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Pemberian Tepung Daun Kelor terhadap Kadar Transferin Darah Tikus Putih Model KEP Sulistyowati, Etik; Julia, Arlik Rio; Mudita, Dhaniar
Indonesian Journal of Human Nutrition Vol 2, No 2 (2015)
Publisher : Jurusan Gizi, Fakultas Kedokteran, Universitas Brawijaya Malang

AbstrakKurang Energi Protein (KEP) merupakan salah satu bentuk malnutrisi yang merupakan faktor utama (60%) penyebab kematian anak di bawah lima tahun (balita) di daerah tropis dan subtropis. KEP disebabkan oleh kekurangan makanan sumber energi dan protein. Pada kondisi KEP konsentrasi transferin darah berkurang dan kadar Fe bebas di dalam plasma meningkat sehingga memicu produksi radikal bebas yang bersifat toksik dan menimbulkan kematian. Daun kelor memiliki kandungan zat besi dan protein tinggi yang memiliki potensi terapi suplementasi untuk anak-anak KEP. Tujuan penelitian ini adalah untuk mengetahui pengaruh pemÂberian tepung daun kelor varietas Nusa Tenggara Timur terhadap kadar transferin darah tikus putih model KEP. Desain penelitian yang digunakan adalah Post Test Only Control Group. Penelitian dilakukan selama 93 hari dengan menggunakan 6 kelompok, yaitu K(-) (diet normal), K(+) (diet non protein dilanjutkan diet normal), P1, P2, P3, dan P4 (diet non protein dilanjutkan diet normal + tepung daun kelor 180 mg, 360 mg, 720 mg, 1440 mg). Variabel yang diukur adalah kadar transferin darah dengan menggunakan metode ELISAkelor 1440epung daun kelor non protein),iberi diet non protein.. Analisis data menggunakan Oneway ANOVA dilanjutkan dengan Post Hoc Duncan. Hasil penelitian menunjukkan penambahan tepung daun kelor varietas NTT per oral sebesar 360 mg (P2) pada diet normal tikus yang KEP memberikan pengaruh terbaik bagi kadar transferin darah tikus (0,23 Â± 0,17 g/dl) sebab mendekati kadar transferin darah kelompok tikus non KEP/ kontrol negatif (0,22 Â± 0,01 g/dl) (p= 0,000). Perlu dilakukan penelitian lebih lanjut tentang uji toksisitas dan formulasi enteral tepung daun kelor varietas NTT pada hewan coba sehingga bisa menjadi pertimbangan alternatif makanan tambahan untuk penanganan anak dibawah lima tahun dengan KEP.Kata kunci: tepung daun kelor, kadar transferin darah, diet non proteinÂ Â AbstractProtein Energy Malnutrition (PEM) is a major factor of child mortality under five years old in the tropics and subtropics. PEM results from lack of food sources of energy and protein. in PEM conditions, serum transferrin concentration decreases, resulting in increased free Fe in the plasma. This circumstance leads to increased production of free radicals that are toxic and cause death. Moringa leaves contain iron and high protein that have therapeutic supplements potential for PEM children. The purpose of this study is to determine the effect of Nusa Tenggara Timur (NTT)âs varieties of moringa leaf powder on serum transferrin in white rats fed non-protein diet. The study design used was the post-test only control group. Research was conducted over 93 days using six groups: K (-) (normal diet), K (+) (non-protein diet, followed by normal diet), P1, P2, P3, and P4 (non protein diet, followed by normal diet + moringa leaf powder 180 mg, 360 mg, 720 mg, dan 1440 mg). The variables measured were serum transferrin levels by using ELISA. Data analysis used Oneway ANOVA followed by Post-Hoc Duncan. Results showed the addition of NTT varieties of moringa leaf powder orally at 360 mg (P2) on the normal diet gives the best effect for rat serum transferrin levels (0,23 Â± 0,17 g/dl) approaching non-PEM groups of rats/ negative control (0,22Â±0,01 g/dl) (p=0,000). Further research needs conducting on the toxicity test and enteral formulations of Moringa leaf powder NTT varieties in experimental animals that could be considered an alternative supplementary food for child under five years old with PEM.Keywords: moringa leaf powder, serum transferrin level, non-protein diet.

Peningkatan Praktik Mandiri Ibu dalam Pemantauan Status Gizi Balita melalui Pendampingan Aktivitis Dasa Wisma Nugraheni S.A; Ronny Aruben; Ike Johan Prihatin; Sari Sari; Etik Sulistyowati
Media Kesehatan Masyarakat Indonesia Vol. 14 No. 4: DESEMBER 2018
Publisher : Faculty of Public Health, Hasanuddin University, Makassar

The incidence of malnutrition in Indonesia, also in Central Java and Semarang is still high, another problemis the lack of awareness and knowledge of the community including mother on monitoring nutritional status,and there has never been a group of community members who care about nutrition. The aim of this study wastoanalyze changes in maternal attitudes and practices related to child nutrition after Dasawisma’s assistance.The research was carried out in the work area of the Tlogosari Wetan Health Center in Semarang, on the groundsthat the Puskesmas area has a number of Dasa Wisma that have been arranged and also have quite a number ofcases of malnutrition and malnutrition in the last few years, namely between 2.3 to 3.2% of total under five.. Thisresearch was a quasi-experimental study, with a pre and post test one group design. The subjects of the study were110 mothers of toddlers in 35 Dawis work areas, who were selected purposively, the Dawis were provided witha weight-bearing tool and a height gauge. The results showed differences in knowledge and practice regardinginfant nutrition, after being accompanied by Dawis for 1 month (p<0.05), with wilcoxon match paired test. Thisresearch can be used as evidence based practice on the proposed new program in the field of health, Dawis’s assistanceas a program in monitoring the nutritional status of children.

Pemberian diet ekstra formula komersial dan diet ekstra filtrat ikan gabus intradialisis serta pengaruhnya terhadap kadar serum albumin dan kreatinin pasien dengan hemodialisis di RSU Dr. Saiful Anwar Malang Etik Sulistyowati; Hamam Hadi; Susetyowati Susetyowati; Atma Gunawan
Jurnal Gizi Klinik Indonesia Vol 5, No 2 (2008): November
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.17550

Background: Nowadays chronic kidney disease (CKD) is a serious health problem because of its increasing incidence. In Indonesia, approximately there are 100 CKD patients per 1 million people per year. Hemodialysis is one of ways to prolong CKD patient’s life that should be done recurrently and for a long time. However, hemodialysis causes loss of nutrients leading to high prevalence of malnutrition among CKD patients. Until today intradialysis diet therapy which can replace loss of nutrients particularly protein has not been initiated as part of diet therapy in Indonesian hospitals. To improve nutritional status and minimize mortality rate, oral intradialysis diet therapy with proper formula is needed.Objective: To study the effect of the supply of commercial formula and local catfish filtrate extra diet to albumin and creatinine serum level among hemodialysis patients.Method: The study was experimental with randomized control trial design carried out at Dialysis Installation of Dr. Saiful Anwar Hospital, Malang. There were as many as 36 hemodialysis patients divided into 3 groups; 1 group with standard diet, 1 group with commercial formula and standard diet, and 1 group with local catfish filtrate and standard diet. Data were obtained through interview, note taking, and laboratory tests which consisted of subject characteristics in weight, height, albumin and creatinin serum level as well as food intake one day before, during and one day after hemodialysis. Data analysis was done descriptively and inferentially using chi square, anova, and paired t-test. The conclusion was based on significance level (α ) 0.05 or p < 0.05.Results: There was no significant difference in the characteristics of the subject at the beginning of the study with average albumin serum level 3.61 ± 0.48 g/dL and creatinine serum level 9.04 ± 2.73 mg/dL. There was no difference in average energy and protein intake of the subject. At the end of the study average albumin serum level was 3.38 ± 0.42 g/dL, creatinine serum level 8.34 ± 3.6 mg/dL, and there was significant difference in albumin serum level (p = 0.000) of the subject. Although there was an increase of creatinine serum level in the group with local catfish filtrate extra diet, it was statistically insignificant.Conclusion: There was significant effect of the supply of commercial formula and local catfish filtrate extra diet to increase of albumin serum level of the subject and there was no significant effect of the supply of extra diet to creatinine serum level; however, the supply of local catfish filtrate extra diet could maintain creatinine serum level.

Asupan Magnesium Hubungannya dengan Kontrol Glukosa Darah pada Penderita DM Tipe 2 Setelah Diberi Intervensi Beras Putih dan Beras Coklat Etik Sulistyowati; Dian Handayani; Achmad Rudijanto
Indonesian Journal of Human Nutrition Vol. 9 No. 2 (2022)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2022.009.02.1

Terapi gizi medis (MNT) sangat penting dalam rencana manajemen diabetes secara keseluruhan. Beras coklat berpotensi mengendalikan kadar glukosa darah, karena indeks glikemiknya yang lebih rendah, serat dan magnesium yang lebih tinggi dibandingkan dengan beras putih. Namun, masih belum diketahui perbedaan pengaruh nasi coklat dan nasi putih terhadap kontrol glukosa darah pasien diabetes tipe 2. Penelitian ini bertujuan untuk membandingkan perubahan kontrol glukosa darah pasien diabetes tipe 2 yang diberikan diet berbasis nasi coklat dan nasi putih. Penelitian ini merupakan penelitian eksperimental cross over design pada 18 pasien wanita diabetes tipe 2 yang memenuhi kriteria inklusi. Subyek diberikan diet beras coklat selama 12 minggu berturut-turut, dilanjutkan dengan wash out selama 2 minggu, dan diet berbasis nasi putih selama 12 minggu berturut-turut. Data glukosa darah diukur sebelum dan sesudah 2 periode intervensi. Riwayat diet sebelum intervensi dikumpulkan melalui Kuesioner Frekuensi Makanan Semi-Kuantitatif, dan asupan makanan selama intervensi dipantau menggunakan formulir catatan makanan, kemudian dianalisis dengan perangkat lunak NutriSurvey. Hasil penelitian menunjukkan bahwa dibandingkan dengan diet berbasis nasi putih, diet berbasis beras coklat secara signifikan meningkatkan asupan magnesium, serta menurunkan kadar glukosa darah puasa (FBG), glukosa darah 2 jam postprandial (PBG 2 jam) dan HbA1c (p<0,05). Kesimpulannya, pasien diabetes tipe 2 yang diberi diet beras coklat selama 12 minggu terbukti mengalami peningkatan asupan magnesium dan menurunkan kadar glukosa darah, dibandingkan saat diberi diet berbasis nasi putih. Oleh karena itu, beras coklat dapat dijadikan sebagai alternatif makanan pokok sehat bagi penderita diabetes tipe 2.

Hubungan Kebiasaan Konsumsi Fast Food, Densitas Energi, Zat Gizi Makro dan Mikro Dengan Status Gizi Pada Remaja SMAN 1 Tanjunganom Sakasiswara, Damara Leylani; Widajati, Endang; Sulistyowati, Etik
NUTRITURE JOURNAL Vol 3 No 1 (2024): Nutriture Journal
Publisher : Politeknik Kesehatan Kemenkes Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31290/nj.v3i1.4058

Latar Belakang: Berdasarkan hasil Riskesdas (2018) menunjukkan 25,7% remaja usia 13-15 tahun dan 26,9% remaja usia 16-18 tahun berstatus gizi pendek dan sangat pendek. Selain itu terdapat 8,7% remaja usia 13-15 tahun dan 8,1% remaja usia 16-18 tahun yang kurus dan sangat kurus, sedangkan prevalensi kegemukan dan obesitas sebesar 16% pada remaja usia 13-15% tahun dan 13,5% pada remaja usia 16-18 tahun. Tujuan: Penelitian ini bertujuan untuk mengidentifikasi hubungan antara konsumsi fast food, kepadatan energi, zat gizi makro dan mikro dengan status gizi. Metode: Metode penelitian menggunakan analisis statistik dengan menggunakan Chi-Square Test. Penentuan sampel berdasarkan metode random sampling dengan jumlah 65 responden. Hasil: Hasil penelitian menunjukkan konsumsi fast food sering (58,5%), jarang (41,5%). Densitas energi fast food rendah (23%), normal (43%), tinggi (34%). Zat gizi konsumsi fast food energi tinggi (60%), lemak tinggi (81,5%), karbohidrat tinggi (52,3%), natrium tinggi (87,7%). Simpulan: Berdasarkan hasil penelitian dapat disimpulkan bahwa terdapat hubungan antara konsumsi fast food, densitas energi, dan zat gizi makro dan mikro dengan status gizi remaja (p>0.05). Saran: Saran yang dapat diberikan supaya memperhatikan jenis dan variasi makanan yang dikonsumsi dengan kandungan gizi seimbang sesuai kebutuhan perhari. Kata kunci: Konsumsi Fast Food, Densitas Energi, Zat Gizi Makro dan Mikro, Status Gizi

Beban Glikemik Diet Diabetes Melitus, Tingkat Konsumsi Energi, Protein, dan Serat Kaitannya dengan Kadar Glukosa Darah Pasien Diabetes Melitus Tipe 2 NISRINA, OKTAVIANI SALWA; Sulistyowati, Etik; Luthfiyah, Fifi; Sutjiati, Endang
NUTRITURE JOURNAL Vol 3 No 2 (2024): Nutriture Journal
Publisher : Politeknik Kesehatan Kemenkes Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31290/nj.v3i2.4200

Latar belakang : Prevalensi DM di Rumah Sakit Tk. II dr. Soepraoen Malang sebesar 3,1%. Penurunan glukosa darah dapat dicapai dengan beban glikemik yang rendah. Dipelajari bagaimana konsumsi energi, protein, dan serat berhubungan terhadap kadar glukosa darah. Tujuan : Mengetahui hubungan antara beban glikemik Diet DM, tingkat konsumsi energi, protein, dan serat dengan kadar glukosa darah pasien DM Tipe 2. Metode : Studi ini menggunakan jenis penelitian observasional analitik dan rancangan survey cross sectional. Sampel yang digunakan yaitu 15 orang pasien rawat inap dengan diagnosa ataupun riwayat DM Tipe 2 pada 24 Mei-12 Juni 2023. Teknik pengambilan sampel menggunakan accidental sampling. Analisis data menggunakan korelasi rank spearman. Hasil : Sebagian besar pasien berusia 55-64 tahun, berjenis kelamin perempuan, tidak bekerja, memiliki status gizi normal, memiliki komplikasi pada sistem kardiovaskular, dan diberikan jenis pengobatan insulin oleh dokter, beban glikemik Diet DM pasien rendah, tingkat konsumsi energi pasien kurang, tingkat konsumsi protein seimbang antara kurang dan baik, dan tingkat konsumsi serat pasien baik. Simpulan : Tidak ada hubungan antara beban glikemik diet DM, tingkat konsumsi energi, dan serat dengan kadar glukosa darah pasien DM Tipe 2 di Rumah Sakit Tk. II dr. Soepraoen Malang. Ada hubungan antara tingkat konsumsi protein dengan kadar glukosa darah pasien DM Tipe 2 di Rumah Sakit Tk. II dr. Soepraoen Malang. Kata Kunci : Beban Glikemik, Diet DM, Tingkat Konsumsi, Zat Gizi

Pengaruh Pemberian Prototype PKMK DM Berbasis Beras Cokelat Dan Jamur Tiram Terhadap Kadar Glukosa Darah Penderita Diabetes Melitus (DM) Tipe 2 Kalsukma Pertiwi, Puspita Sari; Sulistyowati, Etik; Mustafa, Annasari
NUTRITURE JOURNAL Vol 3 No 1 (2024): Nutriture Journal
Publisher : Politeknik Kesehatan Kemenkes Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31290/nj.v3i1.4357

Latar belakang: Diabetes Melitus (DM) adalah kondisi serius jangka panjang atau kronis yang terjadi ketika ada peningkatan kadar glukosa dalam darah karena tubuh tidak dapat memproduksi atau cukup hormon insulin, atau tidak dapat menggunakan insulin yang dihasilkannya secara efektif. Hasil Riskesdas 2018 menunjukkan bahwa pravelensi diabetes melitus mengalami peningkatan dari tahun 2013 hingga tahun 2018. WHO menyatakan bahwa dari sepuluh besar negara dengan penyakit diabetes melitus, Indonesia menduduki peringkat keempat. Pengembangan pangan kesehatan medis khusus (PKMK) merupakan alternatif mengatasi masalah diabetes melitus. Beras cokelat dan jamur tiram dinilai berpotensi dalam menurunkan penyakit sindrom metabolik yang dapat meningkatkan peluang berkembangnya PKMK DM. Metode: Jenis penelitian yang digunakan yaitu quasi experiment dengan desain penelitian one group pretest-posttest. Responden diberikan produk selama 40 hari dengan konsumsi satu kali satu hari. Data glukosa darah diukur sebelum dan sesudah intervensi dan dianalisis menggunakan uji Paired t-test. Jumlah sampel 16 responden yang merupakan penderita diabetes melitus tipe 2 di wilayah kerja Puskesmas Dinoyo, Kota Malang. Pengambilan sampel menggunakan teknik purposive sampling. Hasil: Hasil uji Paired t-test menunjukkan p value 0.04 (p<0.05) yang memiliki arti bahwa ada pengaruh pemberian prototype PKMK DM berbasis beras cokelat dan jamur tiram terhadap glukosa darah penderita Diabetes Melitus (DM) tipe 2. Kesimpulan: Ada pengaruh pemberian prototype PKMK DM berbasis beras cokelat dan jamur tiram terhadap glukosa darah penderita Diabetes Melitus (DM) tipe 2. Kata kunci: diabetes melitus; pangan keperluan medis khusus; beras cokelat; jamur tiram; glukosa darah.

Pengaruh Pemberian Edamame Rebus (Glycine Max (L) Merrill) sebagai Camilan Sehat terhadap Penurunan Tekanan Darah Penderita Hipertensi Abdul Halif, Novi Ramadhanif; Sulistyowati, Etik; Kaswari, Sutomo Rum Teguh; Mustafa, Annasari
Ghidza: Jurnal Gizi dan Kesehatan Vol 8 No 2 (2024): December
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/ghidza.v8i2.1358

Diet yang tepat untuk hipertensi yakni melalui pengaturan asupan makanan. Konsumsi makanan yang kaya akan kalium, serat, asam folat, isoflavon, kalsium, dan magnesium mampu menurunkan tekanan darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kacang edamame rebus terhadap penurunan tekanan darah penderita hipertensi di Puskesmas Dinoyo. Hanya 13 dari 24 responden dalam sampel penelitian yang dipilih berdasarkan kriteria inklusi dan eksklusi menggunakan jenis penelitian pre-eksperimental dan rancangan one group pretest-postest. Pengumpulan data dilakukan dengan cara wawancara menggunakan formulir Food Recall 2x24 Jam, penggunaan garam dapur, dan identitas responden. Intervensi dalam penelitian ini adalah memberikan edamame rebus tanpa garam atau penyedap rasa sebanyak 5 porsi dalam 1 minggu (40 gram/hari) hanya sekali makan di waktu selingan. Analisis data menggunakan uji paired sample t test dan uji wilcoxon dengan tingkat signifikansi 95%. Hasil penelitian menunjukkan terjadi peningkatan rerata asupan Na (2131,5 mg), K (1416,8 mg), Ca (231,6 mg), Mg (212,9 mg), dan Serat (10,4 gram) responden setelah diberikan intervensi walaupun masih tergolong kurang serta pemberian edamame rebus memengaruhi penurunan tekanan darah sistolik dan diastolik responden dengan nilai p-value masing-masing 0,025 dan 0,002. Edamame rebus mampu menurunkan tekanan darah yakni dari 159/100 mmHg menjadi 147/87 mmHg. Disarankan untuk menambahkan sampel kontrol dan variasi bentuk atau jenis intervensi berbahan dasar edamame.

Effect of Brown Rice and Oyster Mushrooms Food Formulation on Blood Sugar and Lipid Profiles of Diabetics Kristianto, Yohanes; Sulistyowati, Etik; Sofiani, Siska Dwi
Indonesian Journal of Human Nutrition Vol. 11 No. 1 (2024)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2024.011.01.7

Foods play an important role in managing diabetes. Brown rice and oyster mushrooms are prospective foods for diabetics due to their low glycemic index and high b-glucan content respectively. This study aimed to determine the impact of food for special dietary use (FSDU) developed with brown rice and oyster mushrooms on the blood sugar and lipid profile of diabetics. The research was conducted using a quasi-experimental design on purposively selected 32 subjects. The subjects were equally assigned into one group receiving the FSDU and the other for commercial formula. The energy and nutrient intakes, blood sugar, and lipid profile were then compared. The results showed that most subjects were female, over 50 years old, and had been living with diabetes for more than five years. The energy intake of the FSDU group and the commercial formula was not significantly different (p > 0.05). However, the FSDU group had higher intakes of protein, carbohydrates, fiber, magnesium, and sodium than those of the commercial group (p < 0.05). Brown rice and oyster mushrooms contributed significantly to fiber intake. Blood glucose levels decreased insignificantly, while LDL increased significantly in the FSDU group. The fasting blood glucose, 2-hour post-prandial blood glucose, HbA1C, and HDL levels of the groups after treatment were not statistically different (p > 0.05). The FSDU formula could be proposed as an alternative to commercial products with the advantage of better nutrient content.

Effect of Brown Rice and Oyster Mushrooms Food Formulation on Blood Sugar and Lipid Profiles of Diabetics Kristianto, Yohanes; Sulistyowati, Etik; Sofiani, Siska Dwi
Indonesian Journal of Human Nutrition Vol. 11 No. 1 (2024)
Publisher : Department of Nutrition, Faculty of Health Sciences, Universitas Brawijaya Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.ijhn.2024.011.01.7

Foods play an important role in managing diabetes. Brown rice and oyster mushrooms are prospective foods for diabetics due to their low glycemic index and high b-glucan content respectively. This study aimed to determine the impact of food for special dietary use (FSDU) developed with brown rice and oyster mushrooms on the blood sugar and lipid profile of diabetics. The research was conducted using a quasi-experimental design on purposively selected 32 subjects. The subjects were equally assigned into one group receiving the FSDU and the other for commercial formula. The energy and nutrient intakes, blood sugar, and lipid profile were then compared. The results showed that most subjects were female, over 50 years old, and had been living with diabetes for more than five years. The energy intake of the FSDU group and the commercial formula was not significantly different (p > 0.05). However, the FSDU group had higher intakes of protein, carbohydrates, fiber, magnesium, and sodium than those of the commercial group (p < 0.05). Brown rice and oyster mushrooms contributed significantly to fiber intake. Blood glucose levels decreased insignificantly, while LDL increased significantly in the FSDU group. The fasting blood glucose, 2-hour post-prandial blood glucose, HbA1C, and HDL levels of the groups after treatment were not statistically different (p > 0.05). The FSDU formula could be proposed as an alternative to commercial products with the advantage of better nutrient content.

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