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Journal : Jurnal MedScientiae

Uji Aktivitas Antibakteri Ekstrak Daun Kelor (Moringa oleifera) Terhadap Staphylococcus aureus Andini, KD Ayu Asti; Dharmawan, Ade; Layanto, Nicolas
Jurnal MedScientiae Vol. 3 No. 3 (2024): Desember
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/JMedScientiae.v3i3.3473

Abstract

Plants are a source of various types of chemical compounds that have many benefits, one of which is as antibacterial agents. One of the plants known for its antibacterial properties is the moringa leaf (Moringa oleifera). This research aims to determine whether moringa leaves (Moringa oleifera) possess antibacterial activity, as well as to identify the minimum inhibitory concentration and minimum bactericidal concentration of moringa leaf extract against Staphylococcus aureus bacteria. This research method uses the dilution method. The results of the research indicate that moringa leaf extract has antibacterial activity against Staphylococcus aureus at concentrations of 20%, 40%, and 80%. It was found that as the concentration increases, the antibacterial activity inhibiting the growth of Staphylococcus aureus also increases.
Sensitivitas Fosfomycin pada ISK Akibat Infeksi Enterobacteriaceae Penghasil ESBL pada Pasien di RS X Tahun 2023 William Dharma Wijaya; Layanto, Nicolas; Dharmawan, Ade
Jurnal MedScientiae Vol. 4 No. 2 (2025): Agustus
Publisher : Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jmedscientiae.v4i2.3575

Abstract

Urinary tract infection (UTI) is one of the most common infections in humans. However, intensive and extensive use and misuse of antibiotics over the past 50 years such as in the use of carbapenems, resistance to antibiotics increased dramatically in recent years, especially in Enterobacteriaceae. This study aims to determine the sensitivity of fosfomycin as an drug option in treating UTI due to Extended-spectrum-β-Lactamase (ESBL)-producing Enterobacteriaceae in the era of increasing antibiotic resistance. This study is an analytical descriptive study with a cross-sectional observational design, by looking at the sensitivity pattern of ESBL-producing Enterobacteriaceae causing UTI at a certain point in time. This study used secondary data in the form of microbiology laboratory results at Hospital X in 2023. The results showed that ESBL-producing Enterobacteriaceae causing urinary tract infections were dominantly found Escherichia coli (79.41%). The level of fosfomycin sensitivity to non-ESBL-producing and ESBL-producing Enterobacteriaceae is very good and there are no significant differences in the results of the use of fosfomycin in urinary tract infections due to non-ESBL-producing and ESBL-producing Enterobacteriaceae, with the percentage being (91.31%) and (91.17%). Thus fosfomycin can be a drug option in treating UTI due to ESBL-producing Enterobacteriaceae infection.