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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Journal of Innovation Research and Knowledge
Gilang Rizki Al Farizi
Universitas Telogorejo Semarang
Humanities Economics, Econometrics & Finance Education Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences

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EFEKTIVITAS PENYEMBUHAN LUKA SAYAT SALEP TAMANU OIL (CALOPHYLLUM INOPHYLLUM L.) Madyo Adrianto; Silvy Aldila; Gilang Rizki Al Farizi; Viony Naulita Sidauruk
Journal of Innovation Research and Knowledge Vol. 5 No. 8 (2026): Januari 2026
Publisher : Bajang Institute

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Abstract

Luka sayat merupakan cedera kulit yang memerlukan terapi topikal untuk mempercepat penyembuhan dan mencegah infeksi. Tamanu oil (Calophyllum inophyllum L.) mengandung asam oleat dan asam linoleat yang berperan dalam regenerasi jaringan, sehingga berpotensi sebagai terapi alternatif penyembuhan luka. Penelitian ini bertujuan mengetahui efektivitas salep tamanu oil terhadap penyembuhan luka sayat pada mencit putih jantan (Mus musculus). Sebanyak 20 ekor mencit dibagi menjadi lima kelompok: kontrol negatif (basis salep), kontrol positif (povidone iodine 10%), serta salep tamanu oil dengan konsentrasi 10%, 15%, dan 20%. Evaluasi meliputi uji organoleptik, homogenitas, pH, viskositas, daya sebar, daya lekat, dan stabilitas. Analisis menggunakan One-Way ANOVA dan uji Post Hoc Duncan menunjukkan adanya perbedaan signifikan antar kelompok (p<0,05), dengan formula tamanu oil (F1, F2, F3) berada pada subset yang sama dengan kontrol positif. Hasil ini menunjukkan bahwa salep tamanu oil konsentrasi 10%, 15%, dan 20% efektif dalam mempercepat penyembuhan luka sayat pada mencit putih jantan.
Antibiotic Utilization and Patient with Sepsis Characteristics: A Multicenter Retrospective Study in Semarang Gilang Rizki Al Farizi; Tunik Saptawati; Yovita Dwi Arini; Rizky Budi Santoso; Suci Arsita Sari; Lutfi Defita Sari
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14468

Abstract

Sepsis remains a critical global health challenge requiring prompt and appropriate antimicrobial intervention to reduce mortality. Despite established guidelines recommending early broad-spectrum antibiotic administration, empirical prescribing patterns and their alignment with clinical recommendations remain insufficiently documented in Indonesian multicenter settings, particularly in Central Java. This study addresses the knowledge gap by evaluating antibiotic utilization profiles and patient characteristics among hospitalized sepsis cases in Semarang, with emphasis on empirical therapy practices and stewardship implications. A multicenter retrospective observational study was conducted involving 200 sepsis patients meeting predefined inclusion criteria from two hospitals in Semarang during 2019–2023. Data were extracted from medical records and analyzed descriptively, considering inter-hospital variability in prescribing practices. Results demonstrated male predominance (51.5%), elderly population representation (42.5% aged >60 years), multiple comorbidity burden (50.5% with two comorbidities), and moderate hospitalization duration (36% for 3–7 days). Broad-spectrum agents active against both Gram-positive and Gram-negative organisms dominated prescribing patterns (89.4%), while time-dependent antibiotics represented 10.5% of prescriptions. Meropenem emerged as the most frequently prescribed agent (33.3%), administered exclusively via the intravenous route (100%). These findings underscore the importance of structured antimicrobial management and robust de-escalation strategies in local hospital settings to effectively balance necessary empirical coverage with the prevention of antimicrobial resistance
Co-Authors Lutfi Defita Sari Madyo Adrianto Rizky Budi Santoso Silvy Aldila Suci Arsita Sari Tunik Saptawati Viony Naulita Sidauruk Yovita Dwi Arini