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All Journal Majalah Kedokteran Bandung Media Dermato-Venereologica Indonesiana
Pangastuti, Miranti
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Health Professions Medicine & Pharmacology

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Keberhasilan Terapi Kombinasi Menggunakan Metotreksat Injeksi dan Siklosporin pada Psoriasis Pustulosa Generalisata Suwarsa, Oki; Devi Nursjamsi, Nadilla Carissa; Pangastuti, Miranti; Sutedja, Endang; Dharmadji, Hartati Purbo
Majalah Kedokteran Bandung Vol 49, No 3 (2017)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1846.617 KB) | DOI: 10.15395/mkb.v49n3.1123

Abstract

Psoriasis pustulosa generalisata (PPG) adalah bentuk khusus dari psoriasis yang bersifat akut dan berat. Etiologi yang belum diketahui secara pasti menyebabkan pengobatan PPG masih menjadi suatu tantangan. Terapi kombinasi dapat diberikan pada PPG yang berat maupun yang tidak memberikan respons terhadap terapi sistemik tunggal, selain itu terapi kombinasi juga dapat meningkatkan efektivitas dari obat tunggal. Dilaporkan satu kasus PPG pada seorang wanita yang diterapi dengan menggunakan kombinasi metotreksat (MTX)  injeksi dan siklosporin. Dari anamnesis dan pemeriksaan fisis didapatkan pustula berkelompok pada dasar makula eritem yang bergabung membentuk lake of pus, disertai gejala sistemik demam dan leukositosis. Keluhan tersebut sudah berulang sejak 13 tahun yang lalu. Pasien diberikan terapi kombinasi injeksi MTX dan siklosporin. Pustula pada pasien menghilang setelah tujuh hari pemberian obat. Terapi kombinasi dengan MTX injeksi dan siklosporin ini baru pertama kali dilakukan 19 Mei–26 Mei 2017 di Departemen Ilmu Kesehatan Kulit dan Kelamin Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Umum Pusat Dr. Hasan Sadikin Bandung dan memberikan hasil yang baik. [MKB. 2017;49(3):208–12]Kata kunci: Metotreksat, metotreksat injeksi, psoriasis pustulosa generalisata, siklosporin Succesful Treatment of Generalized Pustular Psoriasis with a Combination of Methotrexate Injection and CyclosporineGeneralized pustular psoriasis (GPP) is a special form of acute and severe psoriasis. The definite etiology of GPP remains a challenge. Combination therapy may be given to severe GPP or GPP that does not respond to a single systemic therapy sincecombination therapy may also improve the effectiveness of a monotherapy drug. A GPP case was reported in a woman treated with a combination of methotrexate (MTX) and cyclosporine. From anamnesis and physical examination it was revealed that there were clustered  pustules on the base of erythematous macules that form a lake of pus accompanied by systemic symptoms of fever and leukocytosis. This was a recurrent complaint since 13 years ago. Patients were given combination therapy of MTX injection and cyclosporine. Pustules disappeared after seven days of drug administration. This case was the first combination therapy with MTX injection and cyclosporine used during the period of 19 May to 26 May 2017 at the Department of Dermatology and Venereology Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital Bandung, resulting in good results. [MKB. 2017;49(3):208–12]Key words: Cyclosporine, generalized pustular psoriasis, methotrexate, methotrexate injection
Clinical Features of Drug Eruption in An Indonesian Tertiary Hospital Rohmawaty, Enny; Devani, Mochamad; Pangastuti, Miranti
Majalah Kedokteran Bandung Vol 57, No 1 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3839

Abstract

Drug eruption is a response to drugs undergoing sensitization, which is mediated by the immune system. Clinical features of drug eruptions, such as maculopapular drug eruption, Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS), are known as common drug reactions. This study aimed to explore the characteristics and clinical features of patients with drug eruptions at the Department of Dermatology and Venereology of Dr. Hasan Sadikin General Hospital, Bandung, Indonesia. This retrospective descriptive study used data from the department  from patients treated between January 1, 2014 and December 31, 2018. Data were analyzed using Excel and SPSS software. In this study, 200 subjects were included, mainly consisting of female subjects (50.5%) and aged between 19 and 65 (89%). Maculopapular drug eruption (45%) was the most typical clinical presentation, followed by SJS/TEN (37.5%), and DRESS (3%). The analgesics and non-steroidal anti-inflammatory drugs (NSAID) group was the most commonly suspected causative drug (36.91%), with paracetamol (29.18% of total drugs consumed) as the most frequent NSAID causing the eruption. This was followed by the antibiotic-type drugs group (36.48%), with cotrimoxazole (9.87% of total drugs consumed) as the most common one. So, maculopapular drug eruption is the most common clinical presentation of drug eruption, with analgesics and non-steroidal anti-inflammatory drugs (NSAID) class as the most suspected causative drug. Further investigations are needed to get the accurate result.
PREVALENCE AND CHARACTERISTICS OF PITYRIASIS VERSICOLOR RSUP DR. HASAN SADIKIN BANDUNG, PERIOD 2018–2022 Dinantha, Ahmad Zaky; Hidayah, Risa Miliawati Nurul; Fauziah, Nisa; ., Chrysanti; Pangastuti, Miranti
Media Dermato-Venereologica Indonesiana Vol 52 No 3 (2025): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v52i3.480

Abstract

Pendahuluan: Pitiriasis versikolor (PV) merupakan infeksi jamur superfisial yang disebabkan Malassezia spp. yang mengakibatkan perubahan warna kulit, sehingga menurunkan kualitas hidup pasien. Prevalensi PV di Indonesia masih belum pasti. Tujuan penelitian ini untuk mengetahui prevalensi dan karakteristik PV di salah satu rumah sakit rujukan tersier Jawa Barat. Metode: Penelitian ini dilakukan dengan metode deskriptif observasional retrospektif. Data berupa rekam medis pasien PV rawat jalan dan rawat inap di RSUP Dr. Hasan Sadikin, Bandung, periode 2018–2022. Hasil: Pada penelitian ini, didapatkan 47 pasien PV dari 386 pasien dermatomikosis. Pasien PV terbanyak pada kelompok usia 19–44 tahun, yaitu sebanyak 23 (48,9%); terdiri dari laki-laki 31 (66%) dan perempuan 16 (34%) orang. Lesi hipopigmentasi merupakan gejala terbanyak yang ditemukan pada 20 (42,3%) pasien. Badan dan ekstremitas merupakan lokasi terbanyak ditemukannya lesi, yaitu pada 12 (25,5%) pasien. Komorbid ditemukan pada 35 (74,5%) pasien. Tercatat 30 (63,8%) pasien tidak kontrol setelah pemeriksaan dan pemberian obat, serta ditemukan data yang tidak lengkap pada rekam medis. Kesimpulan: Kasus PV masih dapat ditemukan di fasilitas kesehatan tersier, kemungkinan karena terdiagnosis saat melakukan pemeriksaan untuk penyakit lainnya. Mayoritas pasien tidak kembali kontrol karena penyakit ini bersifat asimtomatis dan tidak dirasakan mengganggu 
Co-Authors ., Chrysanti Devani, Mochamad Devi Nursjamsi, Nadilla Carissa Dinantha, Ahmad Zaky Endang Sutedja Enny Rohmawaty Fauziah, Nisa Hartati Purbo Dharmadji, Hartati Purbo Hidayah, Risa Miliawati Nurul Oki Suwarsa