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All Journal International Journal of Integrated Health Sciences Althea Medical Journal Jurnal Kedokteran Gigi Universitas Padjadjaran Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Prihatni, Delita
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Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Engineering Health Professions Medicine & Pharmacology Neuroscience

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The Utility of Micro-R/Hypo-He Ratio Cut-off for Distinguishing Iron Deficiency Anemia and Minor Thalassemia Audiyananda, Dwika; Prihatni, Delita; Surata, Nida; Sugianli, Adhi Kristianto
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 1 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i1.2234

Abstract

     Thalassemia is a genetic disease with impaired synthesis of the globin chain that causes anemia. Thalassemia and Iron Deficiency Anemia (IDA) are both microcytic hypochromic anemia but have different proportions of hypochromic and microcytic erythrocytes due to differences in disease mechanisms. Research parameters of the hematology analyzer: %Micro-R, %Hypo-He, and MH ratio can be used as early screening for thalassemia and IDA. This study aimed to evaluate the cut-off of %Micro-R, %Hypo-He, and MH ratio to differentiate thalassemia from IDA. A cross-sectional study was carried out on 217 subjects. Subjects were divided into two groups, thalassemia and IDA based on hemoglobin electrophoresis, hematology examination, and Mentzer index. Differences and cut-off values of %Micro-R, %Hypo-He, and MH ratio between the two groups were analyzed. The number of collected data was 134, consisting of 89 thalassemia patients and 45 IDA patients. Thalassemia patients had a median %Micro-R value of 51.2 (4.3-79.0), %Hypo-He value of 7.2 (0.2-50.2), and MH ratio of 7.17 (1.10-64.50), higher than IDA patients (p=0.000; p=0.176; p=0.000). The optimal cut-off value for %Micro-R in discriminating thalassemia trait from IDA was >12.7, with the area under the ROC curve (AUC) of 0.945, sensitivity of 92.1%, and specificity of 82.2%. The cut-off value for MH ratio > 3.27 with AUC 0.833, sensitivity of 85.4%, and specificity 77.8% showed lower performance of cut-off value compared to %Micro-R. The algorithm using %Micro-R and MH ratio was proposed for thalassemia trait screening. High %Micro-R and MH are suggestive of thalassemia trait than of IDA.
The Correlation between Interleukin-6 and D-dimer in Severe and Critical COVID-19 Patients Prihatni, Delita; Supriatin, Lastri; Suraya, Nida; Andriyoko, Basti
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 1 (2024)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i1.2263

Abstract

Severe and critical COVID-19 patients are known to experience hyperinflammatory conditions and endothelial damage primarily characterized by increased levels of IL-6 and D-dimer. This group of patients is also considered at risk of experiencing hemostasis disorders including decreased platelet counts, prolonged PT and APTT, as well as increased fibrinogen. Therefore, this study aimed to determine the correlation between IL-6 and D-dimer in severe and critical COVID-19 patients. The relationship between IL-6 and other hemostasis parameters such as platelet count, PT, APTT, and fibrinogen were also analyzed. A descriptive-correlative observational design was used with a retrospective cross-sectional approach. The subjects were severe and critical COVID-19 patients at Hasan Sadikin Hospital, Bandung treated between January to December 2021 and met the inclusion and exclusion criteria. Secondary data were taken from medical records and the Laboratory Information System (LIS). Correlation analysis between IL-6 and D-dimer as well as hemostasis parameters was carried out using the Spearman test. The results showed that among the total 167 subjects, the median age was 60 years. The number of male subjects was 110 (65.86%), while the most common comorbidity was hypertension (45.51%). The analysis showed a very weak and insignificant correlation between IL-6 and platelets (r= -0.044; p=0.571), IL-6 and PT (r=0.115; p=0.137), IL-6 and APTT (r=0.109; p=0.159), as well as IL-6 and fibrinogen (r= -0.087; p=0.264). However, the correlation between IL-6 and D-dimer was significant (r= 0.199; p=0.010). Interleukin-6 did not correlate with hemostasis parameters but correlated with D-dimer. This means that IL-6 and D-dimer may provide information about the inflammatory response in COVID-19 patients and help monitor disease progression.
Prevalence and Resistance Patterns of Candida albicans in Diabetic and Non-Diabetic Patients with Urinary Tract Infections Prijana, Christian; Parwati, Ida; Prihatni, Delita
Althea Medical Journal Vol 11, No 3 (2024)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v11n3.3351

Abstract

Background: Candida spp. is an opportunistic fungi genus that can turn into pathogens, especially in those with inadequate immune response such as in patients with diabetes mellitus (DM), of which Candida albicans is the most common species. This study aimed to determine the prevalence and antifungal resistance patterns of Candida albicans in DM and non-DM patients with urinary tract infections (UTIs).Methods: A retrospective descriptive observational study was conducted in 2023 using medical record data of DM and non-DM patients with UTIs who were treated at a tertiary hospital in Bandung, Indonesia from July 2019 to December 2021. Data on patient characteristics, proportion of fungal species causing UTI, and antifungal resistance patterns of Candida albicans were analyzed using Microsoft Excel 2019 and presented in tabular form and chart.Results: Of a total 291 patient data, 21 were DM patients and 270 were non-DM patients, mostly were female, 71.4% and 58.2%, respectively. The prevalence of Candida albicans in DM patients was 66.7% and in non-DM patients was 70.7%, mostly resistant to micafungin (7.1% and 8.9%, respectively).Conclusion: Female is more susceptible to UTIs. More than half of DM and non-DM patients with UTIs are infected with Candida albicans, and mostly resistant to micafungin. Antifungal treatment guidelines based on resistance patterns and education on personal hygiene to prevent UTIs are recommended.
Female Toddler Presenting with Suspected Gaucher Disease: A Rare Case Report Yunanto, David; Prihatni, Delita
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 31 No. 3 (2025)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v31i3.2323

Abstract

Gaucher disease is a rare metabolism disease caused by a mutation of the glucocerebrosidase (GBA1) gene. The mutation causes an accumulation of glucocerebroside lipids (glycolipid glucocerebroside), which are harmful to the body. The accumulation goes within all areas of the body especially within the marrow, liver, and spleen. In the non-Jewish population, Gaucher disease affects 1 out of every 100,000 people. This case report describes the laboratory approach and interpretation of Gaucher disease. A 20-month-old female toddler with an enlarged abdomen accompanied by a history of severe dehydration and seizure without evidence of vomiting and diarrhea came to the nutrition Outpatient Clinic. Physical examination found hepatomegaly of 10 cm under arcus costa and spleen Schuffner 3. Laboratory findings are as follows:  hemoglobin 10.2 g/dL (10.5-13.5 g/dL) and thrombocyte 73,000/mm3 (150,000-450,000/mm3), total bilirubin 1.289 mg/dL (0.100-1.000 mg/dL), direct bilirubin 0.567 mg/dL (0.100-0.300 mg/dL), ferritin 310.1 ng/mL (4.63-204 ng/mL), APTT 41.30 s (21-41 s), CMV IgG and IgM 747.4 AU/mL (<6.0 AU/mL) and 1.3 index (<0.85 index), respectively. Gaucher disease should be considered in patients with unexplained splenomegaly, thrombocytopenia, frequent nosebleeds, anemia, acute or chronic bone pain, and/or delayed development. Gaucher cells shown in bone marrow examination can help diagnose Gaucher disease although the gold standard is the glucocerebrosidase enzyme test. This case report highlights the examination flow until the patient can be diagnosed with LSD in this case Gaucher disease.
Korelasi antara kadar D-dimer plasma dengan derajat keparahan trauma maksilofasial berdasarkan Maxillofacial Injury Severity Score (MFISS) pada penderita cedera kepala ringan: Studi Cross-Sectional Saleh, Ardian; Syamsudin, Endang; Hadikrishna, Indra; Prihatni, Delita
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 36, No 3 (2024): Desember 2024
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v36i3.58689

Abstract

Pendahuluan: Penderita trauma maksilofasial berisiko mengalami cedera kepala karena letaknya berdekatan dengan kranium. D-dimer plasma merupakan produk akhir pemecahan bekuan darah yang dapat diukur melalui sampel darah, dan berperan sebagai faktor prognostik pada cedera kepala. Maxillofacial Injury Severity Score (MFISS) adalah skoring terbaru untuk menilai derajat keparahan trauma maksilofasial berdasarkan tiga skor cedera tertinggi. Trauma maksilofasial sering disertai cedera kepala dengan peningkatan kadar D-dimer. Penelitian ini bertujuan menganalisis hubungan kadar D-dimer plasma dengan derajat keparahan trauma maksilofasial berdasarkan MFISS sebagai pertimbangan prognostik. Metode: Jenis penelitian adalah kuantitatif cross-sectional. Penelitian dilakukan pada 38 subjek berusia >18 tahun dengan trauma maksilofasial disertai cedera kepala ringan dalam fase 2–24 jam di IGD RS Hasan Sadikin Bandung. Derajat keparahan trauma maksilofasial dinilai menggunakan MFISS, dan cedera kepala ringan dinilai berdasarkan GCS. Sampel darah diambil untuk pemeriksaan D-dimer plasma. Data dianalisis menggunakan uji Spearman Rank. Hasil: Rerata kadar D-dimer plasma sebesar 3,42 pg/dL (p=0,001), dan rerata skor MFISS 6,89 ± 1,91 (p=0,022). Terdapat korelasi positif moderat antara kadar D-dimer dengan skor MFISS (r=0,512). Simpulan: Terdapat peningkatan kadar D-dimer plasma pada trauma maksilofasial disertai cedera kepala ringan. Ditemukan hubungan signifikan antara kadar D-dimer dengan tingkat keparahan trauma maksilofasial berdasarkan MFISS. Correlation between plasma D-dimer levels and the severity of maxillofacial trauma based on the maxillofacial injury severity score (MFISS) in mild head injury patients: Cross-Sectional StudyIntroduction: Patients with maxillofacial trauma are at risk of experiencing head injury because of their proximity to the cranium. Plasma D-dimer is the end product of blood clot breakdown that can be measured through blood samples, and it plays a role as a prognostic factor in head injury. The Maxillofacial Injury Severity Score (MFISS) is the latest scoring system to assess the severity of maxillofacial trauma based on the three highest injury scores. Maxillofacial trauma is often accompanied by head injury with increased D-dimer levels. This study aims to analyze the relationship between plasma D-dimer levels and the severity of maxillofacial trauma based on MFISS, serving as a prognostic consideration. Methods: The present study employed a quantitative cross-sectional design. The study was conducted on 38 subjects aged over 18 years with maxillofacial trauma accompanied by mild head injury in the 2-24 hour phase at the Emergency Department of Hasan Sadikin Hospital, Bandung. The severity of maxillofacial trauma was assessed using MFISS, and mild head injury was assessed based on the Glasgow Coma Scale (GCS). Blood samples were taken for plasma D-dimer examination. Data were analyzed using the Spearman Rank correlation test. Results: The mean plasma D-dimer level was 3.42 pg/dL (p=0.001), and the mean MFISS score was 6.89 ± 1.91 (p=0.022). There was a moderate positive correlation between D-dimer levels and MFISS scores (r=0.512). Conclusion: Plasma D-dimer levels are elevated in maxillofacial trauma accompanied by mild head injury. A significant relationship was found between D-dimer levels and the severity of maxillofacial trauma based on MFISS.
Comparison of Coagulation Parameters between Severe and Non-severe COVID-19 Patients Treated in a Tertiary Hospital in Indonesia Fianza, Pandji Irani; Prihatni, Delita; Purnama, Dasep Bambang
International Journal of Integrated Health Sciences Vol 11, No 2 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v11n2.2967

Abstract

Objective: To determine the differences in coagulation features in patients with severe versus non-severe COVID-19. Method: During the period of the study from July 2020 to June 2021, 371 COVID-19 patients were treated at Dr. Hasan Sadikin Hospital. These patients were divided into two groups based on the WHO critera into severe COVID-19 with clinical signs such as severe acute respiratory syndrome to respiratory failure and non-severe cases with no respiratory symptoms. Data analyzed were Prothrombin Time (PT), Activated Partial Thromboplastin Time (aPTT), International Normalized Ratio (INR), fibrinogen, D-dimer, and platelet count.Results: Median INR was significantly higher in patients with severe cases than in non-severe cases (1.04 vs. 0.94, p<0.001), which was also true for median PT (12.3 vs. 12.0 sec, p=0.030) and median fibrinogen (522 vs. 428.5 mg/dl, p=0.004). Similarly, the median D-dimer was significantly higher in severe patients (1.91 vs. 0.75 mg/dl, p<0.001). Median aPTT and platelet count were in normal limits for both severe and non-severe COVID-19 patients (28.6 vs. 29.15 sec, p>0.652 and 246 vs. 242 x103/mm3, p>0.924, respectively).Conclusions: The INR, PT, fibrinogen, and D-dimer can be considered as features that can be used to predict the severity of the disease and to choose the proper treatment for COVID-19 patients.
Performance Comparison of YOLOv8 and DETR in White Blood Cell Detection Rakhmatsyah, Andrian; Abdurohman, Maman; Erfianto, Bayu; Prihatni, Delita
Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi) Vol 9 No 4 (2025): August 2025
Publisher : Ikatan Ahli Informatika Indonesia (IAII)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29207/resti.v9i4.6864

Abstract

Automated detection and classification of white blood cells (WBCs) from microscopic images play a vital role in supporting the diagnosis of hematological diseases. Accurate and robust object detection algorithms are essential for handling interclass similarities and imbalanced datasets. This study aims to evaluate and compare the performance of two modern object detection algorithms—Detection Transformer (DeTR) and YOLOv8—in performing multiclass WBC classification using public datasets from various sources with diverse visual characteristics. Five experimental scenarios were designed based on varying class distributions and data augmentation techniques, including horizontal/vertical flipping and random rotation. Both methods were trained and evaluated on the same dataset partitions, and their performances were assessed using the following standard metrics: precision, recall, and F1-score for each WBC class. The results show that YOLOv8 consistently achieved superior and more stable performance across all scenarios, with average F1-scores close to 1.00 even in augmented and imbalanced conditions. In contrast, DeTR performed competitively in balanced scenarios but showed lower consistency, particularly in classes such as Neutrophil and Monocyte. Data augmentation positively affected both models, although the gains were more prominent in YOLOv8. This study highlights the strong potential of YOLOv8 in real-time WBC classification tasks and presents DeTR as a viable yet less-optimized approach for this application. These findings contribute to the advancement of medical image-based object detection and offer valuable insights into the selection of appropriate algorithms for hematological image analysis
Association between Maternal Hemoglobin Level and Incomplete Abortion in A West Java Tertiary Hospital, Indonesia Anabela, Lisa Milena; Handono, Budi; Prihatni, Delita; Aziz, Muhammad Alamsyah; Ritonga, Mulyanusa Amrullah
International Journal of Integrated Health Sciences Vol 11, No 1 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v11n1.3284

Abstract

Objective: To evaluate the association between maternal hemoglobin concentrations and incomplete abortion.Methods: An analytic, cross-sectional study with consecutive sampling method was conducted using medical records of 45 pregnant women aged 18 – 35 years old visiting the Obstetrics and Gynecology Department of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia from January 1, 2017 to December 31, 2019. Participants were grouped into incomplete abortion and non-abortion groups.Results: Maternal characteristics in the incomplete abortion group showed that the majority of pregnant women in this group were 25.58 years of age, non-anemic (n=37, 82.22%), had no previous spontaneous abortion (n=40, 88.89%), and were nulliparous (n=25, 55.55%) with a mean interpregnancy interval of 4.03 years. The characteristics in both incomplete abortion group and non-abortion group were homogenous in the level of anemia (p-value=0.380), previous spontaneous abortion (p-value=1.00), and interpregnancy intervals (p-value=0.667). The mean hemoglobin concentration for the incomplete abortion group was 11.81 gr/dL (95% CI, 11.30 to 12.26). Heterogenous data was found in age (p-value=<0.001) and parity (p-value=0.002). Parity was a strong confounder, causing the hemoglobin concentration insignificantly associated to incomplete abortion (p-value=0.884).Conclusion: No statistically significant association is found between hemoglobin concentration and incomplete abortion. Most women with incomplete abortion are around 25 years old, nulliparous, non-anemic with a mean hemoglobin concentration of 11.81 gr/dL with no history of previous abortion, and a rather secure interpregnancy intervals.
Co-Authors Adhi Kristianto Sugianli Anabela, Lisa Milena Andrian Rakhmatsyah Audiyananda, Dwika Aziz, Muhammad Alamsyah Basti Andriyoko Bayu Erfianto Budi Handono Christian Prijana, Christian Endang Syamsudin Ida Parwati Indra Hadikrishna Maman Abdurohman Nida Suraya Pandji Irani Fianza Purnama, Dasep Bambang Ritonga, Mulyanusa Amrullah Saleh, Ardian Supriatin, Lastri Surata, Nida Yunanto, David