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All Journal Biosfer: Jurnal Tadris Biologi Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) Jurnal Teknologi Sistem Informasi dan Aplikasi Biota JURNAL KAJIAN TEKNIK MESIN Jurnal Kesehatan Tambusai Informatics and Computer Engineering Journal Jurnal Inovasi Teknologi Terapan Al-Masail: Journal of Islamic Studies Seminar Nasional Riset dan Teknologi (SEMNAS RISTEK)
Rivaldi, Muhammad
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Phylogenetic relationship of plastid large single copy genome and potential of ginsenoside compounds from Panax in Alzheimer disease Kinasih, Anggiresti; Ahmar, Rasyidah Fauzia; Fatmawati, Dwi Retno; Rivaldi, Muhammad; Suhaemi, Emi; Saputra, Novanda Eka; Haniyyah, Hernanda Afra
Biota Vol 18 No 1 (2025)
Publisher : Universitas Islam Negeri Mataram

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Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the most prevalent cause of dementia, marked by cognitive decline and memory loss. Current treatments are largely symptomatic and do not halt disease progression, underscoring the urgent need for novel therapeutics. Natural products, such as Panax notoginseng, offer promising alternatives due to their structural diversity and multi-target potential. This study investigates the therapeutic potential of 125 terpenoid compounds identified from P. notoginseng, focusing on their relevance to AD. Eight ginsenosides demonstrated notable neuroprotective effects, including improvements in memory and cognitive function. Among them, Ginsenoside Rb1 and Notoginsenoside R1 exhibited low predicted toxicity via oral and intraperitoneal routes, indicating favorable safety profiles. Target prediction and molecular docking suggest these compounds interact with G protein-coupled receptors implicated in cognition and neuroprotection, such as dopaminergic, serotonergic, muscarinic, and adrenergic receptors. However, their deviation from Lipinski’s Rule of Five may limit oral bioavailability. To address this, nanotechnology-based delivery systems are proposed to enhance solubility, permeability, and drug-likeness. These findings support the continued exploration of P. notoginseng ginsenosides as potential anti-dementia agents and highlight nanotechnology's role in overcoming pharmacokinetic limitations
Co-Authors Ahmar, Rasyidah Fauzia Alamsyah, Muhammad Arkan Amalia, Reski Dimas Sondang Irawan Fatmawati, Dwi Retno Ghofar Taufiq, Ghofar Haniyyah, Hernanda Afra Khatimah, Khusnul Kinasih, Anggiresti Lediwara, Nadiza Muhammad Nur Fadhilah Muhammad Yunus Ninditya, Vika Ichsania Norra, Bunga Ihda Nur Fadhilah, Muhammad Pristiansyah, Pristiansyah Ramadhan, Narendra Jumadil Haikal Ramadhany, Defy Rizky Rasyida, Nisa Safun Rahmanto Saputra, Novanda Eka Sentanu, Quinn Abrar Athallah Suhaemi, Emi Sumanto, Sumanto Suryana, Rika Tasmara, Fikhri Astina Triantono, Rishal Rahmad