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All Journal Damianus Journal of Medicine Journal Of Widya Medika Junior IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN) Jurnal Penyakit Dalam Indonesia Jurnal Widya Medika
Ari Christy Muliono
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Health Professions Medicine & Pharmacology Public Health

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DEMOGRAPHIC FACTORS AFFECTS THERAPEUTIC COMPLIANCE OF PATIENTS WITH CHRONIC MYELOCYTIC LEUKEMIA IN SURABAYA Puspitadewi, Selly Andriani; Muliono, Ari Christy; Dewi, Bernadette Dian Novita
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 4, No 2 (2022): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v4i2.3792

Abstract

Background: Leukemia is a hematologic malignancy that can affect all ages. In 2018, the death rate of leukemia in Indonesia reached 11,314 people. Imatinib is the first-line treatment for chronic myelocytic leukemia, which works by inhibiting the tyrosine kinase in the oncoprotein BCR-ABL. In Indonesia, the drug is the preferred therapy provided in hospitals and covered by the Social Security Administrator (BPJS). The side effects of these drugs are different from person to person, such as nausea, vomiting, headaches, indigestion, and joint pain. Compliance with taking medication is a determinant in the success of therapy, but several factors that influence compliance include age, gender, education level, and total income each monthPurpose: To compare the demographic factors that affect patients with chronic myelocytic leukemia in taking drugs in the Gist and Leukemia Community Surabaya.Method: This study used a Cross-Sectional Analytic research design. This research was conducted in September-November 2020 at the Gist and Leukemia Community Surabaya. The Gist and Leukemia Community in Surabaya is a community formed for sufferers of Chronic Myelocytic Leukemia and Gist (Tumors in the Stomach). The sample size required in the study, according to the Slovin formula, is 67 respondents. The sampling technique in this study is non-probability sampling so that this figure is met. Retrieval of patient demographic data and filling out the MMAS-8 questionnaire was done by filling in the form provided by the researcher in the form of a link on the google form. After that, short structured interviews were conducted with several respondents by telephone.Result: Based on the research that has been conducted, the results obtained are 67 respondents with high levels of compliance as many as 28 respondents, 22 respondents with moderate compliance, and 17 respondents with low compliance. With the number of male sex more than female, namely 40 men and 27 women. In addition, 20 respondents were aged 50-60 years, 22 respondents were aged 40-49 years old, 17 respondents were aged 30-39 years old, and eight respondents were aged 20-29 years old. In this study, the results obtained were 28 respondents with education levels of D3 / S1 / S2 / S3, 25 respondents with education levels of high school students, and 14 respondents with education levels of junior high school students. Also obtained the results of respondents with a monthly income of less than Rp 4,200,000 more, namely as many as 44 people compared to respondents with a monthly income, more than Rp 4,200,000 as many as 23 people. After obtaining the research data, the results of hypothesis testing using the Chi-Square test with sig. p <0.05. Results sig. p <0.05 means that the variable affects medication compliance in the respondent during sig. p> 0.05 means that the variable does not affect medication compliance among respondents. The results show that the factor influencing medication compliance in patients with chronic myelocytic leukemia is the monthly income with a sig. 0.025. Meanwhile, other factors such as gender, age, and education level do not affect medication compliance in patients with chronic myelocytic leukemia with sig. > 0.05.Conclusion: In the research that has been conducted with a total of 67 respondents, it can be concluded that Chronic Myelocytic Leukemia patients who are members of the Surabaya Gist and Leukemia Community for the period September-November 2020 are still in the category of obedience in consuming Imatinib drugs. The demographic factor that affects respondents' compliance with medication is the amount of income per month.
PERBEDAAN PROFIL LIPID TIKUS RATTUS NORVEGICUS PADA PEMBERIAN DIET KETOGENIK LEMAK JENUH DAN LEMAK TIDAK JENUH SELAMA EMPAT MINGGU Dewa Ayu Liona Dewi; Ari Christy Muliono; Gladdy Lysias Waworuntu; Evelyn Ongkodjojo
IJCNP : INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN Vol 4 No 2 (2021): IJCNP (INDONESIAN JOURNAL OF CLINICAL NUTRITION PHYSICIAN)
Publisher : Perhimpunan Dokter Gizi Klinik Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54773/ijcnp.v4i2.83

Abstract

Latar Belakang. Diet ketogenik merupakan diet populer untuk menurunkan berat badan dengan efek terhadap profil lipid masih inkonsisten. Tujuan Penelitian. Menganalisis perbedaan profil lipid tikus Rattus norvegicus pada pemberian pakan ketogenik dengan komposisi lemak 80% (jenuh dan tidak jenuh), protein 15% dan karbohidrat 5% selama 4 minggu. Metodologi. Desain penelitian true experimental dengan posttest only control group design. Tikus jantan dengan berat badan 125-150 g dibagi secara random dalam 3 kelompok (P0, P1 dan P2) menerima diet 25-30 kkal/hari sesuai dengan kebutuhan energi harian tikus. P0 kelompok kontrol menerima pakan tikus biasa. P1 menerima diet ketogenik lemak jenuh dari margarin. P2 menerima diet ketogenik lemak tak jenuh dari minyak zaitun ekstra virgin. Kolesterol total, LDL, HDL dan trigliserida diperiksa pada minggu ke 2 dan 4. Data dianalisis dengan Uji t Independen dan Mann Whitney (p<0,05). Hasil. Pada P1 terdapat perbedaan kadar HDL yang signifikan (38 menjadi 22,40 mg/dL, p=0,005) namun perbedaan kadar kolesterol total, LDL dan kadar trigliserida tidak signifikan. Pada P2 didapatkan perbedaan yang signifikan pada kadar kolesterol total (93,20 menjadi 67,80 mg/dL, p=0,042), HDL (29,40 menjadi 22,20 mg/dL, p=0,004), LDL (25,60 menjadi 13,80 mg/dL, p=0,009), dan trigliserida (100,80 menjadi 51,40 mg/dL, p=0,016). Pada P0 tidak ada perbedaan yang signifikan. Kesimpulan. Diet ketogenik dengan lemak tidak jenuh selama 4 minggu menunjukkan efek yang menguntungkan dalam menurunkan kadar kolesterol total, LDL dan trigliserida pada tikus Rattus norvegicus. kata kunci: diet ketogenik, lemak jenuh, lemak tidak jenuh, kolesterol total, HDL, LDL, trigliserida
Efektivitas Ekstrak Strobilanthes crispus terhadap Kadar Glukosa Darah Puasa dan Pasca Tes Toleransi Glukosa Oral pada Rattus norvegicus Diabetes Melitus Gunawan, Alvin; Wihanto, Laura; Muliono, Ari Christy
Jurnal Penyakit Dalam Indonesia Vol. 10, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction. The 2018 Riskesdas data shows that the prevalence of diabetes mellitus is increasing each year. Strobilanthes crispus leaves are known for lowering blood glucose levels. This study aimed to determine the difference in the effectiveness of S. crispus leaves ethanolic extract on fasting blood glucose (FBG) and post-oral glucose tolerance test (OGTT). Methods. True experimental study using post-test only control group design and Rattus norvegicus as experimental animals. Rattus norvegicus were selected by random sampling which were then divided into 4 groups (K, P1, P2, P3), each group consisted of 5 animals. The animals were subsequently induced with diabetes mellitus via a single injection of 160 mg/kgBW/IP alloxan. Group K was given 0.5% NaCMC solution at a dose of 1 ml/200 g BW/day/oral/day. Group P1, P2, and P3 received extract at a dose of 100, 400, 600 mg/kg BW/oral/day for 21 days using oral gavage. Statistical analysis was performed using ANOVA, Tukey, Brown-Forsythe, and Kruskal-Wallis tests. Results. Mean FBG level in group K, P1, P2, P3 were 338.40 mg/dL, 270.80 mg/dL, 200.00 mg/dL, and 138.60 mg/dL, respectively. Mean value of 60 minutes OGTT blood glucose level in group K, P1, P2, P3 were 355.60 mg/dL, 289.00 mg/dL, 188.00 mg/dL, and 164.40 mg/dL, respectively. Meanwhile, mean value of 120 minutes OGTT blood glucose level in group K, P1, P2, P3 were 346.60 mg/dL, 236.20 mg/dL, 175.40 mg/dL, and 117.20 mg/dL, respectively. The hypothesis test results showed a significant difference in 120 minutes OGTT blood glucose level (p= 0.031). Conclusion. The use of ethanol extract from S. crispus leaves is more beneficial in reducing blood glucose levels in 120 minutes OGTT compared to FBG level and 60 minutes OGTT level, with the highest reduction observed in the group given a dose of 600 mg/kgBW/oral/day compared to control. Keywords: DM, fasting blood glucose, OGTT, Rattus norvegicus, Strobilanthes crispus
THE RELATIONSHIP OF SMOKING HABITS WITH HBA1C LEVELS IN TYPE TWO DM PATIENTS AT GOTONG ROYONG HOSPITAL Valencia Dewangker, Audrey Jesie; Muliono, Ari Christy; Hendrata, Adi Pramono
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 6, No 2 (2024): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v6i2.5489

Abstract

Background: Diabetes Mellitus (DM) is a disease whose prevalence continues to increase every year. In 2019, Indonesia was ranked number 7 with the highest number of DM sufferers, namely 10.7 million. Diabetes mellitus is a chronic metabolic disease characterized by increased blood glucose levels, this occurs because there is not enough insulin produced by the pancreas or a condition where the body cannot use the insulin produced effectively. One examination that can be used to assess a patient's glycemic control is the Glycated Hemoglobin (HbA1c) examination. Smoking habit is known to be a risk factor for diabetes mellitus. Even though there are many disadvantages, the number of smokers in Indonesia is still difficult to reduce due to the lack of education and control regulations that suppress smoking behavior in society. This causes smoking to become a risk factor for many uncontrolled diseases in the world of health.Objective: The aim of this study was to analyze the relationship between smoking habits and HbA1c levels in male patients with type two DM at the Gotong Royong Hospital.Research method: This research uses observational analytical research with a case control study approach. In the research sample, namely type two Diabetes Mellitus patients who had their HbA1c levels checked at the Gotong Royong Hospital, a questionnaire was completed regarding the patient's smoking habits. From the results of the questionnaire, patients will be classified into non-smokers, light smokers, moderate smokers, and heavy smokers.Result: There is no significant relationship between smoking habits and HbA1c levels in type two diabetes mellitus patients at Gotong Royong Hospital with a P-value = 0.681.
THE RELATIONSHIP OF LONG TIME SUFFERING FROM TYPE 2 DIABETES MELLITUS ON THE DEGREE OF PERIPHERAL NEUROPATHY AT GOTONG ROYONG HOSPITAL, SURABAYA Kamilah, Hurriyatul; Muliono, Ari Christy; Anggriani, Tabita Novita
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 6, No 2 (2024): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v6i2.5493

Abstract

Background: Peripheral neuropathy is one of the most frequent complications in Diabetes Mellitus. The prevalence of diabetic neuropathy based on studies is 8% in newly diagnosed DM sufferers and 50% in patients who have long suffered from DM. Peripheral neuropathy is defined as damage to the peripheral nerves which can cause damage to sensory, motor and autonomic nerve function.Objective: This study aims to determine the relationship between the duration of suffering from Type 2 Diabetes Mellitus and the degree of peripheral neuropathy at the Gotong Royong Hospital in Surabaya.Method: This research is an observational analytical study with a cross-sectional design using an instrument in the form of a questionnaire on type 2 DM patients at the Gotong Royong Hospital in Surabaya from August to October 2023. The number of samples used in the research was 45 people.Results: The results of the analysis of the relationship between the duration of suffering from Type 2 Diabetes Mellitus and the degree of peripheral neuropathy using the Spearmen's test showed p = 0.023.Conclusion: There is a significant relationship between the duration of suffering from Type 2 Diabetes Mellitus and the degree of peripheral neuropathy at the Gotong Royong Hospital in Surabaya.
Sebuah Sebuah Laporan Kasus: Berbagai Faktor yang Berkontribusi Terhadap Kejadian Statin-Associated Muscle Symptoms ¬Imbas Atorvastatin Marzuki HY, Jefman Efendi; Muliono, Ari Christy
Bahasa Indonesia Vol 23 No 2 (2024): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v23i2.4817

Abstract

Pendahuluan: Adverse drug reaction (ADR) merupakan salah satu masalah kesehatan yang dapat menyebabkan pasien mengalami perawatan rumah sakit dan memperpanjang masa rawat. Statin berpotensi untuk menyebabkan efek samping yang berkaitan dengan gangguan otot. Atorvastatin merupakan salah satu obat golongan statin yang banyak digunakan saat ini. Kasus: Seorang wanita 78 tahun, masuk rumah sakit dengan nyeri pada seluruh badan termasuk kedua tungkai. Pasien rutin menggunakan atorvastatin untuk menurunkan kolesterol. Pasien memiliki riwayat gangguan hati dan penggunaan Syzygium polyanthum. Pasien didiagnosis dengan rabdomiolisis akibat atorvastatin. Pasien diberikan Coenzym Q10 kemudian berangsur membaik setelah atorvastatin dihentikan. Diskusi: Perubahan faktor fisiologis yang dapat memengaruhi farmakokinetik obat. Selain itu, interaksi bersama herbal juga dapat menyebabkan perubahan paparan atorvastatin. Hal ini dapat berkontribusi terhadap kejadian rabdomiolisis. Diagnosis Statin-Associated Muscle Symptom (SAMS) dapat diidentifikasi dengan SAMS Clinical Index. Simpulan: Kejadian efek samping obat dapat disebabkan oleh beberapa faktor yang mendasari. Upaya deteksi dini melalui monitoring aktif dalam pelayanan kesehatan merupakan salah satu upaya peningkatan patient safety di rumah sakit.
THE RELATIONSHIP BETWEEN KNOWLEDGE AND COMMUNITY ACTIONS REGARDING MALARIA INCIDENCE AMONG RESIDENTS LIVING IN KOYA TIMUR SUBDISTRICT, PAPUA PROVINCE Lembang, Vany; Muliono, Ari Christy; Prabantoro, Benedictus Triagung Ruddy
JURNAL WIDYA MEDIKA Vol. 11 No. 1 (2025): April
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v11i1.7503

Abstract

Based on data from the Ministry of Health, malaria cases in Indonesia have decreased; however, there are still three provinces that have not been eliminated, namely Papua, West Papua, and Maluku. The reported cases of malaria in Koya Timur Subdistrict amount to a total of 167 cases. Knowledge and community actions have an influence on malaria incidence, making it crucial to enhance the public’s understanding of the causes of malaria. The objective of this study was to ascertain the relationship between knowledge and community actions regarding malaria incidence among residents of Koya Timur Subdistrict, Papua Province. The research methodology employed was an analytical observational method with a cross-sectional research design the sampling, based on respondents meeting inclusion criteria. The research instruments included a questionnaire and a checklist. The data analysis was conducted using the Spearman test. The research findings showed that of the 61 respondents who completed the questionnaire, 54.1% were male and 45.9% were female. The results indicated that 57.4% had adequate knowledge about malaria, and 65.6% practiced adequate malaria prevention measures. The correlation analysis showed a significant p-value of 0.014 with a correlation coefficient (r) of 0.313. It can be concluded that there is a relationship between community knowledge and actions related to the incidence of malaria among residents in Koya Timur Subdistrict, Papua Province.
Co-Authors Anggriani, Tabita Novita Dewa Ayu Liona Dewi Dewi, Bernadette Dian Novita Evelyn Ongkodjojo Gunawan, Alvin Hendrata, Adi Pramono Kamilah, Hurriyatul Laura Wihanto Lembang, Vany Marzuki HY, Jefman Efendi Prabantoro, Benedictus Triagung Ruddy Puspitadewi, Selly Andriani Valencia Dewangker, Audrey Jesie Waworuntu, Gladdy L.