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All Journal Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Mandala Pengabdian Masyarakat Jurnal Buana Farma Jurnal Sains dan Teknologi Farmasi Indonesia
Riasari, Hesti
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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EXPLORATION OF POTENTIAL NATURAL COMPOUNDS THROUGH IN SILICO APPROACH: A CASE STUDY ON TOKARAMID COMPOUNDS Baroroh, Umi; Sin, Cindy Wan Yik; Riasari, Hesti
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 12, No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58327/jstfi.v12i2.225

Abstract

Indonesia, renowned for its rich biodiversity, boasts diverse marine ecosystems that have long remained untapped in the quest for novel therapeutic compounds. This shows the great potential of Indonesia's biodiversity, particularly within its marine habitats, as a treasure trove for exploring bioactive compounds for disease treatment. These compounds can be explored using in silico analyses, including activity prediction, ADME (absorption, distribution, metabolism, and excretion) prediction, toxicity prediction, and molecular docking, to accelerate the discovery of promising drug candidates. The compound TG-0205221, modified Tokaramide A from the sponge Theonella mirabilis, is reported to have potential as an anti-3CLPro from SARS-CoV-1, which is genomically similar to SARS-CoV-2 by 96%. 3CLPro is the most prospective working target of anti-COVID-19. In this study, the exploration of TG-0205221 and Tokaramide A as anti-3CLPro was conducted using in silico approach. It is shown that based on ADMET prediction, all compounds are anticipated to be suitable for oral consumption and exhibit a non-toxic profile. TG-0205221 is predicted to have activity as a 3CLPro inhibitor higher than others. Furthermore, the potential anti-3CLPro SARS-CoV-2 activity of all ligands in molecular docking is envisaged to be considerably high. The binding energy of Tokaramide A and TG-0205221 is relatively similar, -9.16 and -8.39 kcal/mol, respectively. Both Tokaramide A and TG-0205221 show potential as anti-SARS-CoV-2 agents and may aid in the exploration of natural compounds for drug discovery.
AKTIVITAS ANTIOKSIDAN DAN KADAR TOTAL FENOL DARI EKSTRAK JAMU BERAS KENCUR DENGAN PENAMBAHAN RIMPANG KUNYIT Fitriansyah, Sani Nurlaela; Riasari, Hesti; Melati, Novi; Simanjuntak, Nela
Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Vol 9 No 1 (2024): Pharma Xplore : Jurnal Sains dan Ilmu Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jpx.v9i1.6483

Abstract

Jamu is a traditional medicine from Indonesia. Jamu beras kencur is one of the most popular jamu in Indonesia. Jamu beras kencur are often added with other ingredients to increase the efficacy. Turmeric (Curcuma domestica) was a traditional medicinal plant that has high antioxidant and anti-inflammatory effects. Phenolic compound is the largest secondary metabolite in turmeric. The aimsf this research were to determine antioxidant activity and total phenolic content of extract jamu beras kencur wich was added of various concentrations of turmeric and the differences boiling time in processing jamu preparations. The processing of jamu beras kencur with the addition of turmeric with boiling time (15 minutes and 30 minutes). Variation of concentration of tumeric were 5%, 10% and 20%. The concentration of turmeric used addition 5%, 10% and 20. Each preparation was extracted using ethyl acetat. Aantioxidant activity of each extract was performed by DPPH method wich demonstrated as IC50 DPPH. Determination of total phenolic was performed by UV-Vis spectrophotometry and expressed in g GAE/100 g extract. The highest antioxidant activity (IC50 of 485 μg/mL) and the highest total phenolic (41.336 g GAE /100 g extract) was given by jamu beras kencur wich 20% turmeric and 15 min boiling time. Addition of turmeric and differences of boiling time in processing jamu preparations can affect antioxidant activity and total phenolic content.
A LITERATURE REVIEW: AKTIVITAS ANTIBAKTERI TANAMAN OBAT TERHADAP BAKTERI PENYEBAB PNEUMONIA Sinabutar, Rahel Margarenta; Nurfitriani, Iis; Maharani, Dinda Eka; Riasari, Hesti
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1382

Abstract

Pneumonia is an acute respiratory tract infection caused by various pathogenic bacteria, including Streptococcus pneumoniae, Staphylococcus aureus, and Klebsiella pneumoniae. The increasing prevalence of antibiotic resistance among these pathogens highlights the need for alternative therapeutic strategies derived from natural products. This study aimed to review the antibacterial potential of medicinal plants against pneumonia-causing bacteria and their underlying mechanisms. A systematic literature review was conducted by searching scientific articles in Google Scholar, PubMed, ScienceDirect, and MDPI. Articles were selected based on inclusion criteria covering antibacterial activity, active compounds, and reported mechanisms of action. A total of 30 eligible articles were analyzed descriptively. The medicinal plants reviewed include Etlingera elatior, Cassia alata, Morinda citrifolia, Melaleuca leucadendra, Momordica charantia, Guazuma ulmifolia, Artocarpus altilis, Acacia nilotica, Gynura procumbens, Trigona incisa propolis, and Ficus carica. These plants contain secondary metabolites such as flavonoids, alkaloids, saponins, tannins, and phenols, which exhibit antibacterial activity by disrupting cell membranes, inhibiting protein synthesis, interfering with essential enzymes, and inducing oxidative stress in bacteria. The findings indicate that medicinal plants hold great potential as complementary or alternative therapies for pneumonia caused by antibiotic-resistant bacteria; however, further research, particularly in vivo and clinical studies, is required to confirm their efficacy and safety.
REVIEW ARTIKEL: POTENSI FITOTERAPI DARI TANAMAN HERBAL DALAM PENANGANAN RHEUMATOID ARTHRITIS Nurhayati, Ismaya; Maulani, Sintia Putri; Lathifah, Meira H.; Riasari, Hesti
Jurnal Buana Farma Vol. 5 No. 3 (2025): Jurnal Buana Farma : Jurnal Ilmiah Farmasi
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v5i3.1387

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation of the joints, resulting in progressive damage and a decreased quality of life for patients. Conventional therapies such as NSAIDs and DMARDs are indeed effective, but their long-term use carries the risk of serious side effects and high costs. Therefore, safer and more affordable alternative therapies are needed, one of which is through the use of medicinal plants. This study aims to examine the potential of herbal plants as an additional or alternative therapy for rheumatoid arthritis. The method employed is a literature study, involving the search and analysis of 31 scientific journals retrieved from academic databases, including Google Scholar, PubMed, ScienceDirect, and MDPI. The articles analyzed were selected based on certain criteria and contained information about the content of active compounds, pharmacological activity, and the mechanism of action of plants on the RA inflammation process. The results of the study showed that various herbal plants such as Zingiber officinale, Curcuma longa, Boswellia serrata, and Nigella sativa have significant anti-inflammatory and immunomodulatory activities. The active compounds in these plants work by inhibiting the inflammatory pathway and reducing the production of pro-inflammatory cytokines. In conclusion, medicinal plants have great potential to be used as additional therapy in the treatment of rheumatoid arthritis. However, further research is needed, especially clinical trials, to ensure the long-term safety and effectiveness of their use.
Gambaran Tingkat Pengetahuan Masyarakat Dalam Pemanfaatan Daun Sukun Pada Penyakit Degenerative di Kecamatan Cinunuk, Cileunyi Kabupaten Bandung. Riasari, Hesti; Fitriansyah, Sani Nurlaela; Wibowo, Diki Prayugo; Hasanah, Siti Uswatun; Wirasutisna, Komar Ruslan; Restiasari, Anggi
Jurnal Mandala Pengabdian Masyarakat Vol. 5 No. 1 (2024): Jurnal Mandala Pengabdian Masyarakat
Publisher : Progran Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpm.v5i1.337

Abstract

Health is a very important aspect in human life. Degenerative diseases are a serious challenge faced by modern society. Community service aims to describe the level of knowledge of the community in Cinunuk District, Cileunyi, Bandung Regency, as well as analyzing the extent to which breadfruit leaves are used in efforts to prevent and treat degenerative diseases. This community service was carried out on October 26 2023 at the Sebaguna Building, Cinunuk Cileunyi District, Bandung Regency in collaboration with Medina Farma Pharmacy. A total of 78 people took part in counseling activities related to degenerative diseases, plants used as herbal medicines, healthy lifestyles to prevent degenerative diseases, workshops on making breadfruit leaf tea products, health checks such as blood pressure, instant blood sugar, total cholesterol levels, accompanied by health counseling and distribution of pamphlets, 45 of them filled out the questionnaire online using g-form. The results of respondents before the counseling and workshop were 45.89%, indicating that the level of knowledge of respondents was very poor, after the counseling and workshop on making herbal tea preparations there was an increase in the knowledge of the people of Cinunuk District by 81 .48% with a high category of respondents' knowledge regarding degenerative diseases, plants that can be used as herbal medicine, the use of breadfruit leaves and their processing in the form of herbal tea preparations which makes it easier for people to consume them in traditional treatment efforts as preventive and curative.
Co-Authors Baroroh, Umi Fitriansyah, Sani Nurlaela Komar Ruslan Wirasutisna Lathifah, Meira H. Maharani, Dinda Eka Maulani, Sintia Putri Melati, Novi Nurfitriani, Iis Nurhayati, Ismaya Restiasari, Anggi Simanjuntak, Nela Sin, Cindy Wan Yik Sinabutar, Rahel Margarenta Siti Uswatun Hasanah Wibowo, Diki Prayugo