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All Journal Journal of Biomedical and Techno Nanomaterials Journal of Social Entrepreneurship and Creative Technology
Seo Jiwon
Sogang University
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management

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NANOBODY SYNTHESIS TO TARGET EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) IN COLORECTAL CANCER CELLS Fatima Malik; Sara Hussain; Seo Jiwon
Journal of Biomedical and Techno Nanomaterials Vol. 2 No. 2 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jbtn.v2i2.2016

Abstract

Colorectal cancer (CRC) is a leading cause of cancer-related deaths, with the overexpression of epidermal growth factor receptor (EGFR) playing a critical role in its progression. Current therapies face challenges in targeting EGFR effectively. To synthesize and evaluate nanobodies targeting EGFR in colorectal cancer cells, aiming to improve therapeutic specificity and efficacy. Nanobodies were synthesized using phage display technology and screened for high affinity to EGFR. In vitro studies involved colorectal cancer cell lines (HT-29, SW480, HCT116) to assess binding specificity, internalization, and cytotoxicity. In vivo studies used mouse models implanted with human colorectal tumors to evaluate biodistribution, tumor targeting, and therapeutic outcomes. Synthesized nanobodies demonstrated high binding affinity (KD in nanomolar range) and specificity to EGFR, inhibiting cancer cell proliferation by up to 70% and reducing tumor volume by 65% in mouse models. Stability tests confirmed nanobody resilience under various biological conditions. The study highlights the potential of nanobodies targeting EGFR as an effective therapeutic approach for colorectal cancer, with significant improvements in targeting specificity and tumor reduction. Further clinical trials are necessary to confirm these findings.  
GAMIFYING SOCIAL CHANGE: DESIGNING A MOBILE GAME TO PROMOTE PRO-ENVIRONMENTAL BEHAVIORS AS A SOCIAL ENTREPRENEURSHIP INITIATIVE Lucas Wong; Seo Jiwon; Ingrid Olsson; Dodi Setiawan Riatmaja
Journal of Social Entrepreneurship and Creative Technology Vol. 2 No. 4 (2025)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jseact.v2i4.2642

Abstract

The environmental “attitude-action gap” persists, as most “green apps” fail to motivate users or achieve long-term financial sustainability. This study aims to design, develop, and test a mobile game framework that bridges this gap by integrating behavioral psychology with a sustainable social entrepreneurship model. Design-Based Research (DBR) approach was used, culminating in a 6-week, mixed-methods pilot study (n=500). Data was collected via in-game analytics, pre/post-test surveys (Pro-Environmental Behavior Scale, PEBS; Intrinsic Motivation Inventory, IMI), and qualitative interviews. The intervention yielded strong engagement (28.1% Wk6 retention) and a statistically significant increase in self-reported Pro-Environmental Behaviors (PEBS) (p < .001, Cohen’s d = 0.82). High intrinsic motivation (4.4/5.0 IMI) was observed, with ‘Social Relatedness’ (? = .45) being the strongest predictor of retention. The B2C social enterprise model was validated., when co-designed as a social enterprise, is empirically validated as an effective and sustainable framework for motivating PEBs. The model successfully bridges the attitude-action gap by prioritizing social connection.
Co-Authors Dodi Setiawan Riatmaja Fatima Malik Ingrid Olsson Lucas Wong Sara Hussain