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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Herb-Medicine Journal MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Biomedika Indonesian Journal of Medical Sciences and Public Health Jurnal Medis Umum

Dwi ariningtyas, Ninuk

Muhammadiyah University Of Surabaya

Author-ID : 2439709

Biochemistry, Genetics & Molecular Biology Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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The Effectiveness of Red Grape (Vitis vinifera) Seed and Skin Extract Treatment on Staphylococcus aureus Bacteria that Causes of Urinary Tract Infections in Pregnant Women Examined by using White Mice (Mus musculus) Satriya Manggala Liastra; Ninuk Dwi Ariningtyas; Yelvi Levani
Biomedika Vol 13 No 2 (2020): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v13i2.750

Urinary tract infection or what is often called a UTI is an infectious disease of the urinary tract epithelium and is commonly caused by gram-positive bacteria, namely the Staphylococcus aureus, with a prevalence rate of 68 million patients in the world and 1.2 million patients in Indonesia. The diagnosis of UTI is established with a positive urine culture significance value ≥105 (CFU)/ml. The existing clinical management for cases of urinary tract infections in pregnant women uses amoxicillin to kill gram-positive bacteria, such as Staphylococcus aureus. However, there have been 469 cases of antibiotic resistance in pregnant women in Indonesia due to the non-compliance of using antibiotics for urinary tract infections. Vitis vinifera can be used as an alternative to natural bactericidal resveratrol containing anthocyanidin to kill gram-positive bacteria. This study used 28 white mice (Mus musculus) aged 6-21 weeks and weighing 120-200 grams injected with Staphylococcus aureus. The 28 subjects were divided into 4 groups, each of which consisted of 7 mice. The mice received K1 treatment with 250 mg/kgBW of amoxicillin and treatments with 200, 300, and 500 mg/KgBW red grape seed and skin extract. Before treatments were given, a pre-test was conducted to ensure that the results were not biased. Post-test was also performed after the Staphylococcus aureus injection, which was measured after 5 days of urine culture that reached 107 CFU/ml. The treatment in P3 using 500 mg/KgBW of red grape seed and skin extract contributed to the smallest result with 102 Cfu/ml, equals to the result produced by giving 250 ml/KgBW of amoxicillin.

Pregnancy with Myasthenia Gravis Ninuk Dwi ariningtyas; Laily Irfana
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 4, No 1 (2020)
Publisher : Universitas Muhammadiyah Surabaya

ABSTRACTMyasthenia Gravis (MG) is a serious autoimmune disease, but now can be treated. Symptoms include weakness and fatigue in voluntary muscles caused by an autoantibody reaction to nicotinic acetylcholine receptor (AChR) at the post synapse of the neuromuscular junction. Pregnancy can affect autoimmune diseases so that pregnancy can aggravate MG disease. On the other hand it is also reported that pregnancy does not affect and can even improve MG disease. In this article, We report a 27-year-old woman who was diagnosed with myasthenia gravis that having a pregnancy. Initially she had no problems with pregnancy. Patients underwent pregnancy by taking the drug Mestinon four times daily and roborant. But entering the 33rd-34th week, the examination results showed that the pregnancy experienced oligohydramnios and Intrauterine Growth Retardation (IUGR), it was probably caused by malnutrition. Then we decided to end the patient's pregnancy with a Caesarean section. The operation went well, born to a baby boy / 2450grams / Apgar Score 5-7. Observation for one week the mother's condition continued to improve. Diplopia and weaknesses also improve. Likewise the baby showed a healthy condition. The patient was discharged while still taking MG drugs that had been previously consumed. This case report showed that pregnancy worsened MG disease, but MG did not affect pregnancy.Keywords : Pregnancy, Myasthenia Gravis

CA 125 dan Pemakaian Klinis Dalam Penatalaksanaan Kanker Ovarium Ninuk Dwi ariningtyas
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Surabaya

Today there are three types of ovarian cancer, namely epithelial cell tumors (70%), which are the largest part of the tumor, Germ cell tumors with a smaller frequency, and sex cord-stroma tumors which is the smallest proportion of about 8% of neoplasm. Ovarian cancer is characterized by unusual early symptoms, real symptoms at advanced stages and low survival rates. Therefore, ovarian cancer is the leading cause of death from gynecological cancer. Over the past decade, several studies have been directed at increasing outcomes of ovarian cancer by performing preclinical screening tests, determining the early stages of disease by using radiological examination or tumor marker serum. The purpose of screening for ovarian cancer is to reduce mortality by detection of stage 1 ovarian invasive epithelial cancer that is potential to be cured. Serum CA 125 measurements are often used to monitor disease status or predict residual disease. A number of cell surface antigens and serum proteins are produced by ovarian tumors and can be tested with monoclonal antibodies. Some of these tests have been clinically applied as a marker of disease and are useful in the detection of subclinical diseases and the diagnosis of recurrent ovarian cancer. Among the multiple biochemical markers in ovarian cancer, the most studied are CA 125. CA 125 is a surface glycoprotein detectable cells in more than 80% of cases of ovarian epithelial cancer. This test is clinically used in the evaluation of mass diagnostics in the ovaries, observation of response to treatment, and further evaluation of patients with ovarian cancer

Hubungan Antara Usia Ibu Hamil dengan Preeklampsia Tipe Lambat di Rumah Sakit PKU Muhammadiyah Surabaya Ali Mustofa; Ninuk Dwi Ariningtyas; Kartika Prahasanti; Muhammad Anas
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 4, No 4 (2021): Herb-Medicine Journal Oktober 2021
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v4i4.9737

Preeclampsia is one of the most common complications in pregnancy that can lead to various complications such assevere illness, long-term disability, andmaternal, fetal, and neonatal mortality. The prevalence of preeclampsia, 30%-40% can cause maternal mortality, and 30%-50% can lead to perinatal mortality. Maternal age is one of the riskfactors for late-onset preeclampsia. Maternal age is grouped into two categories; extreme age (<20 years and> 35 years)and reproductive age (21-35 years). This studyaims to determine the relationship between maternal age and late-onsetpreeclampsia at PKU Muhammadiyah Surabaya Hospital from January to June 2020. The research method used isobservational analytic with case control design. The samples involved were pregnant women visiting PKUMuhammadiyah Surabaya Hospital from January to June 2020. The data were analyzed using a statistical test ofcontingency coefficient correlation. The results showed that respondents who experienced late-onset preeclampsia inthe extreme age group (<20 years and> 35 years) were 37 respondents (100%) and in reproductive age (21-35 years)were 28 respondents (80%), the respondent who did not experience late-onset preeclampsia in extreme ages (<20 yearsand> 35 years) was 0 respondents(0%) and in reproductive age (21-35 years) were 7 respondents (20%). The resultsof the statistical test for the contingency coefficient correlation showed a p-value of 0.004 below (≤0.05). All thingsconsidered, there was a significant relationship between maternal age and late-onset preeclampsia at the PKUMuhammadiyah Surabaya Hospital from January to June 2020.

Hubungan Faktor Internal Dan Eksternal Akseptor Terhadap Kepatuhan Akseptor Kontrasepsi Suntik Khofifah Dwi Oktaviana; Muhammad Anas; Ninuk Dwi Ariningtyas; Uning Marlina
Herb-Medicine Journal: Terbitan Berkala Ilmiah Herbal, Kedokteran dan Kesehatan Vol 5, No 1 (2022): Herb-Medicine Journal Januari 2022
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/hmj.v5i2.9953

The population of Indonesian continues to increase, while the total fertility rate is not yet on target. So that an effective family planning program is needed to reduce Indonesia's population growth. Injection contraceptive acceptor adherence is needed to maximize family planning programs for a better future. Objective: to analyze the relationship between age, education, knowledge, work status, and support from husbands of injection contraceptive acceptors in women of childbearing age to compliance with re-injection visits. The study was using an analytical observational, cross-sectional study design. The sampling technique was non-random sampling purposive sampling, a sample size of 96 people, a questionnaire was used to collect data and data analysis using the chi-square test. Results: The number of adherent injecting contraceptive acceptors was 57.3%. The results showed that the variables associated with injection visit compliance were age (p = 0.022), knowledge (p = 0.005), and work status (p = 0.017). Meanwhile, the variables not related to compliance with injection visits were education (p = 0.172), husband's support (p = 0.833) and the number of children (p=0.167). Conclusion: There is a relationship between age, knowledge, and work status on the compliance of injection contraceptive acceptor visits. Jumlah penduduk indonesia terus mengalami peningkatan, sedangkan total fertility rate belum sesuai target. Sehingga diperlukan program keluarga berencana yang efektif untuk menurunkan pertumbuhan penduduk indonesia. kepatuhan akseptor kontrasepsi suntik sangat diperlukan untuk memaksimalkan program keluarga berencana demi masa depan yang lebih baik. Tujuan : menganalisis hubungan usia, pendidikan, pengetahuan, status bekerja, dan dukungan suami akseptor kontrasepsi suntik pada wanita usia subur terhadap kepatuhan melakukan kunjungan suntik ulang. Jenis penelitian yang digunakan dalam penelitian ini yaitu analitik observasional desain Cross-sectional study. Teknik samplingnya menggunakan non random sampling - purposive sampling, besar sampel 96 orang, kuesioner digunakan untuk mengumpulkan data dan analisis data menggunakan uji chii square. Hasil: Jumlah akseptor kontrasepsi suntik yang patuh yaitu sebesar 57,3%. Hasil penelitian diperoleh bahwa variabel yang berhubungan dengan kepatuhan kunjungan suntik yaitu usia (p=0,022), pengetahuan (p=0,005), dan status bekerja (p=0,017). Sedangkan variabel yang tidak berhubungan dengan kepatuhan kunjungan suntik yaitu pendidikan (p=0,172), dukungan suami (p=0,833), dan jumlah anak (p=0,167). Kesimpulan: Terdapat hubungan antara usia, pengetahuan, dan status bekerja terhadap kepatuhan kunjungan akseptor kontrasepsi suntik.

Relationship of Anemia in Pregnancy with Postpartum Hemorrhage in Jombang Regional Hospital Farah Luthfia Nugroho; Ninuk Dwi Ariningtyas; Yudith Annisa Ayu Rezkita; Pribakti Budinurdjaja; Muhammad Anas
Indonesian Journal of Medical Sciences and Public Health Vol 1 No 1 (2020)
Publisher : Future Science

Introduction: Based on the Health Profile of East Java Province it was noted that the maternal mortality rate is still high, with the highest cause of maternal death being preeclampsia/eclampsia which is 28.92%, and hemorrhage by 26.28%. Mothers with anemia have a higher risk of postpartum hemorrhage. This is caused by the lack of oxygen and nutrients in the uterine organs, resulting in a decrease in myometrium muscle contraction that causes hemorrhage. Objective: To determine the relationship between anemia in pregnancy and postpartum hemorrhage in Jombang Regional Hospital 2016-2019. Method: Researchers use analytic research with a case-control approach. The study population of women who experienced hemorrhage at Jombang Regional Hospital in 2016-2019 (as a case group population). And women who did not experience hemorrhage at Jombang Regional Hospital in 2016-2019 (as a control group population). The sample of each study was 36 respondents for the case and control groups with a non-probability sampling technique consecutive sampling, and a matching process was carried out. Results: The significance value in the Mann Whitney test was 0.000 (p<0.05), which means that H0 was rejected, there was a significant relationship between anemia in pregnancy and postpartum hemorrhage in Jombang Regional Hospital. As well as the strength of the relationship between anemia and postpartum hemorrhage which was calculated using the Contingency Coefficient test. shows a figure of 0.582, which shows a positive correlation with sufficient strength correlation. Conclusion: Based on the results of research that has been done shows that there is a relationship between anemia in pregnancy with postpartum hemorrhage in Jombang Regional Hospital 2016-2019.

Relationship between personality traits and perinatal depression at Muhammadiyah Hospital Surabaya Ninuk Dwi Ariningtyas; Putri Aqila; Era Catur Prasetya; Roni Subagyo
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 7 No 2 (2023): Journal Qanun Medika Vol 07 No 02
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v7i2.17634

Perinatal depression is a feeling disorder that occurs in a woman during pregnancy and after childbirth. Perinatal depression can be seen from various factors, one of which is personality traits. This study aims to determine the relationship of personality traits with perinatal depression at Muhammadiyah Hospital Surabaya. This study was observative analytic using a cross-sectional approach, conducted on 96 respondents using the Edinburgh Postnatal Depression Scale (EPDS) and the OCEAN personality trait questionnaire. The result of the multiple linear statistical tests on the F test is p=0.00 (p<0.05), the t-test on the extraversion personality trait is p=0.031 (p<0.05), and the neuroticism personality trait is p=0.000 (p<0.05). The coefficient of determination test R2= 37.0%. In conclusion, there is a relationship between personality traits and perinatal depression at Muhammadiyah Surabaya Hospital.

Anxiety Level of Pregnant Women at Siti Khodijah Muhammadiyah Sepanjang Hospital During COVID-19 Pandemic Ninuk Dwi Ariningtyas; Aulia Nuril Islamy; Roni Subagyo; Muhammad Anas
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 02 (2024): Qanun Medika Vol 08 No 02 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i02.21374

Pregnant women are one of the vulnerable groups who have to face the unpleasant effects of the COVID-19 pandemic. One of the effects is the psychological impact that is bad for both the mother and the fetus. This study aims to describe the level of anxiety experienced by pregnant women during the COVID-19 pandemic at Siti Khodijah Muhammadiyah Sepanjang Hospital. The results of this study are expected to be used as information to help overcome more serious mental health problems. This research uses using quantitative descriptive design with a cross-sectional approach. The sample of this study was 112 pregnant women who met the research criteria. This research was conducted by giving them questionnaires consisting of their age, job, parity, gestational age, history of COVID-19 illness, history of mental problems, knowledge about COVID-19, and level of anxiety. Statistical analysis showed 84.8%, 8.9% and 6.3% of pregnant women experience low, moderate, and concerning levels of anxiety, respectively. The majority of pregnant women are primigravida, aged 20-35 years, with a gestational age of 28-41 weeks, housewives, and the level of knowledge about COVID-19 is very good. Correlation analysis using Kendall's tau-b showed a significance value of 0.038 (<0.05), which means a relationship exists between the level of knowledge about COVID-19 and the level of anxiety of pregnant women. In conclusion, the level of anxiety of pregnant women the most is low anxiety, followed by moderate and concerning levels of anxiety.

Relationship between Pregnant Woman Obesity Grade-1 and Grade-2 with The Incidence of Preeklampsia Mochammad Ilham, Ananda Frifiyant; Ariningtyas, Ninuk Dwi; Mochtar, Nur Mujaddidah; Marlina, Uning
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 9, No 2 (2022): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.9.2.2022.89-95

Background: Preeclampsia is a hypertensive disorder that can increase maternal and fetal morbidity and mortality during pregnancy. Pregnant women with obesity are at higher risk of preeclampsia.Objective: To prove the relationship between pregnant women with grade-1 and grade-2 obesity and the incidence of preeclampsiaMethod: This study used the design of a prospective cohort. The population was pregnant women with obesity who got check-ups in Pregnancy Unit at Wiyung Sejahtera Hospital in Surabaya. This study used a consecutive sampling technique. The samples were pregnant women with BMI ≥ 25 with 34-38 weeks gestational age who signed the consent form. The data were analyzed through the Chi-Square test.Result: The results show that respondents who do not experience preeclampsia are dominated by pregnant women with grade-1 obesity by 70% and grade-2 obesity by 30%. Meanwhile, those who experience preeclampsia are dominated by pregnant women with grade-2 obesity by 75% and grade-1 obesity by only 25%. The results of the Chi-Square test analysis obtain a p-value of 0.007 with an odds ratio of 7,000.Conclusion: Pregnant women classified as grade-2 obesity have a seven times greater risk of experiencing preeclampsia compared to pregnant women with grade-1 obesity.

Comparison of Platelet Levels between Preeclampsia and Eclampsia Patients at Wiyung Sejahtera Hospital, Surabaya Fortuna Maudy Sintya, Reyke; Dwi Ariningtyas, Ninuk; Nurida, Annisa; Salim Ambar, Nabil
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 8, No 1 (2021): February
Publisher : Universitas Muhammadiyah Semarang

Background: Indonesia is a developing country with a high maternal mortality rate (MMR) and perinatal mortality, the third highest in ASEAN and the second highest in the South East Asian Nation Regional Organization. In pregnancy hypertension has been proven that oxidants, especially if increased fat peroxide will damage endothelial cells called endothelial dysfunction. Vasospasm that occurs also induces platelet integration and endothelial damage which adds to the contribution in maintaining platelet dysfunction and triggering the use of platelets. Thrombocytopenia is the most important sign of the severity of preeclampsia.Objective: to determine the comparison of platelet levels in patients with preeclampsia with eclampsia.Methode: This study was observational cross sectional method. The sample in this study was a total sampling, using purposive sampling of patients with preeclampsia and eclampsia at the Wiyung Sejahtera Hospital in January-December 2019. The instrument used was using secondary data of medical records of patients.Results: Patients with preeclampsia have a minimum platelet level of 301,000/mm3, a maximum of 415,000/mm3, and an average of 351,733.33/mm3 with a standard deviation of 33,552.66/mm3. Patients with eclampsia have a minimum platelet level of 122,000/mm3, a maximum of 281,000/mm3, and an average of 209,200/mm3 with a standard deviation of 42,465.45/mm3. There are significant differences in platelet levels of patients with preeclampsia with eclampsia(p <0.05)..Conclusion: there is a significant difference between the platelet levels of patients with preeclampsia and eclampsia.

Co-Authors Absor , Sholihul Ali Mustofa Annisa Nurida Assidiqi Iman, Penta Aulia Nuril Islamy Djalilah , Gina Noor Era Catur Prasetya Fakhrurrozaq, Hilal Farah Luthfia Nugroho Fortuna Maudy Sintya, Reyke Hartati , Edim Islamy, Aulia Nuril Kartika Prahasanti Khofifah Dwi Oktaviana Laily Irfana, Laily Marlina, Uning Mochammad Ilham, Ananda Frifiyant Muhammad Anas Muhammad Anas Nabil Salim Ambar Nur Mujaddidah Mochtar Nur Sucahyo, Eko Nursucahyo, Eko Pribakti Budinurdjaja Putri Aqila Rachma, Ulfie Aulia Raihana, Deva Rista Nabilah, Widya Rochman, Syaiful Roni Subagyo Satriya Manggala Liastra Subagyo , Roni Subagyo, Roni Sudirman, Choiros Sirli Suyuthi, Imam Syafarinah Nur Hidayah Akil Urrachman, Salsabillah Kemangi Yelvi Levani Yudith Annisa Ayu Rezkita Yumna, Insira Zaky Fakhriantono, Haidar

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