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All Journal Jurnal Natur Indonesia Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati JURNAL BIOLOGI INDONESIA Journal of Tropical Marine Science Bioscientist : Jurnal Ilmiah Biologi

Susanto, G. Nugroho

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Author-ID : 1160871

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Environmental Science Immunology & microbiology Social Sciences

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Respon Histopatologis Hepar Mencit (Mus musculus) yang Diinduksi Benzo(α)Piren terhadap Pemberian Taurin dan Ekstrak Daun Sirsak (Annona muricata) Agata, Annisa; Widiastuti, Endang Linirin; Susanto, G. Nugroho; ', Sutyarso
Jurnal Natur Indonesia Vol 16, No 2 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Cancer is a disease that is characterized by the existence of damage and cell abnormality in growth and differentiation. Liver cancer is a disorder of hepar tissue derivated from its tumors. Taurine is known as antioxidant but its role as anticancer needs to be explored more as well the role of Annona muricata leaf extract which is believed to have its role as anticancer substance. This research, therefore, aimed to explore the effect of taurine and Annona muricata leaf extract on the hepar histopathology of male mice (Mus musculus) induced by benzo(α)pyren in vivo. This research was carried out by using a complete randomized design, which consisted of 5 treatment groups which was repeated 5 times. Group I was given 0.2 mL corn oil for 15 days, group II was induced by benzo(α)pyren without taurin nor A. Muricata leaf extract for 10 days, group III was given 7.8 mg taurine/BW/day (twice a day) starting from the 15 th days before the induction of benzo(α)pyren, group IV, after induced with benzo(α)pyren, taurine was given with dosage of 7.8 mg/BW/day, group V, after induced with benzo(α)pyren, soursop leaf extract was given with amount of 277.8 mg/BW/day. Data analyzed by Kruskal-Wallis test and one way ANOVA with Fisher test (p>0.05). The results indicated that taurine had ability to recover the liver tissue induced by benzo(α)pyren as (carcinogenic) while, Annona muricata leaf extract had not shown any recover of tissue damage

Pengaruh Pemberian Senyawa Taurin dan Ekstrak Daun Dewa Gynura segetum (Lour) Merr terhadap Eritrosit dan Leukosit Mencit (Mus musculus) yang Diinduksi Benzo[α]Piren Marlinda, Henny; Linirin Widiastuti, Endang; Susanto, G. Nugroho; ', Sutyarso
Jurnal Natur Indonesia Vol 17, No 1 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Blood cancer (leukemia) is a cancer that occurs due to malignancy of blood cells. Treatment of leukemia generally causes damage to normal cells. Therefore, it needs a drug that has the effect of repairing cell damage and the ability to boost immunity of normal such as taurine and Gynura leaves which are expected to have anticancer and antioxidant properties. The purpose of this study was to investigate the effect of taurine and dewa leaf extract on blood tissues induced by benzo [α] pyrene in vivo, by looking at changes in body weight, the number of red blood cells (erythrocytes), the total number and differentiation of white blood cells (leukocytes) in mice (Mus musculus). Data were analyzed by One Way ANOVA test followed by LSD at 5% significance level. The treatment groups were the group I was given 0.2 mL of corn oil (negative control), group II (given benzo [α] pyrene as a positive control, Group III (given taurine 7.8 mg/BW/day starting from day 1 to 15 before the induction of benzo [α] pyrene until the end of the study), Group IV was given benzo [α] pyrene, then were given taurine 7.8 mg/BW/day were given 2 times a day, as well as the V group was given benzo [α] pyrene, then given a dose of Gynura leaf extract 277.8 mg /BW/day. The results showed taurine and Gynura leaf extract were able to obstruct leukemia by increasing body weight, erythrocyte, leukocyte, and the number of leukocyte differentiation which becomes normal again. In conclusion taurine has better ability for therapoitic than Gynura leaf extact against blood cells induced by benzo[α]piren

Pengaruh Pemberian Taurin terhadap Gambaran Histopatologi Paru Mencit (Mus musculus) yang Diinduksi Karsinogen Benzo(α)Piren secara In Vivo Roselyn, Arini Pradita; Widiastuti, Endang Linirin; Susanto, G. Nugroho; ', Sutyarso
Jurnal Natur Indonesia Vol 17, No 1 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Lung cancer is a disease that causes high mortality. Drugs used to prevent and cure cancer mostly causes intoxicity to the normal tissues due to its less effectiveness. Therefore, it is necessary to find out any agent or substance which works much more effective and safe for cancer treatment. The aim of the study was to elucidate the role of taurine on the lung tissue of mice (Mus musculus) induced by carcinogenic benzo(α)pyrene. The experiment was conducted in a completely randomized design with 5 replications. Six treatment groups were perfomed. Group I was given 0.2 mL of corn oil and given aquadest until the end of the study period, group II was induced by benzo(α)pyrene without administration of taurine, group III before induced with benzo(α)pyrene, was given taurine dosage 7.8 mg/BW/day for two weeks, group IV after induced benzo(α)pyrene, was given taurine with dosage 3.9 mg/BW/day, group V after induced benzo(α)pyrene, was given taurine with dosage7. 8 mg/BW/day, group VI after induced with benzo(α)pyrene, was given taurine with dosage 15.6 mg/BW/day. The results of the Kruskal-Wallis analysis and one way ANOVA with LSD (p>0,05) showed that taurine reduced lung tissue damage 72.73% due to the administration of benzo(α)pyrene of 0.3 mg/BW/day. In addition, the effective dose of taurine reduce lung tissue damage was 15.6 mg/BW/day.

EFEK EKSTRAK METANOL MAKROALGA COKELAT (SARGASSUM SP.), MERAH (GRACILLARIA SP.) DAN TAURIN TERHADAP GAMBARAN HISTOPATOLOGI HEPAR MENCIT JANTAN (MUS MUSCULUS) YANG DIINDUKSI BENZO(?)PIREN Hervidea, Radella; Widiastuti, Endang Linirin; Nurcahyani, Endang; Sutyarso, Sutyarso; Susanto, G. Nugroho
JURNAL BIOLOGI INDONESIA Vol 14, No 1 (2018): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v14i1.3670

ABSTRACTCancer is a disease marked by the existence of abnormal growth of cell continuously and uncontroll in an organism body. Benzo(?)pyrene is one of the substances that can cause a cancer. The methanolic extract of Sargassum sp. and Gracillaria sp. has anticancer and antioxidant activity. Other compounds with antioxidant activity is taurine. The aim of this research is to examine the effect from methanolic extract of Sargassum sp. and Gracillaria sp .and also taurine on hepar histopatology of male mice (Mus musculus) induced by benzo(a)pyrene. This research used Completely Randomized Design. 30 male mice were divided into 6 groups of treatments, those were: K1 = (K-), K2= induced by benzo(?)pyrene for 10 days, K3= after induced by benzo(?)pyrene, were given the Sargassum sp. orally with a dose 8mg/mice during 15 days, K4=after induced by benzo(a)pyrene, were given the combination of Sargassum sp. (8mg/mice) and taurine(15,6mg/mice) orally during 15 days, K5= after induced by benzo (?)pyrene, were given the Gracillaria sp.orally with a dose 8mg/mice during 15 days, and K6=after induced by benzo(a)pyrene, were given the combination of Gracillaria sp. (8mg/mice) and taurine (15,6mg/mice) orally during 15 days. Data were analyzed using ANOVA (? = 5%). The result shows that the combination of Sargassum sp. and Gracillaria sp. and taurine can increase the number of erythrocyte , decrease the number of leucocyte and protect the damage of hepar histopatology of male mice (Mus musculus) induced by benzo (?)pyrene. Combination of extract Gracillaria sp. and taurine is the most effective to protect the damage hepar histopatology of male mice(Mus musculus) induced by benzo(? )pyrene.Keywords: male mice,Sargassum sp., Gracillaria sp., taurine, benzo(a)pyrene, hepar

Bird Species Based on Tree Height Perched in the Liwa Botanical Garden, West Lampung Regency Putra, Bagus Susilo; Kanedi, M.; Nurcahyani, Nuning; Susanto, G. Nugroho
Jurnal Natur Indonesia Vol 20, No 1 (2022): April 2022
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jnat.20.1.9-14

Birds are one of the most diverse animals in the world, especially in Indonesia. Liwa Botanical Garden located in Pekon Kubu Perahu, Balik Bukit District, West Lampung Regency, is a conservation area with the theme of conservation and development of ornamental plants, representing the flora of Southern Sumatra. This research is a continuation of the collaboration between the Department of Biology and Balitbang UPTD Liwa Botanical Garden, West Lampung Regency. The presence of birds in the Liwa Botanical Garden is also a bioindicator of biodiversity for the environment in this area. By maintaining the presence of birds in the Liwa Botanical Garden means protecting their habitat and existing plants. The purpose of this study was to determine the species of birds based on the height of the perched trees in the Liwa Botanical Garden and the abundance of their species. The method used in this research is the point count with the observation time for 9 days in the morning and evening at the height of the tree in 3 different observation stations. Birds on KRL are mostly found on perches at an altitude of 2 - 7 meters, in the category of shrubs and trees, there are 19 out of 25 bird species found. The highest Relative Abundance Index (IKR) was Collocalia esculenta at 39.91% and the lowest IKR value was 7 bird species, each with 0.14% value. The conservation status of the 25 bird species based on IUCN is Least Concern (LC) and based on CITES there is one species that is included in Appendix II, namely Ictinaetus malayensis while based on the Regulation of the Minister of Environment and Forestry of the Republic of Indonesia No. P.20 / MENLHK / SETJEN / KUM.1 / 6/2018 there is one bird species that is included in the protection, namely species Ictinaetus malayensis

Aktivitas Antibakteri Ekstrak Isolat Jamur Endofit Aspergillus sp. yang Berasosiasi dengan Mangrove Rhizhopora apiculata terhadap Patogen Ikan Laut Dharmawati, Verli; Susanto, G. Nugroho; Nurcahyani, Nuning; Damai, Abdullah Aman; Azzuhdy, Afifah Nissa
Journal of Tropical Marine Science Vol 7 No 2 (2024): Journal of Tropical Marine Science
Publisher : Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/jour.trop.mar.sci.v7i2.5418

Exploration of microorganisms containing secondary metabolite compounds with antimicrobial properties, especially in marine fish pathogenic bacteria, is urgently required. This study aims to test the antibacterial effectiveness of endophytic fungal extracts from the mangrove plant Rhizopora apiculata in the Petengoran Mangrove Forest against pathogenic bacteria in marine fish such as V. alginolyticus and P. damselae spp. The endophytic fungal isolate found was a fungus from the genus Aspergillus sp after observing its morphological form macroscopically and microscopically. Ethyl acetate extract of mangrove endophytic fungi with a concentration of 500 µg/disc and 1000 µg/disc was dripped onto a 6mm paper disc and then placed on the pathogenic bacterial isolate. Measurement of the diameter of the clear zone produced around the paper disc after 24 hours concluded that the antibacterial effectiveness of the endophytic fungal extract against V. alginolyticus was 27.27% (500 µg/disc) and 32.32% (1000 µg/disc). Meanwhile, its effectiveness against P. damselae spp is 27.27% (500 µg/disc) and 34.82% (1000 µg/disc). The isolate extract from the endophytic fungus Aspergillus in this study has the potential to produce antibacterial compounds in marine fish pathogens.

Struktur Komunitas Makrozoobentos sebagai Bioindikator Kualitas Air di Sungai Way Awi, Bandarlampung Nugraha, Dwiki Renda; Tugiyono; Susanto, G. Nugroho; Kanedi, M.
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 9, No 3 (2024): October 2024
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v9i3.8744

Makrozoobentos merupakan invertebrata yang masa hidupnya dihabiskan di dasar perairan atau di atas sedimen. Penelitian ini bertujuan untuk mengkaji struktur komunitas makrozoobentos sebagai bioindikator kualitas air di Sungai Way Awi, Bandarlampung. Penelitian dilakukan pada Oktober-Desember 2023. Pengambilan sampel makrozoobentos menggunakan Ekman grab di lima stasiun mewakili hulu, tengah, dan hilir sungai. Analisis dan identifikasi sampel dilakukan di Laboratorium Zoologi FMIPA Universitas Lampung dengan bantuan buku identifikasi Fresh-Water Biology. Hasil penelitian berhasil mengidentifikasi 8 genus makrozoobentos yang terdiri dari phylum Mollusca, Arthropoda, dan Annelida. Struktur komunitas menunjukkan kondisi indeks keanekaragaman yang rendah (H’ < 1), indeks keseragaman sedang hingga tinggi (0,4 < E < 1), indeks dominansi sedang hingga tinggi (0,30 < C < 1), dan indeks kekayaan jenis rendah (Dmg < 2,05). Analisis korelasi antara struktur komunitas dan pengukuran sifat fisika-kimia badan air menunjukkan adanya hubungan signifikan antara oksigen terlarut (DO) dengan indeks keseragaman dan indeks dominansi. Berdasarkan hasil tersebut dapat disimpulkan bahwa parameter fisika-kimia perairan memiliki peran dalam menentukan struktur komunitas makrozoobentos dan dapat dijadikan sebagai indikator dalam penilaian kualitas air.

Keanekaragaman Makrozoobenthos di Sungai Way Umpu Kabupaten Way Kanan Provinsi Lampung Arsitalia, Metari; Tugiyono, Tugiyono; Master, Jani; Susanto, G. Nugroho
Bioscientist : Jurnal Ilmiah Biologi Vol 12, No 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.11524

Way Umpu River, located in Way Kanan Regency, Lampung Province, is widely used by the local community and the waste products are ultimately disposed of into the river. This can cause a decrease in river water quality which can cause changes in the balance of the ecosystem, both biotic and abiotic. One of the organisms that can be used as a bioindicator is macrozoobenthos. This research aims to determine the diversity of macrozoobenthos as a bioindicator of water pollution quality. The method used was a survey method and sampling using Ekmen Grab at 6 sampling stations. Samples were taken 3 times in the left, middle and right bank areas of the river. Apart from that, water analysis was carried out in the form of physical parameters (temperature and TSS) and chemical parameters (pH, DO, COD, BOD). The data was then analyzed using the Diversity Index. The research results found 14 types of macrozoobenthos consisting of 5 phylum, namely Arthopoda, Mollusca, Porifera, Ciliophora, and Annelida. From the results of the analysis of the macrozoobenthos diversity index at station IV, it has a value of 0.56 ind/m2, which states that the location is heavily polluted. Physical and chemical factors show a significant correlation with macrozoobenthos diversity.

Co-Authors ', Sutyarso Abdullah Aman Damai Agata, Annisa Arsitalia, Metari Azzuhdy, Afifah Nissa Dharmawati, Verli Endang Nurcahyani Jani Master, Jani Kanedi, M. Linirin Widiastuti, Endang Marlinda, Henny Nugraha, Dwiki Renda Nuning Nurcahyani Putra, Bagus Susilo Radella Hervidea, Radella Roselyn, Arini Pradita Sutyarso Sutyarso Tugiyono Tugiyono Tugiyono Widiastuti, Endang Linirin

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