Article Per Year (5 Year)
p-Index From 2021 - 2026
2.155
P-Index
This Author published in this journals
All Journal e-GIGI e-Journal Pustaka Kesehatan Dentika Dental Journal Journal of Dentistry Indonesia STOMATOGNATIC- Jurnal Kedokteran Gigi ODONTO Dental Journal Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Material Kedokteran Gigi Odonto dental journal Journal of Fisheries & Marine Dental Agromedis
Didin Erma Indahyani
Bagian Biologi Oral, Fakultas Kedokteran Gigi, Universitas Jember
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Public Health

Published : 27 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 6 Documents
Search
Journal : e-Journal Pustaka Kesehatan

 1 
Jumlah Trombosit pada Mencit Diabetes setelah Pemberian Ekstrak Rumput Laut Merah (Rhodophyceae) Dahna Maudita Kartikasari; Didin Erma Indahyani; Depi Praharani
Pustaka Kesehatan Vol 7 No 3 (2019): Volume 7 No.3, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i3.11350

Abstract

Oxidative stress in diabetes mellitus triggers activation and increases in platelet counts that play a role in the formation of platelet plugs in the blood clotting process. If excessive blood clots occur, there is a risk of cardiovascular disease. Red seaweed extract contains carotenoids, phenols and their derivatives, fikobilin pigments, polysaccharide sulfates, and vitamins. The biggest phenol compound is flavonoids which are compounds that can produce platelet antia-gregation effects. The purpose of this study was to examine the effect of giving red seaweed extract to platelet counts in diabetic mice. The study group consisted of the treatment group of red seaweed extract, normal control, positive control and negative controls. The dosage of seaweed extract as much as 10 mg / 20 grBB is given in condition. The calculation of platelet count is carried out directly with the Brecher Cronkite method using a calculated room Improved Neubauer. The One Way ANOVA test results showed a significance value (p <0.05), that is, the group of diabetic mice given red seaweed extract had a lower platelet count of 280000 μl compared to diabetic mice given metformin as much as 379000 μl. The decrease is due to flavonoids, saponins, alkaloids, β carotene, vitamins and minerals able to stabilize the production of megakaryocytes and platelets, prevent the destruction of pancreatic β cells and prevent free radicals. It was concluded that red seaweed extract can reduce platelet counts of diabetic mice near normal values.
Pengaruh Lama Pemberian Distres Kronis terhadap Aktivitas Sel Osteoklas pada Tulang Alveolar Tikus Sprague-Dawley (The Effect of Chronic Distress Duration to Osteoclast Cells Activity in Alveolar Bone of Sprague-Dawley Rats) Maria Devitha; Didin Erma Indahyani; Happy Harmono
Pustaka Kesehatan Vol 3 No 3 (2015)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Excessive and prolonged distress (chronic) can cause damage to periodontal tissues, specifically alveolar bone resorption. Alveolar bone resorption is caused by osteoclast cells activity. The purpose of the research is to determine effect of chronic distress duration to osteoclast cells activity in alveolar bone of male Sprague-Dawley rats attain the age of 3-4 months. The rats were given an electric shock stressor (Electrical Foot Shock) as distress chronic for 7, 14, and 28 days. Stressors were given for 30 minutes at 9 a.m every day during the treatment period. The amount of electrical current is 2-8 mA, 48 V voltages and 0.5 Hz frequency. Osteoclasts activity were observed histologically with 400x magnification using osteoclast Bone Interface (OBI) Index by dividing the length of howship's lacunae with osteoclasts. Result showed signifficant difference at 0.00 (p<0.05) beetwen the variable.Activity of osteoclasts in alveolar bone of Sprague-Dawley rats which were exposed to the stressor is increased when compared to the group that were not exposed to electrical shock stressor, but at day 14 decreased when compared to the other treatment groups. Keyword : chronic distress, osteoclast activity, alveolar bone
Kadar Kolesterol pada Mencit (Mus-Musculus) Diabetes Setelah Konsumsi Ekstrak Rumput Laut Coklat (Phaeophyta) Irene Fransiska; Didin Erma Indahyani; Ari Tri Wanodyo Handayani
Pustaka Kesehatan Vol 8 No 1 (2020): Volume 8 No. 1, 2020
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v8i1.11349

Abstract

In the case of Diabetes Mellitus, it will trigger some changes in lipid metabolism and lipoprotein composition, one of them is cholesterol. Cholesterol is a lipid that plays an important role in the structure of cell membranes. Seaweed contains bioactive components of flavonoids which reduce cholesterol levels. Brown seaweed contains bioactive components of alkaloids, flavonoids, triterpenoids, saponins, phenol hydroquinone, tannins, chlorophyll and β-carotene pigments. The bioactive component of brown seaweed also has strong antioxidant activity that can prevent damage caused by oxidative stress on pancreatic β cell function and acts as a trap for various free radicals and can reduce diabetic rat lipid peroxidation. This study to analyze the effect of giving brown seaweed extract on cholesterol levels in diabetic mice.This study was divided into 4 sample groups, namely the normal group, negative controls (diabetic mice), positive controls (diabetic mice + 1.3 mg / 20 gr BB metformin), K1 (diabetic mice + brown seaweed extract). The seaweed dose of 10mg / 20grBB is given on a daily basis for 21 days. Checking blood cholesterol levels in serum using the POD CHOD method and measured using biolysers. Diabetic mice with brown seaweed extract were significantly (p <0.05) lower cholesterol level of 68.94 mg / dL than diabetic mice 81.75 mg / dL. It was concluded that brown seaweed extract had an effect on reducing total cholesterol levels in diabetic mice. Keywords : Cholesterol levels, Diabetic mice, Brown Seaweed
Pengaruh Pemberian Monosodium Glutamat pada Induk terhadap Fase Erupsi Gigi Anak Tikus Wistar (Rattus norvegicus) Generasi Pertama (The Effect of Monosodium Glutamate Administration on Mothers Rat (Rattus norvegicus) to the Tooth Eruption Phase of the Fir Mindiya .; Didin Erma Indahyani; Pujiana Endahl Lestari
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Monosodium glutamat (MSG) is a kind of food additives which consumes widely in society. It may damage the hypothalamic arcuate nucleus and disturb the endocrin regulation system. This condition may delay the tooth eruption phase. Aim: To analyze the effect of MSG administration on the neonatal rats tooth eruption phase, whose mothers were given MSG during gestational period also during gestational and lactation period, to determine the difference between neonatal male and female tooth eruption phase. Materials and Methods: The first molar of right mandibular of neonatal rats from the control group (K1), the treatment group which mothers were given MSG during pregnant period (K2) and the mothers which were given MSG during pregnant and lactation period (K3) were collected as samples. The samples were examined by periapical rontgent to observe the tooth eruption phase. The result was measured by Corel Draw X3. Results and Conclusion: The tooth eruption phase in the treatment group (K2 and K3) are slower than the control group (K1), and there is no difference between neonatal male and female tooth eruption phase. Kata Kunci: hypothalamic arcuate nucleus, monosodium glutamate, tooth eruption
Level Glukosa Darah pada Mencit Diabetes Setelah Pemberian Ekstrak Rumput Laut Coklat (Phaeophyta) Mega Bintang Bella Pertiwi; Didin Erma Indahyani; Depi Praharani
Pustaka Kesehatan Vol 9 No 2 (2021): Volume 9 No.2, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i2.12165

Abstract

Diabetes mellitus (DM) is a disorder of hyperglycemia and glucose intolerance caused by insulin deficiency or insulin disorder. Insulin hormone functions in the formation of glucose as an energy source. Consequently, glucose accumulates in the blood in DM patients and affects increased free radicals within the cell and oxidative stress. In DM patients with an imbalance of oxidants and antioxidants in his plasm, therefore, patients with DM require a large amount of antioxidants intake. One alternative treatment is seaweed. Brown seaweed contains bioactive components such as polyphenols and carotenoids, which exhibit antioxidants and reduce blood glucose levels. The study aimed to analyze the effect of brown seaweed extract on the blood glucose levels in diabetic mice. The study used a research design of pre and post-test control group design. The study was divided into 4 sample groups, namely the normal group, negative controls (diabetic mice), positive control (diabetic mice + 1.3 mg / 20 gr BB metformin), P1 (diabetic mice + brown seaweed extract). The seaweed dose of 10mg / 20grBB is given daily for 21 days. Blood glucose level checks using Glucometer and strip test (Autocheck™). Brown seaweed extract has an effect on reducing blood glucose levels in diabetic mice.
Analisis Maturasi Gigi pada Tikus yang Mengkonsumsi Minyak Didin Erma Indahyani
Pustaka Kesehatan Vol 2 No 2 (2014)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dental maturation is a process of anorganic mineral apotition and resorption ofprotein and water content in the matrix of teeth during the stage of growth and developoment.Disturbances in the stage will caused abnormalities of tooth e.i. hypoplasia andhypomineralisation that are known tooth hypomaturation. The disorder may be systemic orlocal, because of trauma, infection, hormonal, systemic diseases, nutritional deficiencies, etc.fish oil of lemuru containing Eicosanoid acid (EPA) and docohexanoic acid (DHA) are highenough. The EPA and DHA are antiinflammatory and play a role in the regulation ofsignaling molecules and imunomudulator. The purpose of this study was to analyze thematuration of teeth in rats consuming fish oil of lemuru after periodontal infection induced byLPS during amelogenesis. 30 male Wistar rats aged 5 days, divided into three groups. Thefirst group was rats induced by lypopolisacharide (LPS) in the molar region (it aims to makedental maturation disorder). The second group was rats inducted LPS and given fish oil, andthe third group was not LPS induction and not given fish oil (normal). After the rats is agesof 21 days, were done decaputation. Upper right molar teeth have been taken to doobservation in macroscopic (clinical) and microscopic (SEM). Microscopic andmacroscopic observations done scoring, and statistically analyzed using one-way ANOVAand LSD. The results of this study showed that significantly (p <0.005) rats fed fish oil oflemuru, maturation teeth better than LPS-induced rats. It was concluded that fish oil affectsthe maturation lemuru rat teeth, and prevent tooth maturation disorder is more severe.Key words : fish oil, tooth maturation, amelogenesis, SEM
Co-Authors Abul Haris Suryo Negoro Achmad Gunadi Al-Supartinah Santoso Anggraeni, Priska Amelia Anis Irmawati Ari Tri Wanodyo Handayani Catur Putri Kinasih Dahna Maudita Kartikasari Depi Praharani Fitria Arifka Rahman Ganefo, Akhmad Happy Harmono Hendri Jaya Permana Inneke Dwi Lestari Irene Fransiska Izzata Barid Kusnadi Kusnadi Luh Putu Ratna Sundari Maria Devitha Marsetyawan HNE Soesatyo Mega Bintang Bella Pertiwi Mindiya . Nafisah Nafisah Negoro, Abdul Haris Suryo Niken Probosari Niken Probosari Prehatin Trirahayu Ningrum Pujiana Endah Lestari Puspita, Indria Dwi Putu Sadaka Putri Rahayu Rahayu, Prehatin Tri Riris Aria Dewanti Rosi Endah Pratiwi Rudianto Sheila Dian Pradipta Sigiq E. Utami Sri Lestari SULISTIYANI SULISTIYANI Sumono, Agus Totok Utoro Verawati Verawati Wardani SWW, L. Dyah Purwita Wazirotus Sakinah Yani Corvianindya Rahayu Yanuar Nurdiansyah, Yanuar Yenny Yustisia Zahreni Hamzah