Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

3.276

P-Index

This Author published in this journals

All Journal Jurnal Bios Logos Jurnal Natur Indonesia JURNAL BIOLOGI INDONESIA Akuatikisle: Jurnal Akuakultur, Pesisir dan Pulau-Pulau Kecil Jurnal Akuatiklestari Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Journal of Tropical Marine Science Akuatikisle: Jurnal Akuakultur, Pesisir dan Pulau-Pulau Kecil Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Hippocampus: Jurnal Pengabdian Kepada Masyarakat Indonesian Science Education Journal (ISEJ) Jurnal Perikanan

Widiastuti, Endang Linirin

Unknown Affiliation

Author-ID : 1160870

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Environmental Science Immunology & microbiology Medicine & Pharmacology Social Sciences Other

Published : 20 Documents Claim Missing Document

Claim Missing Document

Articles

1 2

Respon Histopatologis Hepar Mencit (Mus musculus) yang Diinduksi Benzo(α)Piren terhadap Pemberian Taurin dan Ekstrak Daun Sirsak (Annona muricata) Agata, Annisa; Widiastuti, Endang Linirin; Susanto, G. Nugroho; ', Sutyarso
Jurnal Natur Indonesia Vol 16, No 2 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Cancer is a disease that is characterized by the existence of damage and cell abnormality in growth and differentiation. Liver cancer is a disorder of hepar tissue derivated from its tumors. Taurine is known as antioxidant but its role as anticancer needs to be explored more as well the role of Annona muricata leaf extract which is believed to have its role as anticancer substance. This research, therefore, aimed to explore the effect of taurine and Annona muricata leaf extract on the hepar histopathology of male mice (Mus musculus) induced by benzo(α)pyren in vivo. This research was carried out by using a complete randomized design, which consisted of 5 treatment groups which was repeated 5 times. Group I was given 0.2 mL corn oil for 15 days, group II was induced by benzo(α)pyren without taurin nor A. Muricata leaf extract for 10 days, group III was given 7.8 mg taurine/BW/day (twice a day) starting from the 15 th days before the induction of benzo(α)pyren, group IV, after induced with benzo(α)pyren, taurine was given with dosage of 7.8 mg/BW/day, group V, after induced with benzo(α)pyren, soursop leaf extract was given with amount of 277.8 mg/BW/day. Data analyzed by Kruskal-Wallis test and one way ANOVA with Fisher test (p>0.05). The results indicated that taurine had ability to recover the liver tissue induced by benzo(α)pyren as (carcinogenic) while, Annona muricata leaf extract had not shown any recover of tissue damage

Pengaruh Pemberian Taurin terhadap Gambaran Histopatologi Paru Mencit (Mus musculus) yang Diinduksi Karsinogen Benzo(α)Piren secara In Vivo Roselyn, Arini Pradita; Widiastuti, Endang Linirin; Susanto, G. Nugroho; ', Sutyarso
Jurnal Natur Indonesia Vol 17, No 1 (2016)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Lung cancer is a disease that causes high mortality. Drugs used to prevent and cure cancer mostly causes intoxicity to the normal tissues due to its less effectiveness. Therefore, it is necessary to find out any agent or substance which works much more effective and safe for cancer treatment. The aim of the study was to elucidate the role of taurine on the lung tissue of mice (Mus musculus) induced by carcinogenic benzo(α)pyrene. The experiment was conducted in a completely randomized design with 5 replications. Six treatment groups were perfomed. Group I was given 0.2 mL of corn oil and given aquadest until the end of the study period, group II was induced by benzo(α)pyrene without administration of taurine, group III before induced with benzo(α)pyrene, was given taurine dosage 7.8 mg/BW/day for two weeks, group IV after induced benzo(α)pyrene, was given taurine with dosage 3.9 mg/BW/day, group V after induced benzo(α)pyrene, was given taurine with dosage7. 8 mg/BW/day, group VI after induced with benzo(α)pyrene, was given taurine with dosage 15.6 mg/BW/day. The results of the Kruskal-Wallis analysis and one way ANOVA with LSD (p>0,05) showed that taurine reduced lung tissue damage 72.73% due to the administration of benzo(α)pyrene of 0.3 mg/BW/day. In addition, the effective dose of taurine reduce lung tissue damage was 15.6 mg/BW/day.

EFEK EKSTRAK METANOL MAKROALGA COKELAT (SARGASSUM SP.), MERAH (GRACILLARIA SP.) DAN TAURIN TERHADAP GAMBARAN HISTOPATOLOGI HEPAR MENCIT JANTAN (MUS MUSCULUS) YANG DIINDUKSI BENZO(?)PIREN Hervidea, Radella; Widiastuti, Endang Linirin; Nurcahyani, Endang; Sutyarso, Sutyarso; Susanto, G. Nugroho
JURNAL BIOLOGI INDONESIA Vol 14, No 1 (2018): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v14i1.3670

ABSTRACTCancer is a disease marked by the existence of abnormal growth of cell continuously and uncontroll in an organism body. Benzo(?)pyrene is one of the substances that can cause a cancer. The methanolic extract of Sargassum sp. and Gracillaria sp. has anticancer and antioxidant activity. Other compounds with antioxidant activity is taurine. The aim of this research is to examine the effect from methanolic extract of Sargassum sp. and Gracillaria sp .and also taurine on hepar histopatology of male mice (Mus musculus) induced by benzo(a)pyrene. This research used Completely Randomized Design. 30 male mice were divided into 6 groups of treatments, those were: K1 = (K-), K2= induced by benzo(?)pyrene for 10 days, K3= after induced by benzo(?)pyrene, were given the Sargassum sp. orally with a dose 8mg/mice during 15 days, K4=after induced by benzo(a)pyrene, were given the combination of Sargassum sp. (8mg/mice) and taurine(15,6mg/mice) orally during 15 days, K5= after induced by benzo (?)pyrene, were given the Gracillaria sp.orally with a dose 8mg/mice during 15 days, and K6=after induced by benzo(a)pyrene, were given the combination of Gracillaria sp. (8mg/mice) and taurine (15,6mg/mice) orally during 15 days. Data were analyzed using ANOVA (? = 5%). The result shows that the combination of Sargassum sp. and Gracillaria sp. and taurine can increase the number of erythrocyte , decrease the number of leucocyte and protect the damage of hepar histopatology of male mice (Mus musculus) induced by benzo (?)pyrene. Combination of extract Gracillaria sp. and taurine is the most effective to protect the damage hepar histopatology of male mice(Mus musculus) induced by benzo(? )pyrene.Keywords: male mice,Sargassum sp., Gracillaria sp., taurine, benzo(a)pyrene, hepar

The Effect of Ethanol Extracts of Jeruju (Holy Mangrove) Leaves (Acanthus ilicifolius L.) and Taurine on Hematopoiesis Profiles of Mice (Mus musculus L.) Induced by Alloxan Ardiansyah, Budi Khoiri; Widiastuti, Endang Linirin; Nurcahyani, Nuning; Sutyarso, Sutyarso
Jurnal Natur Indonesia Vol 18, No 2 (2020): oktober
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jnat.18.2.62-68

The high exposure to free radicals and glucose blood levels in diabetes potentially damage the body cells and decrease body immune status that is shown by changes in the number of blood cells that can cause complications. The purpose of this research was to study the effect of ethanol extracts of jeruju (holy mangrove) leaves (Acanthus ilicifolius L.) and taurine on hematopoiesis profile by measuring the number of erythrocytes, the number of leukocytes and the leukocytes differential. This research used a Completely Randomized Design (CRD) by 5 treatments with 5 repetitions conducted for 14 days. The treatment groups were: K1 negative control, K2 positive control (alloxan induced only), P1 induced by alloxan and given 100% ethanol extract of jeruju leaves at dose of 22.4 mg/bb/day, P2 induced by alloxan and given 50% ethanol extract of jeruju leaves dose of 22.4 mg/bb/day, and P3 induced by alloxan and given taurine dose of 15.6 mg/bb/day. Data were analyzed by ANOVA and followed by LSD test at the 5% level. The results showed that the administration of jeruju and taurin can maintain the number of leukocytes and the number of lymphocyte cells that were close to normal after induced by alloxan. But has no effect in the number of erythrocytes in mice

Karakteristik, Warna, Dan Ukuran Mikroplastik Yang Ditemukan Pada Air Dan Kerang Hijau Di Pulau Pasaran, Lampung Romaskila, Ulfanida; Widiastuti, Endang Linirin; Susanto, Gregorius Nugroho; Damai, Abdullah Aman; Juliasih, Ni Luh Gede Ratna
Journal of Tropical Marine Science Vol 6 No 2 (2023): Journal of Tropical Marine Science
Publisher : Universitas Bangka Belitung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33019/jour.trop.mar.sci.v6i2.4236

Plastic waste will be degraded into microplastic which has a size of ≤ 5 mm. These microplastic particles change in size and color due to various natural processes that occur in the environment. The purpose of this study was to determine the shape, color and size characteristics of microplastics found around Pasaran Island. Sampling was carried out by taking microplastic samples in water and green mussels around Pasaran Island. Based on the research results, microplastic fragments, films, fibers, granules and foam were found. Microplastic colors consist of black, blue, green, yellow, red, clear, and white. Microplastic fragments, films and fibers were found in the <50µm to 1000 - 5000 µm size group. Granular microplastic types were found in the <50 µm to 100 - 500 µm size group and foam types were found in the <50 µm to 500 - 1000 µm size group.

Treatment of Songgo Langit Extract (Tridax procumbens) Against Blood Glucose Levels and Pancreatic Histopathology of Hyperglycemic Mice Khoirunisa; Nurcahyani, Nuning; Ernawiati, Eti; Widiastuti, Endang Linirin
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 10 No. 2 (2023)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v10i2.261

Hyperglycemia is an early symptom of diabetes caused by the pancreas not being able to produce enough insulin. This condition can disrupt blood glucose metabolism, thereby damaging organs in the body such as the pancreas. Hyperglycemia can be treated using traditional plant medicines. Songgo Langit leaves (Tridax procumbens L.) are reported to have secondary metabolite compounds that have potential as antidiabetic drugs. This study aims to determine the effect of administering Songgo Langit leaf extract on blood glucose levels and changes in the histopathological structure of the pancreas in hyperglycemic mice induced by alloxan. Using Complete Random Design, mice were divided into 5 groups of 5 mice each. Group K (-) was a negative control (not treated), group K (+) was a positive control (only induced by alloxan), group P1 was induced by alloxan and extract of 0.45 mg/g BW, group P2 was induced by alloxan and extract 0.9 mg /g BW, and group P3 was induced by alloxan and extract 1.8 mg/g BW for 14 days. Glucose level data were analyzed using ANOVA and post hoc test with LSD. Pancreatic histopathological structure data were analyzed using the Kruskal-Wallis test and the Mann-Whitney post hoc test. The results showed that the treatment of ethanol extract of Songgo Langit leaf at doses P1, P2, and P3 were significantly able to reduce blood glucose levels by 61.70%, 65.11%, and 74.79% and was able to repair damage to pancreatic histopathology of mice induced by alloxan.

Analysis of Taurine Content in Microalgae Tetraselmis sp. Cultured at Different Salinities Nurafiah, Eva; Widiastuti, Endang Linirin; Maharani, Henni Wijayanti
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 10 No. 2 (2023)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v10i2.304

Taurine is a non-essential sulfur-containing amino acid with the chemical formula C2H7NO3S. These compounds play an important role in maintaining the smooth running of various processes in the body. Tetraselmis sp. is one of the microalgae known to have a taurine biosynthetic pathway via the serine/sulfate pathway. The purpose of this study was to determine the effect of culture salinity on taurine content produced by microalgae Tetraselmis sp. which was dissolved using 96% ethanol. The samples obtained were then tested using UV-Vis spectrophotometry using standard synthetic taurine as a comparison. Based on the research results, the maximum absorption was obtained at a wavelength of 630 nm, and the regression equation y = 0.001x + 0.033 was obtained and had a correlation coefficient of r = 1. Based on the analysis results showed that all samples contained taurine. Samples at a salinity of 25 ppt contained an average of 2.82 ml/100g of taurine, while a culture salinity of 35 ppt contained an average of 4.03 ml/100g of taurine. From these data it is known that the highest taurine level was found at a culture salinity of 35 ppt, while the lowest taurine level was at a culture salinity of 25 ppt. This indicates that the higher the culture salinity, the higher the taurine content produced by the microalgae Tetraselmis sp. The phenomenon of increased taurine due to salinity stress is thought to be due to an increase in free amino acids in microalgae cells to produce metabolites that are used to defend themselves due to salinity stress. The function of taurine in this microalgae is thought to be an organic osmolyte in the cells of the Tetraselmis sp. microalgae.

Differences in Soaking Time of Sea Urchin Gonad Extract (Diadema setosum) on Nile Tilapia (Oreochromis niloticus) Masculinization with a Dose of 4 mg/L : Perbedaan Lama Perendaman Ekstrak Gonad Bulu Babi (Diadema Setosum) Terhadap Maskulinisasi Ikan Nila (Oreochromis Niloticus) Dengan Dosis 4 Mg/L Sari, Mutiara Pradita; Susanto, Gregorius Nugroho; Widiastuti, Endang Linirin; Tugiyono, Tugiyono
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 10 No. 2 (2023)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v10i2.310

Nile tilapia (Oreochromis niloticus) is a fish that is in demand because of its high economic value and thick meat. Tilapia is easy to breed, uncontrolled spawning can occur so that growth is inhibited. The growth of male tilapia is faster than females at the same age. To increase the growth rate, sex reversal is carried out towards males through immersion in steroid hormones. Bioactive substances contained in sea urchins are steroid compounds. The purpose of this study is to determine the effect of the length of immersion in sea urchin gonad extract (Diadema setosum) on the formation of male phenotypes of tilapia larvae and tilapia survival. The method used is a completely randomized design with 4 treatments and each treatment with 3 replicates at a dose of 4 mg/L with soaking times of 0, 12, 18, and 24 hours. Data are analyzed using SPSS 16 software with analysis of variance (One-way ANOVA). The results show that different lengths of immersion in sea urchin steroid extract at a dose of 4 mg/L affect the formation of male individuals. A soaking time of 18 hours is quite effective in directing the sex of fish to males by 66%. Immersion time also affects the survival of tilapia larvae.

TOXICITY TEST OF LIME PEEL EXTRACT (Citrus aurantifolia) USING THE BRINE SHRIMP LETHALITY TEST (BSLT) METHOD FOR DETECTION OF ANTI CANCER ACTIVITY Khairunnisa, Indah; Widiastuti, Endang Linirin; Nurcahyani, Nuning
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 9 No 2 (2024): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v9i2.2083

Cancer is one of the major problems affecting the people of Indonesia and the world. Lack of public awareness for early detection causes a delay in diagnosis. One of the medicinal plants that are commonly found in Indonesia is lime (C. aurantifolia). In lime peel extract, there is essential oil composed of D-Limonene (38.94%), β-pinen (26.66%), α-terpineol (8.29%), and terpinen-4-ol (4.32%). These compounds are known to have strong effects as anti-cancer. This study used a completely randomized design (CRD) with 5 treatments and 5 repetitions, namely 0, 125, 150, 250, and 1000 ppm. The research methods used were phytochemical test, FTIR (Fourier-Transform Infrared Spectroscopy) analysis, and BSLT test. The probit value was analyzed using SPSS to obtain the LC50 value. Lime peel extract (C. aurantifolia) has an LC50 value of 331.533 ppm including the toxic category and has potential as an anti-cancer agent. Based on phytochemical and FTIR tests, lime peel (C. aurantifolia) contains alkaloid, flavonoid, and tannin compounds which are known to have antioxidant properties and can disrupt the balance of Reactive Oxygen Species (ROS) so as to trigger apoptosis of cancer cells.

Analysis of Microplastic at Sea Water and Sediment in the Pasaran Island Bay Using FT-IR Pamungkas, Galuh Rara; Widiastuti, Endang Linirin; Pratami, Gina Dania; Tugiyono, Tugiyono
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 11 No. 2 (2024)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v11i2.378

Marine pollution from ocean garbage, particularly plastic waste, has significant ecological impacts globally. Plastic debris dominates marine pollution and graadually breaks down into microplastics. This study analyzes microplastic particle count, shapes, and polymer types in water and sediiment around Pasaran Island. Research was conducted across four stations (Station I, II, III, and IV). Microplastics in seawater samples were extracted using solutions of 70% ethanol, 30% H2O2, and 30% NaCl. Sediments were treated with FeSO4 (0.05 M), NaCl, and 30% H2O2. Particle counts and shapes were identified with a digital microscope and polymer types were determined via Fourier Transform Infrared Spectroscopy (FT-IR). Microplastic forms observed included fibers, fragments, film, and pellets, with fibers being the most abundant and pellets the least. Detected polymers included polyamide (PA), polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polystyrene (PS), and polytetrafluoroethylene (PTFE), originating from both local plasstic use and seawater flow around Pasaran Island.

Co-Authors ', Sutyarso Abdullah Aman Damai Agata, Annisa Agus Budi Utomo Agus Setyawan Ardiansyah, Budi Khoiri Arifiyanto, Achmad Arlanda, Revilarita Endah Setyaningrum, Endah Endang Nurcahyani Erna Rochana Ernawiati, Eti Gina Dania Pratami, Gina Dania Hartoyo Hartoyo Henni Wijayanti Maharani Juliasih, Ni Luh Gede Ratna Khairunnisa, Indah Khasana, Devi Ardiyati Khoirunisa Leni, Yusyam Lestari, Sepnina Like Maya Riantini, Maya Nababan, Yolanda Nita Sari Nuning Nurcahyani Nurafiah, Eva Nursafitri, Umy Nurul Khasanah, Nurul Pamungkas, Galuh Rara Qadar Hasani Radella Hervidea, Radella Riris Roiska Rohmawati Bareta, Ainun Romaskila, Ulfanida Rosari, Anastasia Santaulina Putri Roselyn, Arini Pradita RR. Ella Evrita Hestiandari Sari, Mutiara Pradita Supono Supono Susanto, G. Nugroho Susanto, Gregorius Nugroho Susanto, Gregorius Nurgroho Sutyarso Sutyarso , Sutyarso Sutyarso Sutyarso Tugiyono Tugiyono Yuni Astuti

Title

Found 20 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 20 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 20 Documents
Search