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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Biomedika
Syafarinah Nur Hidayah Akil
Faculty Of Medicine, Muhammadiyah University Of Surabaya
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology

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Journal : Biomedika

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Antibacterial Activity of Aqueous Extract Combination of Garlic (Allium sativum) and Red Ginger (Zingiber officinale var. Rubrum) Against Staphylococcus aureus Rahma, Rizka Aulia; Paramita, Ayu Lidya; Akil, Syafarinah Nur Hidayah
Biomedika Vol 17, No 1 (2025): Biomedika Februari 2025
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v17i1.7033

Abstract

Background: Irrational use of antibiotics can increase the resistance, so it is necessary to find alternative solutions by using herbals that have antibacterial activity, such as garlic which contains allicin, alliin, and sulfide derivatives, and red ginger which contains gingerol, flavonoids, and phenols. For traditional use, garlic and red ginger need to be extracted with aqueous solvents. Objective: Proving the antibacterial activity of the combination of garlic extract (Allium sativum) and red ginger extract (Zingiber officinale var. Rubrum) with aqueous solvents against Staphylococcus aureus. Methods: Each garlic extract and red ginger extract were made by the kinetic maceration with aqueous solvents, then mixed in a ratio of 1:1, 1:2, and 2:1. Results: The combination of garlic and red ginger extracts has strong antibacterial activity to inhibit the growth of Staphylococcus aureus. The average diameter of the inhibition zone at a ratio of 1:1, 1:2, and 2:1 was 30.40 mm, 24.51 mm, and 37.67 mm, respectively. The ANOVA test showed a P value of 0.000. Conclusion: The combination of garlic extract (Allium sativum) and red ginger extract (Zingiber officinale var. Rubrum) with aqueous solvent has strong antibacterial activity against Staphylococcus aureus, with the strongest combination at a ratio of 2:1.
Co-Authors Ayu Lidya Paramita Heny Arwati Priangga Adi Wiratama Puspa Wardhani Puspa Wardhani Rizka Aulia Rahma, Rizka Aulia