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Layanto, Nicolas
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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DISTRIBUSI DAN POLA KEPEKAAN BAKTERI PATOGEN PADA UNIT PERAWATAN INTENSIF SEBUAH RS SWASTA DI JAKARTA Dharmawan, Ade; Gunardi, Wani Devita; Layanto, Nicolas
E-Jurnal Medika Udayana Vol 12 No 8 (2023): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2023.V12.i08.P08

Abstract

HAIs merupakan infeksi yang didapat saat pasien mendapatkan perawatan kesehatan. Salah satu faktor terjadinya infeksi nosokomial adalah perawatan di ruang rawat intensif. Penelitian ini menggunakan desain retrospektif potong lintang, menggunakan data sekunder dari data pola bakteri periode Januari – Desember 2020 di salah satu RS Swasta di Jakarta. Hasil penelitian didapatkan 5 bakteri terbanyak pada pasien infeksi di ruang perawatan intensif adalah A. baumannii 32,7%, K. pneumoniae 15,9%, S. maltophilia dan S. epidermidis masing-masing 12%, serta P. aeruginosa 10%. Dari hasil pola sensitivitas antibiotik, A. baumannii sensitif hanya terhadap Colistin (100%), K. pneumonia, cukup baik sensitivitasnya terhadap Amikacin (88,2%) dan Colistin (100%), S. maltophilia sensitif terhadap Trimethoprim-Sulfamethoxazole 84,6% dan Colistin 100%, sedangkan P. aeruginosa masih cukup sensitif terhadap Amikacin (72,7%), Ceftazidime dan Colistin masing-masing 75%.
POLA KEPEKAAN ANTIBIOTIK ORAL PADA INFEKSI SALURAN KEMIH KOMUNITAS PADA PASIEN PEDIATRIK RS X TAHUN 2022 Layanto, Nicolas; Dharmawan, Ade; Gunardi, Wani Devita; Rina, Veronica
E-Jurnal Medika Udayana Vol 13 No 3 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i03.P12

Abstract

Some pediatric urinary tract infection show unspesific symptoms and can be treated as an outpatient. Right oral antibiotic can prevent those infection become more severe. All urin sample from pediatic patient without history of antibiotic before sample were taken were collected for one year to get antibiotic pattern from oral antibiotic such as amoxicillin, amoxicillin clavulanat, cefixime, cotrimoxazole, and fosfomycin from all pathogen. All pediatric patient were classified by age. From 0-1 year group dan 1-3 years old group, Proteus mirabilis, Eschericia coli and Enterococcus sp. are the most common bacteria found while oral antibiotic with highest sentivity are cotrimoxazole and fosfomycin. Most Multi Drug Resistant bacteria found in this study were from 0-1 year old group
Uji Aktivitas Antibakteri Ekstrak Daun Kelor (Moringa oleifera) Terhadap Staphylococcus aureus Andini, KD Ayu Asti; Dharmawan, Ade; Layanto, Nicolas
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3473

Abstract

Plants are a source of various types of chemical compounds that have many benefits, one of which is as antibacterial agents. One of the plants known for its antibacterial properties is the moringa leaf (Moringa oleifera). This research aims to determine whether moringa leaves (Moringa oleifera) possess antibacterial activity, as well as to identify the minimum inhibitory concentration and minimum bactericidal concentration of moringa leaf extract against Staphylococcus aureus bacteria. This research method uses the dilution method. The results of the research indicate that moringa leaf extract has antibacterial activity against Staphylococcus aureus at concentrations of 20%, 40%, and 80%. It was found that as the concentration increases, the antibacterial activity inhibiting the growth of Staphylococcus aureus also increases.
The Outcome of Patients with Sepsis at Tarakan Hospital Central Jakarta in 2018 Dharmawan, Ade; Istia, Mieke Joseba; Tan, Henny Tannady; Suparto, Suparto; Anastasia, Monica Cherlady; Layanto, Nicolas
Muhammadiyah Medical Journal Vol 2, No 2 (2021): Muhammadiyah Medical Journal (MMJ)
Publisher : Faculty of Medicine and Health Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (468.53 KB) | DOI: 10.24853/mmj.2.2.49-54

Abstract

Background: Sepsis is a common, life-threatening organ dysfunction caused by a dysregulated host response to infection. In 2017, estimated cases for sepsis reached 48.9 million worldwide, with 11 million deaths. Adequate antibiotic therapy is crucial for the treatment of sepsis. Purposes: The objective of this study is to find factors related to sepsis patient outcomes. Methods: We conducted a 1-year retrospective descriptive study with the inclusion criteria of all adult sepsis patients in Tarakan District Hospital in 2018. We compiled 39 samples that fit the inclusion criteria. Results: The distribution gender of this study were 51.2% female and 48.8% male patients; with most patients in the age of 65 years old (53.8%), 7 days in the length of stay (72%), and the most common source of infection was gastrointestinal (33.3%) followed by lungs (28.2%). Conclusion: We found a mortality rate of 59%, with the most common source of infection leading to death was the lungs (81.2%) and treated with single ceftriaxone antibiotic therapy (78.3%). Another factor associated with mortality is inadequate single antibiotic therapy.
Profil Bakteri Patogen dan Kepekaannya pada Pasien Ventilator Associated Pneumonia dengan Infeksi COVID- 19 di Rumah Sakit UKRIDA¬ Christopher, Jeremy; Dharmawan, Ade; Pasaribu, Donna Mesina; Layanto, Nicolas
Jurnal Kesehatan Andalas Vol. 11 No. 3 (2022): Online November 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i3.1998

Abstract

The use of ventilators during the COVID-19 pandemic has increased the incidence of Ventilator-Associated Pneumonia (VAP). This is accompanied by a trend of antibiotic resistance resulting from irrational use. The emergence of multi-drug resistant (MDR) bacteria during the pandemic presents a challenge due to limited antibiotic options. Objective: To determined the pathogenic bacterial profile and antibiotic susceptibility in Ventilator Associated Pneumonia (VAP) patients with COVID-19 infection. Methods: This is a descriptive cross-sectional study with a retrospective approach using secondary data from the medical records of UKRIDA Hospital patients from January 2021 to August 2021. Results: Most of the study sample had characteristics of being male (71.9%), aged 25-64 years (78.1%), overweight (40.6%), and hypertension (40.6%) as the comorbid. Gram-negative bacteria is the pre-dominated bacteria in this study, with Acinetobacter baumannii, Klebsiella pneumoniae, and Stenotrophomonas maltophilia being the most isolated bacteria. Antibiotics such as colistin still showed good susceptibility to Acinetobacter baumannii and Klebsiella pneumoniae, with 75% and 90% sensitivities, respectively. Antibiotics such as linezolid, tigecycline, and gentamicin-synergy still showed (100%) sensitivity to all Gram-positive bacteria. Conclusion: The discovery of MDR bacteria in patients with VAP and the limited availability of susceptible antibiotics highlights the importance of conducting antibiotic resistance surveillance and infection control, especially in the era of COVID-19.Keywords:  antibiotic susceptibility, bacteria profile, COVID-19, VAP
Uji Efektivitas Antiseptik Povidone Iodine Terhadap Pseudomonas aeruginosa Juliet, Theresa; Layanto, Nicolas; Liusono, Justinus
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 3 (2025): Volume 12 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i3.18657

Abstract

Pseudomonas aeruginosa berperan dalam meningkatkan infeksi nosokomial sebesar 10-15% di dunia. Hal ini dikarenakan kemampuan resistensi intrinsik dan ekstrinsik yang dimiliki oleh bakteri tersebut. Pseudomonas aeruginosa sering menginfeksi pasien praoperasi, pascaoperasi, dan pasien dengan pemasangan kateter. Povidone iodine merupakan antiseptik yang sering digunakan dalam proses sepsis asepsis karena harganya murah dan mudah digunakan oleh masyarakat.Mengetahui efektivitas povidone iodine melalui konsentrasi dan waktu kontak minimum povidone iodine terhadap pertumbuhan Pseudomonas aeruginosa. Penelitian ini menggunakan metode eksperimental dengan rancangan deskriptif observasional. Penelitian dilakukan dengan meremajakan bakteri, membuat suspensi bakteri, dan memasukkan suspensi Pseudomonas aeruginosa ke dalam tabung reaksi yang berisi povidone iodine dengan konsentrasi yang bervariasi serta waktu tertentu. Setelah diuji, bakteri ditanam pada media Nutrient Broth serta dilakukan uji efektivitas dengan koefisien fenol. Povidone iodine dengan konsentrasi 1% sudah dapat membunuh Pseudomonas aeruginosa PAO1 dalam waktu 1 menit. Nilai koefisien fenol povidone iodine dalam penelitian ini yaitu 5,625 Pseudomonas aeruginosa PAO1 dapat dihambat pertumbuhannya dengan povidone iodine 1%. Povidone iodine efektif dibandingkan dengan fenol karena hasil koefisien fenol lebih dari 1.
Unusual Polymicrobial Wound Infections In Healthy Patient After Cesarean Sectio Tan, Henny Tannady; Elena, Irene Maria; Dharmawan, Ade; Layanto, Nicolas
Jurnal Midpro Vol. 12 No. 1 (2020): JURNAL MIDPRO
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/md.v12i1.151

Abstract

Cesarean delivery often complicated by surgical site infection, wound infection and endometritis. No study mention Multidrug Resistant Klebsiella pneumonia and Acinetobacter lwofii were isolated.Here we report a rare case of polymicrobial wound infections in healthy patient after Cesarean Sectio caused by Pseudomonas aeruginosa, Multidrug Resistant Klebsiella pneumonia and Acinetobacter iwofii. A 30-year-old woman at 37 weeks gestation (G1P0A0) presented to our hospital for cesarean sectio due to oligohydroamnios and malpresentation. She came to us on the eleventh post-delivery day with discharge from her surgical wound. Intraoperative cultures revealed Pseudomonas aeruginosa, Multidrug Resistant Klebsiella pneumonia and Acinetobacter lwofii.The greatest contribution to risk for surgical site infection was associated with maternal obesity and hypertensive disorder, but she has no risk factor.The polymicrobial combination of our patient’s is unique from previously described studies, in this case all were Gram negative bacteria (Pseudomonas aeruginosa, Multidrug Resistant Klebsiella pneumonia and Acinetobacter lwofii).
Sensitivitas Fosfomycin pada ISK Akibat Infeksi Enterobacteriaceae Penghasil ESBL pada Pasien di RS X Tahun 2023 William Dharma Wijaya; Layanto, Nicolas; Dharmawan, Ade
Jurnal MedScientiae Vol. 4 No. 2 (2025): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i2.3575

Abstract

Urinary tract infection (UTI) is one of the most common infections in humans. However, intensive and extensive use and misuse of antibiotics over the past 50 years such as in the use of carbapenems, resistance to antibiotics increased dramatically in recent years, especially in Enterobacteriaceae. This study aims to determine the sensitivity of fosfomycin as an drug option in treating UTI due to Extended-spectrum-β-Lactamase (ESBL)-producing Enterobacteriaceae in the era of increasing antibiotic resistance. This study is an analytical descriptive study with a cross-sectional observational design, by looking at the sensitivity pattern of ESBL-producing Enterobacteriaceae causing UTI at a certain point in time. This study used secondary data in the form of microbiology laboratory results at Hospital X in 2023. The results showed that ESBL-producing Enterobacteriaceae causing urinary tract infections were dominantly found Escherichia coli (79.41%). The level of fosfomycin sensitivity to non-ESBL-producing and ESBL-producing Enterobacteriaceae is very good and there are no significant differences in the results of the use of fosfomycin in urinary tract infections due to non-ESBL-producing and ESBL-producing Enterobacteriaceae, with the percentage being (91.31%) and (91.17%). Thus fosfomycin can be a drug option in treating UTI due to ESBL-producing Enterobacteriaceae infection.
Extensive Subcutaneous Abscess in a Patient with Diabetes Mellitus: A Case Report Tan, Henny Tannady; Wijaya, Jefri; Dharmawan, Ade; Layanto, Nicolas
Journal of Current Research In Multidisciplinary Vol. 3 No. 1 (2025): JCRIM (Journal of Current Research In Multidisciplinary)
Publisher : Yayasan Gema Bina Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abscess is a collection of pus in a tissue, usually caused by bacterial infection. The main symptoms of abscess are local pain, warmth and oedema (if the abscess is located close to the skin layer) or can be accompanied by constitutional symptoms (if the abscess is far from the skin layer or deep). In this case report, we report a case of extensive subcutaneous abscess in a woman with diabetes mellitus complicated by sepsis. The patient came with complaints of enlarged boils in the abdominal area for 2 weeks ago, this complaint was accompanied by other signs and symptoms of infection. The Infectious Diseases Society of America (IDSA) in 2014 classified SSTI into purulent (furuncles, carbuncles, and abscesses) and non-purulent (cellulitis, erysipelas, and necrotizing infections). There are several predisposing factors for skin abscesses, namely skin trauma, oedema caused by impaired lymphatic flow and venous insufficiency, obesity, immunosuppressive conditions (diabetes, HIV), previous infections (tinea, impetigo, varicella) and previous venous actions. Patients with sepsis syndrome or life-threatening infections need immediate surgical intervention and given combination antibiotics.
Prevalensi dan Pola Kepekaan Acinetobacter baumannii di Ruang Rawat Intensif RS Swasta di Jakarta Dharmawan, Ade; Devita, Arleen; Gunardi, Wani Devita; Layanto, Nicolas
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.178-185

Abstract

Background Acinetobacter baumannii is one of the bacteria that cause nosocomial infections, especially in the intensive care unit. These bacteria can cause infections, including bacteremia, pneumonia, urinary tract infections, surgical site infections, and meningitis. Most of these bacteria are multi-resistant to various antibiotics, impacting cure rates and length of stay. This study aimed to determine these bacteria's prevalence and antibiotic susceptibility patterns in the intensive care unit. Methods This research is descriptive research with a retrospective approach. The data was taken from the antibiotic susceptibility report in the intensive care unit of a private hospital in Jakarta in the period January 2020 – December 2021. The antibiotic susceptibility report was processed using the WHONET 2018 software. Results From 681 specimens examined in the intensive care unit, the prevalence of Acinetobacter baumannii was 28.7%, 80% of which came from respiratory specimens. In the sensitivity test results, only the antibiotic Colistin has the best sensitivity to this bacteria, which is 100% sensitive, while other antibiotics have poor sensitivity. Conclusions Acinetobacter baumannii is the bacteria that causes infection in the intensive care unit, with almost all of them being multi-drug resistant bacteria.
Co-Authors Ade Dharmawan Andini, KD Ayu Asti Christopher, Jeremy Devita, Arleen Elena, Irene Maria Henny Tannady Tan Istia, Mieke Joseba Juliet, Theresa Liusono, Justinus Monica Cherlady Anastasia Pasaribu, Donna Mesina Rina, Veronica Suparto Suparto Wani Devita Gunardi Wijaya, Jefri William Dharma Wijaya