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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya Biomedical Journal of Indonesia SRIWIJAYA JOURNAL OF MEDICINE Bioscientia Medicina : Journal of Biomedicine and Translational Research Neurona Indonesian Journal of Global Health Research
Sugiharto, Henry
Universitas Sriwijaya
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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FAKTOR-FAKTOR YANG MEMPENGARUHI NYERI KEPALA PASKA ENDOVASKULAR COILING PADA PERDARAHAN SUBARAKHNOID Puspita Ratnasari, Nurlia; Desti Ramadhoni, Pinto; Sugiharto, Henry; Octavinawaty, Lenny; Haswatty, Bayu
Majalah Kedokteran Neurosains Perhimpunan Dokter Spesialis Saraf Indonesia Vol 40 No 3 (2024): Volume 40, No 3 - Juni 2024
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v40i3.456

Abstract

Introduction: Post endovascular coiling headache, according to ICHD-3, defined as a new headache due to coiling embolization which is still felt by aneurysm rupture subarachnoid patients 3 months after the procedure, which other acute SAH-related headaches have been ruled out. A previous prospective study showed that 50% unruptured aneurysms patients who undergo endovascular coiling experience headache. However, there are currently no studies on headache after endovascular coiling in ruptured aneurysms. Aim: To identify the factors that influence post-endovascular coiling headache in subarachnoid hemorrhage patients with aneurysm rupture. Method: Retrospective cohort study, using medical record data at RSUP Dr. Mohammad Hoesin Palembang. Headache intensity was assessed using the Numerical Pain Rating Scale at 3 months after the procedure according to the ICHD-3 standard. Results: Most patients were > 50 years old, female (60.5%), had a history of hypertension (81.40%), Hunt and Hess grade 2 (41.9%), mFisher grade I (41.9%), located in ICA ( 34.9%), aneurysm diameter 5 mm (69.8%), onset of action at 10 days (58.1%), mRRC class I (53.5%) and Packing Attenuation 25% (53.5%). It was found that 50% of the subjects experienced mild headache after endovascular coiling. In bivariate analysis, it was found that Hunt and Hess 4-5 (p=0.048) and Packing Attenuation >25% (p=0.03) had a significant relationship with incidence of post-endovascular coiling headache. Discussion: Severe Hunt and Hess grade (4-5) and high packing attenuation (> 25%) are associated with the incidence of post-endovascular coiling headache in aneurysm rupture SAH patients Keywords: Subarachnoid haemorrhage, aneurysm rupture, Endovascular coiling, Headache
Perineural Injection of Mecobalamin Versus Dextrose 5% Against Clinical Changes and Electrophysiological Features of Carpal Tunnel Syndrome Patients at Dr. Mohammad Hoesin General Hospital, Palembang, Indonesia Henry Sugiharto; Masita; Andini, Diah; Try Merdeka Puri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 6 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i6.1010

Abstract

Background: Carpal tunnel syndrome (CTS) is a common compression neuropathy with symptoms of pain, tingling, and numbness in the hands. Perineural injections of steroids and mecobalamin have been shown to be effective in relieving CTS symptoms. This study aims to compare the effectiveness of the perineural injection of mecobalamin and 5% dextrose on clinical changes and electrophysiological features in CTS sufferers. Methods: This research is a pilot study open-label randomized controlled trial conducted at Dr. Mohammad Hoesin General Hospital Palembang. A total of 24 CTS patients were randomly divided into two groups: the mecobalamin group (n=12) and the 5% dextrose group (n=12). Patients in both groups received a single perineural injection. Results: In the mecobalamin group, there were significant improvements in pain scores (NPRS), Boston carpal tunnel questionnaire (BCTQ) - symptom severity scale (SSS), and functional status scale (FSS) after 2 weeks. In the 5% dextrose group, there were also significant improvements in pain scores and BCTQ-SSS and BCTQ-FSS scores. However, the electrophysiological picture did not change significantly after 2 weeks of perineural injection. Comparison between groups showed significant differences in NPRS, BCTQ-FSS, and sensory amplitude. Conclusion: Perineural injection of mecobalamin and 5% dextrose is effective in improving clinical symptoms of CTS. Mecobalamin showed better effects on improving NPRS, BCTQ-SSS, and sensory conduction amplitude than 5% dextrose.
Ultrasound vs Nerve Conduction Studies: A Comparative Analysis in Carpal Tunnel Syndrome Diagnosis Hasnawi Haddani; Henry Sugiharto; Afriani; Theresia Christin; Legiran; Ferawaty
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 12 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i12.1145

Abstract

Background: Carpal tunnel syndrome (CTS) is a prevalent entrapment neuropathy. While nerve conduction studies (NCS) remain the gold standard for diagnosis, ultrasound (USG) offers a non-invasive alternative. This study aimed to compare the diagnostic accuracy of USG and NCS in CTS at Dr. Mohammad Hoesin General Hospital Palembang, Indonesia. Methods: A cross-sectional study was conducted on patients presenting with CTS symptoms. Demographic and clinical data were collected. NCS and USG assessments were performed, blinded to each other's results. USG measurements included the cross-sectional area at the carpal tunnel inlet (CSAc), proximal to the carpal tunnel (CSAp), and the difference between them (∆CSA). Diagnostic accuracy was calculated, and agreement was assessed using Cohen's kappa. Results: A total of 86 wrists from 49 patients were included. The mean age was 52 ± 11 years, with a female predominance (86%). The majority had mild CTS based on NCS (55.8%). USG measurements showed mean CSAc of 13.1 ± 3.5 mm², CSAp of 10.6 ± 3.0 mm², and ∆CSA of 2.5 ± 0.9 mm². ∆CSA had the highest sensitivity (92.2%), specificity (88.9%), and accuracy (91.9%), with substantial agreement with NCS (Kappa = 0.65). Conclusion: USG, particularly using ∆CSA, demonstrates high diagnostic accuracy in CTS, comparable to NCS. It can serve as a valuable tool, especially in settings with limited NCS availability.
Comparison of Combined Perineural Injection and Oral Mecobalamin with Oral Mecobalamin Therapy on Sensory Symptom Improvement in Patients with Carpal Tunnel Syndrome Diah Andini; Masita Masita; Henry Sugiharto; Erial Bahar
Indonesian Journal of Global Health Research Vol. 8 No. 2 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i2.1526

Abstract

Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy, predominantly presenting with sensory symptoms such as numbness and tingling. Conservative therapy with oral mecobalamin is widely used; however, the onset of improvement is often slow. Perineural injection of mecobalamin may provide a faster local effect, but clinical evidence remains limited. This study aimed to evaluate the effectiveness of combined perineural injection and oral mecobalamin compared with oral mecobalamin alone on sensory symptom improvement in CTS patients. This was a comparative interventional study conducted in patients with mild to moderate CTS at Dr. Mohammad Hoesin General Hospital, Palembang. Subjects were divided into two groups: a combination therapy group (perineural injection plus oral mecobalamin) and an oral mecobalamin group. Sensory symptoms were assessed using the Visual Analog Scale (VAS) at baseline, week 2, and week 4. Between-group and within-group comparisons were analyzed using t-tests, while mixed ANOVA was used to evaluate the effects of time and treatment group. Multivariate analysis was performed to identify factors independently associated with sensory symptom improvement. A total of 30 CTS patients were included in this study. There were no significant differences in baseline demographic and clinical characteristics between groups. Mixed ANOVA analysis demonstrated a significant time effect (p < 0.001) and a significant time group interaction, indicating a faster pattern of sensory symptom improvement (VAS score reduction) in the combination group. Multivariate analysis showed that combination therapy, sex, and occupation were independently associated with sensory symptom improvement, with occupation being the most dominant factor. The combination of perineural injection and oral mecobalamin is more effective in accelerating and enhancing sensory symptom improvement compared with oral mecobalamin therapy alone in patients with mild to moderate CTS.
Co-Authors Afriani Andini, Diah Chandra, Novy Rosalia Desti Ramadhoni, Pinto Diah Andini Erial Bahar Erial Bahar Ferawaty Haswatty, Bayu Legiran Legiran marisdina, selly Masita Masita Masita Melka Novera Sari MUHAMMAD FAHMI Muhammad Hasnawi Haddani Mutiara Budi Azhar, Mutiara Budi Nia Elisa Ginting Novy Rosalia Chandra Nyimas Fatimah Octavinawaty, Lenny Pinto Desti Ramadhoni Pradian, A Pradian, A Puspita Ratnasari, Nurlia Rizal Zainal Sheila Stephanie Chandra Theresia Christin Try Merdeka Puri Veithzal Rivai Zainal Wijaya, Alifandi Abrianto Wijaya, Alifandi Abrianto Yuki Fitria Yunni Diansari Yusril Yusril Zulkarnain, Muhamad Zulkarnain, Muhamad