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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) The New Ropanasuri Journal of Surgery Jurnal Ilmu Bedah Indonesia Narra J Jurnal Locus Penelitian dan Pengabdian Jurnal Sehat Indonesia (JUSINDO) The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Jurnal Penyakit Dalam Indonesia
Muradi, Akhmadu
Divisi Vaskular Dan Endovaskular, Kelompok Staf Medis Ilmu Bedah, Fakultas Kedokteran Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo, Jakarta
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Navigating the intersection of COVID-19 and lower extremity acute limb ischemia: A retrospective cohort study of clinical characteristics and outcomes at Dr. Cipto Mangunkusumo Hospital Muradi, Akhmadu; Fachriza, Ihza; Pratama, Dedy; Suhartono, Raden; Harunarashid, Hanafiah
Narra J Vol. 5 No. 3 (2025): December 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i3.2557

Abstract

Acute limb ischemia (ALI), a critical condition threatening limb viability and patient survival, has demonstrated an increased incidence during the COVID-19 pandemic, primarily due to virus-associated thrombotic complications. The pandemic has also led to delays in the diagnosis and treatment of non-COVID conditions, including ALI. The aim of this study was to evaluate the clinical characteristics and outcomes of ALI patients treated at Dr. Cipto Mangunkusumo Hospital between 2018 and 2022, comparing outcomes before and during the COVID-19 pandemic. Patients were categorized into two cohorts: pre-pandemic (n=28) and pandemic (n=53), with March 2020 marking the onset of the pandemic period. Treatment outcomes—revascularization success, re-intervention, and mortality—were assessed using multivariate logistic regression. Among the 81 patients, 34.6% were treated before the pandemic and 65.4% during the pandemic. Revascularization success was significantly higher during the pandemic (relative risk (RR): 2.46; 95% confidence interval (CI): 1.16–5.24; p=0.013), whereas no significant differences were observed in re-intervention or mortality rates (both with p>0.05). A prior history of COVID-19 was not significantly associated with revascularization outcome (p=0.933). The use of fluoroscopic guidance was significantly associated with improved revascularization success (RR: 36.58; 95%CI: 6.54–204.6; p=0.001). Rutherford classification was a significant predictor of re-intervention success (p=0.022), while the presence of dyslipidemia and cardiovascular disease were independently associated with mortality (RR: 0.08–0.76, p=0.0o5, and RR: 2.24–25.18, p=0.001, respectively). In conclusion, fluoroscopy appears to enhance revascularization outcomes in the treatment of ALI. Comorbidities such cardiovascular disease, and COVID-19 history should be taken into account when managing patients with ALI.
Recanalization Rates and Complications of Post-Endovenous Microwave Ablation in Chronic Vein Insufficiency with Large GSV Diameter Herwirastri, Novinda; Muradi, Akhmadu
Jurnal Locus Penelitian dan Pengabdian Vol. 4 No. 8 (2025): JURNAL LOCUS: Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v4i8.4763

Abstract

Endovenous Microwave Ablation (EMA) is one of the thermal ablation modalities to treat chronic venous insufficiency (CVI). The effectiveness and safety of EMAs in large-diameter saphena magna veins (GSVs) still require further research. This study aimed to compare the rates of recanalization and post-EMA complications in CVI patients with GSV diameters of <8 mm and ?8 mm. This retrospective cohort study used data from 54 patients from a multicenter (January 2023 – May 2025). Statistical analysis was performed with an unpaired t-test and a Chi-square test. The rate of venous occlusion reached 100% in both groups. The recanalization rate at 3 months post-procedure was higher in the GSV group ?8 mm (11.1%) compared to the GSV <8 mm (3.7%), although the difference was not statistically significant (p=0.299). There were no significant differences in complications of ecchymosis, thermal skin injury, and paresthesia. However, pain was reported to be significantly higher in the ?8 mm GSV group (33.3% vs 7.4%; p=0.018). The EMA is effective in achieving occlusion in a wide range of GSV diameters, but patients with a GSV of ?8 mm (especially ?10 mm) have a higher tendency to recanalize and post-procedure pain. Additional strategies are needed to be considered to increase effectiveness and comfort in the group.
Association of Vitamin D Deficiency and Diabetic Foot Ulcer Patients in Dr Mohammad Hoesin General Hospital Palembang Dahlan, Kemas; Yususf, Fahmi Jaka; Irfannuddin, Irfannuddin; Murti, Krisna; Muradi, Akhmadu; Liberty, Iche Andriyani
Jurnal Sehat Indonesia (JUSINDO) Vol. 7 No. 1 (2025): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v7i01.149

Abstract

Vitamin D plays a role in the healing process of diabetic foot ulcers (DFU); it can improve the immune system, regulate inflammation function, and regulate growth factors in diabetes mellitus (DM). The immunomodulatory effects of vitamin D include reduced production of IL-2, IL-6, and TNF-alpha and increased production of IL-10. It also increases the activity of antimicrobial peptides (AMP) such as cathelicidin, and it promotes the differentiation of monocytes into macrophages, phagocytosis, and the production of lysosomal enzymes. Furthermore, vitamin D stimulates growth factors including vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF-β). In this study, the incidence of DM and DFU in DM patients at RSUP Dr. Mohammad Hoesin Palembang will be compared to serum vitamin D levels. This research uses quantitative methods with an analytical observational design. The Mean vitamin D serum level was 11,727 ng/mL, and there was a significant association between serum vitamin D deficiency and DFU (p-value; 0.036 < 0.05). There was a significant association between serum vitamin D deficiency and DFU occurrence (p-value; 0.036 < 0.05) in Mohammad Hoesin General Hospital Palembang. Based on the results of this study, we proposed that patients with diabetic foot ulcers should have their serum vitamin D levels checked, and that vitamin D should be given to them as part of their therapy.
Literature Review: Role of Vitamin D in Diabetic Foot Ulcer Wound Healing Dahlan, Kemas; Irfanuddin; Murti, Krisna; Muradi, Akhmadu
Jurnal Penelitian Pendidikan IPA Vol 9 No 10 (2023): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i10.5135

Abstract

DFU is a common consequence of DM. Vitamin D has multiple positive effects on DFU. Search data from; Google Scholar, Science Direct, Elsevier, EBSCO, Medline and PubMed. Publication at least ten years (2013 until 2022). Inclusion criteria; full paper in English, Study about vitamin D and DFU in human, exclusion criteria; animal model and invitro study. Results; 27 journals; Seven Randomized Controlled Trial. Vitamin D phase on DFU which one substantially smaller. Severe vitamin D insufficiency known with significance linked for an elevated risk of DFU. Vitamin D supplementation can prevent or improve diabetic foot complications
Co-Authors Adityo Susilo, Adityo Chyntia Olivia Maurine Jasirwan, Chyntia Olivia Maurine Dahlan, Kemas Darwis, Patrianef Dedy Pratama Dimas Putra Asmoro Fachriza, Ihza Gabriella, Stacy Harunarashid, Hanafiah Herwirastri, Novinda Ibrahim, Hilman Iche Andriyani Liberty, Iche Andriyani Ihza Fachriza Irfannuddin Irfannuddin Irfanuddin Karina Zulkarnain Krisna Murti Limianto, Eka A Maria, Suzy Myranda Zahrah Putri Patrianef Darwis Pratomo, Susatyo J Putri, Myranda Zahrah Shalih, Zamzania A Sitorus, Londung B. Stacy Gabriella Suhartono, Raden Suzy Maria Syahidatul Wafa Syahidatul Wafa, Syahidatul Teguh Dwi Nugroho Wulyo Rajabto Yususf, Fahmi Jaka