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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Biomedika MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Medica Arteriana (Med-Art) JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Dian Yuliartha Lestari
Universitas Muhammadiyah Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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A CASE SERIES OF MYOEPITHELIAL CARCINOMA SPINDLE CELL TYPE, CLEAR CELL TYPE, AND PLASMACYTOID TYPE Dian Yuliartha Lestari; Dyah Fauziah
Saintika Medika Vol. 13 No. 2 (2017): DESEMBER 2017
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.v13i2.5524

Abstract

Myoepithelial Carcinoma adalah salah satu keganasan kelenjar liur yang sangat jarang terjadi, dimana terdiri dari komponen sel-sel myoepithelial yang berdifferensiasi sebagai sel spindle, sel jernih (clear), sel epitheloid, sel stelate, maupun sel plasmacytoid. Kami melaporkan 3 kasus myoepithelial carcinoma yang didiagnosis di Rumah Sakit Dr. Soetomo Surabaya dalam kurun waktu 4 tahun terakhir dengan tiga tipe yang berbeda, yaitu; spindle cell type, clear cell type, dan plasmacytoid type. Dua kasus terjadi pada kelenjar parotis, lainnya pada kelenjar submandibula, dimana ketiganya terjadi pada wanita dengan rentang usia 45-76 tahun. Keluhan saat datang berobat adalah timbul benjolan semakin membesar secara perlahan dan tidak menimbulkan nyeri. Hasil pemeriksaan histopatologis menyatakan suatu carcinoma mengesankan myoepithelial carcinoma. Hasil pemeriksaan immunohistokimia smooth muscle actin (SMA) dan S100 mayoritas menunjukkan hasil yang positif, dimana menyokong diagnosis suatu myoepithelial carcinoma Kata kunci:  myoepithelial carcinoma, spindle cell type, clear cell type plasmacytoid type
LYMPHOMA PADA TESTIS Dian Yuliartha Lestari; Etty Hary Kusumastuti
Saintika Medika Vol. 14 No. 1 (2018): JUNI 2018
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol14.SMUMM1.6643

Abstract

Limfoma pada testis pertama kali dikenalkan oleh Malassez dan Curling pada tahun 1866. Keganasan limfomapada testis berkisar 1-7% dari seluruh keganasan pada testis, dan kurang dari 1% dari seluruh Non Hodgkin Lymphoma.Kami melaporkan kasus anak laki-laki berusia 6 tahun tanpa riwayat kesehatan sebelumnya, mengeluhkan adanya pembengkakanpada testis kanan dan periorbita sejak 6 bulan sebelum MRS. Pemeriksaan radiologis menunjukkan adanya pembesarankelenjar limfe paraaorta serta pseuodotumor bulbi. Pemeriksaan immunomarker dengan LDH, ß HcG, dan AFP menunjukkanhasil 2201 ì/l, <1 mì/l, and 0,75 IU/l. Pasien dilakukan orchidectomy dextradandidiagnosis sebagai Malignant Round CellTumor sesuai Non Hodgkin Lymphoma. Pemeriksaan immunohistokimiamenunjukkan positifuntuk CD45 dan negatifuntuk NSE. Limfoma pada testis merupakan keganasan yang termasuk jarang dimana diagnosis ditegakkan berdasarkanhistopatologi. Tidak ada etiologi dan predisposisi yang pasti untuk tumor ini. Terapi meliputi prosedur pembedahan,khemoterapi, dan radioterapi, akan tetapi tidak ada standarisasi untuk prosedur yang akurat. Faktor-faktor yang dihubungkandengan prognosis yang baik meliputi : usia pasien yang lebih muda, lokasi tumor, adanya seklerosis pada analisis patologi,ukuran tumor yang lebih kecil, grade tumor yang lebih rendah dan tidak adanya epididymal atau spermatic cord yang terlibat.Kata Kunci: Non Hodgkin Lymphoma, Testis
The Effect Of Basic Life Support Training On Basic Life Support Knowledge In ‘Aisyiyah Cadre Dian Yuliartha Lestari; Abi Noerwahjono; Cindy Savira
Saintika Medika Vol. 16 No. 1 (2020): June 2020
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol16.SMUMM1.12718

Abstract

Background: Basic life support or BLS is an early emergency intervention cases which possibly happens anywhere. BLS is important to be given accurately and immediately not only by healthcare professionals but also by lay people in order to give early intervention towards emergency cases until medical teams arrives. ‘Aisyiyah cadre, as part of the society, are expected to be able to give early intervention that is BLS correctly.Objective: To assess the impact of basic life support training on the knowledge of ‘Aisyiyah cadre towards basic life support.Method: This study is a analytical observational study with cross-sectional approach. The sample of this study is 38 participants which are ‘Aisyiyah cadre from Malang city. Participants included on this study are those who do not have any medical background. Data analysis were using wilcoxon test.Result and discussion: 13 participants were having knowledge improvement, 24 participants did not have any improvements, and one of the participants were having degradation of knowledge level after the BLS training were given. According to wilcoxon test, the p-value was 0,001 which means that the BLS training given have positive impact on the improvement of ‘Aisyiyah cadre’s knowledge towards BLS.Conclusion: There is a significant impact between BLS training on the knowledge of ‘Aisyiyah cadre towards BLS which indicates that the BLS training given have postivive impact on the improvement of ‘Aisyiyah cadre’s knowledge towards BLS.
Cardioprotectant Effect Of Bay Leaf Extract (Syzygiumpolyanthum) On Myocardium Thickness Of Rat Heart Dian Yuliartha Lestari; Rizky Trimaulidia
Saintika Medika Vol. 17 No. 1 (2021): June 2021
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol17.SMUMM1.15803

Abstract

High salt diet and prednisone administration will increase blood pressure which chronically causes heart muscle remodeling so that it appears macroscopically as left ventricular hypertrophy. Bay leaf extract contains flavonoids which can lower blood pressure and decrease left ventricular thickening. To determine the effect of bay leaf extract (Syzygiumpolyanthum) on the left ventricle thickening of rat heart (Rattus norvegicus wistar strain) in hypertensive model.  True experimental post-test only controls group design with simple random sampling technique. The subjects of this study were 25 male Wistar rats aged 2-3 months weighing 150-200 grams. Rats were induced with prednisone 1.5 mg/ KgBW / day in 2% NaCl for 6 weeks followed by administration of bay leaf extract at a dose of 70 mg/ KgBW, a dose of 140 mg/ KgBW, and a dose of 280 mg/ KgBW. Data analyzed by One Way ANOVA, Post Hoc Bonferroni, followed by Linear: One Way ANOVA test showed significant differences between treatments (p = 0.000). The Bonferroni Post Hoc test concluded that there were significant differences in the treatment of the P2 and P3 groups. Linear regression test obtained R square 0.663 and obtained the equation Y = 1965.838 - 1.275X. The extract of bay leaf (Syzygiumpolyanthum) has an effect on decreasing the left ventricle thickening of the white male rat heart (Rattus norvegicus wistar strain) hypertension model.
The Effect Of Family Support On Stress Level In Muhammadiyah High School 1 Malang Students With Acne Vulgaris Dwi Nurwulan Pravitasari; Anung Putri Illahika; Dian Yuliartha lestari; Febriana Nur Layli; Siska Fitriana
Saintika Medika Vol. 17 No. 2 (2021): December 2021
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/sm.Vol17.SMUMM2.18001

Abstract

Adolescence is a stage that has relatively not reached maturity both emotionally and mentally so that in achieving good development, it is necessary to have positive support in life from the family. Stress that occurs identified as one of the triggering factors for acne vulgaris. To determine the effect of family support on stress levels in Muhammadiyah High School 1 Malang students with acne vulgaris complaints. This research an analytic observational study with a cross-sectional approach. Sampling by purposive sampling and a sample of 52 respondents. Analyzed with Spearman correlation followed by ordinal regression analysis. The results of the ordinal regression test of the effect of family support on stress levels showed a value of p = 0.000 (p<0.05), which means that there is an effect of family support on the stress level of students who have acne vulgaris complaints, with the magnitude of the OR being exp (3.323) = 27.743. The magnitude of the influence of family support in predicting the stress level of students with acne vulgaris complaints is 46.7% There is an effect of family support on stress levels in students of Muhammadiyah High School 1 Malang with acne vulgaris complaints.
PENGARUH BUBUK CANGKANG TELUR BEBEK TERHADAP PERTUMBUHAN OSTEOBLAS FEMUR MENCIT OSTEOPOROSIS Risky Amalia; Dian Yuliartha Lestari; Mochamad Bahrudin
Biomedika Vol 14, No 1 (2022): Biomedika Februari 2022
Publisher : Universitas Muhamadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/biomedika.v14i1.15322

Abstract

ABSTRAKGlucocorticoid induce-osteoporosis merupakan osteoporosis akibat terapi glukokortikoid jangka panjang.  Osteoporosis terjadi akibat adanya hambatan pada faktor pertumbuhan tulang sehingga diferensiasi osteoblas menurun. Peningkatan kalsium ekstraseluler dengan cara suplementasi kalsium mampu mendorong proliferasi sel dan mineralisasi matriks sel mesenkimal, yang merupakan sel induk osteoblas. Kalsium terkandung tinggi dalam bubuk cangkang telur bebek. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian bubuk cangkang telur bebek terhadap pertumbuhan osteoblas tulang femur mencit jantan (Mus musculus) model osteoporosis dengan induksi deksametason. Metode yang digunakan true experimental dengan posttest-only control group design, 24 ekor mencit jantan dibagi menjadi 4 kelompok, yaitu kontrol positif (K+), kelompok perlakuan bubuk cangkang telur bebek dosis 1,04mg/hari (P1), 2,08mg/hari (P2), dan 3,12mg/hari (P3).  Semua tikus diinduksi deksametason 0,0029mg/20gBB/hari selama 28 hari, kemudian kelompok perlakuan diberi bubuk cangkang telur bebek selama 14 hari.. Analisis data menggunakan One-Way Anova, Post Hoc Bonferroni, dan regresi linier. Pada penelitian ini,jumlah osteoblas secara signifikan berbeda (p 0,05) antar kelompok. perlakuan dibandingkan kelompok control positif. Sehingga dapat disimpulkan bahwa bubuk cangkang telur bebek meningkatkan pertumbuhan osteoblas tulang femur mencit jantan (Mus musculus) model osteoporosis.Kata Kunci: Bubuk Cangkang Telur Bebek, Osteoblas, Osteoporosis ABSTRACTGlucocorticoid induce-osteoporosis is osteoporosis due to long-term glucocorticoid therapy. Osteoporosis occurs due to inhibition of bone growth factors so that osteoblast differentiation decreases. The increase of extracellular calcium with calcium supplementation is able to promote cell proliferation and mineralization of mesenchymal cell matrix, which is the stem cell of osteoblasts. Calcium is high in duck egg shell powder. This study aimed to determine the effect of duck egg shell powder suplementation on the growth of male mice (Mus musculus) femoral bone osteoblasts with dexamethasone-induced osteoporosis model. The method used was true experimental with posttest-only control group design, 24 male mice were divided into 4 groups, there were positive control (K+), duck egg shell powder treatment group at a dose of 1.04 mg/day (P1), 2.08 mg/day (P2), and 3.12 mg/day (P3). All rats were induced with dexamethasone 0.0029mg/20gBW/day for 28 days, then the treatment group was given duck eggshell powder for 14 days. Data analysis used One-Way Anova, Post Hoc Bonferroni, and linear regression. In this study, the number of osteoblasts was significantly different (p0.05) between treatment groups compared to the positive control group. So it can be concluded that duck egg shell powder increased the growth of femoral bone osteoblasts of male mice (Mus musculus) osteoporosis model. Keywords: Duck Eggshell Powder, Osteoblast Cell, Osteoporosis
Pengaruh Pelayanan Terhadap Tingkat Kepuasan Pasien Rawat Jalan Laboratorium Rumah Sakit Univeritas Muhammadiyah Malang Dian Yuliartha Lestari; Wafiyah Hasanah
Medica Arteriana (Med-Art) Vol 1, No 2 (2019): Desember 2019
Publisher : University of Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (164.967 KB) | DOI: 10.26714/medart.1.2.2019.28-34

Abstract

Latar Belakang: Keberadaan laboratorium klinik sangat diperlukan untuk membantu menegakkan suatu diagnosis. Pasien rawat jalan yang menggunakan laboratorium dapat menentukan kepuasan melihat dari kemudahan segala bentuk pelayanan, kenyamanan, dan kepecayaan laboratorium. Penilaian pasien rawat jalan terhadap kualitas pelayanan laboratorium merupakan hal yang penting sebagai acuan dalam pembenahan pelayanan sehingga terciptanya suatu kepuasan pasien dan menciptakan suatu loyalitas dari pasien.Metode: Observasional analitik dengan pendekatan cross sectional. Pengambilan sampel menggunakan simple random sampling dengan jumlah 232 pasien rawat jalan laboratorium Rumah Sakit Universitas Muhammadiyah Malang menggunakan 15 pertanyaan. Analisis data bivariat menggunakan Mann-Whitney dan untuk multivariat menggunakan regresi multinomial.Hasil: Analisis bivariat Mann-Whitney menunjukkan bahwa semua komponen pelayanan berpengaruh karena memiliki nilai signifikansi 0,000 (p<0,05). Nilai kepuasan pasien rawat jalan terhadap pelayanan laboratorium adalah 85,3%. Di antara kelima belas variabel pelayanan, yang tertinggi tingkat sangat puas adalah variabel profesionalitas petugas dalam pengambilan sampel yaitu 35,9%, pada tingkat puas variabel tertinggi adalah informasi yang diberikan sebelum pengambilan spesimen 93,5%.Kesimpulan: Terdapat  pengaruh antara pelayanan dengan kepuasan pasien rawat jalan laboratorium Rumah Sakit Universitas Muhammadiyah Malang.
The potency of red onion skin flavonoids in acetaminophen-induced liver injury management: A biomolecular review Radya Kusuma Ardianto; Lucky Dimas Abimanyu; Afif Wafiq Waliyuddin; Abi Noerwahjono; Dian Yuliartha Lestari; Fathiyah Safithri
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 12, No 3, (2021)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol12.Iss3.art12

Abstract

Acetaminophen is widely used as a fever and pain reliever drug. However, acetaminophen intoxication was common and responsible for thousands of acetaminophen-induced liver injury (AILI) cases worldwide. It was understood that glutathione (GSH) depletion causes a deposit of acetaminophen metabolites which are toxic to liver cells. N-acetylcysteine (NAC), used as acetaminophen intoxication therapy, has been reported to cause side effects such as nausea, vomiting, and anaphylactic reaction. This narrative review aimed to discuss other potential candidates in AILI management. The biomolecular approach was used to investigate onion skin in-depth and holistic discussion. According to the results, onion peel extract is rich in flavonoids (quercetin and kaempferol) and potentially be a candidate in the management of AILI through proposed mechanisms such as restoration of reduced glutathione (GSH), inhibition of cytochrome P450 (CYP) enzymes, upregulation of uridine 5'-diphospho-glucuronosyltransferase (UGT) enzyme, and inhibition of TLR4 activity. 
Evaluation of sST-2 Role in LVH Regression Obtained in Hypertensive Mice Models After Blocking Renin-Angiotensin System Lilik Yusetyani; Siti Rofida; Dian Yuliartha Lestari; Wawan Kurniawan; Nursela Hijriani; Ilham Niawan Saputra; Setyawati Soeharto; Mohammad Saifur Rahman
Journal of Tropical Life Science Vol. 9 No. 1 (2019)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Soluble ST2, is a protein which acts as a decoy receptor for interleukin-33, and served as biomarker associated with left ventricular hypertrophy (LVH).  Few data exist in evaluating the effects of anti-hypertensive agents on the role-played form ST2 on regression of LVH. This study was designed to compare the effects of captopril and valsartan on blood pressures, plasma renin and soluble ST2 levels and regression of LVH in hypertensive mice models. Twenty-four male mice (Mus musculus L), were divided into four groups, namely aquadest/control, L-NAME, L-NAME + captopril and L-NAME + valsartan groups respectively. Mice blood pressures were measured on day 14th after induction with L-NAME extract 1.75 mg/25 g BW/day (pretreatment) and day 14th post treatment. Levels of plasma renin, sST2, and ventricular wall thicknesses reflecting LVHs, were measured on day 14th post treatment. Administration of L-NAME within 14 days resulted in making mice models to be hypertensive paralleled by an increase of Ventricular wall thickness. Treatment with captopril and valsartan lowered the blood pressures to normal level within the next 14 days. Valsartan and captopril treatment induced a significant decrease of plasma renin level. Valsartan, but not for captopril treatment prevented wall thickness increase (p < 0.05), while plasma sST2 was not able to mirroring this effect. Captopril and valsartan had similar effect in lowering plasma renin level and   blood pressure, but sST2 seems to be not involved in LVH regression obtained in hypertensive mice models after blocking renin-angiotensin system.
Pengaruh Batas Insisi, Indeks Mitosis, Dan Tumor Nekrosis Terhadap Angka Rekurensi Tumor Phyllodes Lestari, Dian Yuliartha; Prihanti, Gita Sekar
MAGNA MEDICA Berkala Ilmiah Kedokteran dan Kesehatan Vol 1, No 2 (2015): February
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (35.34 KB) | DOI: 10.26714/magnamed.1.2.2015.140-144

Abstract

Effect of Incision Boundary, Mitosis Index, and Tumor Necrosis on the Recurrence Rate of Phyllodes Tumors Background: Phyllodes tumor is one neoplasms fibroepitelial rare, approximately less than 1 % of all breast neoplasms. Determination of prognosis of phyllodes tumors based on histopathologic classification is difficult to implement. To evaluate the phyllodes tumor, an important marker for prognostic factors, mainly based on the criteria of phyllodes tumor itself (such as mitotic index, limits the incision). Objective: To determine the effect limits the incision, mitotic index and tumor necrosis against phyllodes tumor recurrence rate. Methods: An observational analytic study of the period 2009-2011 and followed through 2014. To determine the effect on recurrence rate limit incision Mann Whitney test , to determine the effect on the mitotic index recurrence rate testunpaired t -test , and to determine the effect of the tumor necrosis recurrence rate chi square test. Result: Obtained 16 samples that met the inclusion criteria with 10 samples and 6 samples did not relapse relapse. There were no influences between adjacent incisions (p = 0.05) , mitotic index (p = 0.06) , and tumor necrosis (p = 0.152) for phyllodes tumor recurrence rate Conclusion: There were no influences between adjacent incision, mitotic index , and tumor necrosis against phyllodes tumor recurrence rate
Co-Authors Abi Noerwahjono Afif Wafiq Waliyuddin Anak Agung Istri Sri Wiadnyani Anung Putri Illahika Cindy Savira Dwi Nurwulan Pravitasari DYAH FAUZIAH, DYAH Fathiyah Safithri Febriana Nur Layli Gita Sekar Prihanti Handirosiyanto, Ikhwan Ilham Niawan Saputra Indra Setiawan KUSUMASTUTI, ETTY HARY Lilik Yusetyani Lilik Yusetyani Lucky Dimas Abimanyu Mochamad Bahrudin Mohammad Saifur Rahman Nabila Risma Anjana Nisa, Seftiana Khaerun Radya Kusuma Ardianto Rahman, Mohammad Saifur Risky Amalia Rizky Trimaulidia Saputra, Ilham Niawan Savira, Cindy Setyawati Soeharto Setyawati Soeharto, Setyawati Siska Fitriana Siti Rofida Tiara Lastari Wafiyah Hasanah Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono