Article Per Year (5 Year)
p-Index From 2021 - 2026
2.906
P-Index
This Author published in this journals
All Journal International Journal of Integrated Health Sciences Majalah Kedokteran Bandung Althea Medical Journal Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) EMBRIO : Jurnal Kebidanan Media Penelitian dan Pengembangan Kesehatan
Aziz, Muhammad Alamsyah
Department Of Obstetrics And Gynecology Faculty Of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Environmental Science Health Professions Medicine & Pharmacology Public Health

Published : 20 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 20 Documents
Search

 1   2 
Pengaruh Pemberian Vitamin D3 terhadap Kadar Reactive Oxygen Species (ROS) pada Sel PHM1-41 yang Mengalami Hipoksia Aziz, Muhammad Alamsyah; Krisnadi, Sofie Rifayani; Setiabudiawan, Budi; Handono, Budi
Majalah Kedokteran Bandung Vol 50, No 3 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v50n3.1408

Abstract

Kelahiran preterm (kurang bulan) merupakan salah satu penyebab kematian bayi yang hingga kini menjadi permasalahan di seluruh dunia. Salah satu mekanisme patofisiologis yang menyebabkan kelahiran kurang bulan adalah aktivitas sumbu hipotalamus-pituitari-adrenal (HPA) pada ibu dan janin. Stres maternal biologis berupa hipoksia merupakan salah satu penyebab terjadi mekanisme kelahiran kurang bulan melalui jalur aktivasi sumbu HPA ibu dan sebagai respons terhadap reactive oxygen species (ROS).  Vitamin D3 sebagai salah satu sumber ion Ca2+ dibutuhkan untuk mekanisme kontraksi dan relaksasi otot halus miometrium. Selain itu, vitamin D diduga berpengaruh terhadap kerja sumbu HPA. Tujuan penelitian ini adalah mengetahui pengaruh penambahan vitamin D3 pada sel lini PHM1-41 yang menjadi model in vitro dari kontraksi miometrium pada ibu hamil yang mengalami stres hipoksia terhadap kadar ROS intraseluler sel PHM1-41. Penelitian dilakukan di Laboratorium penelitian Aretha Medika Utama, Biomolecular and Biomedical Research Centre dengan kurun waktu penelitian dari bulan Desember 2017 hingga Februari 2018. Sel PHM1-41 yang telah dikultur dengan keadaan hipoksia selama 24 jam diberi penambahan vitamin D3, kemudian diukur kadar ROS intraselulernya. Hasil menunjukkan bahwa kadar ROS menurun signifikan pada kelompok sel yang diberi penambahan vitamin D3 dengan konsentrasi 150 nM dibanding dengan kelompok sel kontrol hipoksia. Hal ini menunjukkan  bahwa penambahan vitamin D3 150 nM memiliki potensi mencegah kelahiran kurang  bulanEffects of Vitamin D3 Treatment on Reactive Oxygen Species (ROS) Level in PHM1-41 Cell Line Experiencing HypoxiaPreterm birth is one of the major global cause of perinatal mortality. One of the pathophysiologic mechanisms leading to preterm birth is the Hypothalamic-Pituitary-Adrenal (HPA) axis activity of mother and fetus.. Maternal biological stress, such as hypoxia condition, is one of the trigger  of preterm birth through the activation of HPA axis as a response to the reactive oxygen species (ROS). Vitamin D3 as a source of Ca2+ ion is needed for myometrium smooth muscle’s contraction and relaxation mechanism. Vitamin D is also thought to strongly influence the HPA axis’s work. The purpose of this study was to determine the effect of  vitamin D3 provisionon PHM1-41 cell line induced by hypoxia as an  of pregnant women’s myometrium contraction through assessment of intracellular ROS level in PHM1-41 cell lines. This study was conducted in Aretha Medika Utama Biomolecular and Biomedical Research Centre from December 2017 to February 2018. PHM1-41 cells were cultured for 24 hours in hypoxia condition,Vitamin D3 was then added and the level of intracellular ROS was measured. Results showed that the ROS level decreased in cell clusters receiving 150nM vitamin D3 when compared to control hypoxia cell cluster. This indicates that the provision of 150nM vitamin D3 potentially prevents preterm  labor incidents.  
Maternal Mortality Risk Factors in Dr. Hasan Sadikin General Hospital, Bandung in 2009−2013 Shely Karma Astuti; Muhammad Alamsyah Aziz; Insi Farisa Desy Arya
International Journal of Integrated Health Sciences Vol 5, No 2 (2017)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Objective: To discover the factors affecting the occurrence of maternal deaths. The high maternal mortality rate (MMR) in Indonesia is still a common problem which needs urgent solution.Methods: This is an analytic observational, cross-sectional study using a case control approach Fifty two cases were selected as cases, another 52 were selected as control. The sampling was performed by simple random sampling. The instruments used in this study were the medical records of mothers who gave birth in Dr. Hasan Sadikin General Hospital Bandung from 1 January 2009–31 December 2013. Data analysis was performed using chi-square test. Results: In this study, the results showed that the risk factors contributing to maternal deaths were pregnancy complication (p<0.001), delivery complication (p<0.001), puerpural complication (p=0.022), age (p=0.030), parity (p=0.427), prior medical history (p<0.001), antenatal care (p=0.007), maternal education (p=0.527), and area of residence (p=0.049).Conclusions: The risk factors that contribute to maternal deaths include pregnancy complication, delivery complication, puerpural complication, maternal age, prior medical history, antenatal care, and area of residence. Keywords: Complication, maternal deaths, risk factors DOI: 10.15850/ijihs.v5n2.992
Gambaran Karakteristik Dan Luaran Maternal Pasien Obstetri Yang Dirawat di Ruang Perawatan Intensif RSUP Dr. Hasan Sadikin Selama Periode 2017-2018 Katharina Hiria Daundy; Muhammad Alamsyah Aziz; Siti Salima
Indonesian Journal of Obstetrics & Gynecology Science Volume 4 Nomor 1 Maret 2021
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v4n1.213

Abstract

Tujuan: Penelitian ini  dilakukan untuk mengetahui  gambaran  karakteristik dan  luaran maternal   pasien obstetri yang  dirawat di ruang perawatan intensif  RSUP Dr. Hasan Sadikin selama periode  tahun 2017–2018. Metode: Penelitian ini  menggunakan metode studi retrospektif deskriptif. Hasil: Sebanyak 173 pasien obstetri yang dirawat di ruang perawatan intensif  dengan luaran maternal hidup 159 pasien dan kasus meninggal 14 kasus. Luaran maternal hidup dengan penyakit penyerta terbanyak yaitu hipertensi dalam kehamilan, seperti eklamsia  36 (22,6%), impending eklamsia  12 (7,5%)  dan  PEB  52 (32,7%). Selain itu terdapat  penyakit jantung sebanyak 31 (19,5%). Luaran maternal meninggal   terbanyak  dengan penyakit jantung sebanyak 5 pasien (35,7%), eklamsia  sebanyak 4 pasien (28,6%). Kesimpulan: Indikasi rawat ruang intensif  terbanyak adalah hipertensi maligna 62 (39,0%). Jenis persalinan  terbanyak yaitu seksio sesarea 135 (78,0%).  Pasien dengan lama perawatan  selama <5 hari 99 (57,2%), 5–10 hari 63 (36,4%)  dan >10 hari 11 (6,4%).Bedasarkan hasil penelitian ini didapatkan penyakit terbanyak pasien obstetri yang dirawat di ruang perawatan intensif adalah  hipertensi dalam kehamilan meliputi eklamsia, impending eklamsia, dan preeklamsia berat.Description of Maternal Characteristics and Outcomes of Obstetrical Patients  in the Intensive Care Unit  Dr. Hasan Sadikin Hospital  during The Period 2017−2018Abstract:Objective: This study was conducted to determine the characteristics and maternal outcomes of obstetric patients who were treated in the intensive care unit of RSUP Dr. Hasan Sadikin during the 2017-2018 period. Method: a research method using a descriptive retrospective study.Result: A total of 173 obstetric patients were treated in intensive care unit 159 maternal outcomes and 14 cases died. Maternal outcomes of life with the most comorbidities are hypertension in pregnancy, such as eclampsia 36 (22.6%), impending eclampsia 12 (7.5%) and PEB 52 (32.7%). In addition there were heart disease as many as 31 (19.5%). Most maternal outcomes died with heart disease in 5 patients (35.7%), eclampsia in 4 patients (28.6%).Discussion : The most indication of intensive care is malignant hypertension 62 (39.0%). The most type of childbirth is cesarean section 135 (78.0%). Patients with duration of treatment for <5 days 99 (57.2%), 5-10 days 63 (36.4%) and> 10 days 11 (6.4%).Based on the results of this study found that most obstetric patients treated in intensive care are hypertension in pregnancy including eclampsia, impending eclampsia, and severe preeclampsia.Key words: Obstetric patients, intensive unit, maternal outcomes.
Faktor Risiko Preeklampsia di Puskemas Dupak Surabaya: Studi Kasus Kontrol Elga Caecaria Grahardika Andani; Muhammad Alamsyah Aziz; Johanes Cornelius Mose
EMBRIO: Jurnal Kebidanan Vol 14 No 1 (2022): EMBRIO: Jurnal Kebidanan (MAY)
Publisher : Program Studi S1 Kebidanan - Fakultas Ilmu Kesehatan Universitas PGRI Adi Buana Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36456/embrio.v14i1.4069

Abstract

Preeclampsia causes maternal death around 30-40% and tends to increase when accompanied by other organ complications. Preeclampsia is the first target to reduce maternal mortality because screening and prevention can be done. This research aims to analyze the risk factors for the incidence of preeclampsia. This research design is case control using primary data via google form. The research subjects were mothers who had given birth at Dupak Public Health Center Surabaya. Sampling was based on total sampling and simple random sampling technique that met the inclusion and exclusion criterias, each group consisted of 75 peoples. The analysis used was logistic regression and chi square. The results showed multiple pregnancies (AOR 3.89; 95% CI 0.714-21.186), family history of preeclampsia (AOR 5.19; 95% CI 1.287-20.959), previous history of preeclampsia (AOR 7.56; 95% CI 1.999-28.601), obesity (AOR 5.05; 95% CI 1.651-15.470) and chronic hypertension (AOR 5.12; 95% CI 1.294-20.312). The conclusion of this research is the previous history of preeclampsia is the strong risk factors of preeclampsia. Comprehensive antenatal care services and strict supervision of pregnant women with high risk can prevent serious complications for both mother and baby.
Relationship of Age, Body Mass Index, Gravida, and Parity in Pregnant Women with the Incidence Preeclampsia Muhammad Alamsyah Aziz; Aditya Wibowo; Nadia Larastri Almira; Tjut Sutjighassani
Indonesian Journal of Obstetrics & Gynecology Science Volume 5 Nomor 2 September 2022
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v5n2.389

Abstract

AbstractObjective: According to the 2016 Routine Health Profile Report, the exact causes of maternal mortality are hypertension (33.07%) and bleeding (27%). The exact cause of preeclampsia is unknown and is therefore referred to as the “disease of theory”. This study aimed to determine the relationship between age, BMI, gravida and parity with preeclampsia.Methods: This cross-sectional, analytic observational study, conducted in Hasan Sadikin Hospital, Bandung. Subjects are pregnant women undergoing antenatal care at Hasan Sadikin Hospital Bandung, in May 2020 a total of 40 women with a gestational age of  ≥ 20 weeks. The univariate and bivariate data were analyzed with SPSS. The Saphiro Wilk test was used to measure the data normality. The ANOVA one-way test and Fisher test were used to analyze the bivariate data.Results: Results show that of 19 samples with preeclampsia, 13 people (68.4%) were older than 35 years old with p-value of 0.042 which indicates a significant relationship. There is no significant difference between BMI, gravida, and parity, with the incidence of preeclampsia with p-value 0.602, 0.664, and 0.661 respectively.Conclusion: There is a relationship between mother’s age and the incidence of preeclampsia in Dr. Hasan Sadikin Hospital with p value = 0.042. This means older than 35 years old mothers have a tendency to develop preeclampsia.Hubungan Usia, Indeks Massa Tubuh, Gravida, dan Paritas pada Ibu Hamil dengan Insidensi PreeklamsiaAbstrakTujuan: Penelitian ini bertujuan untuk mengetahui hubungan paritas dengan preeklamsia.Metode: Studi observasional analitik potong lintang ini dilakukan di Rumah Sakit Hasan Sadikin Bandung. Subjek adalah ibu hamil yang menjalani pemeriksaan kehamilan di RS Hasan Sadikin Bandung, pada bulan Mei 2020 sejumlah 40 orang dengan usia kehamilan ≥ 20 minggu. Data univariat dan bivariat dianalisis dengan SPSS. Uji Saphiro Wilk digunakan untuk mengukur normalitas data. Uji satu arah ANOVA dan uji Fisher digunakan untuk menganalisis data bivariat.Hasil: Hasil penelitian menunjukkan bahwa dari 19 sampel dengan preeklamsia, 13 orang (68,4%) berusia lebih dari 35 tahun dengan p-value 0,042 yang menunjukkan hubungan yang signifikan.Kesimpulan: Ada hubungan usia ibu dengan kejadian preeklampsia di RSUD Dr. Hasan Sadikin dengan nilai p = 0,042. Ini berarti ibu yang berusia lebih dari 35 tahun memiliki kecenderungan untuk mengalami preeklamsia.Kata kunci: Preeklamsia, usia, IMT, gravida, paritas
Characteristics of Patients with Morbidly Adherent Placenta at Dr. Hasan Sadikin Hospital Bandung Muhammad Alamsyah Aziz; Dewi Retno Wulandari
Indonesian Journal of Obstetrics & Gynecology Science Volume 6 Nomor 1 Maret 2023
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia/v6n1.413

Abstract

AbstractObjective: Morbidly adherent placenta (MAP) is one of the causes of postpartum haemorrhage that impacts morbidity, hysterectomy, and mortality. This study reviewed patient characteristics and disease features in tertiary referral hospital patients with MAP.Methods: This is a quantitative descriptive study conducted on patients with MAP in September 2019–September 2020. Patient data were sourced from medical records. The characteristics described in this study include sociodemographic characteristics, obstetric history (gestation, parity, and abortion), history of caesarean section (CS), history of curettage, comorbidities, and current disease description and outcomes (bleeding, infant outcome, length of stay, death).Result: A total of 24 patients were diagnosed post-operatively as MAP in this study. Most of the patients were multi-parity, had a history of CS or curettage, and had comorbid placenta previa. Most of the patients came for CS plans or went with the chief complaint of bleeding. All patients were managed by hysterectomy. There was one case of maternal death and one case of fetal death.Conclusion: The characteristics of the patients in this study reflect the risk factors and general features of MAP.Karakteristik Pasien MAP di RSUP Dr. Hasan Sadikin BandungAbstrakTujuan: Morbidly adherent placenta (MAP) merupakan salah satu penyebab perdarahan pasca-salin yang berdampak pada morbiditas, tindakan histerektomi, dan mortalitas. Penelitian ini dilakukan untuk meninjau karakteristik pasien dan gambaran penyakit pada pasien dengan MAP di rumah sakit rujukan tersier.Metode: Penelitian ini merupakan deskriptif kuantitatif yang dilakukan pada pasien dengan MAP pada September 2019–September 2020. Data pasien bersumber dari rekam medik. Karakteristik yang dideskripsikan pada penelitian ini meliputi karakteristik sosiodemografi, riwayat obstetrik (gestasi, paritas, dan abortus), riwayat seksio caesarea (SC), riwayat kuretase, komorbid, dan gambaran penyakit terkini serta luarannya (perdarahan, luaran bayi, lama perawatan, kematian).Hasil: Sebanyak 24 pasien yang terdiagnosis pasca-bedah sebagai MAP pada penelitian ini. Sebagian besar pasien multi paritas, memiliki riwayat SC ataupun kuretase, dan memiliki komorbid plasenta previa. Sebagian besar pasien datang untuk rencana SC ataupun datang dengan keluhan utama perdarahan. Semua pasien ditatalaksana dengan histerektomi. Kematian pada ibu terjadi sebanyak satu kasus dan anak terjadi sebanyak satu kasus.Kesimpulan: Karakteristik pasien pada penelitian ini merefleksikan faktor risiko dan gambaran umum MAP.  Kata kunci: morbidly adherent placenta, plasenta akreta, plasenta inkreta, plasenta perkreta.
Pregnant Human Myometrial 1-41 Cell Viability Test on Vitamin D Administration Aziz, Muhammad Alamsyah; Krisnadi, Sofie Rifayani; Handono, Budi; Setiabudiawan, Budi
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2750

Abstract

Background: Preterm labor is one of the universal causes of perinatal mortality worldwide. One of the causes of preterm labor is uterine muscle integrity problems. Some mechanistic studies show insight into vitamin D activity’s possible role in the injured muscle. This study aimed to determine whether vitamin D can increase muscle cell viability.Methods: This experimental research used human smooth muscle uterine myometrium cell line pregnant human myometrial (PHM) 1-41. The cells were cultured for 24 hours in hypoxia condition, then incubated with several doses of vitamin D. The PHM1-41 cell viability was measured using spectrophotometry. Data analysis was conducted using IBM SPSS 24.0. A p-value <0.05 was considered statistically significant. Results: The result showed that the minimum level of muscle cell viability after vitamin D incubation was with 300 nM administration, and the maximum level was after 10nM (88.57%+4.48 and 96.21%+2.13 respectively).Conclusions: Vitamin D at a specific dose can improve cell availability. The optimal dose to improve cell viability is 10 nM. 
Outcome of Fetuses with Anterior Abdominal Wall Defects in A Tertiary Referral Hospital Alifa, Dhara; Aziz, Muhammad Alamsyah; Ritonga, Mulyanusa Amarullah; Pribadi, Adhi
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 2 Juli 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i2.691

Abstract

Introduction: The most common abdominal wall defects are gastroschisis and omphalocele. Gastroschisis is a case of intraabdominal herniation caused by an abdominal wall defect from exposure to amniotic fluid during pregnancy. Omphalocele is a case of intraabdominal herniation covered with a membranous sac on the umbilical cord’s base. Gastroschisis occurred in 1/4000 of the of the global birth rate. Prevalence of omphalocele in between 1/3000 and 1/5000 cases of pregnancy. The purpose of the purpose of the research  is to present an overview of patients with congenital defects such as Gastroschisis and Omphalocele.Method: Research design is observational and descriptive. Data obtained from medical records in Hasan Sadikin tertiary referral hospital Bandung. Sample size was obtained by total sampling and conducted in April 2020–April 2023. Results: The demographics of gastroschisis include male (50%), female (50%), preterm (20%), stillbirth (30%), severe asphyxia (14.29%), moderate asphyxia (57.14%), normal asphyxia (8.57%), newborn mortality (14.29%), and other congenital anomalies (40%). In comparison, the demographics of omphalocele are male (66.67%), female (33.33%), preterm (58.33%), stillbirth (16.67%), severe asphyxia (40%), moderate asphyxia (40%), normal asphyxia (20%), newborn mortality (50%), and other congenital abnormalities (25%). Abdominal wall defects are seldom related with gender.Conclusion: Abdominal wall defect is a very rare congenital abnormality. This abnormality will require primary abdomen closure surgery to enhance the baby’s prognosis. The more other risk factors exist within abdominal wall defect babies, the worse their following prognosis will be. The prognosis for omphalocele is more severe than gastroschisis due to the presence of asphyxia and prematurity.Luaran Janin dengan Defek Dinding Abdominal Anterior di Rumah Sakit Rujukan TersierAbstrakPendahuluan: Cacat dinding depan abdomen yang paling banyak terjadi adalah gastroschisis dan omphalocele. Gastroschisis adalah kasus herniasi intraabdomen yang disebabkan oleh cacat dinding perut akibat paparan cairan ketuban selama kehamilan. Omphalocele adalah kasus herniasi intraabdomen yang ditutupi kantung membran di dasar tali pusat. Gastroschisis terjadi pada 1/4000 angka kelahiran global. Prevalensi omfalokel antara 1/3000 dan 1/5000 kasus kehamilan. Tujuan dari penelitian ini adalah untuk menyajikan gambaran pasien dengan kelainan bawaan seperti Gastroschisis dan Omphalocele.Metode: Desain penelitian adalah observasional dan deskriptif. Data diperoleh dari rekam medis di rumah sakit rujukan tersier Hasan Sadikin Bandung. Besar sampel diperoleh dengan cara total sampling dan dilakukan pada bulan April 2020–April 2023.Hasil: Demografi gastroschisis meliputi laki-laki (50%), perempuan (50%), prematur (20%), lahir mati (30%), asfiksia berat (14,29%), asfiksia sedang (57,14%), asfiksia normal (8,57%). ), kematian bayi baru lahir (14,29%), dan kelainan kongenital lainnya (40%). Sebagai perbandingan, demografi omfalokel adalah laki-laki (66,67%), perempuan (33,33%), prematur (58,33%), lahir mati (16,67%), asfiksia berat (40%), asfiksia sedang (40%), asfiksia normal (20). %), kematian bayi baru lahir (50%), dan kelainan bawaan lainnya (25%). Cacat dinding perut jarang berhubungan dengan jenis kelamin.Kesimpulan: Cacat dinding perut merupakan kelainan bawaan yang sangat tidak biasa. Kelainan ini memerlukan operasi penutupan perut utama untuk meningkatkan peluang hidup bayi. Adanya faktor risiko tambahan pada bayi baru lahir dengan kelainan dinding perut memperburuk prognosisnya. Omphalocele sering menyebabkan asfiksia dan prematur, sehingga prognosisnya lebih buruk dibandingkan gastroschisis.Kata Kunci : Cacat dinding depan abdomen, Gastroschisis, Omphalocele 
Atypical Findings of Suspect Twin to Twin Transfusion Syndrome Quintero V: a Rare Case Report Gusasih, Bahar Sangkur; Irianti, Setyorini; Aziz, Muhammad Alamsyah; Kurniadi, Andi
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 4 October 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i4.2352

Abstract

Introduction: Twin-to-twin transfusion syndrome (TTTS) is a serious complication in monochorionic multiple pregnancies. Case Illustration: A-38 years old woman with G3P2AO felt 8 months pregnant and came for polyclinic control with the diagnosis of G3P2A0 gravida 34-35 weeks; Gemelli; Baby I Breech position; Baby I Polyhydramnios, IUFD; Suspected Twin Twin Transfusion Syndrome (TTTS Quintero V). However, atypical findings of TTTS are rarely found and should be taken as special notes such in this case. We will report a rare finding of TTTS in which the SDP level of the donor fetus was normal (not oligohydramnios). The suspected diagnosis of TTTS Quintero V in this case was made clinically based on the maternal-fetal ultrasound findings of a diamniotic monochorionic gemelli pregnancy with IUFD in the 2nd fetus II. However, there were non-standard findings in this case where the SDP level of the donor fetus was normal (not oligohydramnios). No other sequele complications were found in this case based on other examinations. Conclusions: Several therapies are available for TTTS including amnioreduction, laser ablation of the vascular placental anastomosis, selective feticide, and septostomy. Timing of delivery after management of singleton fetal death in the late second or early third trimester is debatable. Delivery method is determined based on obstetric indications.
Vitamin D Levels and Incidence of Preterm Labor Aziz, Muhammad Alamsyah; Syahbana, Chandra Garnida; Effendi, Jusuf Sulaeman; Purwara, Benny Hasan; Madjid, Tita Husnitawati; Susiarno, Hadi
Majalah Kedokteran Bandung Vol 56, No 1 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3070

Abstract

One pathophysiology of preterm delivery is maternal or fetal hypothalamus-pituitary-adrenal (HPA) axis activation. The HPA axis can be affected by vitamin D, which increases uterine contractions and affects the body’s immune mechanism against bacterial infections. A lower level of vitamin D in pregnant women is suspected to contribute to the incidence of premature conditions. This study aimed to compare the 25-hydroxy-vitamin D3 concentration in preterm parturient with non-preterm parturient, and the correlation between vitamin D level and the incidence of preterm labor. This comparative analytic study used a cross-sectional approach and involved 46 subjects who were divided into case and control groups. This study was conducted in August–September 2017 at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. The Electro-chemiluminescence Immunoassay (ECLIA) method was used to examine the serum 25-hydroxy-vitamin D3 concentration in case and control groups, demonstrating that 25-hydroxy-vitamin D3 concentration in case group (17.26 ng/mL) was significantly (p<0.0001) lower than in control group (24.30 ng/mL). The correlation coefficient between the 25-hydroxy-vitamin D3 and the incidence of preterm labor was -0.837 (p<0.001).  Thus, there was a correlation between the 25-hydroxy-Vitamin D3 level and the incidence of preterm labor that vitamin D supplementation in pregnant women must be considered.
Co-Authors Adhi Pribadi Aditya Wibowo Akhmad Yogi Pramatirta, Akhmad Yogi Alifa, Dhara Almira, Nadia Larastri Ana Mariana, Ana Anabela, Lisa Milena Andi Kurniadi, Andi Aqilah, Nurjihan Syarifah ASTRI ASTUTI Avivi, Safiya Fathina Benny Hasan Purwara Budi Handono Budi Setiabudiawan Cool, Charlotte Johanna Damayani, Ayi Diah Dewanto, Wenardy Dewi Marhaeni Diah Herawati Dewi Retno Wulandari Dida Akhmad Gurnida Dwi Prasetyo Elga Caecaria Grahardika Andani Elly Yana, Elly Fauzi, Ali Amali Gusasih, Bahar Sangkur Harsono, Ali Budi Insi Farisa Desy Arya Johanes C Mose Jusuf Sulaeman Effendi Katharina Hiria Daundy Kharismawati, Nuniek Kurnia Wahyudi, Kurnia Lillah, Alfarisi Syukron Madjid, Tita Husnitawati Nadia Larastri Almira Nugrahani, Annisa Dewi Pramudyo, Miftah Prihatni, Delita Putra, Ridwan Abdullah Ritonga, Mulyanusa Amarullah Ritonga, Mulyanusa Amrullah Sembiring, Gaipyana Setyorini Irianti Shely Karma Astuti Siti Salima Sofie R. Krisnadi Susiarno, Hadi Sutjighassani, Tjut Syahbana, Chandra Garnida Tjut Sutjighassani Windi Nurdiawan Zulvayanti Zulvayanti