Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Jurnal Penyakit Dalam Indonesia Journal Pharmacy of Tanjungpura
Gunawan, Alvin
Unknown Affiliation
Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Efektivitas Ekstrak Strobilanthes crispus terhadap Kadar Glukosa Darah Puasa dan Pasca Tes Toleransi Glukosa Oral pada Rattus norvegicus Diabetes Melitus Gunawan, Alvin; Wihanto, Laura; Muliono, Ari Christy
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. The 2018 Riskesdas data shows that the prevalence of diabetes mellitus is increasing each year. Strobilanthes crispus leaves are known for lowering blood glucose levels. This study aimed to determine the difference in the effectiveness of S. crispus leaves ethanolic extract on fasting blood glucose (FBG) and post-oral glucose tolerance test (OGTT). Methods. True experimental study using post-test only control group design and Rattus norvegicus as experimental animals. Rattus norvegicus were selected by random sampling which were then divided into 4 groups (K, P1, P2, P3), each group consisted of 5 animals. The animals were subsequently induced with diabetes mellitus via a single injection of 160 mg/kgBW/IP alloxan. Group K was given 0.5% NaCMC solution at a dose of 1 ml/200 g BW/day/oral/day. Group P1, P2, and P3 received extract at a dose of 100, 400, 600 mg/kg BW/oral/day for 21 days using oral gavage. Statistical analysis was performed using ANOVA, Tukey, Brown-Forsythe, and Kruskal-Wallis tests. Results. Mean FBG level in group K, P1, P2, P3 were 338.40 mg/dL, 270.80 mg/dL, 200.00 mg/dL, and 138.60 mg/dL, respectively. Mean value of 60 minutes OGTT blood glucose level in group K, P1, P2, P3 were 355.60 mg/dL, 289.00 mg/dL, 188.00 mg/dL, and 164.40 mg/dL, respectively. Meanwhile, mean value of 120 minutes OGTT blood glucose level in group K, P1, P2, P3 were 346.60 mg/dL, 236.20 mg/dL, 175.40 mg/dL, and 117.20 mg/dL, respectively. The hypothesis test results showed a significant difference in 120 minutes OGTT blood glucose level (p= 0.031). Conclusion. The use of ethanol extract from S. crispus leaves is more beneficial in reducing blood glucose levels in 120 minutes OGTT compared to FBG level and 60 minutes OGTT level, with the highest reduction observed in the group given a dose of 600 mg/kgBW/oral/day compared to control. Keywords: DM, fasting blood glucose, OGTT, Rattus norvegicus, Strobilanthes crispus
PENETAPAN KADAR VITAMIN C DALAM SEDIAAN TABLET, SIRUP DAN EMULSI MENGGUNAKAN METODE KROMATOGRAFI CAIR KINERJA TINGGI (KCKT) DENGAN VARIASI FASE GERAK Kurniawan, Hadi; Zaskia, Nayla; Perkasa, Muhammad Rifki; Izzati, Alvi; Luthfiyyah, Nabila; Alilatulbariza, Nailah; Gunawan, Alvin
Journal Pharmacy Of Tanjungpura Vol 3, No 1 (2025): Oktober
Publisher : Universitas Tanjungpura

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Vitamin C (asam askorbat) adalah vitamin larut air yang berperan penting untuk fungsi imun, sintesis kolagen, dan perlindungan sel dari stres oksidatif. Penetapan kadarnya dalam sediaan farmasi penting untuk menjamin mutu dan stabilitas produk. Penelitian ini bertujuan menentukan kadar vitamin C dalam tablet, sirup, dan emulsi menggunakan metode Kromatografi Cair Kinerja Tinggi (KCKT) dengan variasi fase gerak. Analisis dilakukan menggunakan kolom C18 (250 mm × 4,6 mm), detektor UV 244 nm, suhu kolom 35 °C, dan laju alir 1 mL/menit. Fase gerak yang digunakan meliputi: buffer asetat pH 3,5:asetonitril (98:2), buffer asetat pH 3,5:metanol (98:2), dan buffer fosfat pH 3,5:asetonitril (98:2). Hasil menunjukkan bahwa pemilihan fase gerak memengaruhi resolusi, waktu retensi, dan sensitivitas analisis. Pada perlakuan I, kadar vitamin C dalam sirup hanya 20,68% dan tidak valid untuk tablet. Perlakuan II menghasilkan 5,66% (tablet) dan 58,2% (sirup), sedangkan perlakuan III menghasilkan 57,97% (tablet) dan 4,39% (sirup), yang semuanya tidak memenuhi syarat Farmakope Indonesia. Sampel emulsi tidak mengandung vitamin C, sesuai label produk. Oleh karena itu, diperlukan optimasi dan validasi metode lebih lanjut untuk memperoleh hasil yang akurat dan andal. Kata Kunci : Vitamin C, Fase Gerak, KCKT
Co-Authors Alilatulbariza, Nailah Ari Christy Muliono Hadi Kurniawan, Hadi Izzati, Alvi Laura Wihanto Luthfiyyah, Nabila Perkasa, Muhammad Rifki Zaskia, Nayla