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All Journal Indonesian Journal of Pharmaceutical Science and Technology Jurnal Mandala Pharmacon Indonesia Jurnal Riseta Naturafarm Kimia Padjadjaran
Indriyanti, Niken
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Potential Indonesian Medicinal Plants on Aphrodisiac Activity Prasetya, Fajar; Bahar, Zulhaerana; Fricillia, Onny Ziasti; Indriyanti, Niken
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i1.55179

Abstract

The use of Indonesian medicinal plants in empirical ingredients as a jamu in Indonesian tradition is very interesting to be explored. One of them is the use of jamu for aphrodisiac activity. This research is aimed to determine the data about the diversity of Indonesian medicinal plants used for aphrodisiacs. Some aspects reviewed were empirical use, safety data, and scientific research data. The method used in this research is narrative review by using search engine Sciencedirect, Pubmed, Springerlink, and Google Scholar in 24 years (2000-2024). The literature review resulted in 20 Indonesian medicinal plants, which were very potent for aphrodisiac. The plants are Areca catechu L., Pimpinella panatjan Mirb, Zingiber officinale, Dendrocalamus asper, Eurycoma longifolia Jack, Sanrego, Anacardium occidentale L., Imperata cylindrica L., Allium sativum L., Ocimum sanctum, Piper retrofractum Vahl., Piper nigrum L., Eugenia caryophyllata, Myristica Fragans, dan mangrove mangrove M. muticus, R. mucronata, R. apiculata, A. aureum, D. trifoliata and B. parviflora. Therefore, it will be used as a reference based for the further research.   
ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY OF RETICULATED PYTHON FAT OIL (MALAYOPYTHON RETICULATUS) IN VIVO EVALUATION Hajrah, Hajrah; Febriani, Dina Arindha; Indriyanti, Niken
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i1.55201

Abstract

Empirically, python fat oil (Malayopython reticulatus) is used by local people in Miau Baru, Kongbeng, East Kalimantan to treat swelling and inflammation. The purpose of this study was to determine the physical characteristics, anti-inflammatory, and analgesic activities of the python fat oil in reducing pain and inflammation. The methods that are used for determining physical characteristics are organoleptic test, density test, viscosity test, pH test, and refractive index test. The method that is used for determining anti-inflammatory activities is the paw edema method, which is induced by lambda carrageenan, and for analgesic activities using the hot plate method. The results obtained are that python oil has a yellow-orange color, a rancid odor, and has a bland taste, has a density of 0.870 g/mL with a pH of 4.1. The viscosity of the python fat oil is 2.2 Pa.s with a refractive index of 1.463. The percentage of edema formed at 5% concentration was 0.33%, 10% concentration was 0.43%, and 15% concentration was 0.25%. A recent increase in survival time in analgesic testing with a 5% concentration of 4.44%, a 10% concentration of 3.87%, and a 15% concentration of 3.11%. It was concluded that python fat oil has anti-inflammatory and analgesic activity.
Formulasi Sediaan Lip Gel Dari Ekstrak Etanol Kulit Buah Nanas (Ananas comosus (L.) Merr.) Sebagai Pelembab Bibir Fadhila, Fadhila Abadi Zahra; Indriyanti, Niken; Satriani Badawi
Jurnal Riseta Naturafarm Vol. 1 No. 2 (2024): Jurnal Riseta Naturafarm
Publisher : B-Creta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jrn.v1i2.6975

Abstract

Lips are a facial area that is vulnerable to adverse environmental influences, which can lead to discomfort such as dry, chapped lips, and a dull appearance. Lip gels are commonly used in lip care. Pineapple peel waste (Ananas comosus (L.) Merr.) contains compounds that can be utilized for lip care. The objective of this study was to determine the formulation of a lip gel preparation by testing its physical properties, irritation, and effectiveness as a lip moisturizer. This study is an experimental study. Base optimization was carried out, followed by formulation of preparations with pineapple peel extract concentrations of F1=3%, F2=5%, and F3=7%, physical evaluation of the preparation, namely organoleptic tests, homogeneity tests, spreadability tests, adhesiveness tests, viscosity, pH, irritation tests, and moisturizing effectiveness tests. The results showed that pineapple peel extract can be used as an active ingredient in lip gel preparations. The physical properties of the preparations were semi-solid, yellow to brownish in color with a characteristic pineapple aroma, and did not cause irritation or erythema. All formulas were still within the requirements of good characteristics. The lip gel formulation F2 was more effective based on the results of the percentage increase in moisture content, which was 73.18%.
Weight Loss Activity of Boesenbergia rotunda, Zingiber cassumunar, and Hibiscus sabdariffa Combination Extract on Zebrafish Model Indriyanti, Niken
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.50575

Abstract

Boesenbergia rotunda, Zingiber cassumunar, and Hibiscus sabdariffa are potential medicinal plants to be developed as weight loss agent. This research aimed to determine weight loss activity of the 3 plants in combination. The model used was zebrafish wild type. The protocol was approved by the Ethics Committee of Health Research, Faculty of Pharmacy, Mulawarman University. The extraction method was decocta. The flavonoid and phenolic contents were calculated using standard method of analysis in Indonesian Herbal Pharmacopoeia.  The results of rendemen and total flavonoid/phenolic content (TFC/TPC) calculations are Boesenbergia extract 2,7% with the TFC of 49,7 mg/g; Zingiber cassumunar extract 6,5% with the TPC of 41,2 mg/g; Hibiscus extract 31,6% with the TFC of 91,2 mg/g. It forms as dry extracts, brown colour, and hygroscopic. The average of weight loss of zebrafish in 2 weeks treatment is 9-16% in sample 1 group; 28,5% in sample 2 group; and no lowering body weight on sample 3 group. The sample 1 and 2 are promising compared to orlistat activity, 32% weight loss. In conclusion, the highest weight loss activity is in sample 2 which is consisted of combination of Boesenbergia extract and Zingiber cassumunar extract.@font-face {font-family:"Cambria Math"; panose-1:2 4 5 3 5 4 6 3 2 4; mso-font-charset:0; mso-generic-font-family:roman; mso-font-pitch:variable; mso-font-signature:3 0 0 0 1 0;}@font-face {font-family:Calibri; panose-1:2 15 5 2 2 2 4 3 2 4; mso-font-charset:0; mso-generic-font-family:swiss; mso-font-pitch:variable; mso-font-signature:-536859905 -1073732485 9 0 511 0;}p.MsoNormal, li.MsoNormal, div.MsoNormal {mso-style-unhide:no; mso-style-qformat:yes; mso-style-parent:""; margin:0cm; margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Calibri",sans-serif; mso-fareast-font-family:Calibri; mso-bidi-font-family:Arial; mso-ansi-language:EN-US;}.MsoChpDefault {mso-style-type:export-only; mso-default-props:yes; font-size:10.0pt; mso-ansi-font-size:10.0pt; mso-bidi-font-size:10.0pt; font-family:"Calibri",sans-serif; mso-ascii-font-family:Calibri; mso-fareast-font-family:Calibri; mso-hansi-font-family:Calibri; mso-bidi-font-family:Arial; mso-ansi-language:EN-US;}div.WordSection1 {page:WordSection1;}
Antibacterial Activity and Phytochemical Screening of Methanol Extract of Rambai (Baccaurea motleyana Muell. Arg.) Leaves from the Tropical Rainforest of East Kalimantan Widayat, Wahyu; Indriyanti, Niken; Adestia, Talita Shofa; Wibowo, Ekasari Kartika Putri
Kimia Padjadjaran Vol 3, No 1 (2024)
Publisher : Kimia Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Antibiotic resistance is a problem in the health field. Potential sources of raw materials are needed to overcome this problem. Rambai (Baccaurea motleyana Muell. Arg.) is one of the Baccaurea genus which is widespread throughout Asia. Several species of Baccaurea are known for their antimicrobial properties. Extraction was performed using the maceration method with methanol as solvent. Phytochemical screening of the extract was analyzed using a standard method. The antibacterial activity was tested using the agar diffusion method (Kirby-Bauer) with extract concentrations of 2, 4, 6, 8, and 10 mg/disc. The test bacteria used were Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The results showed that the extract contained alkaloids, phenolics, and flavonoids. B. motleyana methanol extract showed antibacterial activity at a concentration of 10 mg/disc, with an inhibition zone of 11 mm. Based on these results, B. motleyana leaves have potential as an antibacterial agent.
Pristane modulates specific changes on T cell dependent pathway of lupus in non-F1 BALB/c mice Indriyanti, Niken; Arifianti, Lusiana; Soeroso, Joewono; Khotib, Junaidi
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia Special Issue for 18th Mulawarman Pharmaceu
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.533

Abstract

Animal modeling for lupus is a crucial step in the process of discovering efficacious drugs. There are many drug candidates that have potential benefits for the treatment of lupus, but finding an appropriate model remains challenging. The appropriate model based on the literature is an induction model that uses 2,6,10,14 tetramethylpentadecane (TMPD) in female Balb/c mice. The TMPD increases the probability of damage beyond lupus, to the joint and kidneys. Therefore, the purpose of this study was to develop a lupus model by TMPD to test a drug candidate. The experimental method was measuring many biomarkers involved in the TMPD mechanism to obtain lupus-like disease mice. We measured CD4+CD25+FOXP3+ and CD4+CD62L+ T-regs, CD123+IFN-?+ dendritic cells (flow cytometry); total leukocytes (Turk staining); anti-Sm antibody (ELISA); and renal and joint histology (HE staining). After the 6th month, there were reduction (p<0.05) of the T regulatory percentage of CD4+CD25L+ T cells (Naïve=19.39±3.06%, TMPD-treated=5.72±3.43%) and CD25+FOXP3 + T cells (Naïve=10.32±4.47%, TMPD-treated=7.70±4.47%), meanwhile, the IFN-? increased significantly (p<0.05), (Naïve=6.92±8.67%, TMPD-treated=11.42±0.95%), and the total leukocytes increased (p<0.05) (Naïve=9,800±1,698, TMPD-treated=17,500±1,490 cells/mm3). The anti-Sm antibody was also present in the TMPD-treated mice as one cause which led to renal and joint structural disorders. The biomarkers were analyzed by using Independent T-test, so this positive lupus model with its tested biomarkers is valid and can be used to test drugs for lupus.
Pemanfaatan Pewarna Alami dari Bunga Asoka (Ixora coccinea) pada Formulasi Lip Cream Nanda, Chintiya Vera; Kurniati, Dwi Elfira; Indriyanti, Niken
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia Special Issue for 18th Mulawarman Pharmaceu
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.534

Abstract

Bunga asoka (Ixora coccinea) mengandung pigmen untuk dimanfaatkan menjadi pewarna alami dalam bidang kosmetik. Tujuan dari  penelitian ini adalah meneliti manfaat ekstrak etanol dari bunga asoka yang menjadi pewarna alami terutama dalam produk lip cream. Studi dimulai melalui ekstrasi bunga asoka menggunakan pendekatan maserasi dimana pelarut etanolnya adalah 96% serta asam sitrat. Kemudian dilaksanakan pengoptimasian basis menggunakan lilin carnauba serta lilin candelilla, kemudian diformulasikan dengan ekstrak bunga asoka dan dievaluasi kualitasnya melalui uji organoleptik, pH, stabilitas sediaan, iritasi, daya lekat, viskositas, homogenitas, uji hedonik. Ekstraksi menghasilkan rendemen sebesar 27,1%. B3, B4, dan B5 adalah basis yang memenuhi kriteria lip cream dengan basis terbaik yaitu B3. Lip cream dengan konsentrasi ekstrak bunga asoka 2%, 4%, serta 6% memberikan hasil berupa warna masing-masing cokelat muda, cokelat sedikit merah, serta merah. Hasil evaluasi menunjukkan aroma khas cokelat, konsistensi semipadat, dan homogenitas yang sesuai dengan persyaratan lip cream. Namun, F3 menunjukkan ketidakstabilan dan tidak memenuhi persyaratan pH. Kesimpulan akhir menunjukkan bahwa F1 dan F2 merupakan formula yang lulus uji kriteria lip cream, sementara F3 adalah formula yang paling disukai. Kesimpulannya adalah hasil pengekstraksian etanol bunga asoka bisa dipergunakan menjadi pewarna alami dalam produk lip cream.
Efektivitas Ekstrak Kratom (Mitragyna speciose) pada Inhibisi Withdrawal Syndrome Model Adiksi Morfin Indriyanti, Niken; Hajrah, Hajrah; Priastomo, Mukti; Samsul, Erwin; Prabowo, Wisnu Cahyo; Prasetya, Fajar
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 1 (2024): Jurnal Mandala Pharmacon Indonesia Special Issue for 18th Mulawarman Pharmaceu
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i1.535

Abstract

Kratom (Mitragyna speciose) secara empiris banyak digunakan di area Kalimantan untuk berbagai keluhan yang berkaitan dengan nyeri. Banyak hasil penelitian bahwa tanaman ini mampu mengatasi kecanduan narkotik, dan sebaliknya. Maka, penelitian ini mengukur potensi kratom pada penanganan gejala withdrawal syndrome adiksi morfin. Pengujian dilakukan secara in vivo pada model mencit yang diinduksi adiksi morfin. Hasil yang didapatkan berupa aktivitas penekanan gejala adiksi pada parameter perilaku psikomotorik, sensitivitas saraf pendengaran, dan sensitivitas saraf mata terhadap cahaya. Pemberian bahan uji aman pada parameter bilirubin dan urobilinogen, serta parameter ginjal. Penelitian lebih lanjut diperlukan untuk menelusuri efek terhadap organ otak dan limpa. Ekstrak kratom memiliki multiple compounds yang memungkinkan adanya penekanan aktivitas adiksi. Maka disimpulkan bahwa pemberian ekstrak etanol kratom dengan dosis 4 mg/kgBB mencit mampu menekan gejala withdrawal syndrome pada model adiksi morfin.
Co-Authors Arifianti, Lusiana Bahar, Zulhaerana Fadhila, Fadhila Abadi Zahra Febriani, Dina Arindha Fricillia, Onny Ziasti Hajrah Hajrah, Hajrah Joewono Soeroso Junaidi Khotib Kurniati, Dwi Elfira Nanda, Chintiya Vera Prabowo, Wisnu Cahyo Prasetya, Fajar Priastomo, Mukti Samsul, Erwin Satriani Badawi Talita Shofa Adestia wahyu widayat Wibowo, Ekasari Kartika Putri