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Aktivitas Antibakteri Ekstrak Etanol Katak Porang (Amorphophallus muelleri Blume) Terhadap Bakteri Propionibacterium acne Dan Staphylococcus epidermis Sapitri, Alfi; Marbun, Eva Diansari; Maimunah, Siti; Ginting, Mandike; Arisetya, Dian; Utama, Rezza Fikrih
BEST Journal (Biology Education, Sains and Technology) Vol 7, No 1 (2024): Juni 2024
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v7i1.9704

Beberapa tahun belakangan ini, penggunaan obat-obatan herbal yang berasal dari tumbuhan dan rempah meningkat. Tidak hanya di negara berkembang, namun juga dinegara maju salah satunya yaitu tanaman porang. Mengatasi infeksi bakteri diperlukan pencarian senyawa alternatif yang berasal dari bahan alam yang mempunyai aktivitas antibakteri terhadap bakteri tersebut, tanaman porang memiliki berbagai kandungan senyawa kimia yang berperan sebagai antijamur, antibakteri, zat sitotoksik, imunomodulator, antelmintik (anti cacing), dan hepatoprotektif. Penelitian bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol dari katak porang terhadap bakteri Propionibacterium acne dan Staphylococcus epidermidis. Serbuk simplisia katak porang dikarakterisasi dan di skrining fitokimia untuk mengetahui kandungan fitokimianya. Serbuk simplisia katak porang diekstraksi secara maserasi dengan menggunakan pelarut etanol, selanjutnya ekstrak etanol dibuat dalam berbagai konsentrasi dan uji aktivitas antibakterinya terhadap bakteri Propionibacterium acne dan dan staphylococcus epidermidis. Uji aktivitas antibakteri dilakukan dengan metode difusi agar menggunakan pencandang kertas. Hasil penelitian ini menunjukkan bahwa simplisia katak porang memiliki kadar air 6,0867%, kadar sari larut dalam air 29,1161%, kadar sari larut dalam etanol 9,7002%, kadar abu total 93,5125%, dan kadar abu larut dalam asam 91,9645%. Simplisia katak porang mengandung senyawa alkaloid, flavonoid dan tanin. Ekstrak etanol katak porang memiliki aktivitas antibakteri pada konsentrasi 1%, 2%, 3%, 4% dan 5%, pada bakteri Propionibacterium acne dengan daerah hambat 6,90 mm; 7,76 mm; 8,66 mm; 9,46 mm; dan 10,16 mm. Pada bakteri Staphylococcus epidermidis 6,76 mm; 7,60 mm; 8,36 mm; 9,03 mm; dan 9,60 mm. Ekstrak etanol dari katak porang memiliki aktivitas antibakteri yang lemah terhadap bakteri Propionibakterium acne dan Staphylococcus epidermidis

Aktivitas Antibakteri Ekstrak Etanol Katak Porang (Amorphophallus muelleri Blume) Terhadap Bakteri Propionibacterium acne Dan Staphylococcus epidermis Sapitri, Alfi; Marbun, Eva Diansari; Maimunah, Siti; Ginting, Mandike; Arisetya, Dian; Utama, Rezza Fikrih
BEST Journal (Biology Education, Sains and Technology) Vol 7, No 1 (2024): Juni 2024
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v7i1.9704

Beberapa tahun belakangan ini, penggunaan obat-obatan herbal yang berasal dari tumbuhan dan rempah meningkat. Tidak hanya di negara berkembang, namun juga dinegara maju salah satunya yaitu tanaman porang. Mengatasi infeksi bakteri diperlukan pencarian senyawa alternatif yang berasal dari bahan alam yang mempunyai aktivitas antibakteri terhadap bakteri tersebut, tanaman porang memiliki berbagai kandungan senyawa kimia yang berperan sebagai antijamur, antibakteri, zat sitotoksik, imunomodulator, antelmintik (anti cacing), dan hepatoprotektif. Penelitian bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol dari katak porang terhadap bakteri Propionibacterium acne dan Staphylococcus epidermidis. Serbuk simplisia katak porang dikarakterisasi dan di skrining fitokimia untuk mengetahui kandungan fitokimianya. Serbuk simplisia katak porang diekstraksi secara maserasi dengan menggunakan pelarut etanol, selanjutnya ekstrak etanol dibuat dalam berbagai konsentrasi dan uji aktivitas antibakterinya terhadap bakteri Propionibacterium acne dan dan staphylococcus epidermidis. Uji aktivitas antibakteri dilakukan dengan metode difusi agar menggunakan pencandang kertas. Hasil penelitian ini menunjukkan bahwa simplisia katak porang memiliki kadar air 6,0867%, kadar sari larut dalam air 29,1161%, kadar sari larut dalam etanol 9,7002%, kadar abu total 93,5125%, dan kadar abu larut dalam asam 91,9645%. Simplisia katak porang mengandung senyawa alkaloid, flavonoid dan tanin. Ekstrak etanol katak porang memiliki aktivitas antibakteri pada konsentrasi 1%, 2%, 3%, 4% dan 5%, pada bakteri Propionibacterium acne dengan daerah hambat 6,90 mm; 7,76 mm; 8,66 mm; 9,46 mm; dan 10,16 mm. Pada bakteri Staphylococcus epidermidis 6,76 mm; 7,60 mm; 8,36 mm; 9,03 mm; dan 9,60 mm. Ekstrak etanol dari katak porang memiliki aktivitas antibakteri yang lemah terhadap bakteri Propionibakterium acne dan Staphylococcus epidermidis

Activity Test of Neem Leaf (Azadirachta Indica A. Juss) Anti-Dambry Shampoo on Fungus (Malassezia Furfur) Ginting, Mandike; Septiana, Lilik; Br. Ginting, Grace Anastasia
International Archives of Medical Sciences and Public Health Vol. 4 No. 2 (2023)
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v4i2.636

Background; Dandruff is a disorder in the form of excessive flaking of dead skin on the scalp, sometimes accompanied by itching and inflammation. One of the causes of dandruff is the Malassezia furfur fungus. Neem leaves contain the main active ingredients of neem, namely azadirachtin, meliantriol, nimbin, nimbidin and salanin, substances that are known to be effective as insecticides. Objective; The aim of the study was to determine the formulation of anti-dandruff shampoo preparations of ethanol extract of neem leaves (Azadirachta indica A. Juss) and Activity Test against Fungus (Malassezia furfur). Method; The research method was experimental, which included taking plants, making simplicia, formula for neem leaf extract shampoo (2%, 4%, 6% and 8%), evaluating preparations and testing antifungal activity. Results; The results of the study were based on organoleptic tests, the preparations were white and brown in color, had a distinctive neem aroma and were viscous in shape; there is no coarse grain in the preparation; pH of preparations F0 (6.0), F1 (5.5), F2 (5.3), F3 (5.3) and F4 (5.2); foam height tests F0 (8 cm), F1 (8.5 cm), F2 (8.7 cm), F3 (9 cm) and F4 (9.5 cm); there is no itching, redness and swelling on the skin of the volunteers; stability test does not change color, aroma and shape of the preparation; antifungal test preparations F0 (0 cm), F1 (11.65 cm), F2 (12.73 cm), F3 (12.86 cm), F4 (13.61 cm) and K+ (22.8 cm). Conclusion; The conclusion of the research is that the ethanol extract of neem leaves (Azadirachta indica A. Juss) can be formulated as a shampoo that meets the requirements for physical evaluation and inhibits the growth of fungus (Malassezia furfur) at a concentration of 8% (13.61 mm) best.

Activity Test of Neem Leaf (Azadirachta Indica A. Juss) Anti-Dambry Shampoo on Fungus (Malassezia Furfur) Ginting, Mandike; Septiana, Lilik; Br. Ginting, Grace Anastasia
International Archives of Medical Sciences and Public Health Vol. 4 No. 2 (2023)
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v4i2.636

Background; Dandruff is a disorder in the form of excessive flaking of dead skin on the scalp, sometimes accompanied by itching and inflammation. One of the causes of dandruff is the Malassezia furfur fungus. Neem leaves contain the main active ingredients of neem, namely azadirachtin, meliantriol, nimbin, nimbidin and salanin, substances that are known to be effective as insecticides. Objective; The aim of the study was to determine the formulation of anti-dandruff shampoo preparations of ethanol extract of neem leaves (Azadirachta indica A. Juss) and Activity Test against Fungus (Malassezia furfur). Method; The research method was experimental, which included taking plants, making simplicia, formula for neem leaf extract shampoo (2%, 4%, 6% and 8%), evaluating preparations and testing antifungal activity. Results; The results of the study were based on organoleptic tests, the preparations were white and brown in color, had a distinctive neem aroma and were viscous in shape; there is no coarse grain in the preparation; pH of preparations F0 (6.0), F1 (5.5), F2 (5.3), F3 (5.3) and F4 (5.2); foam height tests F0 (8 cm), F1 (8.5 cm), F2 (8.7 cm), F3 (9 cm) and F4 (9.5 cm); there is no itching, redness and swelling on the skin of the volunteers; stability test does not change color, aroma and shape of the preparation; antifungal test preparations F0 (0 cm), F1 (11.65 cm), F2 (12.73 cm), F3 (12.86 cm), F4 (13.61 cm) and K+ (22.8 cm). Conclusion; The conclusion of the research is that the ethanol extract of neem leaves (Azadirachta indica A. Juss) can be formulated as a shampoo that meets the requirements for physical evaluation and inhibits the growth of fungus (Malassezia furfur) at a concentration of 8% (13.61 mm) best.

Activity Test of Neem Leaf (Azadirachta Indica A. Juss) Anti-Dambry Shampoo on Fungus (Malassezia Furfur) Ginting, Mandike; Septiana, Lilik; Br. Ginting, Grace Anastasia
International Archives of Medical Sciences and Public Health Vol. 4 No. 2 (2023)
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v4i2.636

Background; Dandruff is a disorder in the form of excessive flaking of dead skin on the scalp, sometimes accompanied by itching and inflammation. One of the causes of dandruff is the Malassezia furfur fungus. Neem leaves contain the main active ingredients of neem, namely azadirachtin, meliantriol, nimbin, nimbidin and salanin, substances that are known to be effective as insecticides. Objective; The aim of the study was to determine the formulation of anti-dandruff shampoo preparations of ethanol extract of neem leaves (Azadirachta indica A. Juss) and Activity Test against Fungus (Malassezia furfur). Method; The research method was experimental, which included taking plants, making simplicia, formula for neem leaf extract shampoo (2%, 4%, 6% and 8%), evaluating preparations and testing antifungal activity. Results; The results of the study were based on organoleptic tests, the preparations were white and brown in color, had a distinctive neem aroma and were viscous in shape; there is no coarse grain in the preparation; pH of preparations F0 (6.0), F1 (5.5), F2 (5.3), F3 (5.3) and F4 (5.2); foam height tests F0 (8 cm), F1 (8.5 cm), F2 (8.7 cm), F3 (9 cm) and F4 (9.5 cm); there is no itching, redness and swelling on the skin of the volunteers; stability test does not change color, aroma and shape of the preparation; antifungal test preparations F0 (0 cm), F1 (11.65 cm), F2 (12.73 cm), F3 (12.86 cm), F4 (13.61 cm) and K+ (22.8 cm). Conclusion; The conclusion of the research is that the ethanol extract of neem leaves (Azadirachta indica A. Juss) can be formulated as a shampoo that meets the requirements for physical evaluation and inhibits the growth of fungus (Malassezia furfur) at a concentration of 8% (13.61 mm) best.

Activity Test of Neem Leaf (Azadirachta Indica A. Juss) Anti-Dambry Shampoo on Fungus (Malassezia Furfur) Ginting, Mandike; Septiana, Lilik; Br. Ginting, Grace Anastasia
International Archives of Medical Sciences and Public Health Vol. 4 No. 2 (2023)
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v4i2.636

Background; Dandruff is a disorder in the form of excessive flaking of dead skin on the scalp, sometimes accompanied by itching and inflammation. One of the causes of dandruff is the Malassezia furfur fungus. Neem leaves contain the main active ingredients of neem, namely azadirachtin, meliantriol, nimbin, nimbidin and salanin, substances that are known to be effective as insecticides. Objective; The aim of the study was to determine the formulation of anti-dandruff shampoo preparations of ethanol extract of neem leaves (Azadirachta indica A. Juss) and Activity Test against Fungus (Malassezia furfur). Method; The research method was experimental, which included taking plants, making simplicia, formula for neem leaf extract shampoo (2%, 4%, 6% and 8%), evaluating preparations and testing antifungal activity. Results; The results of the study were based on organoleptic tests, the preparations were white and brown in color, had a distinctive neem aroma and were viscous in shape; there is no coarse grain in the preparation; pH of preparations F0 (6.0), F1 (5.5), F2 (5.3), F3 (5.3) and F4 (5.2); foam height tests F0 (8 cm), F1 (8.5 cm), F2 (8.7 cm), F3 (9 cm) and F4 (9.5 cm); there is no itching, redness and swelling on the skin of the volunteers; stability test does not change color, aroma and shape of the preparation; antifungal test preparations F0 (0 cm), F1 (11.65 cm), F2 (12.73 cm), F3 (12.86 cm), F4 (13.61 cm) and K+ (22.8 cm). Conclusion; The conclusion of the research is that the ethanol extract of neem leaves (Azadirachta indica A. Juss) can be formulated as a shampoo that meets the requirements for physical evaluation and inhibits the growth of fungus (Malassezia furfur) at a concentration of 8% (13.61 mm) best.

The Antioxidant Activity of Pagoda Flower (Clerodendrum paniculatum L.) Ethanol Extract using Visible Spectrophotometric Method Hafiz, Ihsanul; Ginting, Mandike; Yuermaileni, Yuermaileni
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 2 No. 2 (2019): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Abstract. Pagoda flower is one of the plant species included in the genus Clerodendrum which has a number of different species of 580 species, and is spread evenly in Asia, Africa, America, and Australia. A number of species of this genus have been used in traditional medicine in Asia and Africa. India, China, Korea, Thailand and Japan. The antioxidant activity of this plant is known to be very strong, so in this article the antioxidant activity of the flower part of the Clerodendrum paniculatum L. species will be described. The ability of antioxidant activity was measured by the DPPH method (1,1-diphenyl-2-picrylhydrazyl) which was measured using a Visible spectrophotometer using Vit C as a comparison. The results showed that the ethanol extract of pagoda flowers has antioxidant activity with an IC50 value of 64.889 ppm (strong). The Vit C comparison has an IC50 value of 8.539 ppm (very strong). Keyword: Antioxidant, Clerodendrum Paniculatum L., Visible Spectrophotometric. Abstrak. Bunga Pagoda merupakan salah satu spesies tanaman yang termasuk dalam genus Clerodendrum yang memiliki jumlah spesies yang berbeda sejumlah 580 spesies, dan tersebar merata di Asia, Afrika, Amerika, dan Australia. Sejumlah spesies dari genus ini telah digunakan dalam pengobatan tradisional di kawasan Asia dan Afrika. India, China, Korea, Thailand, dan Jepang. Aktivitas antioksidan dari tanaman ini diketahui sangat kuat, sehingga dalam artikel ini akan dipaparkan aktivitas antioksidan yang dimiliki oleh ekstrak etanol bagian bunga dari spesies Clerodendrum paniculatum L. Pengujian aktivitas antioksidanya dilakukan dengan metode DPPH (1,1-diphenyl-2-picrylhydrazyl) yang diukur menggunakan spektrofotometer Visibel dengan menggunakan Vit C sebagai pembanding. Hasil penelitian menjukkan bahwa ekstrak etanol bunga pagoda memiliki aktivitas antioksidan dengan nilai IC50 sebesar 64,898 ppm (kuat). Pembanding Vit C memiliki nilai IC50 sebesar 8,539 ppm (sangat kuat). Kata Kunci: Antioksidan, Clerodendrum paniculatum L., DPPH, Spektrofotometri Vis.

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