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All Journal Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal EduHealth
Haeni, Linlin
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Dentistry Health Professions Medicine & Pharmacology Public Health Veterinary

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KORELASI INDEKS PLATELET DAN KADAR INTERLEUKIN-6 PADA PASIEN HIPERTENSI Roslaeni, Rini; Priyadi, Hendri; Sa'adah, Hindun; Haeni, Linlin; Linasari, Desy; Hasanah, Laila; Salsabila, Salma Syifa; Isnaeni, Rifat Budi Augustyo; Putra, Dika Kusuma
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 1 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Mekanisme terjadinya hipertensi melibatkan proses inflamasi dan aktivasi sistem imun yang membentuk kondisi proinflamasi dan protrombotik, ditandai pelepasan reactive oxygen species (ROS). Kondisi tersebut menyebabkan disfungsi endotel, aterosklerosis dan pelepasan interleukin-6 (IL-6) yang pada akhirnya mempengaruhi fungsi platelet. Indeks platelet yang terdiri dari Mean Platelet Volume (MPV), Platelet Distribution Width (PDW), Platelet Large Cell Ratio (PLCR), dan Plateletcrit (PCT) dapat menjadi penanda aktivasi platelet dan inflamasi. Disisi lain, IL-6 juga merupakan sitokin inflamasi ang terlibat dalam berbagai penyakit. Tetapi, korelasi antara kedua parameter ini masih belum sepenuhnya dipahami. Penelitian ini bertujuan untuk mengetahui korelasi antara indeks platelet dan kadar IL-6 pada pasien hipertensi. Subjek penelitian berjumlah 42 orang penderita hipertensi tanpa komplikasi. Pemeriksaan indeks platelet menggunakan alat hematology analyzer Maccura 560 Plus, sedangkan pemeriksaan IL-6 menggunakan mikroelisa. Hasil menunjukkan usia subjek rerata 57,8 ± 9,9 tahun, dan mayoritas perempuan 81%. Rerata sistolik 145,26 ± 15,02 mmHg dan diastolik 87,69 ± 11,55 mmHg. Rerata subjek lama menderita hipertensi 5,53 ± 4,24 tahun. Rerata MPV 7,7 ± 0,7 fL, PDW 13,1 ± 1,73 fl, PCT 0,24 ± 0,05%, dan P-LCR 21,6 ± 5,59%. Kadar IL-6 rerata adalah 23,28 ± 2,70 pg/mL. Tidak ditemukan korelasi signifikan antara indeks platelet dan kadar IL-6. Temuan ini mengindikasikan bahwa parameter-parameter tersebut mungkin tidak relevan dalam menggambarkan status inflamasi yang diwakili oleh kadar IL-6 dan indeks platelet pada populasi ini. Kata Kunci: Hipertensi, Indeks platelet, Interleukin-6, MPV, PDW, PCT, P-LCR DOI : 10.35990/mk.v8n1.p71-81
Level of knowledge general practitioners about filling medical certificate causes of death at Gunung Jati regional hospital, Cirebon city 2022 Rusman, Andri Andrian; Taufan, Ali; Haeni, Linlin; Nastiar, Moch Nabil Yazid
Jurnal EduHealth Vol. 15 No. 01 (2024): Jurnal eduHealt, Edition January - March, 2024
Publisher : Sean Institute

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The Medical Certificate of Cause of Death (SMPK) is an official letter that contains the identity of a person and the causes that caused the person to die. The cause of death listed on the SMPK can be used for epidemiology, prevention, and management of certain diseases. Data from the SMPK itself becomes the main data to determine the epidemiology of certain diseases. The format for filling out the medical certificate of the cause of death generally follows the standards issued by the Ministry of Health through BALITBANGKES based on international standards issued by the World Health Organization (WHO). This study aims to determine how the level of knowledge of general practitioners about the medical certificate of the cause of death and its filling in RSDGJ. The research method used in this study is descriptive observational, this research approach is a cross-sectional approach. The sample of this study was a sample that met the inclusion and exclusion criteria using consecutive sampling technique. The sample size in this study was in accordance with total sampling of 42 respondents who worked as general practitioners on duty at Gunung Jati Regional Hospital, Cirebon City. The majority of respondents in this study were female, namely 61.9% with the most age range of 26-35 years by 76.2%. The results of this study showed that most respondents showed a good level of knowledge as much as 66.7%, respondents with sufficient knowledge were 28.6%, and respondents with less knowledge were 4.8%. Based on these results it can be concluded that the level of knowledge of general practitioners at Gunung Jati Regional Hospital, Cirebon City about filling out the Cause of Death Medical Certificate is good.
Co-Authors Hasanah, Laila Isnaeni, Rifat Budi Augustyo Linasari, Desy Nastiar, Moch Nabil Yazid Priyadi, Hendri Putra, Dika Kusuma Roslaeni, Rini Rusman, Andri Andrian Sa'adah, Hindun Salsabila, Salma Syifa Taufan, Ali