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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Proceedings of the International Conference on Applied Science and Health Berita Kedokteran Masyarakat
Pratamawati, Tiar M
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Humanities Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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THE EFFECT OF ORALLY ADMINISTERED CATFISH (Clarias gariepinus) SKIN AND MEAT ON EPITHELIALIZATION THICKNESS AND COLLAGEN DENSITY IN INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Baihaqi, Muhammad Irsyad; Satrianugraha, Muhammad Duddy; Pratamawati, Tiar M; Nauphar, Donny
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Abstract

Background: Alternative medicine using animal is still rare whereas Indonesia have a lot of potential natural resources. Catfish is easily found animal in Indonesia and is common consumed as nutriment sources contains albumin, amino acid and fatty acids which plays an essential role of wound healing process. This study will determine effect of orally administered catfish (Clarias gariepinus) skin and meat on epithelialization thickness and collagen density in incision wound of white male rat (Rattus norvegicus).Methods: This experimental post-test only group design used 30 white male rat (Rattus norvegicus), that randomly divided into 4 tratment goup and one control group. The treatment group was given 12,5 mg/g W, 25 mg/g W, 37,5 mg/g W and 50 mg/g W dose of catfish (Clarias gariepinus) skin and meat flour, in the other hand the contol group were given aquades. Non-parametric analyses using Kruscall-Wallis and Mann Whitney test were used to compare epithelization thickness and collagen density.Result: The comparison results of epithelialization thickness between group C with TGI, C with TG2, C with TG3 and C with TG4 showed significant differences (p<0.05). TG4 was the thickest of all groups. Significant differences were also observed in collagen density result between C with TGI, C with TG2, C with TG3 and C with TG4 (p <0,05) TG4 showed the highest density of all groups.Conclusion: Catfish (Clarias gariepinus) skin and meat flour with 50 mg/200g W dose is effective for wound healing and increasing epithelial thickness and collagen density in Wistar rat (Rattus norvegicus) incision wounds.
EFFECTIVENESS OF ORALLY USE CATFISH (Clarias gariepinus) SKIN AND MEAT ON WOUND LENGTH AND FIBROBLAST DENSITY IN INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Fauziah, Sri Utami; Primanagara, Risnandya; Pratamawati, Tiar M; Nauphar, Donny
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Abstract

Background: Treatment for wounds that are currently often given is use povidone-iodine. But, this antiseptics also kills fibroblast tissue which is useful for forming new tissue. One of the other ways to treatment for wounds is use catfish. The contents found in catfish (Clarias gariepinus) is albumin which is a globular protein that is useful in the formation of body tissues, such as postoperative wounds and burns. This study aims to determine the effect of skin and meat of catfish (Clarias gariepinus) on wound length and fibroblast density in incision wounds of Wistar rat (Rattus norvegicus).Methodology: This study is an experimental study with Post Test Only Control Group Design using Wistar rats which are divided into five groups. The control group (aquadest) and treatment groups 1, 2, 3 and 4 are given the skin and meat of catfish (Clarias gariepinus) orally at a dose of 12.5 mg / 200 g BW, 25 mg / 200 g BW, 37.5 mg / 200 g BW, and 50 mg / 200 g BW. After 10 days, the rats are killed to take the wound tissue for histological preparations to observe fibroblast density. Then, it is analyzed by ANOVA test or the alternative.Results: There is an effect of giving catfish skin and meat (Clarias gariepinus) orally at different dose. The administration of catfish skin and meat (Clarias gariepinus) at a dose of 37.5 mg / 200 g BW and 50 mg / 200 g BW is better than other doses assessed from wound length and fibroblast density in Wistar rat incision wounds (Rattus norvegicus).Conclusion: The use of catfish for wound healing can be applied. This method can reduce wound length and increase fibroblast density at certain doses.
EFFECTIVENESS OF ORALLY USE TILAPIA (Oreochromis niloticus) ON WOUND LENGTH AND FIBROBLAST DENSITY ON INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Syauqia, Sayyidah Vina; Zein, A Fariz Malvi Zamzam; Pratamawati, Tiar M; Nauphar, Donny
Proceedings of the International Conference on Applied Science and Health No 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (568.28 KB)

Abstract

Background: The incidence of a wound in Indonesia has increased from 7.5 percent in 2007 to 8.2 percent in 2013 according to Riskesdas. Wound care that widely used is povidone-iodine, but in case, it has a toxic effect on healthy cells around the wound. The albumin, amino acids, and fatty acids in Tilapia  (Oreochromis niloticus) are the potential substances to accelerate the wound healing process. This study aims to investigate the efficacy of Tilapia (Oreochromis niloticus) on wound length and fibroblast density on the incision wound of Wistar rat (Rattus norvegicus).Methods: The study was conducted in the Food and Nutrition PAU Laboratory and Pathology Anatomy Laboratory of Universitas Gadjah Mada, Yogyakarta. This post-test only control group design experimental study used 30 male white rats that randomly divided into five groups, i.e. control group K, and treatment group P1, P2, P3 and P4 that were each given Tilapia with a dose of 12.5 mg/200gBW, 25 mg/200gBW, 37.5 mg/200gBW dan 50 mg/200gBW. The length of the wound was measured by a ruler each day. The rats were terminated on the 10th day to obtain wound tissue for H&E stained histopathological sections to observe fibroblast density. One Way ANOVA, Tamhane, Kruskal-Wallis and Mann Whitney tests were used to compare the wound length and fibroblasts density.Results: Incision wounds in this study showed the best wound healing on the 10th day. Based on the theory, on the 10th day, a proliferation and remodeling phase occurs. There is an effect of giving Tilapia (Oreochromis niloticus) orally at a different dose. Tilapia at dose 37.5mg/200gBW is more effective compared with the dose of 12.5mg/200gBW, 25mg/200gBW, and 50mg/200gBW to accelerate wound healing for wound length and fibroblast density in Wistar rat (Rattus norvegicus).Conclusion: Consuming Tilapia (Oreochromis niloticus) could be a new alternative for wound healing treatment. The antimicrobial ability of Tilapia should be analyzed.
Karakteristik Klinis Pasien Dengan Diagnosis Karsinoma Payudara Invasif Di Rumah Sakit Umum Daerah 45 Kuningan Tahun 2022-2024 Iryanti, Erin; Larasati, Putri Ajeng Ayu; Pratamawati, Tiar M
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i9.61601

Abstract

Background: Invasive breast carcinoma refers to a large and heterogeneous group of malignant epithelial neoplasms originating from the glandular elements of the breast. Supportive examinations include anatomic pathology and immunohistochemistry for a more accurate diagnosis. Aim: To describe the clinical characteristics of patients with a clinical diagnosis of invasive breast carcinoma at the 45 Kuningan Hospital in 2022-2024. Method: This study used a descriptive observational approach from 2022 to 2024 at RSUD 45 Kuningan. A total sampling of 93 samples was used. Data were then analyzed to describe the frequency distribution of each variable.Results: Of the 93 samples of invasive breast carcinoma patients, the highest prevalence based on age was the most in the early elderly period, namely 46-55 with a percentage of (37.6%), female gender (100%), married status (100%), the most common occupation was housewife (93.5%), the most common location was unilateral (96.8%), the most common histopathological type was Invasive Carcinoma of No Special Type, with 73 patients (78.5%) and the most common molecular profile was Luminal B (16.1%).Conclusion: The highest prevalence of invasive breast carcinoma at RSUD 45 Kuningan is 46-55 years old, female, married with a housewife job, mostly unilateral location with the most histopathological picture of Invasive Carcinoma of No Special Type and the highest molecular profile of luminal B.
Origami activities are effective in improving fine motor skills of stunted children Khasanah, Uswatun; Almadevy M.J, Anindhita; Pratamawati, Tiar M; Suhaeni, Eni; Sulistiyana, Catur Setiya; Wahidin, Dea Triasari Indriyanti
BKM Public Health and Community Medicine Vol 41 No 09 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v41i09.18366

Abstract

Purpose: This study aimed to evaluate the effectiveness of origami activities on fine motor development in stunted children aged 3–5 years. Methods: A quasi-experimental study with a pretest–posttest control group design was conducted at the Babakan Community Health Center, Cirebon District. A total of 60 stunted children were recruited and equally assigned to intervention and control groups (n = 30 each group). The intervention group participated in three origami activity sessions, while the control group did not receive the intervention. Fine motor skills were assessed before and after the intervention using the KPSP questionnaire. Group differences were analyzed using the Mann–Whitney test. Results: Children in the intervention group showed significantly greater improvement in fine motor skills compared with the control group (p = 0.014). Conclusion: Origami activities are effective in enhancing fine motor development among stunted children and may serve as a simple, low-cost intervention in community health settings.
Co-Authors Almadevy M.J, Anindhita Baihaqi, Muhammad Irsyad Catur Setiya Sulistiyana Donny Nauphar Eni Suhaeni Fauziah, Sri Utami Iryanti, Erin larasati, putri ajeng ayu Risnandya Primanagara Satrianugraha, Muhammad Duddy Sugeng, Santoso Syauqia, Sayyidah Vina Wahidin, Dea Triasari Indriyanti Zein, A Fariz Malvi Zamzam