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All Journal Indonesian Journal of Health Sciences Research and Development (IJHSRD) Integrated Science Education Journal Journal of Pharmaceutical and Sciences.
Rahmadevi Rahmadevi
Universitas Adiwangsa Jambi
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences

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THE ANALYSIS OF PHARMACEUTICAL ASPECT OF PRESCRIPTIONS FOR PEDIATRIC PATIENTS IN SUNGAI TUTUNG HEALTH CARE: PRESCRIPTIONS Iisma Rizki Fadhila; Rahmadevi Rahmadevi
INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD) Vol. 8 No. 1 (2026): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
Publisher : STIKes Mandala Waluya Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36566/ijhsrd/Vol8.Iss1/383

Abstract

Background: Pharmaceutical care for pediatric patients requires high accuracy because drug dosage must be adjusted according to age, body weight, and physiological conditions. This study aimed to evaluate the validity of compounded prescriptions for pediatric patients at Sungai Tutung Public Health Center in 2024 based on pharmaceutical aspects, particularly dosage appropriateness. Methods: This study used a descriptive observational design with a retrospective approach. The sample consisted of 60 pediatric compounded prescriptions with 162 drug items. Data were analyzed using descriptive quantitative analysis. Results: The results showed that 42 prescriptions, or 70.0%, were categorized as valid, while 18 prescriptions, or 30.0%, were invalid. Children aged 2–5 years were the most frequent group receiving compounded prescriptions, accounting for 56.7%. Of 162 drug items, 140 items, or 86.4%, had appropriate dosages, while 22 items, or 13.6%, were overdosed. Dosage discrepancies were found in ranitidine, chlorpheniramine maleate, and guaifenesin. Conclusion: This study concludes that the sensuality of pediatric compounded prescriptions was generally adequate; however, improved prescription accuracy and strengthened screening by pharmaceutical personnel are still needed.
Teh Herbal Daun Kelakai (Stenochlaena palustris) sebagai Potensi Fitoestrogen Untuk Produksi ASI : Terinspirasi dari Kearifan Lokal Suku Anak Dalam Jambi Eprina Intami; Ardi Mustakim; Rahmadevi Rahmadevi; Sri Mulyati
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1177

Abstract

This study was conducted in response to the problem of low breast milk production among some breastfeeding mothers, which may adversely affect infant growth and development. One approach to enhancing breast milk production is the utilization of natural substances containing phytoestrogens. Kelakai leaves (Stenochlaena palustris) are a plant traditionally used by the Suku Anak Dalam community as part of local wisdom to support maternal health during the postpartum period. This study aimed to develop kelakai leaf herbal tea as a natural source of phytoestrogens with potential to support increased breast milk production. The research employed a quasi-experimental design using a one-group pre-test and post-test with control group approach, complemented by laboratory analyses including identification of active compounds, simplicia processing, herbal tea formulation, phytochemical screening, and phytoestrogen content analysis. The results demonstrated that kelakai leaves contain flavonoids, saponins, and phytoestrogenic compounds that may contribute to the stimulation of prolactin and oxytocin secretion. Statistical analysis revealed a p-value of 0.000 (p < 0.05), indicating a significant effect of kelakai herbal tea administration on breast milk production among breastfeeding mothers. Based on these findings, it can be concluded that kelakai herbal tea has potential as an alternative herbal beverage derived from local wisdom that may support the success of exclusive breastfeeding programs.
Formulasi Tablet Effervescent Ekstrak Daun Kelor (Moringa oleifera L.) sebagai Pemenuhan Nutrisi untuk Pencegahan Stunting Elpa Giovana Zola; Eka Syafitri; Rahmadevi Rahmadevi; Dea Ayu Agustina
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1239

Abstract

Stunting remains a significant nutritional problem in Indonesia, requiring practical and acceptable nutritional interventions. Moringa oleifera L. leaves are known to contain essential minerals such as zinc, iron, and iodine, which play an important role in supporting optimal growth. This study aimed to formulate effervescent tablets of Moringa leaf extract and evaluate their physical quality as an alternative nutritional supplement for stunting prevention. Moringa leaf extract was obtained through maceration and formulated into four effervescent tablet formulas with varying extract concentrations. The evaluations included granule flow properties, angle of repose, pH, size uniformity, weight uniformity, dispersion time, FTIR analysis, and hedonic testing. The results showed that all formulas met the physical quality requirements of effervescent tablets. The granules exhibited good flow characteristics with an angle of repose below 40°, while the tablet pH values ranged from 4,4 -5,8, indicating suitability for oral administration. All formulas complied with the standards for size and weight uniformity, and the dispersion time ranged from 1 to 2 minutes. FTIR analysis confirmed the presence of hydroxyl, carbonyl, nitroso, and benzene functional groups associated with flavonoids, saponins, and tannins, which contribute beneficial mineral content. Based on physical and organoleptic evaluations, Formula 2 showed the best combination of extract content and granule flow properties, while Formula 1 was the most preferred in terms of taste.
Characteristics, Stability, and Permeation of Yellow Pumpkin Seed Cream (Cucurbita moschata) with Variations of Stearic Acid and Glyceryl Monostearate Sulistiyana Sulistiyana; Rayssa Zaahida; Peby Febriyanti; Rahmadevi Rahmadevi; Elpa Giovana Zola
Integrated Science Education Journal Vol 7 No 5 (2026): September
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/isej.v7i5.3733

Abstract

Purpose of the study: This study aimed to formulate pumpkin (Cucurbita moschata) seed powder cream with variations in stearic acid and glyceryl monostearate concentrations, evaluate its physical characteristics, stability, safety and irritation potential, skin-moisturizing effectiveness, and active-compound permeation, while providing foundational implications for stable and effective plant-based topical cosmetic formulations. Methodology: Pumpkin seed powder was formulated into cream with variations of stearic acid and glyceryl monostearate. The formulations were evaluated for organoleptic properties, pH, viscosity (Brookfield viscometer), skin moisture (CR-302 skin analyzer), active-compound permeation (PermeGear Franz diffusion cell), and stability (cycling test). Data were analyzed using IBM SPSS Statistics version 25 with the Shapiro-Wilk test, Levene’s test, two-way ANOVA, and Bonferroni post hoc test. Main Findings: Pumpkin seed powder met the required quality standards based on moisture content, microbial quality, and particle size. All cream formulations were homogeneous, stable, non-irritating, and complied with physical-quality requirements. Formulations with higher emulsifier concentrations significantly improved skin moisture, oil balance, and skin softness (p< 0.05), while active-compound permeation increased progressively during diffusion. Novelty/Originality of this study: Previous studies focused on pumpkin seed extract or oil, whereas the direct incorporation of yellow pumpkin seed powder and the systematic evaluation of stearic acid and glyceryl monostearate variations on cream stability and skin permeation remained insufficiently explored. This study demonstrates the use of yellow pumpkin seed powder as a natural anti-aging ingredient by systematically comparing how emulsifier variations affect physicochemical characteristics, stability, skin-moisturizing performance, and in vitro skin permeation, providing comprehensive evidence for topical product development.
Formulation of Pumpkin Seed (Cucurbita moschata) Powder Multivitamin Gummies with Varying Concentrations of Added Sucrose and Stevia Sweeteners Sekar Banowati; Rizkha Dwi Nurhalyza Putri; Rahmadevi Rahmadevi; Amraini Amelia
Integrated Science Education Journal Vol 7 No 5 (2026): September
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/isej.v7i5.3735

Abstract

Purpose of the study: This study aimed to formulate yellow pumpkin seed (Cucurbita moschata) powder-based multivitamin gummies and evaluate how varying sucrose and stevia concentrations affected physical characteristics, microbiological quality, zinc concentration, and consumer acceptability. Methodology: This laboratory experimental study used nine formulations: control (F0), sucrose (F1–F4; 30–45%), and stevia (F1–F4; 0.30–0.45%). Evaluations included organoleptic characteristics, weight uniformity, cutting point, homogeneity, stability, microbiological quality, zinc content by AAS, and hedonic acceptability. We analyzed cutting point data using One-Way ANOVA, while we analyzed hedonic results descriptively based on mean scores from 20 respondents. Main Findings: Both sucrose and stevia groups showed significant differences in cut-off point values (p = 0.002 and p = 0.001, respectively). F3 showed cut-off point values of 122 ± 6 g for sucrose and 121.67 ± 5.77 g for stevia. Microbiological testing of F3 showed negative Salmonella sp. results, while ALT and AKK met the requirements. Zinc concentrations were 2.9761 and 2.168 mg/L, respectively. F3 obtained the highest hedonic mean scores, 4.63 for sucrose and 4.45 for stevia. Novelty/Originality of this study: This study provides a formulation approach using yellow pumpkin seed powder rather than an extract and compares sucrose and stevia systems across concentrations. The study identified F3 as a promising formulation based on its characteristics and descriptive acceptability. The study also clarifies that microbiological and zinc results were obtained only from tested F3 samples, supporting further formulation optimization and broader quality evaluation. 
Microcapsule Formulation of Pumpkin Seeds (Cucurbita moschata) as a Potential Supplement to Support Iron and Zinc Adequacy in Stunting Prevention Ade Sitorus; Hena Pebrianti; Luisa Luisa; Desfira Desfira; Rahmadevi Rahmadevi; Amraini Amelia
Integrated Science Education Journal Vol 7 No 5 (2026): September
Publisher : Cahaya Ilmu Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37251/isej.v7i5.3745

Abstract

Purpose of the study: Iron (Fe) and zinc (Zn) deficiencies significantly contribute to childhood stunting. Pumpkin seeds (Cucurbita moschata) are rich in these minerals, but poor palatability and rapid gastric degradation limit their direct use as a food ingredient. This study aimed to microencapsulate pumpkin seed powder with gum arabic via solvent evaporation to protect key micronutrients and enhance targeted mineral delivery. Methodology: The prepared experimental samples were characterized using PSA, FTIR, AAS, and a binocular microscope. We formulated microcapsules with a high-speed homogenizer using the solvent evaporation technique, and statistically analyzed the data using ANOVA in SPSS. Main Findings: The synthesized pumpkin seed microcapsules were powder-shaped, yellow, aromatic, and tasteless. Formulas ranging from 1.5:5 to 3.5:5 were the most stable through the sixth cycle. The yield (38.8%–77%), particle size (54.68–60.70 μm), and particle uniformity were optimal at a 4.5:5 ratio, exhibiting round morphological shapes. Mineral concentrations reached 18–101 mg/L for Fe and 11–79 mg/L for Zn, with encapsulation efficiency between 2.81% and 30.01%. FTIR spectra showed characteristic peaks from both raw materials, and microbiological testing confirmed safety under official BPOM standards. Novelty/Originality of this study: Increasing the active ingredient ratio significantly enhanced mineral uptake without altering the fundamental chemical structure. The primary novelty lies in utilizing pumpkin seed waste encapsulated in gum arabic via solvent evaporation. These stable microcapsules represent a safe, effective, and economical local food fortification agent to address stunting.
Co-Authors Ade Sitorus Amraini Amelia Ardi Mustakim Dea Ayu Agustina Desfira Desfira Eka Syafitri Elpa Giovana Zola Eprina Intami Hena Pebrianti Iisma Rizki Fadhila Luisa Luisa Peby Febriyanti Rayssa Zaahida Rizkha Dwi Nurhalyza Putri Sekar Banowati Sri Mulyati Sulistiyana Sulistiyana