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Suspension Stability and Characterization of Chitosan Nanoparticle–Coated Ketoprofen Based on Surfactants Oleic Acid and Poloxamer 188 Rasyid, Nur Qadri; Sugita, Purwantiningsih; Ambarsari, Laksmi; Syahbirin, Gustini
Makara Journal of Science Vol. 18, No. 3
Publisher : UI Scholars Hub

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In this research, ketoprofen was used as a drug model in the preparation of chitosan nanoparticles as a potential drug delivery system through the ionic gelation process with tripolyphosphate (TPP). The particle size analysis (PSA) revealed that the average particle size, polydispersity index (PI), and entrapment efficiency of chitosan nanoparticles prepared with oleic acid were 253.7 nm and 0.375 with drug entrapment efficiency of 73.30%. Those prepared with poloxamer 188 were 242.94 nm and 0.302 with drug entrapment efficiency of 87.89%. Scanning electron microscopy (SEM) analysis showed that the shapes of the nanoparticles, both prepared with oleic acid and poloxamer 188, were intact and spherical. Fourier transform infrared spectroscopy (FTIR) indicated several differences between the spectra of chitosan- and ketoprofen-loaded chitosan nanoparticles; for example, a new peak at the wavenumber 1409/cm indicated the presence of electrostatic interaction between the carboxyl group of ketoprofen and the amino group of chitosan. The chitosan nanoparticle suspension prepared with poloxamer 188 showed smaller increases in turbidity and viscosity than that prepared with oleic acid after 34 d of storage.

Analisis Kadar Sianida Pada Rebung Berdasarkan Volume Ukuran Dari Kecamatan Bajeng Kabupaten Gowa Arisanti, Dewi; Rasyid, Nur Qadri; Nasir, Muh.
Indonesian Journal of Chemical Research Vol 6 No 1 (2018): Edisi Bulan Juli (Edition For July)
Publisher : Jurusan Kimia, Fakultas Sains dan Teknologi, Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ijcr.2018.6-dew

Bamboo shoots are young shoots from bamboo Terubus. Bamboo shoots contain cyanide if consumed can cause shortness of breath, decreased blood pressure, rapid pulse, headache, nausea, diarrhea, mental disorders and seizures. Continuous consumption with low doses causes mumps and dwarfism and neurological diseases. This study aims to determine how much cyanide levels in bamboo shoots and this type of research is a descriptive laboratory experiment. The sample used in this study were 3 samples based on the size of the volume. The sampling technique is by means of purposive sampling that is looking at the criteria based on large, medium and small size types. Analysis of cyanide levels was obtained by UV-Vis Spectrophotometer with a wavelength of 582 nm. The results showed that large size bamboo shoots were height = 27 cm; diameter = 16 cm has a cyanide content of 21.84 mg/kg, medium size were height = 18 cm; diameter = 7 cm has a cyanide content of 18.40 mg / kg and a small size of height = 8 cm; diameter = 4 cm has cyanide content of 4.65 mg/kg. Thus it can be concluded that the greater the size of bamboo shoots have height level of cyanide.

General Description of Glucose and pH in the Urine of Diabetic Mellitus Patients by using Urine Analyzer Permata, Indra; Rasyid, Nur Qadri; Nurhidayat; Wahyuni, Sri; Muawanah
Hayyan Journal Vol. 1 No. 2 (2024): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i2.1884

Diabetes Mellitus is a chronic disease that occurs due to the failure of the pancreas to produce enough insulin or the body cannot effectively use the insulin produced. One of the complications of diabetes is diabetic ketoacidosis. KAD is an acute complication of Diabetes Mellitus characterized by increased glucose levels. Diabetic Mellitus has higher levels of calcium stones, and uric acid, therefore the pH of the urine of people with Diabetic Mellitus tends to be more acidic. The purpose of the study was to find out the picture of the results of glucose and pH tests in patients with Diabetes Mellitus. The type of research used in this study is laboratory observation. The sampling technique in this study is random sampling. The number of samples in this study was 10 samples, with the Urine Analyzer examination method. The results of the study showed that out of 10 samples studied, 4 samples were found to be glucose-positive, with a pH range of 5 – 7 and 6 samples were not found to be glucose positive with a pH range of 5 - 6.

Effectiveness of Lime Concentration As A Modification of Turk's Reagent in Leucocyte Type Count Examination Arham, Chaerul; Rasyid, Nur Qadri; Rianto, Rifo; Moito, Rahma
Mukhtabar Journal of Medical Laboratory Technology Vol 2 No 2 (2024): Mukhtabar: Journal of Medical Laboratory Technology (October 2024)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/mjmlt.v2i2.695

Background & Objective: Turk solution has a composition of glacial acetic acid, gentian violet, and distilled water. Lime (Citrus aurantifolia S) has a pH of 2.0 which is almost the same as acetic acid. Both components are weak acids that can lyse blood cells other than white blood cells. This study aims to determine the effectiveness of lime concentration as a modification of Turk's reagent in counting the number of leukocytes and knowing the concentration of 1%, 2%, or 3% which is more effective in counting the number of leukocytes. Method: This study aims to provide an overview of the effectiveness of lime concentration as a modification of turk reagent composition in counting the number of leukocytes. The research method used is the Counting Room Method. This research was conducted in August 2024 at the clinical pathology laboratory of the Muhammadiyah Makassar Polytechnic. The number of samples in this study was 4 blood samples obtained from 4 correspondents with treatment, lime concentrations namely 1%, 2%, and 3%, and turk reagent as control. Result: At 1% concentration, the average difference in leucocyte count between the control and the sample was 1,150 cells/mm3, at 2% concentration a difference of 2,788 cells/mm3 was obtained with the control, and at 3% concentration a difference of 3,638 cells/mm3 was obtained. Conclusion: It can be concluded that the concentration of lime that is effective as a modification of Turk's reagent in counting the number of leukocytes is a concentration of 1%.

Identification of Malassezia sp. as a Cause of Dandruff Among Students at Muhammadiyah Polytechnic Makassar Annisa, Riska; Rasyid, Nur Qadri; Basarang, Mujahidah; Faisal, Restu Andini
Mukhtabar Journal of Medical Laboratory Technology Vol 2 No 2 (2024): Mukhtabar: Journal of Medical Laboratory Technology (October 2024)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/mjmlt.v2i2.703

Background & Objective: Dandruff is a scalp condition attributed to the fungus Malassezia sp. It manifests as fine to coarse scales that are grayish or white, resulting from the shedding of the stratum corneum layer on the scalp. Factors contributing to the onset of dandruff include the proliferation of Malassezia fungi, sebaceous gland activity, and individual predisposition. This study aimed to identify Malassezia sp. responsible for dandruff among female students at the Muhammadiyah Polytechnic of Makassar. Method: The research employed a laboratory observational design utilizing a purposive sampling technique. Dandruff samples were collected from 10 female students and cultured on SDA (Sabouraud Dextrose Agar) media, followed by microscopic examination of the resulting colonies. Result: The findings revealed that none of the 10 dandruff samples contained Malassezia sp.; instead, contamination by Aspergillus fumigatus was observed. Conclusion: Therefore, it can be concluded that Malassezia sp. was not identified as a causative agent of dandruff in female students at the Muhammadiyah Polytechnic of Makassar

Analisis Kadar Siklamat Pada Selai Tidak Bermerek Yang Dijual Di Pasar Tradisional Kota Makassar Muawanah, Muawanah; Nurhidayat, Nurhidayat; Rasyid, Nur Qadri; Susanti, Susi
Lontara Journal of Health Science and Technology Vol. 1 No. 2 (2020): Ilmu dan Teknologi Kesehatan
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Politeknik Muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53861/lontarariset.v1i2.72

The jam is a semi-solid food made from fruit or other processed product. The manufacturing process can add food additives (BTP), one of which is artificial sweeteners such as cyclamate. Cyclamate can be harmful to health if consumed in levels that exceed the maximum limit.The purpose of this research was to identificate and determine the cyclamate content of unbranded jam in the traditional market town of makassar. The type of research used is laboratory observation with simple random sampling technique. This research was conducted qualitatively (depositional method) and quantitatively (gravimetric method). Based on the results of the research from 7 (seven) samples of unmerck jam there were 2 (two) positive samples containing cyclamate with cyclamate levels obtained, namely the K sample 0f 42.273,78 mg/kg and sample T3 of 49, 822. 67 mg/kg. In this study it can be concluded that 2 (two) samples of unbranded jam contained cyclamate levels that exceed the maximum limit set by BPOM No. 4 of 2014, namely 1000 mg/kg and so it is not safe for consumption.

Analisis Kualitatif Residu Pestisida Pada Bahan Pangan Dengan Menggunakan Metode Kromatografi Lapis Tipis (KLT) Muawanah, Muawanah; Rasyid, Nur Qadri
Lontara Journal of Health Science and Technology Vol. 2 No. 2 (2021): Ilmu dan Teknologi Kesehatan
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Politeknik Muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53861/lontarariset.v2i2.222

Vegetables and fruits are foodstuffs whose cultivation process requires pesticides. In addition to farmers who apply pesticides, pesticide poisoning can also be experienced by people who consume agricultural products including vegetables through the pesticide residues contained in them, so that it will have a negative impact on human health who consume them continuously. The purpose of the study was to determine the presence of pesticide residues in foodstuffs. This research is a laboratory observation with a simple random sampling technique. In this study, a qualitative analysis of organophosphate and carbamate pesticide residues in food ingredients was carried out using the Thin Layer Chromatography (TLC) method. Based on the results of the study, from 15 (fifteen) samples of vegetables, no organophosphate chlorpyrifos pesticide content was detected, but the carbamate group was detected in samples of spinach, cabbage, and carrots marked with spots and the Rf value was the same as the Furadan standard. Thus, it is hoped that the community will wash the vegetables before they are processed and consumed.

Analisis Kadar Natrium Benzoat Pada Bumbu Dapur yang Diperjualbelikan Di Kota Makassar Rustiah, Waode; Rasyid, Nur Qadri; Ishak, A. Nur Afni
Lontara Journal of Health Science and Technology Vol. 3 No. 1 (2022): Ilmu dan Teknologi Kesehatan
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Politeknik Muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53861/lontarariset.v3i1.260

Bumbu dapur instan adalah campuran dari berbagai macam bumbu rempah yang diolah dan diproses dengan komposisi tertentu. Penggunaan pengawet natrium benzoat pada bumbu dapur instan dapat menghambat pertumbuhan bakteri dan jamur. Penggunaan pengawet natrium benzoat secara berlebihan dapat menyebabkan endema (bengkak), keram perut, rasa kebas di mulut, dan dalam jangka panjang menimbulkan penyakit kanker, serta dapat merusak sistem syaraf. Penelitian bertujuan untuk mengetahui kadar natrium benzoat pada bumbu dapur yang diperjualbelikan di kota Makassar. Jenis penelitian yaitu observasi laboratorik, sampel diambil sebanyak 10 dan masing-masing dianalisis dengan menggunakan alat Spektrofotometer UV-Vis pada panjanggelombang 275 nm. Hasil pengukuran terhadap 10 sampel menunjukkan kadar natrium benzoat pada sampel B1 110.95 mg/kg, sampel B2 320.97 mg/kg, sampel B3 98.91 mg/kg, sampel B4 160.07 mg/kg, sampel B5 483.96 mg/kg, sampel B6 865.41 mg/kg, sampel B7 527.58 mg/kg, sampel B8 213.59 mg/kg, sampel B9 253.90 mg/kg, sampel B10 86.59 mg/kg. Pada sampel B6 kadar natrium benzoatnya sebesar 865.41 mg/kg. Kadar ini melebihi ambang batas yang ditetapkan oleh BPOM No. 36 tahun 2013 yaitu 600 mg/kg, maka sampel tersebut dinyatakan tidak layak untuk dikonsumsi.

Analisis Kualitatif Pewarna Rhodamin B Pada Terasi Dengan Metode Kromatografi Lapis Tipis Muawanah, Muawanah; Arisanti, Dewi; Razak, Abdul; Rasyid, Nur Qadri
Lontara Journal of Health Science and Technology Vol. 4 No. 1 (2023): Ilmu dan Teknologi Kesehatan
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Politeknik Muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53861/lontarariset.v4i1.329

Shrimp paste is one of the fishery products obtained by a fermentation process, and the main ingredients are both small shrimp and fish. In the production of shrimp paste, traders sometimes add prohibited dyes such as rhodamin B, according to the Minister of Health of the Republic of Indonesia, Number 239/Menkes/Per/V/85, because it is a synthetic dye for paper, textiles, and ink. Rhodamin B can cause liver function disorders and cause cancer. When used in food products. This study aims to determine the presence of rhodamin B dye in shrimp paste. The sampling technique was purposive sampling, with a total of 10 samples. This study conducted a qualitative analysis of rhodamin B dye using the Thin Layer Chromatography (TLC) method. Based on the results of the study, 10 samples were obtained, namely 6 positive shrimp paste samples containing rhodamin B dye, as seen based on the stains and Rf value of the sample and the rhodamin B standard. It can be concluded that most of the shrimp paste samples contain rhodamine B dye.

General Description of Glucose and pH in the Urine of Diabetic Mellitus Patients by using Urine Analyzer Permata, Indra; Rasyid, Nur Qadri; Nurhidayat; Wahyuni, Sri; Muawanah
Hayyan Journal Vol. 1 No. 2 (2024): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i2.1884

Diabetes Mellitus is a chronic disease that occurs due to the failure of the pancreas to produce enough insulin or the body cannot effectively use the insulin produced. One of the complications of diabetes is diabetic ketoacidosis. KAD is an acute complication of Diabetes Mellitus characterized by increased glucose levels. Diabetic Mellitus has higher levels of calcium stones, and uric acid, therefore the pH of the urine of people with Diabetic Mellitus tends to be more acidic. The purpose of the study was to find out the picture of the results of glucose and pH tests in patients with Diabetes Mellitus. The type of research used in this study is laboratory observation. The sampling technique in this study is random sampling. The number of samples in this study was 10 samples, with the Urine Analyzer examination method. The results of the study showed that out of 10 samples studied, 4 samples were found to be glucose-positive, with a pH range of 5 – 7 and 6 samples were not found to be glucose positive with a pH range of 5 - 6.

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