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All Journal JURNAL FARMASIMED (JFM) Indonesia Natural Research Pharmaceutical Journal (INRPJ) SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Berdikari : Jurnal Pengabdian kepada Masyarakat
Rangki Astiani
Universitas 17 Agustus 1945 Jakarta
Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences

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Pelatihan dan Edukasi Penggunaan Aplikasi Breast Self Examination Sytem untuk Deteksi Dini terhadap Terjadinya Kanker Payudara di Puskesmas Tanjung Priok Pengalaman Peserta dalam Melakukan SADARI Rajes Khana; Ulfah Fatmala Rizky; Khoirunnisa Khoirunnisa; Panji Wijonarko; Nurcahaya Nainggolan; Rabima Rabima; Rangki Astiani
BERDIKARI Vol 5, No 1 (2022): Jurnal Berdikari
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (536.122 KB) | DOI: 10.52447/berdikari.v5i1.5537

Abstract

ABSTRAKKematian yang disebabkan oleh kanker payudara menduduki urutan kedua di antara jenis kanker lainnya. Perempuan memiliki risiko yang sangat besar untuk terjangkit kanker payudara. Penanganan kasus kanker payudara akan lebih efektif jika penyakit tersebut terdeteksi sejak dini melalui metode SADARI (Periksa Payudara Sendiri). Namun demikian, masih banyak perempuan yang belum pernah melakukan metode SADARI untuk mendeteksi gejala kanker payudara. Penyebab utama kondisi tersebut adalah kurangnya pengetahuan, tingkat pendidikan, dan informasi tentang metode SADARI. Kegiatan pengabdian masayarakat ini bekerja sama dengan Puskesmas Kecamatan Tanjung Priuk yang mengundang kader-kader puskesmas di wilayah Puskesmas Kecamatan Tanjung Priuk. Kegiatan ini bertujuan untuk memberikan pelatihan dan edukasi kepada masyarakat tentang penggunaan aplikasi web Breast-Self Examination (BSE) System untuk mendeteksi gejala kanker payudara secara mandiri. Hasil pengabdian masyarakat ini menunjukkan bahwa pelatihan ini berhasil memperkenalkan masyarakat pada aplikasi web BSE System, yang mana aplikasi ini dapat membantu masyarakat untuk melakukan screening gejala-gejala kanker payudara secara mandiri, dan berkonsultasi dengan dokter secara daring tanpa harus merasa khawatir akan keamanan data yang dibagikan.
PENANGGULANGAN SANITASI DAN PENYULUHAN UNTUK MENINGKATKAN KESEHATAN MASYARAKAT DESA BENJOT PASCA GEMPA CIANJUR diana laila ramatillah; Dinar Ayu chandra Agustin; Sri Endah Susilowati; Rangki Astiani; Ahmad Rofii; Stefanus Lukas
BERDIKARI Vol 6, No 1 (2023): Jurnal Berdikari
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/berdikari.v6i1.6587

Abstract

Indonesia merupakan wilayah rawan bencana alam salah satunya adalah gempa bumi. Bencana alam gempa bumi yang terjadi di Cianjur berdampak pada kualitas hidup masyarakat, baik secara fisik, social dan kesehatan. Permasalahan kesehatan akibat bencana adalah meningkatnya potensi kejadian penyakit menular maupun penyakit tidak menular. Akibat banyak bangunan yang roboh menyebabkan sanitasi menjadi butuk dan rawan penyakit. Untuk kegiatan pengabdian kepada masyarakat perlu dilakukan di desa Benjot, Kecamatan Cugenang, Jawa Barat untuk meningkatkan kualitas kesehatan warga korban pasca gempa. Kegiatan pengabdian masyarakat ini terbagi menjadi dua tahap atau metod yakni pemberian inventaris yang dibutuhkan masyarakat terdampak dan sosialisasi mengenai pentingnya sanitasi, kesehatan dan penyakit menular. Dari kegiatan pengabdian masyarakt ini adalah dihasilkan teknologi sanitasi yang baik untuk masyarakat desa Cianjur yang terdampak gempa. Selain itu pelaksanaan penyuluhan tentang diare dan hubungan nya dengan sanitasi yang baik serta konseling penyakit terhdap warga desa Benjot korban gempa disambut dengan positif oleh warga sehingga memberikan pengetahuan kepada warga untuk mencegah penyakit yang mungkin terjadi akibat kurang baiknya sanitasi. Kegiatan penanggulangan sanitasi kepada masyarakat dan penyuluhan penyakit kepada warga korban gempa cianjur telah terlaksana sehingga dapat membantu warga dalam meningkatkan kualitas kesehatan.
Effectiveness of the Use of Analgetic Drugs in Sectio Caesarea (SC) Patients at RSAL Mintoharjo Atisi; Fajar Amirulah; Rizky Farmasita Budiastuti; Rangki Astiani
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/0jfgbm77

Abstract

Cesarean section (CS) is a common obstetric surgical procedure that is frequently associated with moderate to severe postoperative pain, which may delay early mobilization and prolong recovery. This study aimed to evaluate the effectiveness of analgetic use based on the type and number of analgetics on pain intensity and recovery time in post-cesarean section patients at RSAL Mintoharjo. This research was conducted as an observational analytic study with a prospective cohort design involving 80 post-CS patients. Data were collected through medical records, direct observation, and pain assessment using the Numeric Rating Scale (NRS) at 6 hours, 24 hours and on day 2 or 3 postoperatively. Statistical analysis was performed using univariate analysis, Chi-Square test, and one-way ANOVA. The results show that the type of analgesic significantly affects pain intensity at all measurement times (p < 0,05), with combination analgetic regimens providing better pain control that single analgetics. The number of analgetics does not affect pain intensity at 6 hours postoperatively but shows a significant effect at 24 hours and during follow-up interviews. Recovery time is not significantly influenced by the type or number of analgesics, with most patients discharged within three days. Patient age and comorbidities affect pain intensity, while cesarean history and smoking status do not. In conclusion, multimodal analgesia is effective for controlling acute postoperative pain following cesarean section, whereas recovery time is more strongly influenced by patient clinical factors
ANALYSIS OF CHEMOTHERAPY COSTS IN BREAST CANCER PATIENTS PARTICIPATING BPJS AT DHARMAIS CANCER HOSPITAL JAKARTA Piter Piter; Rangki Astiani; Kristin Monica; Yuri Permatasari
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.7773

Abstract

This study aims to find out how much chemotherapy costs for inpatient breast cancer chemotherapy patients participating in BPJS and whether there is a difference in real hospital costs compared to INA-CBGs rates. This research is a descriptive, observational study taken from secondary data, in the form of medical record data, laboratory data, INA-CBGs e-claim data and financial data on patient medical costs in accordance with the inclusion and exclusion criteria totaling 100 patient data. Data analysis uses One Sample T-test to see whether there is a significant difference between real costs and INA-CBGs rates. Based on the results of the One Sample T-test, it shows that there is a significant difference. According to the statistical results, a significance of p<0.005 was obtained in class 3 and there was no significant difference in class 1 or class 2. The average cost that breast cancer patients have to pay for each procedure chemotherapy, severity level I Rp. 7,129,348, severity level II Rp. 9,323,275 and severity level III Rp. 9,037,426.
ANALYSIS OF DRUG-RELATED PROBLEMS (DRPs) AND THERAPEUTIC RATIONALITY IN TWO DIFFERENT CLINICAL CASES: ABDOMINAL COLIC IN ADOLESCENTS AND VERTIGO IN ADULT PATIENTS IN HOSPITALS Rangki Astiani; Piter Piter; Ria Anggraeni; Maria Sheila Setya Ningtyas; Farisa Luthfiana; Valerie Kezia; Mardianti Borean
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.9418

Abstract

ABSTRACTDrug-Related Problems (DRPs) are common issues in healthcare services and can affect the success of patient therapy. Abdominal colic is a disorder of normal intestinal flow throughout the intestinal tract caused by infection in the abdominal organs, while vertigo is a sensation that the patient is moving or spinning, or that objects around the patient are moving or spinning, usually accompanied by nausea caused by an imbalance in the three types of AKT receptors (Body Balance System) due to excessive stimulation. The purpose of this report is to review the rationality of therapy in two different clinical cases. A retrospective case study was conducted by analyzing patient medical records, DRPS analysis, physical examination, laboratory tests, pharmacological therapy, and clinical response. The first patient was given analgesic, anti-inflammatory, antibiotic, and fluid therapy for hydration. The second patient was given first-line vertigo therapy, antihypertensive drugs, and gastric protection. Therapy adjustments were made according to patient response and laboratory parameters. Clinical pharmacy monitoring ensured pain control and monitored side effects and drug interactions. 
EVALUASI FUNGSI GINJAL BERDASARKAN FARMAKOKINETIK EKSKRESI PADA PASIEN HIPERTENSI DI INSTALASI RAWAT INAP RSUD CILINCING JAKARTA UTARA Egy Octaviani; Fajar Amirulah; Dini Permata Sari; Rangki Astiani
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 11, No 1 (2026)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v11i1.8932

Abstract

Hypertension is a major risk factor for impaired renal function, which may progress to chronic kidney disease (CKD). This study aimed to evaluate renal function based on excretory pharmacokinetic parameters (urea, creatinine, and creatinine clearance) in hypertensive inpatients, and to assess the impact of patient characteristics and types of antihypertensive drugs on renal function decline. This observational analytic study with a cross-sectional design utilized secondary data from 100 medical records of hypertensive inpatients at RSUD Cilincing, North Jakarta, collected during March–April 2025. Most patients were classified in CKD stages 2–3a. The most frequently prescribed therapies were calcium channel blockers (CCBs) and angiotensin receptor blockers (ARBs). Chi-Square analysis revealed significant associations between renal function and gender, age, and CCB use (p < 0.05), while diuretic use was not significantly associated (p = 0.134). These findings highlight the importance of appropriate antihypertensive drug selection and regular renal monitoring to prevent CKD progression in hypertensive patients.
REVIEW ARTIKEL: WAWASAN FARMAKOGENOMIK DAN BIOINFORMATIKA VARIAN GEN ACE DAN PENGARUHNYA TERHADAP RESPONS INHIBITOR ACE PADA HIPERTENSI Ria Anggraeni; Rangki Astiani
SOCIAL CLINICAL PHARMACY INDONESIA JOURNAL Vol 10, No 2 (2025)
Publisher : Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/scpij.v10i2.9109

Abstract

Respons terhadap terapi antihipertensi berbasis angiotensin-converting enzyme inhibitors (ACEIs) bervariasi antar individu, yang sebagian besar dipengaruhi oleh faktor genetik. Gen ACE memiliki sejumlah polimorfisme yang dapat memengaruhi kadar enzim dan efektivitas terapi. Penelitian ini bertujuan mengeksplorasi hubungan antara variasi genetik pada gen ACE dan respons terhadap kaptopril, lisinopril, ramipril, dan enalapril pada pasien hipertensi. Penelitian ini menggunakan pendekatan bioinformatika dan farmakogenomik dengan menganalisis data dari PharmGKB, Ensembl, dan GTEx Portal. Polimorfisme genetik dianalisis untuk mengevaluasi keterkaitannya dengan efektivitas ACEI menggunakan pendekatan statistik deskriptif. Empat polimorfisme nukleotida tunggal (SNP) pada gen ACE ditemukan berasosiasi dengan respons terhadap ACEI. Varian rs4291 dan rs1799752 dikaitkan dengan efikasi kaptopril, di mana genotipe AA menunjukkan penurunan keparahan gagal ginjal. Varian rs1799752 juga terkait dengan lisinopril dan enalapril, dengan genotipe DD memberikan penurunan tekanan darah yang lebih besar. Selain itu, rs4359 dan rs4344 berkorelasi dengan efektivitas ramipril, terutama pada genotipe CC+TT dan AA+GG. Kesimpulan: Variasi genetik pada gen ACE berperan dalam menentukan respons terhadap terapi ACEI. Pendekatan farmakogenetik berpotensi meningkatkan efikasi dan keamanan pengobatan antihipertensi
ANTI-INFLAMANTORY EFFECTS OF ETYL ACETATE FRACTION OF ETHANOL EXTRACT 96% ON CABBAGE WHITE (Brassica oleracae L.) ON Rat (RATTUS NORVEGICUS L.) By IN VIVO Rangki Astiani
INDONESIA NATURAL RESEARCH PHARMACEUTICAL JOURNAL Vol 9, No 2 (2024)
Publisher : Fakultas Farmasi Universitas 17 Agustus 1945 Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52447/inrpj.v9i2.8131

Abstract

Inflammation is a complex biological response of vascular tissue for the presence of danger, such as pathogens, cell damage or irritation. This study aims to determine anti-inflammatory activity of ethyl acetate fraction extract of leaves of white cabbage (Brasiccaoleracea L). This study using white rats Wistar lane and were divided into 5 groups, consisting of a negative control (CMC Na 0,5%), positive control (Diclofenac Sodium 13.5 mg / kg), and dose I, II and III consisting of a suspension of ethyl acetate fraction of white cabbage leaves with a dose of 250 mg / kg, 500mg / kg and 750mg / kg. The results showed fraction of ethyl acetate extract of white cabbage can reduce the volume of edema in the legs of mice induced with karegenan have an effect at a dose of 250mg / kg BW and 500 mg / kg BW.
Co-Authors Ahmad Rofii Atisi Diana Laila Rahmatillah Dinar Ayu Chandra Agustin Dini Permata Sari Egy Octaviani Fajar Amirulah Fajar Amirulah Farisa Luthfiana Khoirunnisa Khoirunnisa Kristin Monica Mardianti Borean Maria Sheila Setya Ningtyas Piter Piter Rabima Rabima Rajes Khana Ria Anggraeni Ria Anggraeni Rizky Farmasita Budiastuti Sri Endah Susilowati Stefanus Lukas Valerie Kezia Wijonarko, Panji Yuri Permatasari