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All Journal Indonesia Natural Research Pharmaceutical Journal (INRPJ) Lumbung Farmasi : Jurnal Ilmu Kefarmasian SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL JIFI (Jurnal Ilmiah Farmasi Imelda)
Farisa Luthfiana
Universitas 17 Agustus 1945 Jakarta
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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IDENTIFIKASI ADVERSE DRUG REACTION (ADR) OBAT ANTI TUBERKULOSIS PADA PASIEN TB DI RSUD PASAR REBO JAKARTA TIMUR Dini Permata Sari; Julita Silitonga; Farisa Luthfiana; Ria Anggraeni
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2044

Abstract

Tuberculosis (TB) remains a major public health problem in Indonesia, ranking second globally in TB burden. Although Anti-Tuberculosis Drugs (ATDs) are effective in curing TB, prolonged treatment and combination regimens may lead to Adverse Drug Reactions (ADRs), potentially affecting patient adherence and treatment outcomes. This study aimed to identify the types of ADRs experienced by TB patients undergoing ATD therapy at Pasar Rebo General Hospital, East Jakarta, and to analyze the relationship between age, gender, and duration of drug use with ADR occurrence. This research employed a descriptive-analytic retrospective design conducted from June to July 2025. A total of 60 adult TB patients receiving first-line ATD therapy (Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol) were included. Data were collected using questionnaires and analyzed using univariate and multivariate statistical methods with SPSS. Causality assessment of ADRs was performed using the Naranjo algorithm. The results showed that 88.33% of patients experienced ADRs. The most frequently reported symptoms were nausea (48.33%), rash/itching (28.33%), and joint pain (26.67%). Most ADRs were categorized as “Probable” based on the Naranjo score. Multivariate analysis revealed that gender was significantly associated with ADR occurrence (p = 0.041), while age and duration of drug use were not statistically significant. In conclusion, ADRs are common among TB patients receiving ATD therapy, with gastrointestinal and dermatological symptoms being the most prevalent. Gender appears to be an important predictor of ADR risk. Therefore, close clinical monitoring and gender-sensitive pharmacovigilance strategies are essential to ensure patient safety, improve adherence, and optimize TB treatment outcomes.
ANALYSIS OF DRUG-RELATED PROBLEMS (DRPs) AND THERAPEUTIC RATIONALITY IN TWO DIFFERENT CLINICAL CASES: ABDOMINAL COLIC IN ADOLESCENTS AND VERTIGO IN ADULT PATIENTS IN HOSPITALS Rangki Astiani; Piter Piter; Ria Anggraeni; Maria Sheila Setya Ningtyas; Farisa Luthfiana; Valerie Kezia; Mardianti Borean
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9418

Abstract

ABSTRACTDrug-Related Problems (DRPs) are common issues in healthcare services and can affect the success of patient therapy. Abdominal colic is a disorder of normal intestinal flow throughout the intestinal tract caused by infection in the abdominal organs, while vertigo is a sensation that the patient is moving or spinning, or that objects around the patient are moving or spinning, usually accompanied by nausea caused by an imbalance in the three types of AKT receptors (Body Balance System) due to excessive stimulation. The purpose of this report is to review the rationality of therapy in two different clinical cases. A retrospective case study was conducted by analyzing patient medical records, DRPS analysis, physical examination, laboratory tests, pharmacological therapy, and clinical response. The first patient was given analgesic, anti-inflammatory, antibiotic, and fluid therapy for hydration. The second patient was given first-line vertigo therapy, antihypertensive drugs, and gastric protection. Therapy adjustments were made according to patient response and laboratory parameters. Clinical pharmacy monitoring ensured pain control and monitored side effects and drug interactions. 
Efektivitas Penggunaan Obat Antikanker Pada Pasien Kanker Serviks di RSUP Fatmawati Tahun 2024 Fajar Amirulah; Azmi Annisa Islamyah; Dini Sari; Farisa Luthfiana
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 1 (2026): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i1.37368

Abstract

Kanker serviks merupakan salah satu penyebab utama kematian akibat kanker pada wanita di Indonesia, yang sebagian besar disebabkan oleh rendahnya cakupan deteksi dini dan keterlambatan diagnosis sehingga efektivitas terapi antikanker menjadi kurang optimal. Penelitian ini bertujuan untuk mengevaluasi efektivitas penggunaan obat antikanker berdasarkan respons klinis pada pasien kanker serviks rawat inap di RSUP Fatmawati tahun 2024. Penelitian ini menggunakan pendekatan observasional dengan desain cross-sectional, menggunakan data dari 156 pasien yang memenuhi kriteria inklusi. Hasil penelitian menunjukkan bahwa kemoterapi kombinasi paklitaksel dan sisplatin merupakan jenis terapi yang paling banyak digunakan. Respons klinis terbanyak adalah respons parsial (56,41%) dan respons lengkap (18,59%), menunjukkan efektivitas terapi berdasarkan dominasi respons klinis positif dibandingkan progresi penyakit. Progresi penyakit terjadi pada 17,95% pasien dan penyakit stabil pada 7,05%. Analisis bivariat menunjukkan bahwa hanya stadium kanker yang memiliki hubungan signifikan terhadap respons klinis (p = 0,017). Penelitian ini menyimpulkan bahwa terapi antikanker yang digunakan cukup efektif, terutama pada pasien dengan stadium awal. Pemilihan terapi yang tepat dan deteksi dini menjadi faktor penting dalam meningkatkan keberhasilan pengobatan kanker serviks
UJI AKTIVITAS ANTIBAKTERI Propionibacterium Acnes TERHADAP EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava L) Farisa Luthfiana
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 9, No 2 (2024)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v9i2.8114

Abstract

Acne is a common skin condition influenced by various factors, including Propionibacterium acnes infection.This study aims to evaluate the antibacterial activity of ethanol extract from guava leaves (Psidium guajava L.) against P. acnes and determine the most effective concentration for inhibiting bacterial growth. This research utilizes a quantitative approach using the disc diffusion method, with 96% ethanol extraction. Phytochemical screening revealed the presence of alkaloids, flavonoids, saponins, tannins, and quinones, which possess antibacterial properties. The antibacterial assay results indicate that the inhibition zones at concentrations of 25%, 50%, and 75% measured 5.67 mm, 12.4 mm, and 16.0 mm, respectively. In comparison, clindamycin (positive control) exhibited an inhibition zone of 21.84 mm, while the negative control (distilled water) showed no inhibitory effect.The findings of this study confirm that the ethanol extract of guava leaves demonstrates antibacterial activity against P. acnes, with the 75% concentration exhibiting the highest efficacy. However, its inhibitory effect remains lower than that of clindamycin, highlighting the need for further research to optimize its potential as anatural antibacterial agent.
Co-Authors Azmi Annisa Islamyah Dini Permata Sari Dini Sari Fajar Amirulah Julita Silitonga Mardianti Borean Maria Sheila Setya Ningtyas Piter Piter Rangki Astiani Ria Anggraeni Valerie Kezia