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All Journal International Journal of Integrated Health Sciences Althea Medical Journal Folia Medica Indonesiana Sari Pediatri Majalah Kesehatan FKUB Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Adhi Kristianto Sugianli
Department Of Clinical Pathology RSHS/Faculty Of Medicine Padjadjaran University
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health Other

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Role of Kletik oil, Ginger and Garlic Extracts towards Soft Tissue Injury Qing Nan, Benjamin Yong; Ismiarto, Yoyos Dias; Sugianli, Adhi Kristianto
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (137.926 KB)

Abstract

Background: There is an increased consumption of herbal medicines throughout the world as an alternative treatment for curing health problems. Several herbal medicines are believed to contain anti-inflammatory properties that could trigger healing process. But little is known about the combination effect of herbal medicines. Therefore, the objective of the study was to determine the effects of garlic, ginger and coconut oil (kletik oil) on soft tissue injury (swelling).Methods: The study was held in the research laboratory of Faculty of Medicine Universitas Padjadjaran, from 24th September until 1st October 2014. This experimental study used 7 healthy rabbits (Lepus curpaeums, ±2.5kg) as animal models for each control and intervention group with induced soft tissue injury in the dorsal ear to mimic swelling (inflammation). The mixture of herbs was applied on the injured site in the trial group, while the healing process was denoted by the thickness of edema and time of observation. The data was analyzed using Wilcoxon test.Results: The study results showed that after observation time of 0.5 hour, 2 hours, and 5 hours, edema thickness was unvaried. Onset of action of the herbal mixture began 24 hours after induced injury, with significant difference of edema thickness on both groups; hence the p-value 0.019 (p<0.05).Conclusions: The herbal mixture of ginger, garlic, and coconut oil (kletik oil) contains anti-inflammatory properties to enhance the healing process of soft tissue injury. [AMJ.2016;3(3):421–4]DOI: 10.15850/amj.v3n3.870 
Monocyte to Lymphocyte Ratio in Peripheral Blood of Tuberculous Meningitis with HIV Patients in Tertiary Hospital in West Java Amalia, Ridha; Turbawaty, Dewi Kartika; Sugianli, Adhi Kristianto; Aminah, Siti
International Journal of Integrated Health Sciences Vol 6, No 1 (2018)
Publisher : International Journal of Integrated Health Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (85.27 KB) | DOI: 10.15850/ijihs.v6n1.1140

Abstract

Objective: To describe peripheral blood monocyte to lymphocyte (ML) ratio in tuberculous meningitis (TBM) patients with human immunodeficiency virus (HIV) infection in Dr. Hasan Sadikin General Hospital Bandung as a tertiary hospital in West Java Province, Indonesia.Method: A cross-sectional study with retrospective data approach was done in Dr. Hasan Sadikin General Hospital, Bandung. Data were collected from TBM patients who were hospitalized in Dr. Hasan Sadikin General Hospital, Bandung in the period of 2014–2016. The sample size was determined using total sampling method. General data, clinical manifestation data, and laboratory finding data were collected. The ML ratio was collected and presented into three groups of percentile (25th, 25–75th and 75th) based on the pre-defined cut-off.Result: Six subjects (40%) had an ML ratio of ≤0.47 and 3 subjects had an ML ratio of ≥1.22 in TBM with HIV population. Among TBM with HIV-negative population, there were 16 subjects had ML ratio ≤0.47, and 19 subjects had ML ratio ≥1.22.Conclusion: The ML ratio in TBM with HIV infection has become additional tool for detecting the development of TBM with HIV-infected, as well as TBM with non-HIV-infected. Therefore, it could help directing the patients with clinical suspicious of TBM into the diagnosis algorithm and treatment of TBM, to have better outcome.Keywords: Human immunodeficiency virus infection,lymphocyte, monocyte, monocyte to lymphocyte ratio, tuberculous meningitis DOI: 10.15850/ijihs.v6n1.1140
Role of Kletik oil, Ginger and Garlic Extracts towards Soft Tissue Injury Benjamin Yong Qing Nan; Yoyos Dias Ismiarto; Adhi Kristianto Sugianli
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (57.845 KB)

Abstract

Background: There is an increased consumption of herbal medicines throughout the world as an alternative treatment for curing health problems. Several herbal medicines are believed to contain anti-inflammatory properties that could trigger healing process. But little is known about the combination effect of herbal medicines. Therefore, the objective of the study was to determine the effects of garlic, ginger and coconut oil (kletik oil) on soft tissue injury (swelling).Methods: The study was held in the research laboratory of Faculty of Medicine Universitas Padjadjaran, from 24th September until 1st October 2014. This experimental study used 7 healthy rabbits (Lepus curpaeums, ±2.5kg) as animal models for each control and intervention group with induced soft tissue injury in the dorsal ear to mimic swelling (inflammation). The mixture of herbs was applied on the injured site in the trial group, while the healing process was denoted by the thickness of edema and time of observation. The data was analyzed using Wilcoxon test.Results: The study results showed that after observation time of 0.5 hour, 2 hours, and 5 hours, edema thickness was unvaried. Onset of action of the herbal mixture began 24 hours after induced injury, with significant difference of edema thickness on both groups; hence the p-value 0.019 (p<0.05).Conclusions: The herbal mixture of ginger, garlic, and coconut oil (kletik oil) contains anti-inflammatory properties to enhance the healing process of soft tissue injury. [AMJ.2016;3(3):421–4]DOI: 10.15850/amj.v3n3.870 
Clinical Manifestation and Hematologic Interpretation of Pediatric Systematic Lupus Erythematosus at Initial Presentation: 2-Years Observation Hasti Savira Yudiana; Reni Ghrahani; Adhi Kristianto Sugianli
Althea Medical Journal Vol 8, No 2 (2021)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v8n2.2153

Abstract

Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disease characterized by a spectrum of clinical manifestations, immunological abnormalities, and varied laboratories results. In children, SLE manifestation is particularly more severe, involving more organs. Hematological manifestation has been known as the most common manifestation. The purpose of this study was to describe the clinical manifestations and hematologic interpretation of pediatric SLE at initial presentation.Methods: This retrospective data collection study was conducted at the Department of Child Health Dr. Hasan Sadikin General Hospital Bandung on medical records from a two-year period of 2017–2018. The clinical manifestations were categorized into malar rash, discoid rash, photosensitivity, oral ulcers, arthritis, renal disorders, and neurological disorders. The hematologic interpretations were categorized into anemia, leukopenia, neutropenia, lymphopenia, and thrombocytopenia. Clinical manifestations and hematological interpretations were presented as occurrence percentages and stratified into three age-group of pre-pubertal, peri-pubertal, and post-pubertal.Results: Among 79 pediatric SLE patients (median age 14 years old; IQR 11–16), female gender was predominant. Abnormalities hematologic interpretation occurs in more than half of the patients (83.5%). Malar rash and anemia were the commonest findings among all age groups. Increased occurrence of neuropsychiatric and renal disorders were observed in all age-groups.Conclusions: Malar rash and anemia are important findings among pediatric SLE patients. Furthermore, the occurrences of the neuropsychiatric and renal disorders are also important.
Clinical Manifestations and Laboratory Examination Findings of Hepatocellular Carcinoma at a Tertiary Care Facility in Bandung: An Annual Observation Study Grace Amanda Maharani; Eka Surya Nugraha; Adhi Kristianto Sugianli
Althea Medical Journal Vol 8, No 3 (2021)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v8n3.2333

Abstract

Background: Hepatocellular Carcinoma (HCC) is the most prevalent liver cancer with high mortality. Early detection is important for better patient outcomes. The aim of this study was to explore clinical manifestations and laboratory examinations among HCC patients in a tertiary care facility.Methods: This was a cross-sectional descriptive study with a total sampling method, reviewing the medical record of patients with HCC in the Outpatient Clinic of Dr. Hasan Sadikin General Hospital between January to December 2019. Clinical manifestations, laboratory findings, and imaging results data were collected.Results: Of the 112 HCC patients included in this study, the HCC findings among new patients at the outpatient clinic were 8.4%, with hepatitis B (80.8%) as the major etiology. Complaints of abdominal pain (65.2%) was frequent. Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were increased in 89.8% and 67% of patients, as well as total bilirubin levels in 58.8% of patients. In contrast, hemoglobin and albumin levels decreased in 55.3% and 78.1% of patients, respectively. The characteristics of tumor were mainly multinodular, with a size of 3-10 cm.Conclusions: The annual proportion of HCC in Dr. Hasan Sadikin General Hospital in 2019 is 8.4% among all outpatient gastrointestinal and hepatology cases, with hepatitis B as the most common etiology. Abdominal pain is the predominantly prevalent clinical manifestation with increased ALT and AST levels.
Prevalence of Hematotoxic Effect of Intravenous Chemotherapy among Retinoblastoma Population in Tertiary Hospital in Bandung, Indonesia Jennifer Hadiman; Susi Susanah; Adhi Kristianto Sugianli
International Journal of Integrated Health Sciences Vol 7, No 1 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (484.591 KB) | DOI: 10.15850/ijihs.v7n1.1520

Abstract

Objective: To observe the prevalence of hematotoxic effect in retinoblastoma patients who were given intravenous chemotherapy with vincristine, etoposide, and carboplatin (VEC) regimen. Retinoblastoma is the second most common cancer in children in Indonesia. Standard chemotherapy agents used in retinoblastoma treatment is VEC given in 7 cycles intravenously. The most common side effect of VEC regimen is hematotoxic effect which might lead to chemotherapy failure.Methods: This study used descriptive method with cross sectional study design. Data were collected from medical records of retinoblastoma patients in Dr. Hasan Sadikin General Hospital Bandung, Indonesia, from 2014 until 2016 using total sampling technique.Results: Forty-six patients were included in this study. Of those subjects, 36 (78.3%) patients experienced hematotoxic effect. The most common hematotoxic effect occurred were anemia and neutropenia, that occurred in 32 (69.6%) and 18 (39.1%) patients, respectively. The most common hematotoxic effect severity occurred were grade 1 anemia, grade 1 leukopenia, grade 1 neutropenia, and grade 3 thrombocytopenia. Percentage of patients experienced anemia tended to increase until the 7th cycle. Seven (15.2%) patients had anemia prior to chemotherapy administration.Conclusion: The majority (78.3%) of the patients experienced hematotoxic effect on intravenous chemotherapy administration with VEC regimen. Anemia was the most common hematotoxic effect occurred.Keywords: Hematotoxic effect, intravenous chemotherapy, retinoblastoma 
Clinical Manifestations and Hematological Profiles of Pediatric Acute Myeloblastic Leukemia Patients: 3 Years Observational Study in A West Java Tertiary Hospital, Indonesia Agustinus Wiraatmadja; Nur Suryawan Hidayat; Adhi Kristianto Sugianli
International Journal of Integrated Health Sciences Vol 7, No 2 (2019)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v7n2.1480

Abstract

Objective: To determine and describe the clinical manifestations and hematological profiles of pediatric Acute Myeloblastic Leukemia (AML) in Dr. Hasan Sadikin General Hospital (RSHS), Bandung as a tertiary hospital in West Java, Indonesia.Methods: A retrospective cross-sectional study using the total sampling method was performed on the medical records of pediatric patients (0-18 years old)who were diagnosed as AML for the first time through bone marrow examination during the period of January 1, 2015 – December 31, 2017. Results: Of the 54 subjects who met the inclusion criteria, 42.6% were AML patients in the age group 6-12 years with male patients comprised 59.3% of the total number of subjects. Patients generally experienced pallor (83.3%), fever (75.9%), and decreased appetite (70.4%). The hematological profiles showed that 35.2% of patients had Hb <6.5 g/dL and 44.4% had a leukocyte count of  of >50,000 cells/mm3. The majority of the subjects had a platelet count of <50,000 cells/mm3 (83.3%) and almost half of them had a peripheral blasts count of >50% (46.3%).      Conclusion: Clinical manifestations and hematological profiles are important to diagnose AML, especially in pediatric patients. By assessing the manifestations and profiles, it is feasible to access and detect suspected cases of AML.
Gambaran Cairan Serebrospinal pada Pasien Anak dengan Infeksi Susunan Saraf Pusat di Rumah Sakit Rujukan Jawa Barat Ariel Bagoes Prakoso; Mia Milanti Dewi; Adhi Kristianto Sugianli
Sari Pediatri Vol 21, No 6 (2020)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp21.6.2020.339-45

Abstract

Latar belakang. Infeksi pada susunan saraf pusat (SSP) dapat memberikan dampak permanen, seperti ganguan fungsi kognitif dan fisik apabila terlambat mendapatkan penanganan. Perubahan komposisi cairan serebrospinalis (LCS) dapat digunakan sebagai indikator pada infeksi SSP. Studi kepustakaan pada karakteristik perubahan komposisi LCS masih sulit ditemukan sehingga diperlukan studi lebih lanjut mengenai hal ini.Tujuan. Mengetahui gambaran LCS pada pasien anak dengan infeksi susunan saraf pusat.Metode. Deskriptif potong lintang terhadap rekam medis pasien anak dengan infeksi susunan saraf pusat rawat inap di RSUP Dokter Hasan Sadikin Bandung periode Januari 2015-Agustus 2019.Hasil. Dari 211 subjek penelitian dengan rentang usia 1 bulan hingga 18 tahun diperoleh rerata usia 7,18, median usia 5, dan standar deviasi usia 6,53. Diperoleh pada kelompok usia 1 bulan-2 tahun 39,8%, 3-6 tahun 14,7%;, 7-12 tahun 12,8%; dan 13-18 tahun 32,7%. Diperoleh 45,5% sampel merupakan infeksi tuberkulosis (TB), 21,3% sampel infeksi virus, 9,5% sampel infeksi bakteri, dan 23,7% sampel infeksi tidak spesifik.Kesimpulan. Pemeriksaan LCS sangat penting dilakukan untuk menunjang diagnosis infeksi SSP. Sebagian besar LCS menunjukkan gambaran infeksi yang disebabkan oleh TB
Laboratory Diagnostic Approach and Interpretation in Gram-Negative Bacterial Infection: A-Case Report of Sepsis in Secondary Hospital Settings Adhi Kristianto Sugianli; Ida Parwati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 26, No 3 (2020)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v26i3.1563

Abstract

Gram-Negative Bacteria (GNB) have been widely reported to cause worldwide infections and life-threatening. The high prevalence of drug-resistant GNB causes the treatment of GNB to become difficult. This case report describes a stepwise laboratory approach and interpretation for Gram-negative bacteria infection in sepsis patients. An 84-year-old female patient with a history of congestive heart failure, after three weeks of hospitalization, GNB was proven as the cause of sepsis. Laboratory approach for inflammation (C-reactive protein, procalcitonin) was made and confirmed with a positive culture of several specimens (sputum, urine, and blood). The identification of bacterial-culture revealed as Carbapenem-resistance Klebsiella pneumoniae and Extended-spectrum Beta-lactamases Escherichia coli. This case highlights GNB as a potential agent to worsen the infection (sepsis) and also a useful approach for the detection of multidrug-resistant bacteria, particularly in secondary hospital settings. The application and interpretation of integrated clinical and laboratory criteria may bring out better and effective patient management.
PENGANGKAAN (KUANTIFIKASI) PERIKSAAN PULASAN GRAM DI BERBAGAI JENIS BAHAN PEMERIKSAAN Adhi Kristianto Sugianli; Ida Parwati
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 1 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i1.1048

Abstract

In a clinical microbiology laboratory the Gram staining is used to classify bacteria on the basis of their forms, sizes, cellularmorphologies, and Gram reactions. Additionally it is a critical test for rapid presumptive diagnosis of infectious agents and serves toassess the quality of clinical specimens. Several methods of Gram staining quantification are already applied: Canadian Coalition forQuality in Laboratory Medicine (CCQLM), Clinical Microbiology Proficiency Testing (CMPT), and World Health Organization (WHO).Each method consists of several criteria for quantification and its interpretation, such as neutrophil cell (polymorphonuclear cells),squamous epithelial cell, and number of microorganisms. Those methods aren't limited in sputum specimen, but also could be used forother specimen such as urine, vaginal discharge, and other body fluids. These methods are also could be used as screening for specimenbefore it is continued into further testing. Even though there is several limitation for each method, quantification method of Gramstaining could be provide better diagnostic value in microbiology laboratory as an early detection in the examination to get betterdiagnosis as well as treatment.
Co-Authors Adrian Gunawan, Adrian Agus Sunardi Agustinus Wiraatmadja Amalia, Ridha Amiliana M. Soesanto Andaru Dahesihdewi Ariel Bagoes Prakoso Audiyananda, Dwika Benjamin Yong Qing Nan Coriejati Rita Dewi Kartika Turbawaty Eka Surya Nugraha Emmy Hermiyanti Pranggono Endah Nurul Aini Fatimah Grace Amanda Maharani Hasti Savira Yudiana Hermawan Nagar Rasyid, Hermawan Nagar Horian, Erinca Ida Parwati Jennifer Hadiman Leni Lismayanti Lilik Indrawati, Lilik Mia Milanti Dewi Nadjwa Zamalek Dalimoenthe Nita Elvina Wisudawati Nur Suryawan Hidayat Prakoso, Baskoro Justicia Prihatni, Delita Qing Nan, Benjamin Yong Rarsari Soerarso Reni Ghrahani Siti Aminah Surata, Nida Susi Susanah Uun Sumardi, Uun Yovita Hartranti Yoyos Dias Ismiarto