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Unusual Polymicrobial Wound Infections In Healthy Patient After Cesarean Sectio Tan, Henny Tannady; Elena, Irene Maria; Dharmawan, Ade; Layanto, Nicolas
Jurnal Midpro Vol 12, No 1 (2020): JURNAL MIDPRO
Publisher : Universitas Islam Lamongan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30736/md.v12i1.151

Cesarean delivery often complicated by surgical site infection, wound infection and endometritis. No study mention Multidrug Resistant Klebsiella pneumonia and Acinetobacter lwofii were isolated.Here we report a rare case of polymicrobial wound infections in healthy patient after Cesarean Sectio caused by Pseudomonas aeruginosa, Multidrug Resistant Klebsiella pneumonia and Acinetobacter iwofii. A 30-year-old woman at 37 weeks gestation (G1P0A0) presented to our hospital for cesarean sectio due to oligohydroamnios and malpresentation. She came to us on the eleventh post-delivery day with discharge from her surgical wound. Intraoperative cultures revealed Pseudomonas aeruginosa, Multidrug Resistant Klebsiella pneumonia and Acinetobacter lwofii.The greatest contribution to risk for surgical site infection was associated with maternal obesity and hypertensive disorder, but she has no risk factor.The polymicrobial combination of our patientâ€™s is unique from previously described studies, in this case all were Gram negative bacteria (Pseudomonas aeruginosa, Multidrug Resistant Klebsiella pneumonia and Acinetobacter lwofii).

A Gyssens Evaluation On Antibiotics Usage On Inpatients With Urinary Tract Infection In Hospital X, Central Jakarta, on January 2017 â€“ June 2019 Tan, Henny Tannady; Dharmawan, Ade; Cahyadi, Agus; Layanto, Nicolas; Harahap, Elisabeth
Afiasi : Jurnal Kesehatan Masyarakat Vol 5 No 3 (2020): Afiasi
Publisher : Universitas Wiralodra

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31943/afiasi.v5i3.113

Urinary tract infections are infections from the bladder to the renal parenchyma, and can affect all ages. Empirical therapy can reduce morbidity, but due to the use of antibiotics that are not appropriate will have an impact on resistance that will cause increase morbidity, mortality, and health costs. In the Southeast Asian region, high use of antibiotics were found almost more than 80% in various provinces in Indonesia. This study aims to assess the appropriatness use of antibiotics in hospitalized patients with UTIs in the District Hospital X in the period January 2017 - June 2019 using gyssens criteria. This is retrospective study. Research data sourced from medical records. Data was collected and assessed with Gyssens flow, then processed using Microsoft Excel. The results found 15 cases (46.88%) with the appropriate use (category 0), 3 cases (9.37%) incorrect interval (category IIB), 1 case (3.33%) incorrect dosage (category IIA ), 10 cases (31.25%) too short given (category IIIB), 3 cases (9.37%) too long given (category IIIA). Empirical therapy inpatients with diagnosis urinary tract infections atvDistrict Hospital X, 46.8% of antibiotics were used appropriately.

A Gyssens Evaluation On Antibiotics Usage On Inpatients With Urinary Tract Infection In Hospital X, Central Jakarta, on January 2017 – June 2019: Gyssens Evaluation On Antibiotics Usage On Inpatients With Urinary Tract Infection In Hospital X, Central Jakarta, on January 2017 – June 2019 Henny Tannady Tan; Ade Dharmawan; Agus Cahyadi; Nicolas Layanto; Elisabeth Harahap
Afiasi : Jurnal Kesehatan Masyarakat Vol. 5 No. 3 (2020): Afiasi
Publisher : Universitas Wiralodra

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31943/afiasi.v5i3.113

Urinary tract infections are infections from the bladder to the renal parenchyma, and can affect all ages. Empirical therapy can reduce morbidity, but due to the use of antibiotics that are not appropriate will have an impact on resistance that will cause increase morbidity, mortality, and health costs. In the Southeast Asian region, high use of antibiotics were found almost more than 80% in various provinces in Indonesia. This study aims to assess the appropriatness use of antibiotics in hospitalized patients with UTIs in the District Hospital X in the period January 2017 - June 2019 using gyssens criteria. This is retrospective study. Research data sourced from medical records. Data was collected and assessed with Gyssens flow, then processed using Microsoft Excel. The results found 15 cases (46.88%) with the appropriate use (category 0), 3 cases (9.37%) incorrect interval (category IIB), 1 case (3.33%) incorrect dosage (category IIA ), 10 cases (31.25%) too short given (category IIIB), 3 cases (9.37%) too long given (category IIIA). Empirical therapy inpatients with diagnosis urinary tract infections atvDistrict Hospital X, 46.8% of antibiotics were used appropriately.

Profil Bakteri Patogen dan Kepekaannya pada Pasien Ventilator Associated Pneumonia dengan Infeksi COVID- 19 di Rumah Sakit UKRIDA¬ Jeremy Christopher; Ade Dharmawan; Donna Mesina Pasaribu; Nicolas Layanto
Jurnal Kesehatan Andalas Vol 11, No 3 (2022): Online November 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v11i3.1998

The use of ventilators during the COVID-19 pandemic has increased the incidence of Ventilator-Associated Pneumonia (VAP). This is accompanied by a trend of antibiotic resistance resulting from irrational use. The emergence of multi-drug resistant (MDR) bacteria during the pandemic presents a challenge due to limited antibiotic options. Objective: To determined the pathogenic bacterial profile and antibiotic susceptibility in Ventilator Associated Pneumonia (VAP) patients with COVID-19 infection. Methods: This is a descriptive cross-sectional study with a retrospective approach using secondary data from the medical records of UKRIDA Hospital patients from January 2021 to August 2021. Results: Most of the study sample had characteristics of being male (71.9%), aged 25-64 years (78.1%), overweight (40.6%), and hypertension (40.6%) as the comorbid. Gram-negative bacteria is the pre-dominated bacteria in this study, with Acinetobacter baumannii, Klebsiella pneumoniae, and Stenotrophomonas maltophilia being the most isolated bacteria. Antibiotics such as colistin still showed good susceptibility to Acinetobacter baumannii and Klebsiella pneumoniae, with 75% and 90% sensitivities, respectively. Antibiotics such as linezolid, tigecycline, and gentamicin-synergy still showed (100%) sensitivity to all Gram-positive bacteria. Conclusion: The discovery of MDR bacteria in patients with VAP and the limited availability of susceptible antibiotics highlights the importance of conducting antibiotic resistance surveillance and infection control, especially in the era of COVID-19.Keywords: antibiotic susceptibility, bacteria profile, COVID-19, VAP

Efektivitas Ceftazidime-Avibactam terhadap Bakteri Gram Negatif Penghasil Enzim Karbapenemase Ade Dharmawan; Nicolas Layanto
Jurnal MedScientiae Volume 1 No 01 : Mei - Agustus 2022
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Antibiotic therapy is a major concern in the health sector. There is an increase in the resistance of gram-negative bacteria that produce carbapenemase enzymes to certain antibiotics, especially the β-lactam group, thus creating a new challenge for the health world to find stronger antibiotics to fight the resistance of these gram-negative bacteria. Currently, there are several new antibiotics that have been approved as treatment options, such as Ceftazidime-Avibactam. It is hoped that this new treatment can be an option, especially for gram-negative bacteria that produce carbapenemase enzymes.

Pengaruh Pemberian Probiotik pada Infeksi Clostridium Difficile Ade Dharmawan; Dhimas Garin Dewa Agista; Sinsanta Sinsanta; Nicolas Layanto; Deby Deby
Jurnal MedScientiae Volume 1 No 2 : September - Desember 2022
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Clostridium difficile (C. difficile) is a gram-positive, anaerobic, spore-forming bacterium, and is an important pathogen in antibiotic-associated diarrhea. These bacteria are normal flora in the human digestive tract but can become pathogenic and form toxins consisting of 2, namely toxin A and toxin B. Due to antibiotics including risk factors for C. difficile infection (CDI), the treatment that can be given is probiotics. Probiotics may be effective in the prevention and treatment of CDI in several ways: alteration of gut flora, enhancement of antimicrobial activity, and as immunomodulators. The effect of probiotics, the method of administration, and the varying duration of administration make probiotics unable to be used as a therapy for C. difficile infection. However, probiotics can still be an option for adjuvant therapy in the treatment of CDI.

Efektivitas Ceftazidime-Avibactam terhadap Bakteri Gram Negatif Penghasil Enzim Karbapenemase Ade Dharmawan; Nicolas Layanto
Jurnal MedScientiae Vol. 1 No. 1 (2022): August
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscie.v1i1.2453

Antibiotic therapy is a major concern in the health sector. There is an increase in the resistance of gram-negative bacteria that produce carbapenemase enzymes to certain antibiotics, especially the β-lactam group, thus creating a new challenge for the health world to find stronger antibiotics to fight the resistance of these gram-negative bacteria. Currently, there are several new antibiotics that have been approved as treatment options, such as Ceftazidime-Avibactam. It is hoped that this new treatment can be an option, especially for gram-negative bacteria that produce carbapenemase enzymes.

Pengaruh Pemberian Probiotik pada Infeksi Clostridium Difficile Ade Dharmawan; Dhimas Garin Dewa Agista; Sinsanta Sinsanta; Nicolas Layanto; Deby Deby
Jurnal MedScientiae Vol. 1 No. 2 (2022): Desember
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscie.v1i2.2567

Clostridium difficile (C. difficile) is a gram-positive, anaerobic, spore-forming bacterium, and is an important pathogen in antibiotic-associated diarrhea. These bacteria are normal flora in the human digestive tract but can become pathogenic and form toxins consisting of 2, namely toxin A and toxin B. Due to antibiotics including risk factors for C. difficile infection (CDI), the treatment that can be given is probiotics. Probiotics may be effective in the prevention and treatment of CDI in several ways: alteration of gut flora, enhancement of antimicrobial activity, and as immunomodulators. The effect of probiotics, the method of administration, and the varying duration of administration make probiotics unable to be used as a therapy for C. difficile infection. However, probiotics can still be an option for adjuvant therapy in the treatment of CDI.

Hubungan Antara Vulva Hygiene Dan Penggunaan Alat Kontrasepsi Dalam Rahim dengan Keputihan pada Wanita Usia Subur Petri Damiani Anindyajati; Ade Dharmawan; Nicolas Layanto; Monica Cherlady
Jurnal MedScientiae Vol. 2 No. 1 (2023): April
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v2i1.2821

Pathological vaginal discharge is an abnormal disorder that often occurs in women of childbearing age and is characterized by a white discharge with a thick, white-yellow or white-greenish consistency, sometimes accompanied by an unpleasant odor and itching, often caused by several problems such as vulvovaginal infections. This happens because the composition of the vaginal microflora changes, which is influenced by internal factors (age, hormonal changes during menarche, menstruation, and pregnancy) and external factors (hygiene practices, sexual relations, and contraceptive use). The purpose of this article is to look at the relationship between vulva hygiene and intrauterine contraceptives with the incidence of vaginal discharge in women of childbearing age. The data was searched using Google Scholar and PubMed and found 8 articles that met the criteria. Various risk factors that affect the occurrence of vaginal discharge due to the use of non-hormonal intrauterine contraceptive devices that occur in women of childbearing age and through good vulvar hygiene behavior, can reduce the risk of physiological and pathological vaginal discharge. Based on the analysis conducted, it was concluded that there is a relationship between vulva hygiene and the use of intrauterine contraceptive devices with vaginal discharge in women of childbearing age

Correlation Between Vulva Hygiene And Intrauterine Device Use And The Event Of Vaginal Discharge In Women Of Reproductive Age Petri Damiani; Ade Dharmawan; Nicolas Layanto; Donna Mesina Rosadini Pasaribu
Jurnal MedScientiae Vol. 2 No. 3 (2023): Desember
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Ukrida

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v2i3.2857

Pathological leucorrhoea is an abnormal disorder in women of childbearing age that occurs in the body in the form of thick white, yellowish, greenish discharge. This is because the composition of the vaginal microflora fluctuates as a function of internal factors such as age,hormonal changes during menarche,menstruation,and pregnancy. External factors such as hygiene practices, sexual relations, and contraceptive use.In the use of Intrauterine devices, there is vaginal discharge that occurs as a result of the initial reaction to the presence of a foreign body, the use of intrauterine contraceptives which can change the chemical balance of the vagina and is thought to cause vaginitis. The research method for this literature review analyzed 8 research articles and assessed the articles based on predetermined inclusion and exclusion criteria. This literature reviews various risk factors that influence the occurrence of vaginitis due to the use of non-hormonal intrauterine contraceptive devices that occur in women of childbearing age and through good vulva hygiene behavior,can reduce the risk of physiological and pathological vaginal discharge.Based on these sources,it can be concluded that there is a relationship between vulva hygiene and the use of Intrauterine device with the incidence of vaginal discharge in women of childbearing age.

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