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All Journal Jurnal Kesehatan Folia Medica Indonesiana Biota JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Universa Medicina BIOTROPIC The Journal of Tropical Biology Journal of Health Science and Prevention AGRIPEAT AL-HAYAT: Journal of Biology and Applied Biology Biota Scripta Biologica Al-Ard: Jurnal Teknik Lingkungan Jurnal Riset Biologi dan Aplikasinya Indian Journal of Forensic Medicine & Toxicology Nusantara Journal of Community Engagement Global Health Science (GHS) JURNAL BIOLOGI PAPUA Engagement: Jurnal Pengabdian Kepada Masyarakat
Moch. Irfan Hadi
Universitas Islam Negeri Sunan Ampel Surabaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Analysis of the Moringa oleifera Seed Oil Extract on Insulin Level in Alloxan-Induced Diabetic Rat (Rattus norvegicus) Estri Kusumawati1 , Sri Hidayati L.1 , Nova Lusiana1 , Risa Purnamasari1 , Moch. Irfan Hadi1
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10695

Abstract

Moringa oleifera is a plant that can be used and grown intensively in several Southeast Asian countries. This study aims to determine the effect of Moringa oleifera seed oil extract on the levels of the insulin and blood glucose levels of Rattus norvegicus induced by alloxan. This study used 30 female Wistar white rats induced by alloxan. Rats were divided into 6 groups. Groups 3 to 6 were injected 100, 200, 300, 400 mg/kg BW extract of Moringa oleifera seed oil, respectively. Group 1 neither had alloxan induction nor treatment while group 2 had been induced alloxan but no treatment. Data were analyzed using the Kruskal-Wallis test with a significance level of 0.05. The results showed that there was no effect of Moringa oleifera seed oil extract on insulin level (p value = 0.161). Conversely, there was an effect on blood glucose levels in alloxan-induced Rattus norvegicus (p value = 0.036).
Detection of Emerging Infectious Disease in Cynopterus brachyotis and Rhinolopus boorneensis as Reservoirs of Zoonotic Diseases in Indonesia Moch. Irfan Hadi1 , Munawir1 , Muhammad Yusuf Alamudi2 , Dedi Suprayogi1 , Mirna Widiyanti3
Indian Journal of Forensic Medicine & Toxicology Vol. 14 No. 3 (2020): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v14i3.10725

Abstract

Bats are mammal species that have the highest diversity. During the last two decades, various types of infections caused by microorganisms have again become epidemic in many countries, this phenomenon is known as a new infectious disease that arises and re-emerges or Re-Emerging Infectious Diseases (EID/ REID). The purpose of this study was to identify EID in bats in the karst area of South Malang. The research method of bat sampling is conducted in the karst area of South Malang, bats are identified by species, taken by blood, prepared and carried out by NGS (next generation sequencing). From the results of the research conducted, obtained 2 types of bats namely fruit-eating bats (Chiroptera brachjatis) and insect bats (Rhinolopus boorneensis). From the results of the NGS, we get specific viruses and bacteria in bats. The conclusion of this research is that bat in South Malang Karst has potential as a carrier of EID and zoonotic disease.
Body mass index increases CD4+ count in HIV/AIDS patients on first-line therapy Widiyanti, Mirna; Hadi, Moch Irfan; Kumalasari, Mei Lina Fitri; Natalia, Evi Iriani; Purba, Dedi Ananta; Adiningsih, Setyo
Universa Medicina Vol. 39 No. 2 (2020)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2020.v39.121-127

Abstract

BackgroundThe body mass index (BMI) may contribute somewhat to drug metabolism, thus affecting the efficacy of antiretroviral therapy (ART). CD4+ counts   in people infected with HIV are essential in determining the stage of the disease, initiation of antiretroviral therapy, opportunistic infections and evaluating treatment outcomes. The aim of this study was to determine the association of BMI and clinical stage with CD4+ counts in HIV patients seeking treatment using first-line antiretroviral therapy (ART).MethodsAn analytic study with a cross-sectional approach was conducted involving 251 HIV/AIDS patients who had received first-line antiretrovirals over six months. BMI, clinical staging according to WHO and CD4 + were collected. Multiple linear regression was used to evaluate the relationship between BMI, clinical stage and CD4+.ResultsAmong the enrolled patients, the median age was 36 years, 135 (55%) of the patients was female, 102 (40.6%) was overweight/obese, 161 (64.1%) was in stage 3 of the disease, and the median CD4+ count was 389 cells/mm3. Multiple linear regression test showed two variables with a significant effect on CD4+ count, namely BMI (B=69.247; 95 % CI : 42.886-95.608) and clinical stage (B=61.590; 28.910-94.270). BMI was the most influencing factor for CD4+ count (β=0.307) compared to clinical stage (β=0.216). ConclusionsBody mass index was the most influencing factor for CD4 + counts of HIV/AIDS patients. Regular ART can increase CD4+ counts and maintain the health of HIV/AIDS patients.
Immunoinformatics Analysis of SARS-CoV-2 Isolated from Karst of Bats in Malang, Indonesia Moch Irfan Hadi; Aditya Sukma Prawira; Khuliyah Candraning Diyanah; Dedy Suprayogi; Soedjajadi Keman; Yudied Agung Mirasa; M Yusuf Alamudi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 2 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i2.14805

Abstract

In December 2019, cases of mysterious pneumonia were first reported in Wuhan, Initially, the diseasewas temporarily named as 2019 novel coronavirus (2019-nCoV), then WHO announced a new name onFebruary 11, 2020, namely Coronavirus Disease (COVID-19) which is caused by a virus Severe AcuteRespiratory Syndrome Coronavirus-2 (SARS-CoV-2). This virus can be transmitted from person toperson and has spread widely in China and more than 190 other countries and territories. Meanwhile inIndonesia, up to September 2020, 203 thousand cases of COVID-19 were found and 8336 deaths. Batsact as important disease reservoirs for various etiologic agents of disease that can be transmitted betweenspecies, infecting humans and mammals, both domestic and wild. The purpose of this study was to analyzeSARS-CoV-2 immunoinformatics in bats in Karst Malang Indonesia as the basis for making SARS-CoV-2vaccines. This research method is SARS-CoV-2 amino acid bats in Karst Malang, Indonesia analyzed byimmunoinformatics. From the research results, it was found that SARS-CoV-2 protein from Malang Karstbats were antigen, non-allergen and non-toxin, so that they could be used as vaccine candidates, diagnostickits and immunotherapy.
Leptospirosis Transmission in Ponorogo District of East Java, Indonesia Aditya Sukma Pawitra; Khuliyah Candraning Diyanah; Corie Indria Prasasti; Moch Irfan Hadi; M. Yusuf Alamudi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15596

Abstract

This study aims to identify Leptospira bacterial infection in livestock owners and their livestock, as well as to examine potential risk factors correlated with the incidence. 50 participants were selected and their blood samples were collected. 50 urine samples were collected from livestock owned by the participants. Polymerase Chain Reaction (PCR) was used to identify the existence of the Leptospira bacteria. The questionnaire instrument was used to obtain information about individual characteristics and hygiene. The Chi-Squared test was adopted to examine the correlation between outcome and explanatory variables. The confirmation PCR test detected the bacterial DNA in 2 out of 50 blood samples examined (4%) and 3 out of 50 urine samples examined (6%). Human leptospirosis incidence is significantly correlated with occupation type (p=0.035), personal protective equipment (PPE) use (p=0.044), water puddle contact (p=0.044), cage sanitation (p=0.044) and Leptospira bacteria presence in livestock urine (p=0.007). Insignificant correlation was showed in owners’ age variable. The presence of Leptospira bacteria both in livestock and the owners indicates the real threat of animal to human transmission. Further study with larger sample size and wider range variables and meticulous examination technique is required to comprehend the investigation.
Leptospirosis Transmission in Ponorogo District of East Java, Indonesia Corie Indria Prasasti; Aditya Sukma Pawitra; Khuliyah Candraning Diyanah; Moch Irfan Hadi; M. Yusuf Alamudi
Indian Journal of Forensic Medicine & Toxicology Vol. 15 No. 3 (2021): Indian Journal of Forensic Medicine & Toxicology
Publisher : Institute of Medico-legal Publications Pvt Ltd

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37506/ijfmt.v15i3.15737

Abstract

This study aims to identify Leptospira bacterial infection in livestock owners and their livestock, as well as to examine potential risk factors correlated with the incidence. 50 participants were selected and their blood samples were collected. 50 urine samples were collected from livestock owned by the participants. Polymerase Chain Reaction (PCR) was used to identify the existence of the Leptospira bacteria. The questionnaire instrument was used to obtain information about individual characteristics and hygiene. The Chi-Squared test was adopted to examine the correlation between outcome and explanatory variables. The confirmation PCR test detected the bacterial DNA in 2 out of 50 blood samples examined (4%) and 3 out of 50 urine samples examined (6%). Human leptospirosis incidence is significantly correlated with occupation type (p=0.035), personal protective equipment (PPE) use (p=0.044), water puddle contact (p=0.044), cage sanitation (p=0.044) and Leptospira bacteria presence in livestock urine (p=0.007). Insignificant correlation was showed in owners’ age variable. The presence of Leptospira bacteria both in livestock and the owners indicates the real threat of animal to human transmission. Further study with larger sample size and wider range variables and meticulous examination technique is required to comprehend the investigation.
Optimalisasi Pengetahuan Tentang Menstruasi Pada Siswa Putri Kelas 5 dan 6 SDN Janti 1 Waru Sidoarjo Dengan Pendekatan PAR Mei lina Fitri Kumalasari; Nova Lusiana; Estri Kusumawati; Dedy Suprayogi; Moch. Irfan Hadi
Nusantara Journal of Community Engagement Vol. 1 No. 1 (2020): MARET
Publisher : Lembaga Penelitian dan Pengabdian (LP2M) Sekolah Tinggi Agama Islam Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.2020/njce.v1i1.3664

Abstract

Anak perempuan yang mengalami menarche (menstruasi pertama) pada usia yang muda merasa belum siap untuk menghadapi menstruasi pertamanya sehingga dapat menimbulkan dampak takut, bingung, minder, merasa tidak normal dan panik. Pengabdian masyarakat ini bertujuan untuk optimalisasi pengetahuan tentang menstruasi pada siswa putri kelas 5 dan 6 di SDN Janti 1. Metode kegiatan yang dilakukan adalah dengan pendekatan PAR. Didapatkan hasil bahwa dari 89 siswa putri, terdapat 40 siswa putri (44,94%) yang sudah mendapatkan menstruasi. Siswa putri tersebut mengalami menarche pada usia 10 sampai dengan 12 tahun. Terdapat 22 siswa putri (55%) yang mengalami dismenorea dan belum mengetahui apa yang harus dilakukan apabila mengalami keluhan tersebut. Materi diberikan dengan media powerpoint dan video. Siswa putri kelas 5 dan 6 SDN Janti 1 aktif dalam kegiatan dengan memberikan pertanyaan-pertanyaan dan saling berbagi pengalaman.
Analisis Kadar Glukosa, Hemoglobin, dan Kolesterol Mencit (Mus Musculus) Setelah Diinduksi Aspartam Esti Tyastirin; Risa Purnamasari; Irul Hidayati; Eva Agustina; Moch. Irfan Hadi; Nova Lusiana; Mei Lina Fitri Kumalasari
Biotropic : The Journal of Tropical Biology Vol. 2 No. 2 (2018): Biotropic, Volume 2, Nomor 2, 2018
Publisher : Program Studi Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (582.901 KB) | DOI: 10.29080/biotropic.2018.2.2.119-125

Abstract

Aspartame has a lower calorie rating than other sweeteners. for example, cyclamate, lactose, saccharin, fructose and maltosa. Although it has low calorie, aspartame have 60 times sweeter than sugar (sucrose). Induction of aspartame can cause elevated levels of blood glucose and damage to the pancreatic β cells of mice. The purpose of this study was to analyze the dosing of aspartame levels; 13 mg/Kg body weight, 39 mg/Kg and 78 mg/Kg and those effect to the levels of glucose, cholesterol and haemoglobin of female mice (Mus musculus). The methode of research laboratory experiments using a complete randomized design (RAL). This study was using 24 mice with 4 treatment groups. Mice were given aspartame during surgical treatment, mice were made to perform measurement of Hb levels, glucose levels and cholesterol levels of neonatal mice. Data analysis using the Kruskal Wallis because Gaussian data but not homogeneous. The results showed an increase in the levels of glucose and cholesterol levels, but statistically there is no difference in glucose levels (p = 0,087), Hb (p = 0,899) and cholesterol (p = 0,168) in mice (Mus musculus) who were given variations of the dose of aspartame.
Identifikasi Senyawa Aktif dari Ekstrak Daun Jambu Air (Syzygium aqueum) dengan Perbandingan Beberapa Pelarut pada Metode Maserasi Eva Agustina; Funsu Andiarna; Nova Lusiana; Risa Purnamasari; Moch. Irfan Hadi
Biotropic : The Journal of Tropical Biology Vol. 2 No. 2 (2018): Biotropic, Volume 2, Nomor 2, 2018
Publisher : Program Studi Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (610.742 KB) | DOI: 10.29080/biotropic.2018.2.2.108-118

Abstract

Daun jambu air (Syzygium aqueum) dikenal sebagai salah satu obat tradisional, untuk menyembuhkan beberapa infeksi akibat antigen berupa bakteri. Penelitian ini bertujuan untuk mengetahui kandungan senyawa aktif yang terdapat dalam daun jambu air dengan beberapa pelarut pada proses maserasi. Metode ekstraksi yang digunakan dalam penelitian ini adalah ekstraksi dingin berupa maserasi dengan pemilihan pelarut yakni metanol (CH3OH), etil asetat dan n-heksana. Uji fitokimia yang dilakukan adalah uji saponin, flavonoid, alkaloid dan triterpenoid/steroid. Dari uji yang dilakukan diketahui sampel ekstrak daun jambu air dengan pelarut metanol positif mengandung beberapa senyawa aktif berupa flavonoid, saponin, alkaloid dan triterpenoid. Ekstrak daun jambu air dengan pelarut etil asetat dan n-heksana positif mengandung beberapa senyawa aktif berupa flavonoid, alkaloid dan triterpenoid. Pelarut yang paling bagus untuk mendapatkan banyak senyawa aktif adalah metanol. Kata kunci : Jambu air (Syzygium aqueum), maserasi, senyawa aktif
Dogs (Canis lupus familiaris) as Virus Carrier in Indonesia Moch Irfan Hadi; Muhammad Yusuf Alamudi; Mei Lina Fitri Kumalasari; Sri Hidayati; Tatag Bagus Prakarsa; Eva Agustina; Muhamad Ratodi; Misbakhul Munir; Eko Teguh Pribadi; Hanik Faizah
Biotropic : The Journal of Tropical Biology Vol. 2 No. 2 (2018): Biotropic, Volume 2, Nomor 2, 2018
Publisher : Program Studi Biologi, Fakultas Sains dan Teknologi, Universitas Islam Negeri Sunan Ampel Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (579.994 KB) | DOI: 10.29080/biotropic.2018.2.2.100-107

Abstract

A Virus is an individual that cannot be described as an animal or a plant. If animals and plants contain two nucleic acids (DNA and RNA), on the contrary, the virus only has one of them. These nucleic acids can stimulate a complete virus replication cycle. The virus can only replicate and live on a living host if the host is finally dead, then the virus will move on the cells that are still alive. The virus has genetic material which is a protective protein coat called a capsid. Viruses can infect various varieties of organisms, both eukaryotes (animals, plants, protists, and fungi) and prokaryotes (bacteria and archaea). The Virus infects bacteria known as bacteriophage (phage). The Virus can cause serious diseases for humans such as AIDS, HIV, rabies, etc. Dogs belonging to Canidae family are the sibling of wolves, foxes and raccoon dogs. Among all members of Canidae, dogs have the most closely related to wolves which are the ancestors of dogs. The Canidae family generally has a small elongated body, sharp ear and muzzle, sharp smelling, can run fast and can swim. Dogs are human best friends. While taking care of the dogs, they can be attacked by various diseases. The closeness of the relationship between humans and dogs raises the potential for disease transmission, especially zoonosis and pandemics viruses. Keywords: Canis lupus familiaris, Carier, Influenza, virus
Co-Authors Abdul Azis Adiningsih, Setyo Aditya Sukma Pawitra Aditya Sukma Prawira Agung, Tri Sunan AGUSTINA, EVA Albarkah, M. Rafly ANDYARINI, ESTI NOVI Annisa Inda Sanabila Asri Sawiji Atiqoh Zummah Ayudya Fitri Arifa Choiriyah, S.Si, Chumaidatul Corie Indria Prasasti Dedi Ananta Purba Dedy Suprayogi Dian Tugu Warsito Taufiq Eko Teguh Pribadi Esti Tyastirin Estri Kusumawati Eva Agustina Eva Agustina, Eva Evi Iriani Natalia Faizah, Hanik Fatih, M. Fachrul Funsu Andiarna Hanik Faizah Ika Mustika Irul Hidayati Izza Mahendra Kartika Dewi Kartika Dewi Khuliyah Candraning Diyanah Linggar Dwi Kinasih M Yusuf Alamudi M. Chusnan Ma'arif M. Yusuf Alamudi Ma’arif, M. Chusnan Mei lina Fitri Kumalasari Mei Lina Fitri Kumalasari Mei Lina Fitri Kumalasari Mei Lina Fitri Kumalasari Mei Lina Fitri Kumalasari Mei Lina Fitri Kumalasari Mirna Widiyanti Mirna Widiyanti Mirna Widiyanti Mirna Widiyanti MISBAKHUL MUNIR Misbakhul Munir Misbakhul Munir Muhamad Ratodi Muhammad F. Musyaffa Muhammad Falikhul Musyaffa' Muhammad Yusuf Alamudi Muhammad Yusuf Alamudi Muhammad Yusuf Alamudi Muhammad Yusuf Alamudi Muhid , Abdul Nadlir Nadlir Nadlir Nadlir, Nadlir Nanang Supriatna Natalia, Evi Iriani Nirmala Fitria Firdhausi Nova Lusiana Nugraha, Dimas Putra Wahyu Nur Maulida Safitri Nusa, Raras Widya Puji Maryono Purba, Dedi Ananta Putra, Riswanda Rangga Risa Purnamasari Rizqiyah, Ziadatur Robayanto Robayanto Sanabila, Annisa Inda Setyo Adiningsih Setyo Adiningsih Sigit Ari Saputro Soedjajadi Keman Sri Hidayati Sri Hidayati Suhardi, Haidar Rafli Putra Syahrul Afifa Ratna Sari Tatag Bagus Prakarsa Teguh Taruna Utama Violando, Wiga Alif Widia Purnamasari Yuanita Rachmawati Yudied Agung Mirasa