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Karakteristik Penderita Polineuropati Akibat Penggunaan Fenitoin di Poliklinik Saraf RSUP Dr. Mohammad Hoesin Palembang Handayani, Sri; Veny, Veny; Haddani, Hasnawi; Marisdina, Selly; Bahar, Erial
Sriwijaya Journal of Medicine Vol. 2 No. 1 (2019): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.947 KB)

Fenitoin merupakan antikonvulsi yang sering digunakan untuk mengobati kejang umum tonik-klonik, kejang parsial, dan status epileptikus. Salah satu efek samping dari penggunaan fenitoin adalah polineuropati. Di Indonesia sendiri, belum ada data mengenai kejadian polineuropati akibat penggunaan fenitoin. Penelitian ini bertujuan untuk mengetahui karakteristik penderita polineuropati secara klinis maupun elektrofisiologi pada pengguna fenitoin yang berobat ke Poliklinik Saraf RSMH Palembang periode Januari 2017 sampai Maret 2017. Penelitian ini merupakan penelitian deskriptif dengan metode cross sectional pada 23 sampel yang memenuhi kriteria inklusi dari bulan Januari 2017 â€“ Maret 2017. Dilakukan analisis univariat untuk melihat distribusi sampel penelitian, analisis bivariat chi-squareuntuk menilai hubungan antara polineuropati dengan variabel independen, dan untuk melihat faktorâ€“faktor yang berhubungan dengan terjadinya polineuropati secara terintegrasi dilakukan analisis logistik regresi. Proporsi kejadian polineuropati secara klinis pada pengguna fenitoin di Poliklinik RSUP Dr. Mohammad Hoesin Palembang sebesar 26,1%, sedangkan proporsi kejadian polineuropati secara elektrofisiologi sebesar 30,4%. Penelitian ini menunjukkan bahwa banyaknya antikonvulsi yang digunakan dan durasi penggunaan fenitoin berhubungan dengan kejadian polineuropati.

DRY NEEDLING CAN BE AN ALTERNATIVE TREATMENT FOR HEMIFACIAL SPASM Marisdina, Selly; Sugiharto, Henry; Pradian, A
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.11802

Back Ground: Hemifacial spasm is one of movement disorder case that commonly found in daily clinical practice. Epidemiological data are very limited, the average prevalence is 11 per 100,000 population, 14.5 per 100,000 in women and 7.4 per 100,000 in men. In Germany, the estimated prevalence is 8000 to 9000 peoples.1 The incidence of women is more than that of men with a ratio of 2:1. Based on Yaltho and Jankovic study in 2011, out of 215 patients, the ratio of men to women was 1:1.8.2 One study in Indonesia also reported that most of the subjects were female (64.7%).3 Treatment with botulinum toxin injections is preferred to microvascular decompression surgery therapy, but this injection is only effective in a few months and quite expensive. This study is the first study to assess the effectiveness of dry needling on clinical improvement of hemifacial spasm compared to standard therapy of botulinum toxin injection.Methods: The study design was quasi experimental. Total of 24 subjects were divided into two groups. The first group underwent dry needling intervention while the other had botulinum injection. Clinical severity before and after treatment in both groups was assessed using Jankovic and HFS7 scores.Results: In dry needling group there were significant differences between Jankovic and HFS7 score at baseline and at week 1, 2, 3 and 4. While in botox group significant differences were also Jankovic and HFS7 score at baseline and at weeks 2 and 4. There were also a significant difference of Jankovic and HFS7 score when we compared dry needling group to botulinum toxin group.Conclusion: Dry needling can be an alternative treatment for hemifacial spasm, although clinical improvements based on Jankovic and HFS7 scores in dry needling group were not as effective as those with botulinum toxin injections.

DRY NEEDLING CAN BE AN ALTERNATIVE TREATMENT FOR HEMIFACIAL SPASM Marisdina, Selly; Sugiharto, Henry; Pradian, A
Biomedical Journal of Indonesia Vol 6, No 2 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i2.11802

Back Ground: Hemifacial spasm is one of movement disorder case that commonly found in daily clinical practice. Epidemiological data are very limited, the average prevalence is 11 per 100,000 population, 14.5 per 100,000 in women and 7.4 per 100,000 in men. In Germany, the estimated prevalence is 8000 to 9000 peoples.1 The incidence of women is more than that of men with a ratio of 2:1. Based on Yaltho and Jankovic study in 2011, out of 215 patients, the ratio of men to women was 1:1.8.2 One study in Indonesia also reported that most of the subjects were female (64.7%).3 Treatment with botulinum toxin injections is preferred to microvascular decompression surgery therapy, but this injection is only effective in a few months and quite expensive. This study is the first study to assess the effectiveness of dry needling on clinical improvement of hemifacial spasm compared to standard therapy of botulinum toxin injection.Methods: The study design was quasi experimental. Total of 24 subjects were divided into two groups. The first group underwent dry needling intervention while the other had botulinum injection. Clinical severity before and after treatment in both groups was assessed using Jankovic and HFS7 scores.Results: In dry needling group there were significant differences between Jankovic and HFS7 score at baseline and at week 1, 2, 3 and 4. While in botox group significant differences were also Jankovic and HFS7 score at baseline and at weeks 2 and 4. There were also a significant difference of Jankovic and HFS7 score when we compared dry needling group to botulinum toxin group.Conclusion: Dry needling can be an alternative treatment for hemifacial spasm, although clinical improvements based on Jankovic and HFS7 scores in dry needling group were not as effective as those with botulinum toxin injections.

Skrining kognitif pada dewasa dan lansia di Kelurahan Gunung Ibul Kota Prabumulih Nindela, Rini; Yusril, Yusril; Marisdina, Selly; Junaidi, Achmad; Okparasta, Andika; Anggraeni, Dya
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 4 No 2 (2023): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V4l2.126

Development progress in various fields, including health, has an impact on increasing people's life expectancy and increasing the elderly population in Indonesia. The increase in the number of elderly people has resulted in an increase in the prevalence of non-communicable diseases (NCDs), including dementia. Dementia decreases patient’s independency, until it eventually becomes a burden for the family and the state both in terms of economy and psychosocial. With early detection, people with dementia can get treatment earlier so that the progressivity of the disease can be inhibited. Community service activities have been carried out in the form of cognitive function screening with the Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina) examination, which is followed by counseling and distribution of pamphlets about dementia, in Gunung Ibul Village, Prabumulih City, South Sumatra province. This activity was attended by 40 people, consisting of 5 (12.5%) men and 35 (87.5%) women with an average age of 60.68 ± 9.22 years. There were 29 (72.5%) adults and elderly people with decreased cognitive function (MoCA-Ina score less than 26). Memory and visuospatial/executive are the most affected cognitive domains. Early detection of dementia needs to be carried out periodically, especially in at-risk populations. Dementia education activities also need to be intensified to raise public awareness about dementia.

Impact of Age Initiation and Duration of Hemodialysis on Impaired Cognitive Function Experienced by Chronic Kidney Disease (CKD) Patients Nindela, Rini; Prastowo, Sigit Nur; Zulissetiana, Eka Febri; Marisdina, Selly; Fazzaura Putri, Siti Sarahdeaz
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 18 No 1 (2024): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v18i1.7830

The prevalence of people with chronic kidney disease (CKD) in Indonesia increases with age. Various complications to death can occur in CKD patients, one of which is impaired cognitive function. In addition, end-stage CKD treatment options, such as hemodialysis, further increase the risk of complications of cognitive impairment in CKD patients. About 10%-40% of CKD patients experience a decline in cognitive function. This study aims to determine the factors that influence the occurrence of cognitive impairment in hemodialysis patients. This study was conducted at Mohammad Hoesin Hospital Palembang in October-November 2022. Cognitive decline was detected by examination of the Montreal Cognitive Assessment-Indonesian version (MoCA-Ina) while other variables were obtained through interviews. The data were analyzed with Chi-square or Fisher exact tests. Age, education level, and age at hemodialysis initiation affect global cognitive function in CKD patients. In cognitive domain analysis, a significant relationship was found between age and duration of hemodialysis and attentional function, as well as the impact of age, sex, and age at hemodialysis initiation on executive/visuospatial function. Several demographic and hemodialysis characteristics are associated with cognitive decline in hemodialysis patients. Education and periodic cognitive screening are necessary to prevent and detect cognitive decline in these at-risk populations.

COGNITIVE FUNCTION OF THE ELDERLY IN PALEMBANG CITY NURSING HOMES: AN EPIDEMIOLOGICAL STUDY Nindela, Rini; Nurusman, Fadilah Aisyah; Suryani, Puji Rizki; Marisdina, Selly; Aini, Syarifah
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 11 No. 3 (2024): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v11i3.431

Elderly refers to individuals who have reached the final stage of life, namely 60 years old and above. Physiologically, the elderly will experience various declines in body functions. The decline in cognitive function is among the most common in the elderly. The incidence of cognitive decline in the elderly in Indonesia is relatively high, which is as much as 32.4%, and is most vulnerable at the age of 65 years. Cognitive impairment can cause older adults to have difficulty in doing daily activities (bathing, dressing, washing, cooking), managing finances, getting lost on the road, and other disturbances that make the elderly less independent and confident, then tend to withdraw from social activities. The disturbances can also lead to anxiety disorders and depression. This study aims to determine the profile of cognitive function in the elderly at Palembang Nursing Homes. This cross-sectional study involves all elderly individuals in Palembang City Nursing Homes who meet the inclusion-exclusion criteria. The Indonesian version of the Montreal Cognitive Assessment (MoCA-Ina) was used to assess cognitive function. In this study, as many as 69 elderly (87.34%) had experienced a decline in cognitive function. Then, the dominant characteristics in the group that experienced a decrease in cognitive function were >90 years old (100%), women (91.38%), college graduates (100%), never worked (100%), had a history of stroke (92.86%), did not remember or did not know about cognitive impairment history in the family (93.33%). Delayed recall was the aspect that experienced the most disruption (96.2%). This study has revealed that the prevalence of cognitive impairment in Palembang Nursing Homes is exceptionally high. Therefore, it is imperative to implement routine screenings to identify early cognitive impairment in the elderly to provide immediate treatment.

THE QUALITY OF SLEEP IN BRAIN TUMOR PATIENTS Diansari, Yunni; Handayani, Sri; Mukhlisa; Marisdina, Selly; Syahputri, Rizka Aprillia; Susanty, Tri; Irfannuddin
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 12 No. 1 (2025): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v12i1.553

The Quality of Sleep in Brain Tumors Patients. Sleep quality is often compromised in patients with brain tumors. The underlying factors contributing to sleep quality disturbances in this patient population are multifaceted, and investigating these factors remains scarce. Sixty-eight patients with brain tumors, aged ≥ 18 years, were selected consecutively, and data was recorded in the form of sociodemographic characteristics (gender and age), clinical characteristics (clinical manifestations, tumor type, location, comorbid diseases) and therapy characteristics (management and types of drugs). Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Data were analyzed bivariate with chi-square and multivariate with logistic regression. Around 45.6% experienced poor sleep quality. Age, gender, systemic malignancies, pain, type of primary brain tumor, tumor location, operation, radiotherapy, and steroid have a significant relationship with sleep quality in patients with brain tumors (p-value <0.05). Multivariate analysis shows that age is the factor that most strongly influences the sleep quality of patients with brain tumors. Age, gender, systemic malignancies, pain, type of primary brain tumor, tumor location, operative treatment, radiotherapy, and steroids influence the quality of sleep in patients with brain tumors, but age has the most decisive influence.

Factor Associated with Orthostatic Hypotension in Parkinson’s Disease Marisdina, Selly; Nindela, Rini; Haddani, Muhammad Hasnawi; Minda Nur'aini; Ratnasari, Nurlia Puspita
AKSONA Vol. 5 No. 2 (2025): JULY 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v5i2.65006

Highlight: Neurogenic orthostatic hypotension is commonly found in Parkinson’s disease (PD) and unnoticed by both patients and clinicians. Underweight has been associated to orthostatic hypotension in Parkinson’s disease, among other factors. ABSTRACT Introduction: Orthostatic hypotension (OH) affect approximately 30% of patients with Parkinson's disease (PD). This condition not only reduces quality of life but is also associated with increased mortality. OH has been shown to double the risk of falls in the elderly, worsens motor function, and accelerate cognitive decline. There has been limited study into the prevalence and contributing factors of OH in Parkinson’s disease patients in Indonesia. Objective: This study aimed to determine factors associated with OH in patients with Parkinson’s disease. The variables analyzed included age, sex, duration of PD, disease stage based on the Hoehn and Yahr scale, levodopa equivalent dose (LED), the length of antiparkinsonian agents use, MoCA Ina (Montreal Cognitive Assessment Indonesian version) score, comorbid conditions, use of antihypertensive agents, and body mass index (BMI). Methods: This is a descriptive-analytic study with a cross-sectional design. The study population consisted of all Parkinson’s disease patients who visited the neurology polyclinics at two hospitals in Palembang. Patients were selected based on specific inclusion and exclusion criteria. To discover associations, bivariate and multivariate analyses were performed. Results: The study involved 41 patients with PD at Mohammad Hoesin Hospital and Pusri Medika Hospital in Palembang, from June to December 2024. OH, was found in 43.9% of PD patients, most of whom reported symptoms. Bivariate and multivariate analyses revealed no significant associations between OH and factors such as comorbidities, the length of antiparkinsonian medication use, total LED, age, sex, duration of PD, disease stage (Hoehn and Yahr scale), and of the use of antihypertensive agents. However, underweight BMI was significantly associated with OH in PD patients (p = 0.002, OR = 34.571, 95% CI: 3.77–317.28). Conclusion:Underweight was identified as a significant associated factor for OH in PD patients.

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