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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal Of Physical Activity and Sport Development Media Penelitian dan Pengembangan Kesehatan
Aisyah, Andi Nur
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Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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Efek Sitotoksik Ekstrak dan Fraksi Umbi Paku Atai Merah (Angiopteris ferox Copel) Terhadap Sel Kanker Payudara T47D: Cytotoxic Effects of Paku Atai Merah (Angiopteris ferox Copel) Tuber Extract and Fractions against T47D Breast Cancer Cells Aisyah, Andi Nur; Nur, Syamsu; Lukitaningsih, Endang; Rumiyati, Rumiyati; Burhan, Asril; Adjara, Syafia Mustika; Rahim, Kurnia
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 2 (2020): (October 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2020.v6.i2.15255

Abstract

The use of natural products has been widely used as a resource of new bioactive chemical compounds. One of them is the Paku Atai Merah (Angiopteris ferox Copel) tuber which has long been used empirically by the Dayak tribe of East Kalimantan as an anti-cancer. The purpose of this study was to determine the anticancer cytotoxic activity of the extract and fractions of Paku Atai Merah tuber against T47D breast cancer cells in vitro. Extract of Paku Atai Merah tubers was obtained by maceration method using ethanol solvent until obtained the ethanolic extract then fractionated using various solvents to obtain n-hexane, ethyl acetate, and aqueous-ethanol fractions. The cytotoxic effect was carried out based on the MTT assay. Phytochemical screening tests showed positive results for the presence of flavonoid, phenolic, tannin, saponin and steroid compounds. The results of the cytotoxic activity study showed that the ethyl acetate fraction had moderate cytotoxic activity in T47D cancer cells with an IC50 value of 84.8 µg/ml. Ethanol extract (513.06 µg/ml) and n-Hexane frsction (881.97 µg/ ml) were also included in the weak category. This study indicates that ethyl acetate fraction can be developed as a supportive therapy for breast cancer treatment.
Analysis of Deol Chagi Kick Accuracy in Athletes from Tamarunang Taekwondo Club Yon Armed 6/3 Kostrad Makassar Aisyah, Andi Nur; Hakim, Hikmad
Indonesian Journal Of Physical Activity and Sport Development (IJPASD) Vol. 2 No. 1 (2024): Indonesian Journal Of Physical Activity and Sport Development
Publisher : Indonesian Journal Of Physical Activity and Sport Development (IJPASD)

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Abstract

Taekwondo is a Korean martial art that uses bare feet and hands to destroy targets, which is increasingly popular in Indonesia. Technological developments have simplified the kyorugi match system in taekwondo martial arts through the Protector Scoring System (PSS), which gives points based on the accuracy of the kick with impact on the target or sensor. The deol chagi kick is a straight forward kick that is done by lifting the leg linearly which is jerked straight down like an axe movement targeting the head. This study aims to analyze the accuracy of the Deol chagi kick of Tamarunang Taekwondo Club Yon Armed 6/3 Kostrad Makassar athletes. The research method is a quantitative approach with a survey assessment type. The sample used was 20 female athletes selected using the purposive sampling technique. Data collection was carried out through tests and measurements of kick accuracy. The results of the data analysis showed that the average value of the level of accuracy of the Deol chagi kick of Tamarunang Taekwondo Club athletes with the highest frequency was in the moderate category.
Effectiveness of breadfruit leaf extract in mouthwash formula to inhibit the bacteria of Streptococcus mutans that causes caries Khairi, Nur; Aisyah, Andi Nur; Indrisari, Maulita; Sukmawati, Sukmawati; Nisa, Michrun
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.2722

Abstract

Background: Dental caries is caused by Streptococcus mutans, which forms biofilms and produces acid that damages tooth enamel. Prevention is often achieved through mouthwashes containing antibacterial agents, but commercial products may have side effects due to chemical ingredients. Artocarpus altilis (breadfruit) leaves contain bioactive compounds like flavonoids and tannins, which have potential as natural antibacterial agents. Objective: This study aimed to evaluate the antibacterial activity of Artocarpus altilis leaf extract and formulate an effective mouthwash against Streptococcus mutans. Methods: The study used a true experimental design with a pretest-posttest control group. The extract was obtained by maceration with 96% ethanol. Three mouthwash formulations were prepared with varying glycerin concentrations (15%, 20%, and 25%). Antibacterial activity was assessed using the paper disk method, and data were analyzed using Kruskal-Wallis and Mann-Whitney tests. Results: The 2-4% extract had strong antibacterial activity, with inhibition zones ranging from 20.25–23.81 mm, significantly different from the negative control (p<0.05). The mouthwash formulations were liquid, yellow-green in color, with a characteristic breadfruit and mint scent, pH ranging from 5.5 to 7.9, and viscosity of 1 cPs. The mouthwash exhibited strong antibacterial activity, with inhibition zones between 18.81±1.5 mm and 18.94±0.5 mm, showing no significant differences across formulas (p>0.05). Conclusion: The 2% Artocarpus altilis extract and 15% glycerin formula was stable and effectively inhibited Streptococcus mutans
Co-Authors Adjara, Syafia Mustika Burhan, Asril Endang Lukitaningsih HIKMAD HAKIM Khairi, Nur Maulita Indrisari, Maulita Michrun Nisa Rahim, Kurnia Rumiyati, Rumiyati Sukmawati Sukmawati Syamsu Nur, Syamsu