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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Biomedika MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Medica Arteriana (Med-Art) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Dian Yuliartha Lestari
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Myoepithelial Carcinoma Spindle cell type, Clear cell type, and Plasmacytoid type: Serial Kasus A Case Series of Myoepithelial Carcinoma Spindle cell type, Clear cell type, and Plasmacytoid type Lestari, Dian Yuliartha; Fauziah, Dyah
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 2, No 4 (2018): August
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1093.288 KB) | DOI: 10.26714/magnamed.2.4.2018.27-39

Abstract

Myoepithelial Carcinoma adalah salah satu keganasan kelenjar liur yang sangat jarang terjadi, dimana terdiri dari komponen sel-sel myoepithelial yang berdifferensiasi sebagai sel spindle, sel jernih (clear), sel epitheloid, sel stelate, maupun sel plasmacytoid.Kami melaporkan 3 kasus myoepithelial carcinoma yang didiagnosis di Rumah Sakit Dr. Soetomo Surabaya dalam kurun waktu 4 tahun terakhir dengan tiga tipe yang berbeda, yaitu; spindle cell type, clear cell type, dan plasmacytoid type. Dua kasus terjadi pada kelenjar parotis, lainnya pada kelenjar submandibula, dimana ketiganya terjadi pada wanita dengan rentang usia 45-76 tahun. Keluhan saat datang berobat adalah timbul benjolan semakin membesar secara perlahan dan tidak menimbulkan nyeri. Hasil pemeriksaan histopatologis menyatakan suatu carcinoma mengesankan myoepithelial carcinoma. Hasil pemeriksaan immunohistokimia smooth muscle actin (SMA)dan S100 mayoritas menunjukkan hasil yang positif, dimana menyokong diagnosis suatu myoepithelial carcinoma Myoepithelial Carcinoma is one of the most rare salivary gland malignancies, which consists of components of myoepithelial cells that differentiate as spindle cells, clear cells, epitheloid cells, stellate cells, and plasmacytoid cells.We report 3 cases of myoepithelial carcinoma diagnosed at Dr. Hospital. Soetomo Surabaya in the last 4 years with three different types, namely; spindle cell type, clear cell type, and plasmacytoid type. Two cases occurred in the parotid gland, the other in the submandibular gland, of which all three occurred in women with a range of45-76 years old. Complaints when coming for treatment is a lump that grows slowly and does not cause pain. The results of histopathological examination revealed a carcinoma suggesting myoepithelial carcinoma. The results of the immunohistochemical examination of smooth muscle actin (SMA) and S100 the majority showed positive results, which supported the diagnosis of myoepithelial carcinoma.
Effectiveness Of Watermelon (Citrullus lanatus) Red Flesh Extract On Reducing Coronary Artery Foam Cells and Thinning Of The Aortical Intima In Wistar Rats (Rattus norvegicus strain Wistar) Atherosclerosis Model Bahrudin, Mochamad; Dian Yuliartha Lestari; Nabila Risma Anjana; Tiara Lastari
Saintika Medika Vol. 19 No. 2 (2023): December 2023
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol19.SMUMM2.32403

Abstract

Introduction: Atherosclerosis (AS) is a process of narrowing of the lumen of arteries due to progressive plaque buildup. Foam Cell and plaque appear as a result of lipoprotein metabolism disorders which result in inflammatory reactions. The incidence of AS in the world is increasing, resulting in various complications that can lead to death. Lycopene is contained in the red flesh of watermelon, which is an antioxidant that can control free radicals and can reduce the risk of AS. Objective: To determine the effectiveness of watermelon (Cittrulus lanatus) red flesh extract on reducing coronary artery foam cells and thinning of the aortic intima in Wistar rats (Rattus norvegicus strain Wistar) atherosclerosis model. Method: This research was an experimental study (true experimental) using the Post Test Only Control Group Design method, which measures the number of coronary artery foam cells and the thickness of the aortic intima in Wistar rats (five groups) after administration of a hypercholesterolemic diet and watermelon red flesh extract at a dose of 250,500,750 mg /kgBW. Data analysis was carried out using One-Way ANOVA and Post Hoc Bonferroni tests. Results: The One-Way ANOVA statistical test showed results of 0.020 for foam cells and 0.008 for thickness of the intimal tunica, which means that there was a real influence of watermelon red flesh extract on decreasing foam cells and significant thinning of the intimal tunica in the treatment group. Furthermore, the Post Hoc Bonferroni test showed that the dose of 750 mg/kgBW had the most effect on reducing foam cells (p=0.046) and thinning the intima (p=0.015). Conclusion: Watermelon (Citrullus lanatus) red flesh extract at a dose of 750 mg/kgBW has a significant effect on reducing the number of foam cells and thinning of the aorta of the Wistar rat model of atherosclerosis.
Effectiveness of Petai (Parkia speciosa) Ethanol Extract in Controlling Foam Cell Numbers in Atherosclerosis-Induced Male Wistar Rats Handirosiyanto, Ikhwan; Indra setiawan; Nisa, Seftiana Khaerun; Lestari, Dian Yuliartha
Saintika Medika Vol. 20 No. 1 (2024): June 2024
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol20.SMUMM1.38652

Abstract

Atherosclerosis is a chronic inflammatory disease that causes the narrowing of the arterial lumen, and it is considered the primary cause of cardiovascular diseases such as myocardial infarction (MI), heart failure, and stroke. Cardiovascular disease is the leading of death globally. Atherosclerosis has a complex pathophysiology, such as endothelial dysfunction, thickening of the tunica intima, and the formation of atheromatous plaques. After that process, foam cells will form, which is the key to the development of atherosclerosis. Petai ethanol extract contains antioxidants, which are flavonoids, saponins, and tannins, that can reduce the number of Low-Density lipoproteins (LDL). The purpose of this study was to evaluate the effect of petai ethanol extract on the number of atherosclerotic foam cells in male white rats (Rattus norvegicus strain wistar) induced by lard. The method of this study was a genuinely experimental and post-test-only control group design with 25 rats divided into five control groups, which are one negative control group, one positive control group, and three treatment groups with extract doses of 100mg/kgBW, 200mg/kgBW and 400mg/kgBW. Observation of foam cells was carried out using a microscope with 400x magnification. Data were analyzed using Oneway ANOVA and Post Hoc Tamhane's test. The results of the study using the Oneway ANOVA test showed that there were significant differences between groups (p: 0.000). Post Hoc Tamhane's test between the positive control group and treatment groups 1, 2, and 3 can be seen that there is a significant difference between the formation of foam cells due to the administration of petai ethanol extract compared to positive control (p <0.05). This study concludes that Petai ethanol extract was effective in reducing the number of atherosclerotic foam cells formed.
Co-Authors Abi Noerwahjono Afif Wafiq Waliyuddin Anak Agung Istri Sri Wiadnyani Anung Putri Illahika Cindy Savira Dwi Nurwulan Pravitasari DYAH FAUZIAH, DYAH Fathiyah Safithri Febriana Nur Layli Gita Sekar Prihanti Handirosiyanto, Ikhwan Ilham Niawan Saputra Indra Setiawan KUSUMASTUTI, ETTY HARY Lilik Yusetyani Lilik Yusetyani Lucky Dimas Abimanyu Mochamad Bahrudin Mohammad Saifur Rahman Nabila Risma Anjana Nisa, Seftiana Khaerun Radya Kusuma Ardianto Rahman, Mohammad Saifur Risky Amalia Rizky Trimaulidia Saputra, Ilham Niawan Savira, Cindy Setyawati Soeharto Setyawati Soeharto, Setyawati Siska Fitriana Siti Rofida Tiara Lastari Wafiyah Hasanah Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono