasi O2 (Sat O2 90%) buruk. Rerata penanda gangguan koagulasi (D-dimer, fibrinogen) dan inflamasi akut (CRP, prokalsitonin) meningkat, berturut-turut 3937,4 ng/mL; 496,1 mg/dL; 16,6 mg/L; 12 ng/mL. Tidak ada beda bermakna antara kelompok hidup dan mati. Kesimpulan Mortalitas dan morbiditas COVID-19 sangat tinggi pada DM. Hampir seluruh pasien mengalami gangguan koagulasi dan inflamasi akut. Kata kunci: COVID-19, DM, RS Kariadi Introduction Central Java province has the 4th largest cases of COVID-19 in Indonesia with more than 8.000 cases. Dr. Kariadi General Hospital (RSDK) is one of the referral hospital with 436 confirmed cases of COVID-19 until July 10th 2020. Diabetes mellitus (DM) known to decreases the immune system and worsens the inflammatory reaction. The characteristics and outcomes of patients with COVID-19 and DM in the RSDK have not been reported yet. Method Data were taken from the RSDK medical record. Diagnosis of DM: history of diabetes and/or RBG >200 mg/dL or HbA1c >7%. Diagnosis of COVID-19 infection: positive PCR from nasopharyngeal-oropharyngeal smear. Baseline characteristics: age, sex, chief complaints, contact and travel history, type and place of care, duration of treatment, comorbidity, and diabetes treatment options. Laboratory result: RBG, HbA1c, creatinine, O2 saturation, C-reactive protein (CRP), proclasitonin, D-dimers, and fibrinogen were grouped according to patient output (life vs. death) and different tests was performed. Data analysis was performed with SPSS v.24 (IBM, New York, USA). Result The number of patients with COVID-19 and DM was 42 out of 436 cases (9.63%). Men was more prevalent (59.5%). Most cases were >50 years of age (64.3%). Cough, fever, and shortness of breath were the most prevalent chief complaints. The majority of patients denied contact or travel history (>75%). Nearly half of the cases needed intensive care (40.5%) at arrival. Hypertension was the no.1 comorbid. Half cases received insulin therapy. Percentage of death was 42.9% (18 out of 42). Average of glycemic control (HbA1c 9.7%) and O2 saturation (Sat O2 90%) were poor. Coagulation (D-dimer, fibrinogen) and acute inflammatory (CRP, procalsitonin) markers were increased, respectively 3937.4 ng/mL; 496.1 mg/dL; 16.6 mg/L; 12 ng/mL. There was no significant difference between the life and death groups. Conclusion Mortality and morbidity of patients with COVID-19 and DM was very high. Almost all patients suffered from disseminated intravascular coagulation (DIC) and severe acute inflammation. Key words: COVID-19, DM, Kariadi Hospital
Sleeve Gastrectomy And Liver Cyst Unroofing In Morbid Obesity With Multiple Liver Cysts: A Case Report Mughni, Abdul; Renata, Bella; Nugrahadi, Dimas Erlangga; Pemayun, Tjokorda Gde Dalem; Rudiman, Reno; Riwanto, Ignatius
Medica Hospitalia : Journal of Clinical Medicine Vol. 11 No. 2 (2024): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v11i2.1110

Abstract

Background: Obesity has become a major global health issue which leads to various complications, including hepatic diseases. However, we found a rare case of morbid obesity and symptomatic multiple liver cysts. Aim: This article aims to represent a rare case of morbid obesity and multiple liver cysts surgically managed by sleeve gastrectomy and liver cyst unroofing which were performed in a single surgery. Case report: 41-year-old female presented with morbid obesity and blunt intermittent abdominal pain in the right upper quadrant. Stage II hypertension, tenderness on the right upper quadrant of the abdomen and epigastrium were found in clinical assessment. Lipid profiles were shown to be elevated. Abdominal CT revealed fatty liver and multiple cystic lesions in all hepatic segments. Discussion: Non-parasitic liver cysts affect 2-18% of the global population, with a higher prevalence in females possibly due to hormonal factors. Obesity is associated with hormonal alterations, potentially leading to increased secretion of FSH and LH. Conclusion: Sleeve gastrectomy and liver cyst unroofing may be considered as a treatment strategy for patients with morbid obesity and multiple liver cysts.
Co-Authors Abdul Mughni Achmad Rudijanto Alida Harahap Anindita, Yohana Prima Ceria Ardy Santosa Asmarinah Asmarinah Banundari Rachmawati Darmono SS dharma Lindarto, dharma Edi Dharmana Fatimah Eliana, Fatimah Ignatius Riwanto, Ignatius Joedo Prihartono K. Heri Nugroho HS, K. Heri Kumala, Poppy Kurniawati, Dewi M Maretina W Wiyati, Maretina W Minuljo, Tania Tedjo Muchlis Achsan Udji Sofro Muliawati, Ratna Novitasari, Sherly Nugrahadi, Dimas Erlangga Pibriyanti, Kartika Pradana Suwondo Puteri, Happy Helene Sulung Renata, Bella Reno Rudiman Ridho Naibaho, Ridho Samsuridjal Djauzi Siti Marwati Soeharyo Hadisaputro Suharyo Hadisaputro Wismandari Wisnu