Timely and appropriate community response to medical and environmental emergencies remains a critical public health concern, particularly in settings with limited access to immediate professional care. Gaps in community knowledge of first aid and basic emergency response continue to constrain early action at the grassroots level. As a community-based organization, ‘Aisyiyah plays a strategic role in strengthening emergency response capacity through its cadres. This study examined changes in emergency response knowledge following community-based education and simulation training among ‘Aisyiyah cadres. A quasi-experimental single-group pre–post design without a control group was conducted among 34 cadres who participated in structured educational sessions, hands-on simulations, and role-play activities focusing on burn management and Basic Life Support (BLS). Knowledge was assessed using a validated true–false questionnaire and analysed using the Wilcoxon Signed-Rank test with effect size estimation. The results showed significant improvements across all domains. The median overall knowledge score increased from 80 (IQR=13) to 90 (IQR=0) (p<0.001) with a large effect size (r=0.56). Burn management knowledge reached the maximum score for all participants after the intervention (median=50; IQR=0), indicating a strong standardisation effect. BLS knowledge also improved significantly (p=0.003) with a moderate effect size (r=0.36), although variability in improvement was observed. These findings highlight the potential of multimodal, community-based training as an entry point for strengthening emergency response knowledge. Achieving optimal and sustained outcomes requires training continuity, periodic reinforcement, and integration with broader community health and disaster management systems through cross-sectoral collaboration.