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All Journal Sari Pediatri Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Cermin Dunia Kedokteran
Kadaristiana, Agustina
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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The Importance of Induced Pluripotent Stem Cell Research in Medical Science Kadaristiana, Agustina
Cermin Dunia Kedokteran Vol 42, No 11 (2015): Kanker
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i11.942

Abstract

The degenerative diseases that are currently incurable, such as heart disease, stroke, and diabetes, became the global leading causes of death in 2010 and 2011. This fact urges scientists to find alternative treatment for those conditions. In 2006, Takahashi and Yamanaka succeeded in generating an alternative source of stem cells called induced pluripotent stem cell (iPSC). This groundbreaking work holds the promise of new ways to repair cell damage and improve treatment of currently untreatable conditions without raising ethical debates. Many scientists still question whether iPSC is completely interchangeable with ESC in terms of pluripotency and cell mortality. Indeed, iPSC clones and ESC clones have overlapping degrees of variation. It can be concluded that different cell lines will be best suited for different applications. This essay will describe the development stem cell research, comparison between IPSC and ESC, the promise of IPSC technology and current challenges in the applications of iPSCs.Penyakit degeneratif yang saat ini belum dapat disembuhkan, seperti penyakit jantung, stroke, dan diabetes, menjadi penyebab kematian utama di dunia pada tahun 2010 dan 2011. Fakta ini mendorong peneliti untuk mencari terapi yang bersifat kuratif. Tahun 2006, Takahashi dan Yamanaka berhasil menemukan sumber alternatif sel punca bernama sel punca pluripoten yang diinduksi/Induced Pluripotent Stem Cell (iPSC). Penemuan besar ini memberi harapan dalam memperbaiki sel rusak dan meningkatkan kualitas terapi penyakit yang belum bisa disembuhkan tanpa menimbulkan perdebatan etika. Masih dipertanyakan apakah pluripoten dan kematian sel klon sel iPS sama dengan sel punca embrionik (Embrionic Stem Cells/ ESC). Ternyata, terdapat variasi tumpang tindih antara klon iPSC dan ESC. Dapat disimpulkan bahwa sel yang berasal dari alur berbeda, cocok untuk penggunaan yang berbeda. Makalah ini bertujuan untuk memaparkan perkembangan penelitian sel punca, perbandingan antara sel iPSC dan ESC, keunggulan teknologi iPSC sekaligus tantangan dalam aplikasinya. 
Penggunaan Protokol Penyapihan Sedasi dalam Mencegah Sindrom Putus Obat pada Anak yang Sakit Kritis Kadaristiana, Agustina; Djer, Muljadi M; Prawira, Yogi
Sari Pediatri Vol 26, No 1 (2024)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp26.1.2024.54-62

Abstract

Latar belakang. Sedasi merupakan obat esensial pada perawatan anak sakit kritis, tetapi penggunaan jangka panjang dapat menimbulkan sindrom putus obat. Sampai saat ini belum ada pedoman penyapihan sedasi di unit intensif anak. Tujuan. Mengetahui peran protokol penyapihan sedasi dalam menurunkan kejadian sindrom putus obat. Metode. Penelusuran literatur dilakukan melalui PubMed, Cochrane Library, dan Embase untuk mencari artikel yang relevan. Hasil. Tiga studi memenuhi kriteria eligibilitas, yaitu dua uji klinis terandomisasi dan satu kohort prospektif. Masing-masing memiliki protokol penyapihan sedasi yang berbeda. Meskipun tingkat keabsahannya lemah, penggunaan protokol penyapihan sedasi menggunakan titrasi dan konversi obat bermanfaat dalam menurunkan sindrom putus obat, mempersingkat durasi penyapihan sedasi, dan lama rawat.Kesimpulan. Protokol penyapihan sedasi yang mudah digunakan dengan obat-obatan yang ada di Indonesia perlu dikembangkan.
Kasus Kateter Dialisis Peritoneal yang Terpuntir pada Seorang Anak Ambarsari, Cahyani Gita; Rahman, Farhan Haidar Fazlur; Bermanshah, Evita Karianni; Kadaristiana, Agustina
Majalah Kedokteran Indonesia Vol 70 No 2 (2020): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.70.2-2020-175

Abstract

Objective: Mechanical complications of peritoneal dialysis (PD) may occur because of surgical complications when inserting a Tenckhoff catheter or non-surgical complications during chronic care of a PD catheter. We aim to highlight the latter by presenting a case report of twisted external catheter. Method: We report an 11-year-old Indonesian girl with end-stage renal disease on continuous ambulatory PD at Cipto Mangunkusumo Hospital who was hospitalized due to repeat peritonitis.Result: Upon examination, the external catheter seemed twisted without inflow, outflow, or ultrafiltration problems. Her exit score was 4 with gaping. Both abdominal X-ray and ultrasound showed that the catheter and its cuffs were properly placed. The patient frequently pulled and manipulated her PD catheter. Additionally, the catheter-site care procedure was frequently done by untrained caregivers and catheter fixation was also not performed. A retraining program for all involved caregivers was carried out. Peritonitis resolved after 14-day-treatment using intraperitoneal gentamicin. We determined that the twisted catheter and repeat peritonitis were due to a combination of mechanical trauma, poor chronic catheter-site care, and suboptimal PD catheter training. Conclusion: Maintaining compliance for chronic PD catheter exit-site care by well-trained caregivers and by patients themselves, as well as the external catheter fixation are important.
Co-Authors Bermanshah, Evita Karianni Cahyani Gita Ambarsari Djer, Muljadi M Rahman, Farhan Haidar Fazlur Yogi Prawira, Yogi