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All Journal Jurnal Pendidikan dan Pembelajaran Khatulistiwa (JPPK) Jurnal Farmasi Klinik Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Surya Medika Majalah Farmaseutik JFIOnline Indonesian Journal of Global Health research Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)
Widyati, Widyati
Rumah Sakit Angkatan Laut Dr. Ramelan, Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Other

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Laporan Kasus Tentang Aspirin Dosis Rendah Memicu Anemia Aplastik Widyati, Widyati
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 2 (2014)
Publisher : Indonesian Research Gateway

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Abstract

Aspirin has been reported could trigger aplastic anemia in an elderly patient who used aspirin as antiplatelet therapy for secondary prevention of coronary heart diseases. Assessment methods used are time series data collection followed by causality analysis using Naranjo Scale. The results of analysis reveals a Naranjo scale of 11 which was then interpreted as definite. This report concluded that low-dose aspirin triggered acquired aplastic anemia. The mechanism of the AA presumably through destruction of immunemediated bone marrow or through direct destruction of blood cells. Keywords: Aspirin, antiplatelet, aplastic anemia, Naranjo scale  Aspirin dilaporkan telah memicu anemia aplastik (AA) pada seorang pasien manula yang menggunakan aspirin sebagai antiplatelet untuk prevensi sekunder penyakit jantung koroner. Metode asesmen yang digunakan adalah pengumpulan data secara time series dilanjutkan dengan analisis kausalitas menggunakan Skala Naranjo. Hasil telaah kasus menunjukkan skala Naranjo 11 (definite) yang diinterpretasikan bahwa insiden anemia aplastik tersebut pasti dipicu oleh aspirin. Disimpulkan bahwa aspirin dosis rendah memicu anemia aplastik dengan tipe acquired Aplastic Anemia. Mekanisme terjadinya AA tersebut diduga melalui pengrusakan sumsum tulang yang diperantarai immun atau melalui pengrusakan langsung sel-sel darah Kata kunci: Aspirin, antiplatelet, anemia aplastik, skala Naranjo 
Laporan Kasus Tentang Aspirin Dosis Rendah Memicu Anemia Aplastik Widyati, Widyati
Jurnal Farmasi Indonesia Vol 7, No 2 (2014)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.351 KB) | DOI: 10.35617/jfi.v7i2.169

Abstract

Aspirin has been reported could trigger aplastic anemia in an elderly patient who used aspirin as antiplatelet therapy for secondary prevention of coronary heart diseases. Assessment methods used are time series data collection followed by causality analysis using Naranjo Scale. The results of analysis reveals a Naranjo scale of 11 which was then interpreted as definite. This report concluded that low-dose aspirin triggered acquired aplastic anemia. The mechanism of the AA presumably through destruction of immunemediated bone marrow or through direct destruction of blood cells. Keywords: Aspirin, antiplatelet, aplastic anemia, Naranjo scale  Aspirin dilaporkan telah memicu anemia aplastik (AA) pada seorang pasien manula yang menggunakan aspirin sebagai antiplatelet untuk prevensi sekunder penyakit jantung koroner. Metode asesmen yang digunakan adalah pengumpulan data secara time series dilanjutkan dengan analisis kausalitas menggunakan Skala Naranjo. Hasil telaah kasus menunjukkan skala Naranjo 11 (definite) yang diinterpretasikan bahwa insiden anemia aplastik tersebut pasti dipicu oleh aspirin. Disimpulkan bahwa aspirin dosis rendah memicu anemia aplastik dengan tipe acquired Aplastic Anemia. Mekanisme terjadinya AA tersebut diduga melalui pengrusakan sumsum tulang yang diperantarai immun atau melalui pengrusakan langsung sel-sel darah Kata kunci: Aspirin, antiplatelet, anemia aplastik, skala Naranjo 
Co-Authors Agung Endro Nugroho Arrang, Sherly Tandi Fauzi, Rifani Giyantolin, Giyantolin Harijono, Pandu Ika Puspita Sari Lukman Hakim Putri, Cyndi Yulanda Rahmatullah, Daril Rahmatullah, Daril Regina Regina Sari, Juwita Permata Setiadi, Diga Albrian Setiawan, Stefanie Simorangkir, Timbul Partogi Haposan Soediatmoko, Soediatmoko Subiakto, Yuli Sutapa, Y. Gatot Yakti, Kuntjoro