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All Journal IDJP (Indonesian Journal of Pharmaceutics) Jurnal Ilmu Kefarmasian Indonesia Jurnal Abdimas Kartika Wijayakusuma Jurnal Farmasi Indonesia
Selifiana, Nita
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Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health Social Sciences Other

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Formulation and Evaluation of Platelet Rich Plasma (PRP) Lotion Preparations with Asiaticoside as an Antioxidant Mardhiani, Yanni Dhiani; Selifiana, Nita; Arna Ningsih1, Endah; Rusdiana, Taofik
Indonesian Journal of Pharmaceutics Vol 5, Issue 2, May - August 2023
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v5i2.51883

Abstract

Currently, the use of PRP requires a person to visit a skin care clinic by doing a series of treatments directly. Therefore, in order to facilitate the use of PRP, asiaticoside lotion base products containing antioxidants can be used as a PRP product base. asiaticoside antioxidants serve to stabilize PRP when added to the base. This research uses Platelet-Rich Plasma (PRP) and Asiaticosida as active substances, Fancor® Uni-Embase as emollient and emulgator, DMDM hydantoin as preservative, and distilled water as carrier. The stages in this research include preparation of tools and materials, lotion base optimization, lotion preparation formulation, addition of active substances, lotion preparation evaluation, physical stability test, and antioxidant activity test. The results of the PRP lotion stability test with asiaticoside for 10 days showed significant results (p<0.05) which means that for 10 days there is a tendency to be unstable. Antioxidant activity test results obtained IC50 results on Asiaticosida of 57.63 µg/mL, on PRP of 196.1 µg/mL, on the base with the addition of Asiaticosida of 77.19 µg/mL, on F0 of 166.90 µg/mL, on F1 of 96.727 µg/mL, on F2 of 88.395 µg/mL, and on F3 of 82.017 µg/mL.Keywords: Lotion, PRP, asiaticoside, Antioxidant
Evaluation of antipsychotic utilization among outpatient schizoprenia patients at the mental health facility in West Java Sutrisno, Entris; Selifiana, Nita; Sodik, Jajang Japar; Fajarrini, Uvika Nurul
JURNAL ILMU KEFARMASIAN INDONESIA Vol 23 No 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1632

Abstract

Rational use of drugs aims to give therapy according to patient’s clinical needs. Based on Ni komang's research (2021) there are still inaccuracies in the use of antipsychotic drugs. The purpose of this study was to determine the evaluation of the use of Antipsychotics based on the parameters of right indications, drugs, dosage, and frequency in outpatient schizophrenia patients at the West Java Provincial Mental Hospital. The study used a method with descriptive presentation of data and retrospective data collection. Data obtained period October-December 2022 from 130 patients, this study evaluated the use of Antipsychotics with the parameters of right indications, drugs, dosage, and frequency then the data will be analyzed based on the criteria for drug use from Pharmacotherapy A Pathophysiologic Approach 11th and PIONAS. The results of the study on the use of Antipsychotics in schizophrenic patients at the Java Provincial Mental Hospital based on Pharmacotherapy A Pathophysiologic Approach 11th and PIONAS obtained the right indications as much as (100%), the right drugs (100%), the right dose (98%), and the right frequency (98%).
Evaluation of antipsychotic utilization among outpatient schizoprenia patients at the mental health facility in West Java Sutrisno, Entris; Selifiana, Nita; Sodik, Jajang Japar; Fajarrini, Uvika Nurul
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 23 No. 1 (2025): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v23i1.1632

Abstract

Rational use of drugs aims to give therapy according to patient’s clinical needs. Based on Ni komang's research (2021) there are still inaccuracies in the use of antipsychotic drugs. The purpose of this study was to determine the evaluation of the use of Antipsychotics based on the parameters of right indications, drugs, dosage, and frequency in outpatient schizophrenia patients at the West Java Provincial Mental Hospital. The study used a method with descriptive presentation of data and retrospective data collection. Data obtained period October-December 2022 from 130 patients, this study evaluated the use of Antipsychotics with the parameters of right indications, drugs, dosage, and frequency then the data will be analyzed based on the criteria for drug use from Pharmacotherapy A Pathophysiologic Approach 11th and PIONAS. The results of the study on the use of Antipsychotics in schizophrenic patients at the Java Provincial Mental Hospital based on Pharmacotherapy A Pathophysiologic Approach 11th and PIONAS obtained the right indications as much as (100%), the right drugs (100%), the right dose (98%), and the right frequency (98%).
Edukasi Penyakit Disminore, DAGUSIBU, dan Pelatihan Pembuatan Produk Minuman untuk Penanganan Disminore Saputro, M. Ramadhan; Pratama, Reza; Selifiana, Nita; Fajarwati, Kania; Nurfazri, Aulia; Andriansyah, Ivan
Jurnal Abdimas Kartika Wijayakusuma Vol 7 No 1 (2026): Jurnal Abdimas Kartika Wijayakusuma
Publisher : LPPM Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/jakw.v7i1.1162

Abstract

Kegiatan pengabdian kepada masyarakat ini dilaksanakan di SMK Bhakti Kencana Cileunyi, Kabupaten Bandung, dengan tujuan meningkatkan pengetahuan dan keterampilan peserta mengenai edukasi penyakit dismenore dan pengelolaan obat melalui program DAGUSIBU (Dapatkan, Gunakan, Simpan, Buang obat dengan benar). Selain itu, kegiatan ini juga memberikan pelatihan pembuatan minuman herbal berbahan jahe merah (Zingiber officinale var. rubrum) dan kayu manis (Cinnamomum burmannii) sebagai alternatif penanganan nyeri haid secara alami. Metode kegiatan dilakukan dalam dua tahap, yaitu penyuluhan interaktif menggunakan media presentasi dan diskusi kelompok, serta pelatihan praktik pembuatan produk minuman herbal yang meliputi proses pembuatan simplisia, penimbangan, pengemasan, dan penyeduhan. Evaluasi kegiatan dilakukan melalui pre-test dan post-test untuk menilai peningkatan pengetahuan peserta. Hasil kegiatan menunjukkan adanya peningkatan nilai rata-rata dari 86 menjadi 99,67, menandakan bahwa kegiatan edukasi efektif dalam meningkatkan pengetahuan peserta. Peserta juga mampu mempraktikkan pembuatan produk secara lebih efektif, efisien, dan berkualitas. Kegiatan ini berkontribusi terhadap peningkatan literasi kesehatan masyarakat serta pemanfaatan tanaman herbal sebagai solusi alami yang aman dan mudah diterapkan.
Peran Ekstrak Kunyit dan Pegagan dalam Modifikasi Ekspresi Gen eNOS: Implikasi Terhadap Gangguan Ginjal pada Obesitas Sulaeman, Agus; Perayani, Eci; Muhsinin, Soni; Selifiana, Nita; Susilawati, Elis; Kaniawati, Marita; Nafilah, Aghnia Nurvianti; Mahakam, Hendra; Putra, Putra
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 18 No 2 (2026): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v18i2.763

Abstract

Obesity is a global health problem closely associated with endothelial dysfunction, oxidative stress, and renal impairment, where endothelial nitric oxide synthase (eNOS) expression and nitric oxide (NO) levels serve as critical biomarkers for endothelial function. This study aimed to evaluate the effects of turmeric (Curcuma longa) extract, pegagan (Centella asiatica) extract, and their combination on body weight, organ index, fat index, blood biomarkers, and renal eNOS gene expression in obese rats. Male white rats were randomly divided into six groups: normal control, negative control (high-fat diet), positive control (orlistat 10.8 mg/kgBW), turmeric extract (200 mg/kgBW), pegagan extract (200 mg/kgBW), and a combination of turmeric–pegagan extracts (200:100 mg/kgBW). Treatments were administered for 60 days, and parameters assessed included body weight, organ index, fat index, blood biomarkers (ITT, creatinine, NO, elastin), and renal eNOS expression using PCR. Statistical analysis was performed using one-way ANOVA followed by Tukey’s post hoc test. The results demonstrated that the combination of turmeric and pegagan extracts significantly reduced body weight, liver, kidney, and heart indices, as well as visceral fat index, while improving blood biomarkers through the reduction of creatinine levels, along with an increase in NO serum approaching normal compared with the negative control group; the respective mean values were -10.14±0.57%, 5.52±0.73%, 1.23±0.21%, 0.64±0.06%, 1.35±0.05%, 0.33±0.06 mg/dL, dan 5.14±0.58 mmol/L. Renal eNOS expression exhibited an increasing trend in the combination group, although not statistically significant. In conclusion, the combination of turmeric and pegagan extracts exerts synergistic effects in improving endothelial dysfunction and renal impairment in obesity through lipid profile modulation, reduction of organ damage biomarkers, and enhancement of NO bioavailability.
Co-Authors Agus Sulaeman Andriansyah, Ivan Arna Ningsih1, Endah Fajarrini, Uvika Nurul Fajarwati, Kania Jajang Japar Sodik Mahakam, Hendra Mardhiani, Yanni Dhiani Marita Kaniawati Nafilah, Aghnia Nurvianti Nurfazri, Aulia Perayani, Eci Pratama, Reza Putra, Putra Saputro, M. Ramadhan Soni Muhsinin Susilawati, Elis Sutrisno, Entris Taofik Rusdiana